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| 1 | Inequalities in care in patients with acute myocardial infarction显示文摘Coronary heart disease is the single largest cause of death in developed countries. Guidelines exist for the management of acute myocardial infarction(AMI),yet despite these,significant inequalities exist in the care of these patients. The elderly,deprived socioeconomic groups,females and non-caucasians are the patient populations where practice tends to deviate more frequently from the evidence base. Elderly patients often had higher mortality rates after having an AMI compared to younger patients. They also tended to present with symptoms that were not entirely consistent with an AMI,thus partially contributing to the inequalities in care that is seen between younger and older patients. Furthermore the lack of guidelines in the elderly age group presenting with AMI can often make decision making challenging and may account for the discrepancies in care that are prevalent between younger and older patients. Other patients such as those from a lower socioeconomic group,i.e.,low income and less than high school education often had poorer health and reduced life expectancy compared to patients from a higher socioeconomic group after an AMI. Lower socioeconomic status was also seen to be contributing to racial and geographical variation is the care in AMI patients. Females with an AMI were treated less aggressively and had poorer outcomes when compared to males. However even when females were treated in the same way they continued to have higher in hospital mortality which suggests that gender may well account for differences in outcomes. The purpose of this review is to identify the inequalities in care for patients who present with an AMI and explore potential reasons for why these occur. Greater attention to the management and a better understanding of the root causes of these inequalities in care may help to reduce morbidity and mortality rates associated with AMI. | Shabnam Rashid Alexander Simms Phillip Batin John Kurian Chris P Gale | 2015 | World Journal of Cardiology2015，7，12： | 4 |
| 2 | Genotype phenotype correlation in Wilson's disease within families-a report on four south Indian families显示文摘AIM: To study the genotype phenotype correlation in Wilson's disease (WD) patients within families. METHODS: We report four unrelated families from South India with nine members affected with WD. Phenotype was classified as per international consensus phenotypic classifi cation of WD. DNA was extracted from peripheral blood and 21 exons of ATP7B gene and flanking introns were amplified by polymerase chain reaction (PCR). The PCR products were screened for mutations and the aberrant products noted on screening were sequenced. RESULTS: Four separate ATP7B mutations were found in the four families. ATP7B mutations were identical amongst affected members within each family. Three families had homozygous mutations of ATP7B gene while one family had compound heterozygous mutation, of which only one mutation was identifi ed. We noted concordance between ATP7B gene mutation and Wilson's disease phenotype amongst members within each family. The age of onset of symptoms or of detection of asymptomatic disease, baseline serum ceruloplasmin and baseline urinary copper levels were also similar in affected members of each family. Minor differences in phenotype and baseline serum ceruloplasmin level were noted in one family.CONCLUSION: We report concordance between ATP7B mutation and WD phenotype within each family with > 1 member affected with WD. Homozygous ATP7B mutation was present in 3 of the 4 families studied. Our report supports allelic dominance as a determinant of WD phenotype. However, in one family with compound heterozygous mutation, there was a similar WD phenotype which suggests that there may be other factors determining the phenotype. | S Santhosh RV Shaji CE Eapen V Jayanthi S Malathi P Finny N Thomas M Chandy G Kurian GM Chandy | 2008 | World Journal of Gastroenterology2008，14，29： | 3 |
