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	题名	作者	年代	出处	被引量
1	Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing.	Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann	2022	Bone Research2022，10，3：	2
2	Curcum ininhib its the proteasome activity in human coloncan cercells in-vitro and in-vivo 显示文摘	Milacic V Banerjee S Landis-Piwowar KR	2008	Cancer Res2008，68，18：	1
3	A nuclear export sequence located on beta-strand in fibroblast growth factor-1显示文摘	Nilsen T Rosendal KR S?rensen V		0，，36：	1
4	Optical deconstruction of parkinsonian neural circuitry 显示文摘	Gradinaru V Mogri M Thompson KR	2009	Science2009，324，5925：	1
5	Anti-HHV-6 antibodies in normal population and in cancer patients in India显示文摘	Shanavas KR Kala V Vasudevan DM	1992	J Exp Pathol1992，6，12：	1
6	Sexual dimorphic expression pattern of asplice variant of zebrafish vasa during gonadal development显示文摘	KRVEL A V OLSEN L C	2004	Develop-mental Biology2004，271，1：	1
7	In situ Raman analysis of gas formation in NiMH batteries显示文摘	Mank a J G Belfadhel-Ayeb a Krüsemann P V E	2005	Applied Spectroscopy2005，59，1：	1
8	Circulating tumor cells in metastatic breast cancer: biologic staging beyond tumor burden显示文摘	Cristofanilli M Broglio KR Guarneri V	2007	Clin Breast Cancer2007，7，：	1
9	Factors affecting outcome after percutaneous renal artery stent insertion显示文摘	Perkovi V Thomson KR Becker GJ	2002	J Nephrol2002，15，：	1
10	A subset of Toil-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells显示文摘	Datta SK Redecke V Prilliman KR	2003	J Immunol2003，270，8：	1
11	Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta:implications for plaque vulnerability显示文摘	Moreno PR Purushothaman KR Fuster V	2004	Circulation2004，110，14：	1
12	Optimization and charaterization of repaglinide biodegradable polymeric nanop- article loaded transdermal patchs: In vitro and in vivo studies 显示文摘	Vijayan V Reddy KR Sakthivel S	2013	Colloids Surf B Biointerfaces2013，111，1：	1
13	Sputum pro- cessing methods to improve the sensitivity of smear microscopy for tuberculosis : a systematic review 显示文摘	Steingart KR Ng V Henry M	2006	Lancet Infect Dis2006，6，10：	1
14	The proteasome as a potential target for novel anticancer drugs and chemosensitizers显示文摘	Landis-Piwowar KR Milacic V Chen D	2006	Drug Resist Updat2006，9，：	1
15	FTY720: Targeting G-protein cou- pled receptors for sphingosine 1-phosphate in transplantation and autoimmunity显示文摘	Brinkmann V Lynch KR	2002	Curr Opin Immunol2002，14，：	1
16	Expression of biologi- cally active recombinant porcine interleukin-12 from Escherichia coli 显示文摘	Morris KR Bruce MP Janardhana V	2008	Vet Immunol Immunopathol2008，126，34：	1
17	Sputum processing methods to improve the sensitivity of smear microscopy for tuberculosis: a systematic review显示文摘	Steingart KR Ng V Henry M	2006	Lancet Infect Dis2006，6，10：	1
18	Tamoxifen: an altemative to clomiphene in women with polycystic ovary syndrome显示文摘	Dhaliwal LK Suri V Gupta KR	2011	JHum ReprodSci2011，4，2：	1
19	Outcomes of angio- some and non-angiosome targeted revascularization in critical lower limb ischemia显示文摘	Kabra A Suresh KR Vivekanand V	2013	J Vasc Surg2013，57，1：	1
20	Development of a fluorescence polarization - based diagnostic assay for equine infection anemia virus显示文摘	Tencza SB Islam KR Kalia V	2000	J Clin Microbiol2000，38，5：	1

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