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| 1 | SIRT3多酚激活剂的筛选及其对UVB诱导HaCaT细胞衰老的修复作用显示文摘沉默信息调节因子2相关酶类3(silent mating type information regulation 2 homolog 3,SIRT3)是位于线粒体基质中的一种去乙酰化酶,在线粒体能量代谢、氧化应激调节、延缓衰老等方面具有重要的作用。本研究通过采用SIRT3-EGFP报告基因系统及实时荧光定量聚合酶链式反应技术,从白藜芦醇、山柰酚、石榴皮鞣素、安石榴苷、漆树黄酮、咖啡醇、矢车菊素、飞燕草素葡萄糖苷这8种多酚类化合物中筛选SIRT3激活剂,并评价筛选得到的SIRT3多酚激活剂对于中波紫外线(ultraviolet radiation B,UVB)诱导的人正常皮肤永生化角质形成细胞(human immortalized keratinocytes,HaCaT)衰老的抑制作用。结果表明,白藜芦醇、山柰酚、安石榴苷、漆树黄酮和咖啡醇具有显著增强SIRT3基因表达水平的作用(P<0.05);白藜芦醇、安石榴苷、漆树黄酮以及咖啡醇均能有效降低UVB诱导的细胞内活性氧水平;这5种多酚均显著提高了谷胱甘肽(reduced glutathione,GSH)/氧化型谷胱甘肽(oxidized glutathione,GSSG)比值(P<0.05),白藜芦醇与咖啡醇显著增强了超氧化物歧化酶2活性(P<0.05、P<0.01);此外,安石榴苷不仅可以激活SIRT3,修复细胞的抗氧化系统,且显著降低了细胞衰老标志物SA-β-gal的相对活力(P<0.05)。结论:白藜芦醇、山柰酚、安石榴苷、漆树黄酮和咖啡醇均能激活SIRT3基因的表达,其中安石榴苷能够显著修复UVB诱导的HaCaT细胞衰老,其抗衰老机制可能与SIRT3-烟酰胺腺嘌呤二核苷酸磷酸-GSH/GSSG抗氧化途径有关。 | 陈慧 YOSHINORI Katakura 扈洪波 尹淑涛 赵冲 | 2021 | 食品科学2021，42，5： | 6 |
| 2 | 固定化酶-离子交换组合系统进行青霉素G水解生产6-APA的模型化研究显示文摘采用固定化青霉素酰化酶(Penicillin acylase)在反应器中进行青霉素G水解生产6-APA,同时与离子交换柱相组合以连续地去除反应混合液中的苯乙酸。建立了离子交换柱的分格模型(Compartment model),在确定了青霉素G和苯乙酸沿柱高的浓度分布的基础上,与描述固定化酶反应器的状态方程相结合,得到了固定化酶-离子交换组合系统的数学模型。在将计算机模拟值与实验值进行验证后,探讨了组合系统中树脂量、循环流速和组合起始时间对青霉素G酶解过程的影响。 | 陈坚 Takeshi Omasa Yoshio Katakura Suteaki Shioya Ken-ichi Suga | 1995 | 生物工程学报1995，11，4： | 6 |
| 3 | Pancreatic involvement in chronic viral hepatitis显示文摘AIM: To elucidate the frequency and characteristics of pancreatic disorders in the course of chronic viral hepatitis. METHODS: We prospectively assessed the serum pancreatic enzyme levels and imaging findings in patients with chronic viral hepatitis and healthy control subjects. RESULTS: Serum amylase (t-Amy), salivary amylase (s-Amy), pancreatic amylase (p-Amy) and serum lipase levels were higher in hepatitis patients in comparison to control subjects. However, in asymptomatic viral carriers, only the serum t-Amy levels were higher than those of the controls. The levels of each enzyme rose with the progression of liver disease in patients with hepatitis B or C; whereas the levels of each enzyme within the same clinical stage of the disease did not differ between patients diagnosed with either hepatitis B or hepatitis C virus. Imaging findings demonstrated chronic pancreatitis in only 1 out of 202 patients (0.5%).CONCLUSION: Our data suggest that serum levels of pancreatic enzymes increase with the progression of liver disease in patients diagnosed with viral hepatitis. Pancreatic disease, asymptomatic in most cases, may represent an extrahepatic manifestation of chronic viral hepatitis. | Yoshiki Katakura Hiroshi Yotsuyanagi Kiyoe Hashizume Chiaki Okuse Noriaki Okuse Kohji Nishikawa Michihiro Suzuki Shiro Iino Fumio Itoh | 2005 | World Journal of Gastroenterology2005，11，23： | 5 |
