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| 1 | 美国国家卒中协会短暂性脑缺血发作处理指南显示文摘目的:短暂性脑缺血发作(TIA)是常见和重要的卒中先兆。其处理方法多样,大多数发表的指南在近年来均未被更新。我们试图制定一个全面的、无偏倚的、循证的TIA处理指南。方法:根据一种客观标准(可以预测在该研究领域中执业医师对专家提名的文献测量学方法)挑选出15名专家组成员。通过系统回顾检索到过去发表的指南,由专家对其中的推荐意见的质量进行独立评价。选择出质量最高的推荐意见,然后让专家组采用改良Delphi法通过多次问卷调查的方式进行修订,从而对新的修改达成共识。给专家们提供近期临床研究的系统评价,要求专家根据新的证据判断措辞修改的合理性并且根据证据等级和质量对最终的推荐意见进行评定。不允许专家在预期有可能存在任何利益冲突的专题方面提出推荐意见。结果:通过系统回顾检索到257个指南,其中有13篇文献包括的137条推荐意见符合所有纳入标准。需要6次重复的问卷调查对53条最终推荐意见的措辞达成共识。最终的推荐意见涉及TIA的初步处理、评价、内科治疗、外科治疗和危险因素控制。结论:对TIA患者医疗诊治的最终推荐意见强调了紧急评价和治疗的重要性。这种用于制定本指南的新方法是可行的,考虑到了快速更新并能减少偏倚。 | S. Claiborne Johnston Mai N. Nguyen-Huynh Miriam E. Schwarz Kate Fuller Christina Williams S. Andrew Josephsort Graeme J. Hankey Robert G. Hart Steven R. Levine Jose Biller Robert D. Brown Ralph L. Sacco L. Jaap Kappelle Peter J. Koudstaal Julien Bogousslavsky Louis R. Caplan Jan van Gijn Ale Algra Peter M. Rothwell Harold P. Adams Gregory W. Albers 李海峰(译) | 2007 | 国际脑血管病杂志2007，15，3： | 5 |
| 2 | Aspirin responsive platelet thrombophilia in essential thrombocythemia and polycythemia vera显示文摘Essential thrombocythemia(ET) and polycythemia vera(PV) frequently present with erythromelalgia and acrocyanotic complications, migraine-like microvascular cerebral and ocular transient ischemic attacks(MIAs) and/or acute coronary disease. The spectrum of MIAs in ET range from poorly localized symptoms of transient unsteadiness, dysarthria and scintillating scotoma to focal symptoms of transient monocular blindness, transient mono- or hemiparesis or both. The attacks all have a sudden onset, occur sequentially rather than simultaneously, last for a few seconds to several minutes and are usually associated with a dull, pulsatile or migraine-like headache. Increased hematocrit and blood viscosity in PV patients aggravate the microvascular ischemic syndrome of thrombocythemia to major arterial and venous thrombotic complications. Phlebotomy to correct hematocrit to normal in PV significantly reduces major arterial and venous thrombotic complications, but fails to prevent the platelet-mediated erythromelalgia and MIAs. Complete long-term relief of the erythromelalgic microvascular disturbances, MIAs and major thrombosis in ET and PV patients can be obtained with low dose aspirin and platelet reduction to normal, but not with anticoagulation. Skin punch biopsies from the erythromelalgic area show fibromuscular intimal proliferation of arterioles complicated by occlusive plateletrich thrombi leading to acrocyanotic ischemia. Symptomatic ET patients with erythromelalgic microvascular disturbances have shortened platelet survival, increased platelet activation markers β-thromboglobulin(β-TG), platelet factor 4(PF4) and thrombomoduline(TM), increased urinary thromboxane B2(TXB2) excretion, and no activation of the coagulation markers thrombin fragments F1+2 and fibrin degradation products. Inhibition of platelet cyclooxygenase(COX1) by aspirin is followed by the disappearance and no recurrence of microvascular disturbances, increase in platelet number, correction of the shortened platelet survival times to normal, and reduction of increased plasma levels of β-TG, PF4, TM and urinary TXB2 excretion to normal. These results indicate that platelet-mediated fibromuscular intimal proliferation and platelet-rich thrombi in the peripheral, cerebral and coronary end-arterial microvasculature are responsible for the erythromelalgic ischemic complica-tions, MIAs and splanchnic vein thrombosis. Baseline platelet P-selectin levels and arachidonic acid induced COX1 mediated platelet activation showed a highly significant increase of platelet P-selectin expression(not seen in ADP and collagen stimulated platelets), which was significantly higher in JAK2V617 F mutated compared to JAK2 wild type ET. | Jan Jacques Michiels Fibo WJ Ten Kate Peter J Koudstaal Perry JJ Van Genderen | 2013 | World Journal of Hematology2013，2，2： | 4 |
