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| 1 | Effect of preoperative immunonutrition and other nutrition models on cellular immune parameters显示文摘AIM:To evaluate the effects of preoperative immunonutrition and other nutrition models on the cellular immunity parameters of patients with gastrointestinal tumors before surgical intervention.In addition,effects on postoperative complications were examined. METHODS:Patients with gastrointestinal tumors were randomized into 3 groups.The immunonutrition group received a combination of arginine,fatty acids and nucleotides.The second and third group received normal nutrition and standard enteral nutrition,respectively.Nutrition protocols were administered for 7 d prior to the operation.Nutritional parameters,in particular prealbumin levels and lymphocyte subpopulations(CD4+,CD8+,CD16+/56+,and CD69 cells)were evaluated before and after the nutrition protocols.Groups were compared in terms of postoperative complications and duration of hospital stay. RESULTS:Of the 42 patients who completed thestudy,16 received immunonutrition,13 received normal nutrition and 13 received standard enteral nutrition. prealbumin values were low in every group,but this parameter was improved after the nutritional protocol only in the immunonutrition group(13.64±8.83 vs 15.98±8.66,P=0.037).Groups were similar in terms of CD4+,CD16+/56,and CD69+prior to the nutritional protocol;whereas CD8+was higher in the standard nutrition group compared to the immunonutrition group.After nutritional protocols,none of the groups had an increase in their lymphocyte subpopulations.Also,groups did not differ in terms of postoperative complications and postoperative durations of hospital stay. CONCLUSION:Preoperative immunonutrition provided a significant increase in prealbumin levels,while it did not significantly alter T lymphocyte subpopulation counts,the rate of postoperative complications and the duration of hospital stay. | Yusuf Gunerhan Neset Koksal Umit Yasar Sahin Mehmet Ali Uzun Emel Ek■ioglu-Demiralp | 2009 | World Journal of Gastroenterology2009，15，4： | 21 |
| 2 | Clinical probability and risk analysis of patients with suspected pulmonary embolism显示文摘BACKGROUND: Pulmonary embolism(PE) is one of the most frequent diseases that could be missed in overcrowded emergency departments as in Turkey. Early and accurate diagnosis could decrease the mortality rate and this standard algorithm should be defi ned. This study is to fi nd the accurate, fast, non-invasive, cost-effective, easy-to-access diagnostic tests, clinical scoring systems and the patients who should be tested for clinical diagnosis of PE in emergency department.METHODS: One hundred and forty patients admitted to the emergency department with the fi nal diagnosis of PE regarding to anamnesis, physical examination and risk factors, were included in this prospective, cross-sectional study. The patients with a diagnosis of pulmonary embolism, acute coronary syndrome or infection and chronic obstructive pulmonary disease(COPD) were excluded from the study. The demographics, risk factors, radiological fi ndings, vital signs, symptoms, physicallaboratory fi ndings, diagnostic