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| 1 | Female hepatology:Favorable role of estrogen in chronic liver disease with hepatitis B virus infection显示文摘Chronic hepatitis B virus (HBV) infection is the most common cause of hepatic fibrosis and hepatocellular carcinoma (HCC),mainly as a result of chronic necroinflammatory liver disease. A characteristic feature of chronic hepatitis B infection,alcoholic liver disease and nonalcoholic fatty liver disease (NAFLD) is hepatic steatosis. Hepatic steatosis leads to an increase in lipid peroxidation in hepatocytes,which,in turn,activates hepatic stellate cells (HSCs). HSCs are the primary target cells for inflammatory and oxidative stimuli,and these cells produce extracellular matrix components. Chronic hepatitis B appears to progress more rapidly in males than in females,and NAFLD,cirrhosis and HCC are predominately diseases that tend to occur in men and postmenopausal women. Premenopausal women have lower hepatic iron stores and a decreased production of proinflammatory cytokines. Hepatic steatosis has been observed in aromatase-deficient mice,and has been shown to decrease in animals after estradiol treatment. Estradiol is a potent endogenous antioxidant which suppresses hepatic fibrosis in animal models,and attenuates induction of redox sensitive transcription factors,hepatocyte apoptosis and HSC activation by inhibiting a generation of reactive oxygen species in primary cultures. Variant estrogen receptors are expressed to a greater extent in male patients with chronic liver disease than in females. These lines of evidence suggest that the greater progression of hepatic fibrosis and HCC in men and postmenopausal women may be due,at least in part,to lower production of estradiol and a reduced response to the action of estradiol. A better understanding of the basic mechanisms underlying the sex-associated differences in hepatic fibrogenesis and carciogenesis may open up new avenues for the prevention and treatment of chronic liver disease. | Ichiro Shimizu Nao Kohno Katsuyoshi Tamaki Masayuki Shono Hui-Wei Huang Jiang-Hong He Deng-Fu Yao | 2007 | World Journal of Gastroenterology2007，13，32： | 49 |
| 2 | Regional lymphadenectomy for gallbladder cancer: Rational extent, technical details, and patient outcomes显示文摘AIM: To define the rational extent of regional lymphadenectomy for gallbladder cancer and to clarify its effect on long-term survival. METHODS: A total of 152 patients with gallbladder cancer who underwent a minimum of 'extended' portal lymph node dissection (defined as en bloc removal of the first-and second-echelon nodes) from 1982 to 2010 were retrospectively analyzed. Based on previous studies, regional lymph nodes of the gallbladder were divided into first-echelon nodes (cystic duct or pericholedochal nodes), second-echelon nodes (node groups posterosuperior to the head of the pancreas or around the hepatic vessels), and more distant nodes. RESULTS: Among the 152 patients (total of 3352 lymph nodes retrieved, median of 19 per patient), 79 patients (52%) had 356 positive nodes. Among nodepositive patients, the prevalence of nodal metastasis was highest in the pericholedochal (54%) and cystic duct (38%) nodes, followed by the second-echelon node groups (29% to 19%), while more distant node groups were only rarely (5% or less) involved. Disease-specific survival after R0 resection differed according to the nodal status (P < 0.001): most node-negative patients achieved long-term survival (median, not reached; 5-year survival, 80%), whereas among nodepositive patients, 22 survived for more than 5 years (median, 37 mo; 5-year survival, 43%). CONCLUSION: The rational extent of lymphadenectomy for gallbladder cancer should include the first-and second-echelon nodes. A considerable proportion of node-positive patients benefit from such aggressive lymphadenectomy. | Yoshio Shirai Toshifumi Wakai Jun Sakata Katsuyoshi Hatakeyama | 2012 | World Journal of Gastroenterology2012，18，22： | 35 |
