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| 1 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 2 | Femtojoule electro-optic modulation using a silicon– organic hybrid device显示文摘Energy-efficient electro-optic modulators are at the heart of short-reach optical interconnects,and silicon photonics is considered the leading technology for realizing such devices.However,the performance of all-silicon devices is limited by intrinsic material properties.In particular,the absence of linear electro-optic effects in silicon renders the integration of energy-efficient photonic–electronic interfaces challenging.Silicon–organic hybrid(SOH)integration can overcome these limitations by combining nanophotonic silicon waveguides with organic cladding materials,thereby offering the prospect of designing optical properties by molecular engineering.In this paper,we demonstrate an SOH Mach–Zehnder modulator with unprecedented efficiency:the 1-mm-long device consumes only 0.7 fJ bit^(-1) to generate a 12.5 Gbit s^(-1) data stream with a bit-error ratio below the threshold for hard-decision forward-error correction.This power consumption represents the lowest value demonstrated for a non-resonant Mach–Zehnder modulator in any material system.It is enabled by a novel class of organic electro-optic materials that are designed for high chromophore density and enhanced molecular orientation.The device features an electro-optic coefficient of r33<180 pm V^(-1) and can be operated at data rates of up to 40 Gbit s^(-1). | Sebastian Koeber Robert Palmer Matthias Lauermann Wolfgang Heni Delwin L Elder Dietmar Korn Markus Woessner Luca Alloatti Swen Koenig Philipp C Schindler Hui Yu Wim Bogaerts Larry R Dalton Wolfgang Freude Juerg Leuthold Christian Koos | 2015 | Light(Science & Applications)2015，4，1： | 4 |
| 3 | Effect of simulated gastric fluid and bile on survival of Vibrio vulnificus andVibrio vulnificus phage 显示文摘 | Koo J DePaola A Marshall D L | 2000 | J Food Prot2000，63，12： | 1 |
| 4 | Carcinogens in the indoor air of Hong Kong homes:levels, sources, and ventilation effects on 7 polunuclear aromatic hydrocarbons 显示文摘 | Koo L C Matsushita H Ho JH - C | 1994 | Environ Technol1994，15，： | 1 |
| 5 | Endothelial cell protection against ischemia/reperfusion injury by lecithinized superoxide dismutase显示文摘 | Koo D D Welsh K L West N E | 2001 | Kidney International2001，60，： | 1 |
| 6 | Effect of levetiracetam monotherapy on background EEG activity and cognition in drug-naive epilepsy pa- tients显示文摘 | Cho J R Koo D L Joo E Y | 2012 | Clin Neurophysiol2012，123，5： | 1 |
| 7 | Pharmacological effects of green tea on the gastrointestinal system 显示文摘 | Marcel W L Koo Chi H | 2004 | European Journal of Pharmacology2004，500，： | 1 |
| 8 | Effects of compounds found in propolis on streptococcus mutans growth and on glucosyltransferase activity显示文摘 | KOO H ROSALEN P L CURY J A | 2003 | Antimicrobila a Gents and Chemotherapy2003，46，5： | 1 |
| 9 | Gender differences in etiology and outcome of open globe injuries显示文摘 | Koo L Kapadia MK Sing RP | 2005 | J Trauma2005，59，1： | 1 |
| 10 | Detection of L isteria monocytogenes from a model food by fluorescence resonance energy trunsferbased PCR with an asymmetric fluorogenic probe set显示文摘 | KOO K JAYKUS L A | 2003 | App 1 Environ Microbiol2003，69，2： | 1 |
| 11 | Origin of the D peak in the Raman spectrum of microcrystalline graphite显示文摘 | Hundhausen M Koos M Ley L | 1998 | Journal of Non-crystalline Solids1998，230，： | 1 |
| 12 | Phenolic and furan type eompounds isolated from Gastrodia elata and their anti-platelet effects显示文摘 | Pyo M K Jin J L Koo Y K | 2004 | Arch Pharm Res2004，27，4： | 1 |
| 13 | Pharmacological effects of green tea on the gast rointestinal system 显示文摘 | Marcel W L Koo Chi 14 | 2004 | European Journal of Pharmacology2004，500，： | 1 |
| 14 | Tumor-targeting peptide conjugated pH-responsive micelles as a potential drug carrier for cancer therapy显示文摘 | WU X L KIM J H KOO H | 2010 | Bioconjug Chem2010，21，2： | 1 |
| 15 | Pharmacological effects of green tea on the gast rointestial system显示文摘 | Marcel W L Koo Chi H | 2004 | European Journal of Pharmacology2004，500，： | 1 |
| 16 | A Study of Visibility Trends in Hong Kong显示文摘 | CHANG W L KOO E H | 1986 | Atmospheric Environment1986，20，10： | 1 |
| 17 | The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism 显示文摘 | Koo S H Flechner L Qi L | 2005 | Nature2005，437，7062： | 1 |
| 18 | Examination of a novel,specified local antibiotic therapy through polymethylmethacrylate capsules in a rabbit osteomyelitis model显示文摘 | Borzsei L Mintal T Koos Z | 2006 | Chemotherapy2006，52，2： | 1 |
| 19 | Microwave-assisted separation of ionic liquids from aqueous solution of ionic liquids显示文摘 | Sung H H Ngoc L M Y M Koo | 2010 | Joumal of Chromatography A2010，1217，： | 1 |
| 20 | A structured SWOT approach to develop strategies for the government of Macau, SAR显示文摘 | KOO H CHAU K Y KOO L C | 2011 | Journal of Strategy and Management2011，4，1： | 1 |
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