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| 1 | Contrast enhanced ultrasound of hepatocellular carcinoma显示文摘Sonazoid(Daiichi Sankyo,Tokyo,Japan),a secondgeneration of a lipid-stabilized suspension of a perfluorobutane gas microbubble contrast agent,has been used clinically in patients with liver tumors and for harmonic gray-scale ultrasonography(US)in Japan since January 2007.Sonazoid-enhanced US has two phases of contrast enhancement:vascular and late.In the late phase of Sonazoid-enhanced US,we scanned the whole liver using this modality at a low mechanical index(MI)without destroying the microbubbles, and this method allows detection of small viable hepatocellular carcinoma(HCC)lesions which cannot be detected by conventional US as perfusion defects in the late phase.Re-injection of Sonazoid into an HCC lesion which previously showed a perfusion defect in the late phase is useful for confirming blood flow intothe defects.High MI intermittent imaging at 2 frames per second in the late phase is also helpful in differentiation between necrosis and viable hypervascular HCC lesions.Sonazoid-enhanced US by the coded harmonic angio mode at a high MI not only allows clear observation of tumor vessels and tumor enhancement, but also permits automatic scanning with Sonazoidenhanced three dimensional(3D)US.Fusion images combining US with contrast-enhanced CT or contrastenhanced MRI have made it easy to detect typical or atypical HCC lesions.By these methods,Sonazoidenhanced US can characterize liver tumors,grade HCC lesions histologically,recognize HCC dedifferentiation, evaluate the efficacy of ablation therapy or transcatheter arterial embolization,and guide ablation therapy for unresectable HCC.This article reviews the current developments and applications of Sonazoid-enhanced US and Sonazoid-enhanced 3D US for diagnosing and treating hepatic lesions,especially HCC. | Kazushi Numata Manabu Morimoto Masaaki Kondo Yosuke Kunishi Tomohiko Sasaki Akito Nozaki Katsuaki Tanaka | 2010 | World Journal of Radiology2010，2，2： | 15 |
| 2 | Efficacy of fusion imaging combining sonography and hepatobiliary phase MRI with Gd- EOB-DTPA to detect small hepatocellular carcinoma显示文摘 | Kunishi Y Numata K Morimoto M | 2012 | AJR Am J Roentgenol2012，198，1： | 1 |
| 3 | Maize root length, density and mycorrhizal inferction as in?uenced by tillage and soil phosphorus显示文摘 | ANDERSON E L MILLNER P D KUNISHI H M | 1987 | Journal of Plant Nutrition1987，10，： | 1 |
| 4 | Down-regulated expression of CD44 variant 6 inoral squamous cell carcinomas and its relationship to regional lymph node metastasis显示文摘 | Kunishi M Kayada Y Yoshiga K | 1997 | IntJ Oral Maxillofac Surg1997，26，： | 1 |
| 5 | CD44 Variant 6 expression as a propression marker in benign, Premalignant and malignant oral epithelial tissues显示文摘 | Kunishi M Kayada Y | 1997 | Int J Oral Maxillface Surg1997，26，： | 1 |
| 6 | Tidal Exchange through a Strait: A Numerical Experiment Using a Simple Model Basin显示文摘 | Awaji T Imasato N Kunishi H | 1980 | Journal of Physical Oceanography1980，10，10： | 1 |
| 7 | Down-regulated expression of CD44 variant 6 in oral squamous cell carcinomas and its relationship to regional lymph node metastasis显示文摘 | Kayda Y Yoshiga K | 1997 | Int J Oral Maxillofac Surg1997，26，4： | 1 |
| 8 | CD44 variant 6 (CD44v6) expression as a progression marker in benign, premalignant and malignant oral epithelial tissues 显示文摘 | Bahar R Kunishi M Kayada Y | 1997 | Int J Oral Maxillofac Surg1997，26，： | 1 |
| 9 | Down-regulated expression of CD44 variant 6 in oral squamous cell carcinomas and its rela-tionship to regional lymph node metastasis显示文摘 | Kunishi M Kayada Y Yoshiga K | 2007 | Int J Oral Maxiilofac Surg2007，26，4： | 1 |
| 10 | Stimulation of ethylene production in apple tissue slices by methionine显示文摘 | LIEBERMAN M KUNISHI A MAPSON L W | 1966 | Plant Physiol1966，41，： | 1 |
| 11 | Down-regulated expression of CD44 variant 6 in oral squamous cell carcinoma and its relationship to regional lymphnode metastasis 显示文摘 | Kunishi M Kayada Y | 1997 | IntJ Oral Maxillofac Surg1997，26，4： | 1 |
| 12 | CD44 variant 6(CD44V6) expression as a prognosis marker in benign premalignant and ma- lignant oral epithelial tissues 显示文摘 | Bahar R Kunishi M Kayada Y | 1997 | Int J oral Maxillofac Surg1997，26，6： | 1 |
| 13 | Tidal exchange through a strait: A numerical experiment using a simple model basin显示文摘 | Awaji T Imasato N Kunishi H | 1980 | Journal of Physical Oceanography1980，10，10： | 1 |
| 14 | Dynamic wavelength tuning of channel drop device in two dimensional photonic crystal slab 显示文摘 | ASANO T KUNISHI W NAKAMURA M | 2005 | Electroltics Letters2005，41，1： | 1 |
| 15 | Stimulation of ethylene production in apple tissue slices by mcthioninc显示文摘 | LIEBERMAN M KUNISHI A MAPSON L W ct al | 1966 | Plant Physiology1966，41，3： | 1 |
| 16 | CD44 variant 6 (CD44v6) expression as a progression marker in benign, premalignant and malignant oral epithelial tissues显示文摘 | Bahar R Kunishi M Kayada Y | 1997 | Int J Oral Maxillofac Surg1997，26，6： | 1 |
| 17 | Responses to adenine nucleotide and related compounds of isolated dog cerebral, Coronay and mesenteric arteries显示文摘 | Toda N Kunishi H Taiyama K | 1982 | Blood Vessls1982，19，5： | 1 |
| 18 | Down-regulated expression of CD44 variant 6 in oral squamous cell carcinomas and its rela tionship to regional lymph node metastasis显示文摘 | Kunishi M Kayada Y Yoshiga K | 1997 | Int J Oral Maxillo fac Surg1997，26，4： | 1 |
| 19 | Phosphate Equilibria on Stream Sediment and Soil in a Watershed Draining an Agricultural Region显示文摘 | Taylor A W Kunishi H M | 1971 | Journal of Agricultural and Food Chemistry1971，19，5： | 1 |
| 20 | Phosphate equilibria on stream sediment and soil in watershed draining an agricultural region显示文摘 | Taylor A W Kunishi H M | | 0，，05： | 1 |
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