| 3 | Catheter tract implantation metastases associated with percutaneous biliary drainage for extrahepatic cholangiocarcinoma显示文摘AIM: To estimate the incidence of catheter tract implantation metastasis among patients undergoing percutaneous transhepatic biliary drainage (PTBD) for extrahepatic cholangiocarcinoma, and to provide data regarding the management of this unusual complication of PTBD by reviewing cases reported in the literature.METHODS: A retrospective analysis of 67 consecutive patients who underwent PTBD before the resection of extrahepatic cholangiocarcinoma was conducted. The median follow-up period after PTBD was 106 mo. The English language literature (PubMed, National Library of Medicine, Bethesda, MD, USA), from January 1966through December 2004, was reviewed.RESULTS: Catheter tract implantation metastasis developed in three patients. The cumulative incidence of implantation metastasis reached a plateau (6%)at 20 mo after PTBD. All of the three patients with implantation metastasis died of tumor progression at 3, 9, and 20 mo after the detection of this complication. Among the 10 reported patients with catheter tract implantation metastasis from extrahepatic cholangiocarcinoma (including our three patients), two survived for more than 5 years after the excision of isolated catheter tract metastases.CONCLUSION: Catheter tract implantation metastasis is not a rare complication following PTBD for extrahepatic cholangiocarcinoma. Although the prognosis for patients with this complication is generally poor, the excision of the catheter tract may enable survival in selected patients with isolated metastases along the catheter tract. | Jun Sakata Yoshio Shirai Toshifumi Wakai Tatsuya Nomura Eiko Sakata Katsuyoshi Hatakeyama | 2005 | World Journal of Gastroenterology2005，11，44： | 31 |
| 4 | Effects of Danhong Injection(丹红注射液) and Its Main Components on Anticoagulation and Fibrinolysis in Cultured Vein Endothelial Cells显示文摘Objective: To observe the effects of Danhong Injection(丹红注射液) and its main components, including daiclzein and hydroxysafflor yellow A(HSYA), on the anticoagulation, fibrinolysis, anti-apoptosis in hypoxia model of vein endothelial cells(VECs). Methods: VECs were prepared and were put in a hypoxia environment, which consisted of mixed gas of 95% N_2 and 5% CO_2 mixed gas, when reached confluent culture. Five groups used different treatments, including normal control group, hypoxia group, daiclzein group, HSYA group and Danhong Injection group. The VECs were identified by fluorescence double labeling methods. The morphology was observed by a phase contrast microscopy. The effects of Danhong Injection, daiclzein and HSYA on 6 keto prostaglandin F1α(6-keto-PGF1α) level was measured by the method of radioimmunoassay(RIA). Superoxide dismutase(SOD) activity was tested by water soluble tetrazolium salt. The content of malondialdehyde(MDA) was measured by thiobarbituric acid. The activities of tissue-type plasminogen activator(t-PA) and plasminogen activator inhibitor(PAI) were measured by the method of chromogenic substrate. The contents of endothelin(ET) and nitric oxide(NO) were detected by non-equilibrium RIA and enzymelinked immunosorbent assay. Cells apoptosis rate was determined by flow cytometry. Results: Compared with the normal control group, the floating cells number, PAI activity, ET and MDA contents, and cells apoptosis rate in the culture solution of hypoxia group were all significantly increased, whereas the 6-keto-PGF1α and NO contents, and t-PA and SOD activities were decreased significantly(P<0.01). Compared with the hypoxia group, Danhong Injection markedly increased the 6-keto-PGF1α content and SOD activity, regulated PAI and t-PA activities, ET and NO contents, and decreased MDA content and cells apoptosis rate(P<0.05 or P<0.01). Conclusions: Danhong Injection and its main components played an important role in protecting primary VECs from hypoxic damage by regulating the secretion and vasomotor function of VECs. The function of Danhong Injection was most remarkable. | 张宇燕 周惠芬 杨洁红 何昱 陈小强 Katsuyoshi Nishinari 万浩芳 万海同 | 2016 | Chinese Journal of Integrative Medicine2016，22，4： | 14 |
