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| 1 | New insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brainrelated diseases显示文摘Brain-derived neurotrophic factor(BDNF) attracts increasing attention from both research and clinical fields because of its important functions in the central nervous system. An adequate amount of BDNF is critical to develop and maintain normal neuronal circuits in the brain. Given that loss of BDNF function has beenreported in the brains of patients with neurodegenerative or psychiatric diseases, understanding basic properties of BDNF and associated intracellular processes is imperative. In this review, we revisit the gene structure, transcription, translation, transport and secretion mechanisms of BDNF. We also introduce implications of BDNF in several brain-related diseases including Alzheimer's disease, Huntington's disease, depression and schizophrenia. | Naoki Adachi Tadahiro Numakawa Misty Richards Shingo Nakajima Hiroshi Kunugi | 2014 | World Journal of Biological Chemistry2014，5，4： | 30 |
| 2 | Functional interactions between steroid hormones and neurotrophin BDNF显示文摘Brain-derived neurotrophic factor(BDNF),a critical neurotrophin,regulates many neuronal aspects including cell differentiation,cell survival,neurotransmission,and synaptic plasticity in the central nervous system(CNS) .Though BDNF has two types of receptors,high affinity tropomyosin-related kinase(Trk) B and low affinity p75 receptors,BDNF positively exerts its biological effects on neurons via activation of TrkB and of resultant intracellular signaling cascades including mitogenactivated protein kinase/extracellular signal-regulated protein kinase,phospholipase Cγ,and phosphoinositide 3-kinase pathways.Notably,it is possible that alteration in the expression and/or function of BDNF in the CNS is involved in the pathophysiology of various brain diseases such as stroke,Parkinson's disease,Alzheimer's disease,and mental disorders.On the other hand,glucocorticoids,stress-induced steroid hormones,also putatively contribute to the pathophysiology of depression.Interestingly,in addition to the reduction in BDNF levels due to increased glucocorticoid exposure,current reports demonstrate possible interactions between glucocorticoids and BDNF-mediated neuronal functions. Other steroid hormones,such as estrogen,are involved in not only sexual differentiation in the brain,but also numerous neuronal events including cell survival and synaptic plasticity.Furthermore,it is well known that estrogen plays a role in the pathophysiology of Parkinson's disease,Alzheimer's disease,and mental illness,while serving to regulate BDNF expression and/or function.Here,we present a broad overview of the current knowledge concerning the association between BDNF expression/function and steroid hormones(glucocorticoids and estrogen). | Tadahiro Numakawa Daisaku Yokomaku Misty Richards Hiroaki Hori Naoki Adachi Hiroshi Kunugi | 2010 | World Journal of Biological Chemistry2010，1，5： | 7 |
| 3 | Development and implementation of a power system fault diagnosis expert system显示文摘 | MINAKAWA T ICHIKAWA Y KUNUGI M | 1995 | IEEE Trans on Power Systems1995，10，2： | 1 |
| 4 | Preparation of High - Modulus Poly( ethylene terephthalate ) Fibers by Vibrating Hot Drawing 显示文摘 | Kunugi T Suzuki A | 1996 | Journal of Applied Polymer Science1996，62，5： | 1 |
| 5 | Low serum cholesterol in sui-cide attempters显示文摘 | Kunugi H Takei N Aoki H | 1997 | Biol psychiatry1997，41，2： | 1 |
| 6 | Application of a Continuous Zone - Drawing Method to Nylon 66 Fibers显示文摘 | Suzuki A Chen Y Kunugi T | 1998 | Polymer1998，39，22： | 1 |
| 7 | Inhibition of matrimetal oproteinases reduces ischemia-reperfusion acute kidney injury显示文摘 | Kunugi S Shimizu A Kuwahara N | | 0，，02： | 1 |
| 8 | Application of the High - Tension Multiannealing to Nylon 46 Fibers 显示文摘 | Suzuki A Endo A Kunugi T | 1998 | Journal of Polymer Science1998，36，15： | 1 |
| 9 | Review of advanced absorption cycles: performance improvement and temperature lift nhancement显示文摘 | Kang YT Kunugi Y Kashiwagi T | 2000 | International Journal of Refrigeration2000，23，： | 1 |
| 10 | Epigenetic aberration of thehuman REELIN gene in psychiatric disorders显示文摘 | Tamura Y Kunugi H Ohashi J | 2007 | Mol Psychia-try2007，12，51： | 1 |
| 11 | Appilcation of a Zone -drawing and Zone - annealing Method to Poly ( ethylene - 2, 6 -naphtbelate) Fibers显示文摘 | Suzuki A Kuwabara T Kunugi T | 1998 | Polymer1998，39，18： | 1 |
| 12 | The effect of high pressure on thermolysin显示文摘 | KUNUGI S KITAYAKI M YANAGI Y | 1997 | Eur J Biochem1997，248，2： | 1 |
| 13 | Microstrure and Mechanical Properties of Hot - air Drawn Poly ( ethykene - 2 - 6 -naphthalate) Fibers显示文摘 | Suzuki A Nakamura Y Kunugi T | 1999 | Polymer1999，40，18： | 1 |
| 14 | Dynamic Mechanical Properties of Poly ( p-phenylene terephthalamide ) Fiber显示文摘 | Kunugi T Watanabe H Hashimoto M | 1979 | Journal of Applied Polymer Science1979，24，4： | 1 |
| 15 | Thermal Mixing Test of Coolant in the Core Bottom Structure of a High Tem perature Engineering Test Reactor显示文摘 | Kunugi T Miyamoto Y | 1990 | Nuclear Engineering and Design1990，123，2： | 1 |
| 16 | Catechol-omethyltransferase polymorphisms and schizophrenia:a transmission disequilibrium study in multiply affected families显示文摘 | Kunugi H Vallada HP Sham PC | 1997 | Psychiatr Genet1997，7，： | 1 |
| 17 | Brain-derived neurtrophic factor gene and schizophrenia: polymorphism scree- nin and association analysis 显示文摘 | Nanko S Kunugi H Hirasawa H | 2003 | Schizophr Res2003，，： | 1 |
| 18 | Inhibition of matrix metalloproteinases reduces ischemia-reperfusion acute kidney injury 显示文摘 | Kunugi S Shimizu A Kuwahara N | 2011 | Lab Invest2011，91，2： | 1 |
| 19 | Review ofadvanced absorption cycles: performance improvementand temperature lift enhancement显示文摘 | KANG Y KUNUGI Y KASHIWAGI T | 2000 | International Journalof Refrigeration2000，23，5： | 1 |
| 20 | Electrical and Mechanical Properties of the Zone - Drawn Polypyvrole Films 显示文摘 | Kunugi T Okuzaki H | 1996 | Journal of Polymer Science1996，34，7： | 1 |
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