tests and clinical scoring systems of patients(Wells and Geneva) were noted. The diagnostic criteria for pulmonary emboli were: fi lling defect in the pulmonary artery lumen on spiral computed tomographic angiography and perfusion defect on perfusion scintigraphy.RESULTS: Totally, 90(64%) of the patients had PE. Age, hypotension, having deep vein thrombosis were the risk factors, and oxygen saturation, shock index, BNP, troponin and fi brinogen levels as for the biochemical parameters were signifi cantly different between the PE(+) and PE(–) groups(P<0.05).The Wells scoring system was more successful than the other scoring systems.CONCLUSION: Biochemical parameters, clinical findings, and scoring systems, when used altogether, can contribute to the diagnosis of PE. | Gulden Ozeren Yetgin Sule Akkose Aydin Ozlem Koksal Fatma Ozdemir Dilek Kostak Mert Gokhan Torun | 2014 | World Journal of Emergency Medicine2014，5，4： | 20 |
| 3 | Possible association of the 5-HTTLPR serotonin transporter promoter gene polymorphism with premature ejaculation in a Turkish population显示文摘我们与早泄(PE ) 在病人评估了血清素 transporter 基因(5-HTT ) 的遗传型在 PE 并且可能的 etiopathogenesis 决定基因因素的角色识别耐心的亚群。70 个 PE 病人和 70 控制的一个总数在这研究被包括。所有人是异性爱的,没有另外的混乱并且是结婚的任何一个或在一种稳定的关系中。PE 被定义为射精发生在阴道插入的 1 min 以内。从病人和控制的 Genomic DNA 用血清素 transporter 基因(5-HTTLPR ) 的倡导者区域的聚合酶链反应,和突变而产生之遗传的变化被分析被决定。5-HTTLPR (血清素 transporter 倡导者基因) 在 PE 病人对控制的遗传型如下被散布:L/L 16% 对 17% , L/S 30% 对 53% 并且 S/S 54% 对 28% 。我们为 5-HTTLPR 基因的三多型性检验了 haplotype 分析:LL, LS 和 SS。在 5-HTTLPR 基因的等位基因频率的适当被 Hardy-Weinberg 平衡用 2 测试分析。5-HTTLPR 基因的短(S) 等位基因是显著地在 PE 病人更经常比在控制(P < 0.05 ) 。我们建议 5-HTTLPR 基因在所有主要 PE 盒子的 pathophysiology 起一个作用。进一步的研究被需要评估在 5-HTTLPR 基因多型性和耐心的亚群之间的关系(例如主要、第二等的 PE ) 对选择血清素举起禁止者以及种族差别的回答。 | Emin Ozbek Ali I. Tasci Volkan Tugcu Yusuf O. Ilbey Abdulmuttalip Simsek Levent Ozcan Emre C. Polat Vedat Koksal | 2009 | Asian Journal of Andrology2009，11，3： | 19 |
| 4 | 精索静脉曲张导致的睾丸功能障碍发病机理中TNF相关的调亡诱导配体的角色显示文摘不育男性中频发的精索静脉曲张备受关注,面向治疗的分子水平的研究也随之增加。本研究的目的是探讨大鼠模型中肿瘤坏死因子相关凋亡诱导配体(TRAIL)及其受体在精索静脉曲张起的睾丸功能障碍中的作用。大鼠被随机分为三组:对照组,假手术组和精索静脉曲张组。部分结扎左肾静脉与左睾丸构建大鼠精索静脉曲张模型。对手术13周后的大鼠进行分析。睾丸细胞内DNA片段程度用末端脱氧核苷酸转移酶的脱氧尿苷三磷酸缺口未端标记法(TUNEL)检测。用约翰逊得分评估肾小管退化情况。用免疫组化和Westernblot技术检测TRAIL及其受体的表达。检测了细胞凋亡指数,约翰逊得分,TRAIL和TRAIL受体的表达。数据以平均值±标准偏差(s.d.)表示,并用计算机软件进行了分析。用Kruskal—Wallis和Dunn’s多重比较试验进行数捌分析。与假手术组和对照组相比,精索静脉曲张的大鼠生殖细胞凋亡指数增加(P=0.0031),约翰逊得分显著下降(P〈0.0001)。免疫组化和Western blot分析表明,精索静脉曲张后,生殖细胞中的TRAIL-R1和TRAIL—R4的表达增加,TRAIL—R2的表达下降。在TRAIL和TRAIL—R3受体的表达上,各组间没有显著差异。这一研究结果表明,TRAIL及其受体可能神精索静脉曲张引起的罩丸功能障碍的发病机制中有潜在的作用。 | Orcun Celik Omer Kutlu Merih Tekcan CUer Celik-Ozenci Ismail T Koksal | 2013 | Asian Journal of Andrology2013，15，2： | 12 |
| 5 | Association of CagA and VacA presence with ulcer and non-ulcer dyspepsia in a Turkish population显示文摘AIM: The mostly known genotypic virulence features, of H. pyloriare cytotoxin associated gene A (ragA) and Vacuolating cytotoxin gene A (VacA). We investigated the association of these major virulence factors with ulcer and non-ulcer dyspepsia in our region.METHODS: One hundred and forty two dyspeptic patients were studied (average age 44.8±15.9 years, range 15-87years, 64 males and 78 females). Antral and corpus biopsies were taken for detecting and genotyping of H. pylori. 