| 3 | Acute coronary syndromes: an old age problem显示文摘在老年的增加的人口将导致他们的更大的数字与急性冠的症候群(交流) 介绍。这在全球保健资源上有含意并且为基于证据的治疗要求更好的管理和选择。老比更年轻的交流是有更重要的治疗好处的一个高风险组。不过,在交流的相关不平等在乎的年龄被认出并且坚持。到某程度,在照顾的这差异被不正常、推迟的演讲的更高的频率在表示在老、不太诊断的心电图解释,加强在交流的延期诊断。在死亡风险在的评价下面由于为生理的脆弱,合作病态,认知 / 心理的缺陷和物理残疾的有限考虑老,由心病学专家和 randomised 的缺乏的更少的输入,指导管理在的控制试用数据老可以进一步使照顾的不平等惊讶。当这些不平等存在时,在那里仍然是一个实质的机会改进年龄相关交流结果。为特定的治疗和药政体的老病人的选择是未答复的。对 randomised 有成长需要,人口更代表性并且与合作病态先进年龄注册那些的控制试用数据。不利事件报导的缺乏,张贴冠的 angiography 例如肾的缺陷,在老进一步的限制风险利益决定。在老交流病人的照顾的实质的改进被要求并且应该被倡导。最终,这些改进是可能的导致更好的结果柱子交流。然而,在结果的改进不是无限的并且将由年龄相关的风险的非可修改的因素有限。 | Alexander D Simms Philip D Batin John Kurian Nigel Durham Christopher P Gale | 2012 | Journal of Geriatric Cardiology2012，9，2： | 3 |
| 4 | 显示文摘 | Feinfeld DA Kurian P Cheng JT | 1996 | Ren Fail1996，18，1： | 1 |
| 5 | Barium rare-earth zirconates:synthesis,characterization and their possible application as substrates for YBa2Cu3O7-δ superconduction显示文摘 | Koshy J Sajith P K Kurian J | 1995 | Mater Res Bull1995，30，11： | 1 |
| 6 | 显示文摘 | Koshy J Sajith P K Kurian J | 1995 | Materials Research Bulletin1995，30，11： | 1 |
| 7 | Correlating nanoscale titania structure with toxicity:A cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells显示文摘 | Sayes C M Wahi R Kurian P A Liu Yunping | 2006 | Toxicol Sci2006，92，1： | 1 |
| 8 | Settlement of reinforced sand in foundations显示文摘 | Kurian P N Beena S K Kumar K R | 1997 | Journal of Geotechnical and Geo-environmental Engineering1997，123，9： | 1 |
| 9 | Performance enhancement of DS/CDMA system using chaotic complex spreading Sequence显示文摘 | Kurian A P Puthussery S Htut S M | 2005 | IEEE Transactions on Wireless Communications2005，4，98： | 1 |
| 10 | Wave attenuation due to bottomfriction across the southwest Indian continental shelf显示文摘 | Kurian N P Baba M | 1987 | Journal of Coastal Research1987，3，4： | 1 |
| 11 | Transport properties of natural rub her latex layered clay nanocomposites显示文摘 | Jacob A Kurian P | 2008 | Journal of Applied Polymer Science2008，108，： | 1 |
| 12 | Cure Ki- netics and Sorption Charact eristics of Neoprene-Based Rub- ber Ferrite Composites显示文摘 | Prem a K H Kurian P Anantharaman M R | 2010 | International Journal of Polymeric Materials2010，59，3： | 1 |
| 13 | Vitamin D receptor gene variants of FokI, BsmI,ApaI and TaqI polymorphisms in spinaltuberculosis显示文摘 | zelvaraj P Kurian SM Chandra G | 2004 | Clin Genet2004，65，1： | 1 |
| 14 | NRAMP1 gene polymorphism in pulmonary and spinal tuberculosis显示文摘 | SELVARAJ P CHANDRA G KURIAN S M | 2002 | Curt Sci2002，82，： | 1 |
| 15 | 显示文摘 | Jamal E M A Joy P A Kurian P etal | 2009 | Materials Science and Engineering: B2009，156，1： | 1 |
| 16 | NRAMP1 gene polymorphism in pulmonary and spinal tuberculosis 显示文摘 | SELVARAJ P CHANDRA G KURIAN SM | 2002 | Curr Sci2002，82，3： | 1 |
| 17 | Weak signal estimation in chaotic clutter using model-based coupled synchronization显示文摘 | Kurian A P Leung H | 2009 | IEEE Transactions on Cir- cuits and Systems I: Regular Papers2009，56，4： | 1 |
| 18 | Vitamin D receptor gene variants of BsmI,ApaI,TaqI,and FokI polymorphisms in spinal tuberculosis显示文摘 | Selvaraj P Kurian SM Chandra G | 2004 | Clin Genet2004，65，1： | 1 |
| 19 | 显示文摘 | Malini K A Kurian P Anantharaman M R | 2003 | Materials Letters2003，57，22： | 1 |
| 20 | Modification of dielectric and mechanical properties of rubber ferrite composites containing manganese zinc ferrite显示文摘 | Mohammed M Malini K A Kurian P | 2002 | Materials Research Bulletin2002，37，4： | 1 |
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