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| 1 | 紫杉醇局部治疗抑制猪静脉桥新生内膜形成和增厚的实验研究显示文摘目的 :局部药物治疗是一个很好的防治静脉桥病变的策略。本研究用抗细胞增殖药物紫杉醇处理大隐静脉桥后植入猪的颈动脉 ,以观察紫杉醇的抗细胞增殖作用在抑制静脉桥内膜平滑肌细胞增殖、迁移导致内膜形成和增厚的效果。方法 :将 10头猪的 2 0只大隐静脉桥分为两组。治疗组 :将大隐静脉桥 10只置于含有 10 μmol/L浓度的紫杉醇溶液中 (先用该溶液灌洗 )浸泡 1h后植入猪的颈动脉 ,紫杉醇是溶解在 2 5 μl/L的无水酒精中 ,对照组 10只大隐静脉桥置于单纯的酒精中浸泡。 4周后取开放的静脉桥进行组织学分析。结果 :①治疗组静脉桥新生内膜面积 (1 5 9± 0 95 )mm2 ,对照组新生内膜面积高达 (2 43± 1 3 5 )mm2 ,治疗组显著低于对照组 ,两组比较有非常显著的差异 ,P <0 0 1;②治疗组内膜平滑肌细胞密度均值为 (3 681± 193 5 ) /mm2 ,对照组为 (4 60 7± 1993 ) /mm2 ,两组比较有显著性差异 ,P <0 0 5 ;中膜平滑肌细胞密度均值治疗组 (2 13 9± 73 4) /mm2 ,对照组(3 62 9± 3 2 0 7) /mm2 ,两组比较有显著性的差异 ,P <0 0 5。结论 :紫杉醇可显著抑制静脉桥内膜、中膜平滑肌细胞的增殖 ,抑制新生内膜的形成 ,证明紫杉醇可在防治静脉桥闭塞方面发挥独特作用。 | 吴隐雄 Martin H Chamberlain Thomas Johnson Jason L Johnson Andrew C Newby Gianni D Angelin Martin Oberhoff Karl K Karsch | 2003 | 中国循环杂志2003，18，6： | 2 |
| 2 | 查看详情显示文摘 | James I L Tom D M Salah E Andrew F Karl H S Russell P N | | 0，，： | 1 |
| 3 | Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma显示文摘 | Matthias L?hr Anne Hoffmeyer Jens-Christian Kr?ger Mathias Freund Johannes Hain Albrecht Holle Peter Karle Wolfram T Kn?fel Stefan Liebe Petra Müller Horst Nizze Matthias Renner Robert M Saller Thomas Wagner Karlheinz Hauenstein Walter H Günzburg Brian Sa | 2001 | The Lancet2001，，9268： | 1 |
| 4 | Combinatorial interactions between positive and negative cis-acting elements control spatial patterns of 4cl-! Expression in transgenic tobacco显示文摘 | STEPHEN P L RAJAGOPAL S | 1993 | The Plant Journal1993，4，2： | 1 |
| 5 | β- Peptide foldamers: Robust helix formation in a new family of fl-amino acid oligomers 显示文摘 | Appella D H Christianson L A Karle I L | 1996 | J Am Chem Soc1996，118，13： | 1 |
| 6 | Study on hydro- mechanical deep drawing with uniform pressure onto the blank 显示文摘 | Lang L H Joachim Danckert Karl Brian Nielsen | 2004 | International Journal of Machine Tools & Manfaclure2004，，44： | 1 |
| 7 | A fre quency dependent finite-difference time-domain formu lation for transient propagation in plasma 显示文摘 | RAYMOND J L FORREST H KARL S K | 1991 | IEEE transactions on antennas and propagation1991，39，1： | 1 |
| 8 | Journal of Systems and Software显示文摘 | L Karl H Lazuo | 2001 | ACM2001，55，3： | 1 |
| 9 | The effect of capital structure when expected agency costs are extreme 显示文摘 | Campbell H Karl L Andrew R | 2004 | The Journal of Financial Economics2004，74，： | 1 |
| 10 | On the mechanism of asymmetric nucleophilic ring-opening of epoxides catalyzed by (Salen)CrⅢ complexes显示文摘 | KARL B H JAMES L L JACOBSEN E N | 1996 | J Am Chem Soc1996，118，10： | 1 |
| 11 | Nitrogen modulates phytoplankton growth in spring in the South China Sea显示文摘 | CHEN Y L CHEN H Y KARL D M | 2004 | Continental Shelf Research2004，24，： | 1 |
| 12 | Nitrogen modulates phytoplankton growth in spring in the South China Sea显示文摘 | CHEN Y L CHEN H Y KARL D M | 2004 | Continental Shelf Research2004，24，： | 1 |
| 13 | A domain-specific software architecture for adaptive intelligent systems显示文摘 | BARBARA H R KARL P PHILIPPE L | 1995 | IEEE Transactions on Software Engineering1995，21，4： | 1 |
| 14 | The treat- ment of hand burns显示文摘 | Kamolz L P Kitzinger H B Karle B | 2009 | Burns2009，35，3： | 1 |
| 15 | Spatial analysis of Honolulu motor vehicle crashes: Ⅰ,spatial patterns 显示文摘 | Ned L Karl E K Lawrence H N | 1995 | Accident Analysis and Prevention1995，27，5： | 1 |
| 16 | Distributed algorithms for transmission power control in wireless sensor networks 显示文摘 | Kubisch M Karl H Wolisz A Zhong L C Rabaey J M | 2003 | IEEE WCNC 2003 New Orleans Louisiana March 16-202003，，： | 1 |
| 17 | 8-Hydroxydeoxyguanosine A marker of oxidative DNA damage in systemic lupus mythematosus显示文摘 | JOSEPH L KARL H SUSAN B HELEN R G PAUL E | 1994 | FEBS Lett1994，348，2： | 1 |
| 18 | Characterization of gap junctional intercellular communication in immortalized human pancreatic ductal epithelial cells with stem cell characteristics 显示文摘 | Tai M H Karl O L Burra V M | 2003 | Pancreas2003，26，1： | 1 |
| 19 | The treatment of hand bums显示文摘 | Kamolz L P Kitzinger H B Karle B | 2009 | Bums2009，35，3： | 1 |
| 20 | Location estimation via support vector regression 显示文摘 | Wu H L Ng J K Karl R | 2007 | Mobile Computing2007，6，3： | 1 |
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