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| 1 | Echoplanar diffusion - weighted MRI with intravenous gadolinium - DTPA显示文摘It is occasionally necessary to repeat diffusion weighted imaging(DWI)after giving intravenous contrast medium(CM).However,the effects of CM on DWI and apparent diffusion coefficients(ADC)have not been fully ex-amined.The aim of this prospective study was to investigate whether there are any diagnostically significant dif-ferences between echo-planar imaging(EPI)-DWI before and after intravenous CM.EPI-DWI was acquiredtwice in 203 consecutive patients before and after i.v.CM.Three blinded readers rated the diagnostic | Fitzek C Mentzel HJ Fitzek S Sauner D Kaiser WA Reichenbach JR | 2003 | 中国神经肿瘤杂志2003，1，4： | 15 |
| 2 | Bacterial growth state distinguished by single-cell protein profiling:dose chlorination kill coliforms in municipal effluent 显示文摘 | Rockabrand D Austin T Kaiser B | 1999 | Appl Environ Microbiol1999，65，： | 2 |
| 3 | Negundoside,an irridiod glycoside from leaves of Vitex negundo,protects human liver cells against calcium-mediated toxicity induced by carbon tetrachloride显示文摘AIM:To evaluate the protective effect of 2'-p-hydroxy benzoylmussaenosidic acid [negundoside(NG) ,against carbon tetrachloride(CCl4) -induced toxicity in HuH-7 cells. METHODS:CCl4 is a well characterized hepatotoxin,and inducer of cytochrome P450 2E1(CYP2E1) -mediated oxidative stress. In addition,lipid peroxidation and accumulation of intracellular calcium are important steps in the pathway involved in CCl4 toxicity. Liver cells(HuH-7) were treated with CCl4,and the mechanism of the cytoprotective effect of NG was assessed. Silymarin,a known hepatoprotective drug,was used as control. RESULTS:NG protected HuH-7 cells against CCl4 toxicity and loss of viability without modulating CYP2E1 activity. Prevention of CCl4 toxicity was associated with a reduction in oxidative damage as reflected by decreased generation of reactive oxygen species(ROS) ,a decrease in lipid peroxidation and accumulation of intracellular Ca2+ levels and maintenance of intracellular glutathione homeostasis. Decreased mitochondrial membranepotential(MMP) ,induction of caspases mediated DNA fragmentation and cell cycle arrest,as a result of CCl4 treatment,were also blocked by NG. The protection afforded by NG seemed to be mediated by activation of cyclic adenosine monophosphate(cAMP) synthesis and inhibition of phospholipases(cPLA2) . CONCLUSION:NG exerts a protective effect on CYP2E1-dependent CCl4 toxicity via inhibition of lipid peroxidation,followed by an improved intracellular calcium homeostasis and inhibition of Ca2+-dependent proteases. | Sheikh A Tasduq Peerzada J Kaiser Bishan D Gupta Vijay K Gupta Rakesh K Johri | 2008 | World Journal of Gastroenterology2008，14，23： | 2 |
| 4 | Short-term outcomes of 23-gauge pars plana vitrectomy显示文摘 | Gupta OP Ho A Kaiser PK Regillo C Chen S Dyer D | 2008 | Am J Ophthalmol2008，146，2： | 1 |
| 5 | Hoek-Brown parameters for predicting the depth of brittle failure around tunnels显示文摘 | MARTIN C D KAISER P K MCCREATH D R | 1999 | Canadian Geotechnica1 Journal1999，36，1： | 1 |
| 6 | Reversal of multidrug resistance of tumor cells显示文摘 | Szabo D Keyzer H Kaiser HE | 2000 | Anticancer Res2000，20，6： | 1 |
| 7 | Relationship of pretreatment transurethral resection of the prostate to survival without distant metastases in patients treated with ^125I-implantation for localized prostatic cancer显示文摘 | Fowler J E Jr Fisher H A Kaiser D L | 1984 | Cancer1984，53，9： | 1 |
| 8 | Feline calicivirus p32,p39and p30proteins localize to the endoplasmic reticulum to initiate replication complex formation显示文摘 | Bailey D Kaiser W J Hollinshead M Moffat K Chaudhry Y Wileman T Sosnovtsev S V Goodfellow I G | 2010 | J Gen Virol2010，91，3： | 1 |
| 9 | Competition for attachment of aquaculture candidate probiotic and pathogenic bacteria on fish intestinal mucus 显示文摘 | Vine N G Leukes W D Kaiser H | 2004 | Journal of fish diseases2004，27，6： | 1 |
| 10 | The self-priming effect of gonadotropin-releasing hormone on luteinizing hormone release : Observations using rat anterior pituitary fragments and dispersed cells continually perifused in parallel 显示文摘 | Evans W S Uskavitch D R Kaiser D L | 1984 | Endocrinology1984，114，3： | 1 |
| 11 | Hoek-Brown parameters for predicting the depth of brittle failure around tunnels显示文摘 | MARTIN C D KAISER P K MCCREATH D R | 1999 | Canadian Geotechnical Journal1999，36，13： | 1 |
| 12 | Analysis of total cloud amount over China 显示文摘 | Kaiser D P | 1998 | Geophys Res Lett1998，25，19： | 1 |
| 13 | Modelling brittle failure of rock显示文摘 | HAJIABDOLMAJID V KAISER P K MARTIN C D | 2002 | International Journal of Rock Mechanics and Mining Sciences2002，39，6： | 1 |
| 14 | Anisotropic properties of magnesium sheet AZ31显示文摘 | Kaiser F Letzig D Bohlen J | 2003 | Materials Science Forum2003，41，9420： | 1 |
| 15 | Teatment of parapneumonic pleural effusion and empyema-conservative view 显示文摘 | Loddenkemper R Kaiser D Frank W | 2004 | Eur Respir Mon2004，29，1： | 1 |
| 16 | Analysis of total cloud amount over China, 1951- 1994 显示文摘 | Kaiser D P | 1998 | Geophysical Research Letters1998，25，19： | 1 |
| 17 | Calcineurin Abeta gene targeting predisposes the myocardium to acute ischemia-induced apoptosis and dysfunction显示文摘 | Bueno OF Lips D J Kaiser RA | 2004 | Circ Res2004，94，1： | 1 |
| 18 | Modelling brittle failure of rock显示文摘 | HAJIABDOLMAJID V KAISER P K MARTIN C D | 2002 | International Journal of Rock Mechanics and Mining Sciences2002，39，6： | 1 |
| 19 | Determination of fault-related sloughage in open stopes显示文摘 | Suorineni F T Tannant D D Kaiser P K | 1999 | International Journal of Rock Mechanics and Mining Sciences1999，36，7： | 1 |
| 20 | The regulation of nitrate and ammonium transport systems in plants 显示文摘 | GLASS A D M BRITTO D T KAISER B N | 2002 | Journal of Experimental Botany2002，53，370： | 1 |
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