| 4 | Toll-like receptor 9 gene mutations and polymorphisms in Japanese ulcerative colitis patients显示文摘Abnormal innate immune responses toward luminal bacteria play an important role in the pathogenesis of inflammatory bowel disease.It has been demonstrated that bacteria having CpG DNA ameliorate experimental colitis in mice,and Toll-like receptor 9 (TLR9) signaling mediates the anti-inflammatory effects in mouse colonic inflammation.A gene variation in NOD2/CARD15 has been reported in Crohn's disease (CD) patients in Western countries,but this variation has not been identified in Japanese CD patients.Therefore,we hypothesized that TLR9 is a key factor in the development of ulcerative colitis (UC),and we investigated gene mutations and polymorphisms of TLR9 in Japanese UC patients.Three single nucleotide polymorphisms (SNPs) in TLR9 were identified in healthy controls,and were assessed in 48 UC patients and 47 healthy controls.Control subjects were matched for age,sex and date of blood sampling from among a subgroup of participants.We found that TLR9-1486CC,1174GG and 2848AA increase the risk of UC [odds ratio (OR) 2.64,95% confidence interval (95% CI):1.73-6.53,P=0.042],and TLR9-1486TT,1174AA and 2848GG decrease the risk of UC (OR 0.30,95% CI:0.10-0.94,P=0.039),although there were no correlations between SNPs and disease phenotype or TLR9 mRNA expression.These findings suggest that TLR9 polymorphisms are associated with increased susceptibility to UC. | Kaori Fuse Kyoko Katakura Natsumi Sakamoto Hiromasa Ohira | 2010 | World Journal of Gastroenterology2010，16，46： | 4 |
| 5 | Obstructive jaundice caused by secondary pancreatic tumor from malignant solitary fibrous tumor of pleura:A case report显示文摘对胸膜的恶意的独居的含纤维的肿瘤的手术后的双边的多重肺转移的全身的化疗上的一个 77 岁的人受不了瘙痒和黄疸。血检查显示出肝胆管酶的提高的层次。腹的计算断层摄影术在胰腺的头与外部改进显示出一个肿瘤,与 intra 肝、额外肝的胆汁管的膨胀伴随了。他作为把妨碍的黄疸被一个胰腺的头肿瘤引起了被诊断。胰腺的头肿瘤大概作为胸膜的恶意的独居的含纤维的肿瘤的转移被诊断,因为腹的 CT 上的胰腺的头肿瘤上的调查结果类似于胸膜的恶意的独居的含纤维的肿瘤的主要的肺损害上的那些。胰腺的肿瘤在胆总管的劣等的部分在金属性的斯滕特氏印模膏的培植以后很快成长了。病人死于肺的癌性淋巴管炎。尸体揭示了从胰腺的头传播了到肝的核的一个肿瘤。用显微镜,和骨胶原免职展出原子 atypicality 或分割的塑造锭子的房间被观察。Immunohistochemically 胰腺的头肿瘤房间为 alpha 光滑的肌肉肌动朊(alpha-SMA ) 或 CD117 染色是否定的,但是为 vimentin, CD34 和 CD99 积极。这些调查结果与胸膜的恶意的独居的含纤维的肿瘤上的那些一致。我们报导一个第二等的胰腺的肿瘤从胸膜的恶意的独居的含纤维的肿瘤引起的妨碍的黄疸的第一个案例。 | Norie Yamada Chiaki Okuse Masahito Nomoto Mayu Orita Yoshiki Katakura Toshiya Ishii Takuo Shinmyo Hiroaki Osada Ichiro Maeda Hiroshi Yotsuyanagi Michihiro Suzuki Fumio Itoh | 2006 | World Journal of Gastroenterology2006，12，30： | 2 |
| 6 | Effect of the Prol2Ala variant of the human peroxisome proliferator activated receptor γ gene on adiposity, fat distribution, and insulin sensitivity in Japanese men显示文摘 | Mori Y Kim-motoyama H Katakura T | 1998 | Biochem Biophys ResCommun1998，251，： | 2 |