107patients who were H. pylori positive by histological assessment were divided into three groups according to endoscopic findings: Duodenal ulcer (DU), gastric ulcer (GU)and non-ulcer dyspepsia (NUD). The polymerase chain reaction (PCR) was used to detect CagA and VacA genes of H.pylori using specific primers.RESULTS: H.pyloriwas isolated from 75.4 % (107/142) of the patients. Of the 107 patients, 66 (61.7 %) were cagApositive and 82 (76.6 %) were Vacl-positive. CagA gene was positively associated with DU and GU (P<0.01, P<0.02),but not with NUD (P>0.05). Although VacA positivity in ulcer patients was higher than that in NUD group, the difference was not statistically significant (P>0.05).CONCLUSION: There is a significantly positive association between CagA genes and DU and GU. The presence of VacA is not a predictive marker for DU, GU, and NUD in our patients. | Kantarceken Bulent Aladag Murat Atik Esin Koksal Fatih Harputluoglu MMMurat Harputluoglu Hakan Karincaoglu Melih Ares Mehmet Yildirim Bulent Hilmioglu Fatih | 2003 | World Journal of Gastroenterology2003，9，7： | 8 |
| 6 | Gorenstein dimensions of unbounded complexes and change of base (with an appendix by Driss Bennis)显示文摘For a commutative ring R and a faithfully flat R-algebra S we prove,under mild extra assumptions,that an R-module M is Gorenstein flat if and only if the left S-module S?_R M is Gorenstein flat,and that an R-module N is Gorenstein injective if and only if it is cotorsion and the left S-module Hom R(S,N)is Gorenstein injective.We apply these results to the study of Gorenstein homological dimensions of unbounded complexes.In particular,we prove two theorems on stability of these dimensions under faithfully flat (co-)base change. | CHRISTENSEN Lars Winthe KOKSAL Fatih LIANG Li | 2017 | Science China Mathematics2017，60，3： | 5 |
| 7 | General characteristics of patients with electrolyte imbalance admitted to emergency department显示文摘BACKGROUND:Fluid and electrolyte balance is a key concept to understand for maintaining homeostasis,and for a successful treatment of many metabolic disorders.There are various regulating mechanisms for the equilibrium of electrolytes in organisms.Disorders of these mechanisms result in electrolyte imbalances that may be life-threatening clinical conditions.In this study we defined the electrolyte imbalance characteristics of patients admitted to our emergency department.METHODS:This study was conducted in the Emergency Department(ED) of Uludag University Faculty of Medicine,and included 996 patients over 18 years of age.All patients had electrolyte imbalance,with various etiologies other than traumatic origin.Demographic and clinical parameters were collected after obtaining informed consent from the patients.The ethical committee of the university approved this study.RESULTS:The mean age of the patients was 59.28±16.79,and 55%of the patients were male.The common symptoms of the patients were dyspnea(14.7%),fever(13.7%),and systemic deterioration(11.9%);but the most and least frequent electrolyte imbalances were hyponatremia and hypermagnesemia,respectively.Most frequent findings in physical examination