| 3 | Silent brain infarcts: a systematic review显示文摘 | Sarah E Vermeer William T Longstreth Peter J Koudstaal | 2007 | Lancet Neurology2007，，7： | 2 |
| 4 | Lipoprotein-Associated Phospholipase A2 Activity Is Associated With Risk of Coronary Heart Disease and Ischemic Stroke: The Rotterdam Study显示文摘 | Hok-Hay S. Oei Irene M. van der Meer Albert Hofman Peter J. Koudstaal Theo Stijnen Monique M.B. Breteler Jacqueline C.M. Witteman | 2005 | Circulation2005，，5： | 2 |
| 5 | Common carotid intima-media thickness and risk of stroke and myocardial infarction:the Rotterdam study显示文摘 | Bots ML Hoes AW Koudstaal PJ | 1997 | Circulation1997，96，5： | 1 |
| 6 | Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam study 显示文摘 | BOTS M L HOES A W KOUDSTAAL P J | 1997 | Circulation1997，96，： | 1 |
| 7 | Prevalence and Risk Factors of Silent Brain Infarcts in the Population-Based Rotterdam Scan Study显示文摘 | Sarah E. Vermeer Peter J. Koudstaal Matthijs Oudkerk Albert Hofman Monique M.B. Breteler | 2002 | Stroke: Journal of the American Heart Association2002，，1： | 1 |
| 8 | Duration of antihypertensive drug use and risk of dementia: A prospective cohort study 显示文摘 | M D M Haag A Hofman P J Koudstaal | 2009 | Neurology2009，，72： | 1 |
| 9 | International epidemiology of intrac- erebral hemorrhage 显示文摘 | Ikram MA Wieberdink RG Koudstaal PJ | 2012 | Curr Atheroscler Rep2012，14，4： | 1 |
| 10 | International epidemiology of intracerebral hemorrhage显示文摘 | Ikram MA Wieberdink RG Koudstaal PJ | 2012 | Current Atherosclerosis Reports2012，14，4： | 1 |
| 11 | Uirc acid is a risk factor of myocardial infarction and stroke:The Rotterdam study显示文摘 | Bos MJ Koudstaal PJ Hofman A | 2006 | Stroke2006，37，6： | 1 |
| 12 | Transient ischemic attacks in patients with atrial fibrillation-lmplications for secondary prevention:The European Atrial Fibrillation Trial and stroke prevention in Atrial Fibrillation Ⅲ Trial显示文摘 | Hart RG Pearce LA Koudstaal PJ | 2004 | STROKE2004，35，4： | 1 |
| 13 | Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study 显示文摘 | Bos M J Koudstaal PJ Hofman A | 2006 | Stroke2006，37，6： | 1 |
| 14 | Know显示文摘 | Maasland L Koudstaal PJ Habbema JD et d | 2007 | Cerebrovasc Dis2007，23，： | 1 |
| 15 | Stability, tipping and relapse of bone-borne versus tooth-borne surgically assisted rapid maxillary expansion: a prospective randomized patient trial 显示文摘 | Koudstaal M J Wolvius E B Schulten A J M | 2009 | International Journal of Oral & Maxillofacial Surgery2009，38，4： | 1 |
| 16 | Association between the intima-media thickness of the common carotid and subsequent cardiovascular events in subjects,55 years and older,in the Rotterdam Study(ERGO) 显示文摘 | Bots ML Hoes AW Koudstaal PJ | 1998 | Ned Tiidsehr Geneeskd1998，142，19： | 1 |
| 17 | High von WiUebrand factor levels increase the risk of stroke: the Rotterdam study显示文摘 | Wieberdink RG van Sehie MC Koudstaal PJ | 2010 | Stroke2010，41，： | 1 |
| 18 | Common carotid intima-media thickness and risk of stroke and myocardial infarction : the Rotterdam study显示文摘 | Bots ML Hoes AW Koudstaal PJ | 1997 | Circulation1997，96，： | 1 |
| 19 | Serum uric acid levels and the risk of Parkinson disease 显示文摘 | De Lau LM Koudstaal PJ Hofman A | 2005 | Ann Neurol2005，58，5： | 1 |
| 20 | Plasma homoeysteine is a risk faeor for recurrent vascular events in young patients with an ischacmic stroke or TIA显示文摘 | Bos MJ van Goor ML Koudstaal PJ | 2005 | J Neural2005，252，3： | 1 |
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