| 7 | Usefulness of endoscopic ultrasound to diagnose the severity of chronic pancreatitis显示文摘 | Atsushi Irisawa Kyoko Katakura Hiromasa Ohira Ai Sato Manoop S. Bhutani Lyndon V. Hernandez Masaru Koizumi | 2007 | Journal of Gastroenterology2007，，17： | 2 |
| 8 | Immortalization by gene transfection 显示文摘 | Alam S Shirahata S | 1998 | Methods Cell Biol1998，57，： | 1 |
| 9 | Interhemispheric approach through lamina terminalis to tumors of the anterior part of the third ventricle显示文摘 | Katakura R Mori T | 1984 | Surg Neurol1984，22，： | 1 |
| 10 | Preventive effect of selenium against the testicular injury by cadmium显示文摘 | Katakura M | 1999 | Nippon Eiseigaku Zasshi1999，54，2： | 1 |
| 11 | Highly efficient and aberration-corrected spectrometer for advanced Raman spectroscopy显示文摘 | FUTAMATA M TAKENOUCHI T KATAKURA K | 2002 | Applied Optics2002，41，22： | 1 |
| 12 | Effects of docosahexaenoic acid on in vitro amyloid beta peptide 25-35 fibrillation 显示文摘 | HASHIMOTO M SHAHDAT H KATAKURA M | 2009 | BBA-mol Cell Biol L2009，1791，： | 1 |
| 13 | Effect of the Pro12Ala variant of peroxisome proliferator-activated receptorγ2 on adiposity,fat distribtuion,and insulin sensitivity in Japanese men显示文摘 | Mori Y Kim-Motoyama H Katakura T | 1998 | Biochem Biophys Res Commun1998，251，1： | 1 |
| 14 | Nuclear Data sheets for A=125显示文摘 | Katakura J | 1999 | NuclearDatasheets1999，86，4： | 1 |
| 15 | Preventive effect of selenium against the testicular injury by cadmium显示文摘 | Katakura M Sugawara N | 1999 | Nippon - Eiseigaku - Zasshi1999，54，2： | 1 |
| 16 | Epitope analysis of human monoclonal antibody specific for rice allergenic protein generated by in vitro immunization 显示文摘 | Sun-Yup Shim Yoshinori Katakura | 2001 | Cytotechnology2001，36，： | 1 |
| 17 | Car- bon dioxide emission model in actual road vehicular traf- fic conditions 显示文摘 | OGUCHI T KATAKURA M TANIGUCHI M | 2002 | Journal of JSCE Division D= Infra- structure Planning and Management2002，695，： | 1 |
| 18 | Docosa hexaenoie acid promotes neuronal differentiation by regulating basic helix-loop-helix transcription factors and cell cycle in neural stem cells 显示文摘 | Katakura M Hashimoto M Shahdat HM | 2009 | Neuroscience2009，160，3： | 1 |
| 19 | Endostatin inhibits lymph node metastasis by a down-regulation of the vascular endothelial growth factor C expression in tumor cells显示文摘 | Fukumoto S Morifuji M Katakura Y | 2005 | Clin Exp Metastasis2005，22，： | 1 |
| 20 | Postprandial hyperglycemia is an independent risk for retinopathy in el- derly patients with type 2 diabetes mellitus, especially in those with near-normal glycosylated hemoglobin 显示文摘 | AIZAWA T KATAKURA M NAKA M | 2010 | J Am Geriatr Soc2010，58，7： | 1 |
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