were confusion(14%),edema(10%) and rales(9%);and most frequent pathological findings in ECG were tachycardia in24%,and atrial fibrillation in 7%of the patients.Most frequent comorbidity was malignancy(39%).Most frequent diagnoses in the patients were sepsis(11%),pneumonia(9%),and acute renal failure(7%).CONCLUSIONS:Electrolyte imbalances are of particular importance in the treatment of ED patients.Therefore,ED physicians must be acknowledged of their fluid-electrolyte balance dynamics and general characteristics. | Arif Kadri Balci Ozlem Koksal Ataman Kose Erol Armagan Fatma Ozdemir Taylan Inal Nuran Oner | 2013 | World Journal of Emergency Medicine2013，4，2： | 3 |
| 8 | Diagnostic value of plasminogen activity level in acute mesenteric ischemia显示文摘AIM: To investigate the changes in plasminogen activity level during mesenteric ischemia. METHODS: We performed laparotomy in 90 female Wistar-Albino rats (average weight 230 g). In sham groups (SL) (GroupsⅠand Ⅱ) the superior mesenteric artery (SMA) and vein (SMV) were explored, but not tied. In SMA groups (Groups Ⅲ and Ⅳ) the SMA was ligated, and in SMV groups (Groups Ⅴ and Ⅵ) the SMV was ligated. On re-laparatomy 2 mL of blood was drawn at 1 h in groupsⅠ, Ⅲ and Ⅴ, and at 3 h in groups Ⅱ, Ⅳ and Ⅵ. Plasminogen levels were assessed and comparisons were made between groups and within each group. RESULTS: The mean plasminogen activity in the SL group was significantly higher than SMA (25.1 ± 10.8 vs 11.8 ± 4.6, P < 0.001) or SMV (25.1 ± 10.8 vs 13.7 ± 4.4, P < 0.001) groups both at 1 h and at 3 h (29.8 ± 8.9 vs 15.1 ± 5.7, P < 0.0001; 29.8 ± 8.9 vs 14.2 ± 2.9, P < 0.0001). There were no significant differences between the values of SMA and SMV groups at 1 h (P = 0.28) and at 3 h (P = 0.71). In each group, plasminogen activity levels did not change significantly between the two measurements performed at 1 h and 3 h. CONCLUSION: We conclude that blood plasminogen activities decrease during early phases of both arterial and venous mesenteric ischemia which may be a useful marker for early diagnosis. | Yusuf Gunerhan Neset Koksal Munire Kayahan Yavuz Eryavuz Hilal Sekban | 2008 | World Journal of Gastroenterology2008，14，16： | 3 |
| 9 | Pentacam Scheimpflug成像测量晶状体密度与torsional超声乳化参数间的关系(英文)显示文摘目的:评价运用Pentacam Scheimpflug成像测量晶状体核密度与torsinal超声乳化动力学参数(如:运用于老年核性白内障患者的超声能量水平、液体留存时间及液体量)间的关系。方法:此研究为前瞻性双盲研究。瞳孔扩大后运用Pentacam Scheimpflug 成像进行测量。白内障的等级由pentacam核密度测定法[ pentacam nucleus densitometry, PND;又名Pentacam核分段( Pentacam nucleus staging, PNS)软件]自主分为1到5个等级。超声乳化术后,自动在Infiniti Ozil IP超声乳化系统监视器上计算并显示总超声( U/S)时间、累计耗散能、Torsional U/S时间以及估算液体的使用情况。组间差异运用单因素方差分析( ANOVA )进行评定,多组分析运用Tamhane测试法,PND测量的晶状体密度与torsinal超声乳化动力学参数间的关系运用Spearman相关分析进行评定。界定P〈0.05时具有统计学意义。结果:此项研究包括125例患者(125眼),平均年龄为69.7±9.4岁(范围:48~88岁),其中61例男性、64例女性。 U/S总时间、torsional U/S时间、CDE及估算液体使用情况的范围分别为0.70~158.9s,0.70~158.5s,0.11~42.65和21~98mL. PND组间数据有统计学差异。评估超声乳化动力学参数与PND数据间关系后得出PND数据与总超声时间( r=0.767; P〈0.01)、torsional超声时间(r=0.767;P〈0.01)、CDE(r=0.758; P〈0.01)及液体使用量(r=0.602;P〈0.01)均有显著相关性。结论:白内障手术前运用PND评分法获得核密度的客观程度可为超声乳化术中的参数提供可靠的预见性。因此,对每一位患者进行每一单项超声乳化参数的评估,有助于降低超声乳化能量的使用量,减少内皮细胞丢失和类固醇的使用,加速视力的恢复。 | Suleyman Demircan Mustafa Atas Murat Koksal Emine Pangal Isa Yuvaci Altan Goktas | 2014 | 国际眼科杂志2014，14，10： | 2 |
