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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | Hot deformation of Mg-Y-Zn alloy with a low content of the LPSO phase studied by in-situ synchrotron radiation diffraction显示文摘The compressive deformation behavior of the extruded WZ42(Mg98.5Y1Zn0.5 in at.%)magnesium alloy containing a low amount of long-period stacking ordered(LPSO)phase was studied by in-situ synchrotron radiation diffraction technique.Tests were conducted at temperatures between room temperature and 350℃.Detailed microstructure investigation was provided by scanning electron microscopy,particularly the backscattered electron imaging and electron backscatter diffraction technique.The results show that twinning lost its dominance and kinking of the LPSO phase became more pronounced with increasing deformation temperature.No cracks of the LPSO phase and no debonding r at the interface between the LPSO phase and the Mg matrix were observed at temperatures above 200℃.At 350℃,the LPSO phase lost its strengthening effect and the deformation of the alloy was mainly realized by the dynamic recrystallization of the Mg matrix. | Klaudia Horváth Fekete Daria Drozdenko Jan Capek Kristián Máthis Domonkos Tolnai Andreas Stark Gerardo Garcés Patrik Dobron | 2020 | Journal of Magnesium and Alloys2020，8，1： | 5 |
| 3 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries显示文摘冠的动脉把血流动带到心肌肉。理解冠的动脉的发展程序提供卓见进冠的动脉疾病的治疗。多重来源被描述了为包括 proepicardium,湾穴 venosus (SV ) ,和心内膜贡献冠的动脉。然而,冠的容器的发展起源仍然在强烈学习下面。我们为学习冠的开发生产了一个新基因工具,一只 AplnCreER 老鼠在开发冠的容器明确地衬里 recombinase,它表示可诱导的 Cre。冠的开发和 AplnCreER 命运跟踪的预定正式就职的定量分析证明 subepicardial endothelial 房间(EC ) 的子孙两个都入侵紧缩的心肌层形成冠的动脉并且在表面上留下生产静脉。我们发现这些 subepicardial EC 是 intramyocardial 的主要来源在发展中的心的冠的容器。在 vitro 将生物的活组织移植于培养基中培养,试金显示这些 subepicardial EC 的多数从 SV 和中庭的心内膜,然而并非从室的心内膜产生。Apln 积极的房间的同种细胞的分析显示单个 subepicardial EC 同等地作出贡献到冠的动脉和静脉。一起,这些数据建议 subepicardial EC 是 intramyocardial 的主要来源在室的冠的动脉墙,和那冠的动脉和静脉在发展中的心有普通起源。 | Xueying Tian Tianyuan Hu Hui Zhang Lingjuan He Xiuzhen Huang Qiaozhen Liu Wei Yu Liang He Zhongzhou Yang Zhen Zhang Tao P Zhong Xiao Yang Zhen Yang Yan Yan Antonio Baldini Yunfu Sun Jie Lu Robert J Schwartz Sylvia M Evans Adriana C Gittenberger-de Groot Kristy Red-Horse Bin Zhou | 2013 | Cell Research2013，23，9： | 3 |
| 4 | Global burden of hypertension: analysis of worldwide data显示文摘 | Patricia M Kearney Megan Whelton Kristi Reynolds Paul Muntner Paul K Whelton Jiang He | 2005 | The Lancet2005，，9455： | 2 |
| 5 | Global burden of hypertension: analysis of worldwide data显示文摘 | Patricia M Kearney Megan Whelton Kristi Reynolds Paul Muntner Paul K Whelton Jiang He | 2005 | The Lancet . 2005 (9455)2005，，9455： | 2 |
| 6 | Global burden of hypertension: analysis of worldwide data显示文摘 | Patricia M Kearney Megan Whelton Kristi Reynolds Paul Muntner Paul K Whelton Jiang He | 2005 | The Lancet2005，，9455： | 2 |
| 7 | Global burden of hypertension: analysis of worldwide data显示文摘 | Patricia M Kearney Megan Whelton Kristi Reynolds Paul Muntner Paul K Whelton Jiang He | 2005 | 2005 (9455)2005，，9455： | 2 |
| 8 | Drosophila nemo is an essential gene involved in the regulation of programmed cell death显示文摘 | Ivana Mirkovic Kristi Charish Sharon M Gorski Kristen McKnight Esther M Verheyen | 2002 | Mechanisms of Development2002，，1： | 1 |
| 9 | Plasmin is not protective in experimental renal interstitial fibrosis 显示文摘 | Kristy L Edgtton J Renae M | 2004 | Kidney Int2004，，2： | 1 |
| 10 | Wireless sensors for monitoring corrosion in reinforced concrete members显示文摘 | J T Simonen M M Andringa Kristi M Grizzle | 2004 | SPIE2004，5391，： | 1 |
| 11 | The potential impact of physical activity during pregnancy on maternal and neonatal outcomes显示文摘 | Zachary F M Laura G Kristi A B | 2012 | Obstet Gynecol Survey2012，67，2： | 1 |
| 12 | Behavioral treatments for persistent psychophysiological insomnia alone and combined: Compared with sleep hygiene education and dalmane显示文摘 | Willian M H Waters P B Kristi F | 1998 | Sleep1998，21，15： | 1 |
| 13 | Anti- microbial activity of chicken and Turkey heterophil pep- tides CHP1, CHP2, THP1, and THP3 显示文摘 | ELLEN W E BEACH F G KRISTI M M | 1995 | Veterinary Microbiology1995，47，3： | 1 |
| 14 | Global burden of hypertension: analysis of worldwide data显示文摘 | Patricia M Kearney Megan Whelton Kristi Reynolds Paul Muntner Paul K Whelton Jiang He | 2005 | The Lancet2005，，9455： | 1 |
| 15 | Cell Adhesion on Nanofibrous Polytetrafluoroethylene (nPTFE)显示文摘 | Kristy M Ainslie Eric M Bachelder Sachin Borkar | 2007 | Langmiur2007，23，： | 1 |
| 16 | Enhancing the relevance of Shared Socioeconomic Pathways for climate change impacts, adaptation and vulnerability research显示文摘 | Bas J. Ruijven Marc A. Levy Arun Agrawal Frank Biermann Joern Birkmann Timothy R. Carter Kristie L. Ebi Matthias Garschagen Bryan Jones Roger Jones Eric Kemp-Benedict Marcel Kok Kasper Kok Maria Carmen Lemos Paul L. Lucas Ben Orlove Shonali Pachauri Tom M | 2014 | Climatic Change2014，，3： | 1 |
| 17 | Loss of Raf-1 Kinase Inhibitor Protein Expression Is Associated With Tumor Progression and Me- tastasis in Colorectal Cancer显示文摘 | Parham M Inti Z Kristi B | 2007 | American Society for Clinical Pa- thology2007，127，9： | 1 |
| 18 | Comparison of three generations of ActiGraph? activity monitors in chil- dren and adolescents 显示文摘 | KRISTI M ROBUSTO STEWART G TROST | 2012 | Journal of Sports Sciences2012，30，13： | 1 |
| 19 | A protein sequestering system reveals control of cellular programs by the transcriptional coactivator HCF-1显示文摘 | Khurana B Kristie T M | 2004 | J Biol Chem2004，279，33： | 1 |
| 20 | Plasmin is not protective in experimental renal interstitial fibrosis显示文摘 | Kristy L Edgtton Renae M | 2004 | Kidney Int2004，66，2： | 1 |
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