|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatitis B-specific T helper cell responses in uninfected infants born to HBsAg^(+)/HBeAg^(-) mothers显示文摘Vertically transmitted hepatitis B virus(HBV)usually causes chronic infection.While combined active–passive immunoprophylaxis in neonates of hepatitis B surface antigen-positive(HBsAg1)mothers at birth prevents vertical transmission,it is not yet clear whether neonates encounter the virus or its products in the absence of hepatitis B e antigen(HBeAg).This study was undertaken to investigate HBV antigen-specific T-cell responses in vaccinated neonates of HBsAg1/HBeAg2 mothers.Blood was collected from 46 HBsAg1 mothers and their neonates(subjects)as well as 24 age-matched controls.All neonates of HBsAg1 mothers received appropriate immunoprophylaxis,and HBsAg and hepatitis B surface antibody(anti-HBs)antibody titers were determined after completion of the vaccination course.Peripheral blood mononuclear cells(PBMCs)from infants at birth,1 and 6 months of age were stimulated with recombinant HBsAg,hepatitis B core antigen(HBcAg)and mitogen,and interferon(IFN)-c concentrations were determined by ELISA.HBsAg-induced production of IL-2,IL-5,IL-6 and IL-10 was assessed using a cytometric bead array kit on cells from 6-month-old neonates post-vaccination.All neonates were HBsAg2 and responded to vaccination.Increased IFN-c production following HBcAg stimulation was seen in 30.4%of neonates born to HBsAg1/HBeAg2 mothers.Subjects demonstrated significantly higher IL-2 production post-HBsAg stimulation,whereas IL-5,IL-6 and IL-10 cytokine responses were not significantly different.Almost one-third of uninfected neonates developed viral antigen-induced IFN-c production,suggesting that they had been exposed to virions or viral derivatives.This encounter,however,did not impair their T-cell responses to vaccination. | Lemonica Koumbi Antonio Bertoletti Vassiliki Anastasiadou Maria Machaira Winnie Goh Nikolaos G Papadopoulos Dimitris A Kafetzis Vassiliki Papaevangelou | 2010 | Cellular & Molecular Immunology2010，7，6： | 4 |
| 2 | The significance of Ureaplasma urealyticum as a pathogenic agent in the paediatric population显示文摘 | Pinna GS Skevaki CL Kafetzis DA | 2006 | Curr Opin Infect Dis2006，19，3： | 1 |
| 3 | Chronic&ugh in children: Recent advance显示文摘 | Velissarious LM Kafetzis DA | 2004 | Expert Rev Anti Infect Ther2004，2，1： | 1 |
| 4 | Kawasaki disease:an overview显示文摘 | Pinna GS Kafetzis DA Tselkas OI | 2008 | Curr Opin Infect Dis2008，21，3： | 1 |
| 5 | Preterm birth due to maternal infection : causative pathogens and modes of prevention 显示文摘 | Pararas MV Skevaki CL Kafetzis DA | 2006 | European Journal of Clinicalmicrobiology&Infectious Diseases2006，25，9： | 1 |
| 6 | Procalcitoninas a predictor of severe appendicitis in children显示文摘 | Kafetzis DA Velissariou IM Nikolaides P | 2005 | Eur Clin Microbiol Infect Dis2005，24，7： | 1 |
| 7 | Immunologic markers in the neonatal period : Diagnostic value and accuracy in infection 显示文摘 | Kafetzis DA Tigani GS Costalos C | 2005 | Expert Rev Mol Diagn2005，5，2： | 1 |
| 8 | Neonatal necrotizing enterocolitis: an overview显示文摘 | Kafetzis DA Skevaki C Costalos C | 2003 | Curr Opin Infect Dis2003，16，4： | 1 |
| 9 | Maternal genital colonization with Ureaplasma urealyticum promotes preterm delivery: association of the respiratory colonization of premature infants with chronic lung disease and increased mortality显示文摘 | Kafetzis DA Skevaki CL Skouteri V | 2004 | Clin Infect Dis2004，39，8： | 1 |
| 10 | Epidemiology ofrespiratory syncytial virus bronchiolitis in hospitalized infants inGreece 显示文摘 | Tsolia MN Kafetzis D Danelatou K | 2003 | Eur J Epidemiol2003，18，1： | 1 |
| 11 | Kawasaki disease: an overview显示文摘 | PINNA G S KAFETZIS D A TSELKAS O I | 2008 | Curt Opin Infect Dis2008，21，3： | 1 |
| 12 | Multi-investigator evaluation of the efficacy and safety of cefprozil,amoxicillin-clavulanate,cefixime and cefaclor in the treatment of acute otitis media显示文摘 | | 1994 | Europ J Clin Mcrobiol Infect Dis1994，13，10： | 1 |
| 13 | Kawasaki disease:an overview显示文摘 | Pinna GS Kafetzis DA Tselkas OI | 2008 | Current Opinion in Infectious Diseases2008，21，3： | 1 |
| 14 | The significance of Ureaplasma urealyticum as a pathogenic agent in the paediatric population显示文摘 | Pinna GS Skevaki CL Kafetzis DA | 2006 | Curr Opin infect Dis2006，19，3： | 1 |
| 15 | Neonatal necrotizing entero- colitis: an overview显示文摘 | Kafetzis DA Skevaki C Costalos C | 2003 | Curr Opin Infect Dis2003，16，3： | 1 |
| 16 | Iseparnicn versus arnikacirn for the treatment of acute pyelonephritis in children显示文摘 | Kafetzis DA Maltezou HC Marrikou M | 2002 | Int J Antirnierob Agents2002，14，： | 1 |
| 17 | Neonatal necrotizing enterotizing;an overview显示文摘 | Kafetzis DA Skevaki C Costalos C | 2003 | Current Opinion in Infect Dis2003，16，4： | 1 |
| 18 | Burden of respiratory syncytial viral infections on paediatric hespitals: a two-year prospective epidemiological study显示文摘 | Constantopoulos AG Kafetzis DA Syrogiannopoulos GA | 2002 | Eur J Clin Microbial Infect Dis2002，21，10： | 1 |
| 19 | Kawasaki disease: an overview 显示文摘 | Pinna GS Kafetzis DA Tselkas OI | 2008 | Curt Opin Infect Dis2008，21，3： | 1 |
| 20 | Evaluation ofpotential medical and economic benefits of universal rotavirusvaccination in Greece显示文摘 | Syriopoulou V Kafetzis D Theodoridou M | 2011 | Acta Paediatr2011，100，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员