| 10 | Hardness and yield strength of dentin from simulated nano-indentation tests显示文摘 | M. Toparli N.S. Koksal | 2004 | Computer Methods and Programs in Biomedicine2004，，3： | 2 |
| 11 | ABT-450, Ritonavir, Ombitasvir, and Dasabuvir Achieves 97% and 100% Sustained Virologic Response With or Without Ribavirin in Treatment-experienced Patients with HCV Genotype 1b Infection显示文摘 | Pietro Andreone Massimo G. Colombo Jeffrey V. Enejosa Iftihar Koksal Peter Ferenci Andreas Maieron Beat Müllhaupt Yves Horsmans Ola Weiland Henk W. Reesink Lino Rodrigues Yiran B. Hu Thomas Podsadecki Barry Bernstein | 2014 | Gastroenterology2014，，： | 2 |
| 12 | Carcinosarcoma of the gallbladder: Report of a case显示文摘 | Mehmet Ali Uzun Neset Koksal Yusuf Gunerhan Atilla Celik Pembegul Gune? | 2009 | Surgery Today2009，，2： | 2 |
| 13 | Evaluation of penile hemodynamic status and adjustment of treatment alternatives in Peyronie's disease显示文摘Aim:Erectile dysfunction may be observed in up to 80%of patients with Peyronis's disease.An objective evaluation of the erectile function is attempted to work out in patients with Peyronie's disease.Methods:Penile deformity,sexual function and penile vascular status were analyzed in 123patients with Peyronis's disease,who had not received any pertinent treatment.Results:Penile edformity,palpable plaque and pain on erection were seen in112(91%),97(78.8%)and27(21.9%)of the123patients,respectively.Of the 76patients evaluated by color Doppler ultrasounography,veno-occlusive dysfunction as the vascular component for erectile dysfunction was found in 17(22.3%),arterial insufficiency in10(13.1%)and a mixed picture in 23(30.2%).Conclusion:The documentation of penile erectile function and the determination of the vascular status using color Doppler ultrasonography can guide the appropriate therapeutic choice. | Tibet Erdogru Murat Savas Namik Yilmaz Mustafa Faruk Usta Turker Koksal Mutlu Ates Mehmet Baykara | 2002 | Asian Journal of Andrology2002，4，3： | 2 |
| 14 | Annual cycles of solar insolation predict spawning times of Caribbean corals 显示文摘 | WOESIK R VAN LACHARMOISE F KOKSAL S | 2006 | Ecology Letters2006，9，： | 1 |
| 15 | Business failures in the construction industry 显示文摘 | Arditi D Koksal A Kale S | 2000 | Engineering Construction and Architectural Management2000，7，2： | 1 |
| 16 | Thoracofemoral bypass for treatment of juxtarenal aortic occlusion显示文摘 | Koksal C Sarikaya S Zengin M | 2002 | Asian Cardiovasc Thorac Ann2002，10，2： | 1 |
| 17 | Isolated splenic vein thrombosis:an unusual cause and review of the literature显示文摘 | Koklu S Koksal A Yolcu OF | 2004 | Can J Gastroenterol2004，18，3： | 1 |
| 18 | Multicasting for all-optical muhifiber networks显示文摘 | KOKSAL F ERSOY C | 2007 | Journal of Optical Networking2007，6，2： | 1 |
| 19 | Thoracofemoral bypass for treatment of juxtarenal aortic occlusion显示文摘 | Koksal C Sarikaya S Zengin M | 2002 | Asian Cardiovasc Thorac Ann2002，10，2： | 1 |
| 20 | An input/output model for business failures in the construction industry 显示文摘 | Koksal A Arditi D | 2004 | Journal of Construction Research2004，5，1： | 1 |
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