| 5 | 'Extended' radical cholecystectomy for gallbladder cancer:Long-term outcomes, indications and limitations显示文摘AIM:To delineate indications and limitations for 'ex tended' radical cholecystectomy for gallbladder cancer:a procedure which was instituted in our department in 1982. METHODS:Of 145 patients who underwent a radi cal resection for gallbladder cancer from 1982 through 2006, 52 (36%) had an extended radical cholecystec tomy, which involved en bloc resection of the gallblad der, gallbladder fossa, extrahepatic bile duct, and the regional lymph nodes (first-and second-echelon node groups). A retrospective analysis of the 52 patients was conducted including at least 5 years of follow up. Residual tumor status was judged as no residual tumor (R0) or microscopic/macroscopic residual tumor (R1 2). athological findings were documented according tothe American Joint Committee on Cancer Cancer Stag ing anual (7th edition). RESULTS:he primary t mor as classified as patho-logical T1 (pT1) in 3 patients, pT2 in 36, pT3 in 12, and pT4 in 1. Twenty three patients had lymph node metastases; 11 had a single positive node, 4 had two positive nodes, and 8 had three or more positive nodes. None of the three patients with pT1 tumors had nodal disease, whereas 23 of 49 (47%) with pT2 or more advanced tumors had nodal disease. One patient died during the hospital stay for definitive resection, giv ing an in hospital mortality rate of 2%. Overall survival (OS) after extended radical cholecystectomy was 65% at 5 years and 53% at 10 years in all 52 patients. OS differed according to the p classification ( < 0.001) and the nodal status ( = 0.010). All of 3 patients with pT1 tumors and most (29 of 36) patients with pT2 tu mors survived for more than 5 years. Of 12 patients with pT3 tumors, 8 who had an R1 2 resection, distant metastasis, or extensive extrahepatic organ involve ment died soon after resection. Of the remaining four pT3 patients who had localized hepatic spread through the gallbladder fossa and underwent an R0 resection, 2 survived for more than 5 years and another survived for 4 years and 2 mo. The only patient with pT4 tumor died of disease soon after resection. Among 23 node positive patients, 11 survived for more than 5 years, and of these, 10 had a modest degree of nodal disease (one or two positive nodes). CONCLUSION:Extended radical cholecystectomy is indicated for pT2 tumors and some pT3 tumors with localized hepatic invasion, provided that the regional nodal disease is limited to a modest degree (up to two positive nodes). Extensive pT3 disease, pT4 disease, or marked nodal disease appears to be beyond the scope of this radical procedure. | Yoshio Shirai Jun Sakata Toshifumi Wakai Taku Ohashi Katsuyoshi Hatakeyama | 2012 | World Journal of Gastroenterology2012，18，34： | 11 |
| 6 | 共轭亚油酸水包油型乳液的物理化学稳定性显示文摘共轭亚油酸(conjugated linoleic acid,CLA)是一种具有多重生理功效的不饱和脂肪酸,其氧化稳定性较差,对光、热、氧气很不稳定。以亲水胶体为乳化剂制备CLA的水包油(O/W)型乳液可改善其氧化稳定性,扩大其在食品中的应用。该研究采用改性阿拉伯胶EM2为乳化剂、2种不同黏度的CLA为油相,通过测定乳液颗粒的粒径和粒径分布以及乳液在40℃贮存过程中的过氧化值和茴香胺值,研究了CLA的水包油(O/W)型乳液的物理化学稳定性。结果表明,高质量分数的EM2有利于形成粒径更小且分布均一的乳液颗粒。乳液的氧化稳定性很大程度上依赖于其物理稳定性。对于黏度较小的CLA,在各测试EM2质量分数下,CLA乳液具有较好的物理稳定性,且随着EM2质量分数的增大,乳液氧化稳定性提高。对于黏度较大的CLA,EM2质量分数为5%时,乳液具有较好的物理化学稳定性;增大EM2的质量分数,其稳定性下降。该研究可为今后研究基于乳液技术的功能性因子保护和增效提供参考,有利于CLA在食品行业中的推广应用。 | 徐琼 姚晓琳 王娜娜 田大志 方亚鹏 Glyn O.Phillips Katsuyoshi Nishinari | 2013 | 农业工程学报2013，29，11： | 10 |
| 7 | Genetic changes of p53,K-ras,and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary显示文摘AIM: To disclose geographic differences in genetic changes involved in gallbladder carcinogenesis between two distinct high-incidence areas of Japan and Hungary.METHODS: We examined 42 cases of gallbladder carcinoma: 22 Japanese and 20 Hungarian cases. p53 mutations at exons 5 to 8 and K-ras mutations at codon 12 were tested by direct sequencing. Microsatellite instability was determined from fluorescent dye-labeled PCR amplifications of five-microsatellite markers (BAT-25, BAT-26, D2S123, D5S346, and D17S250).RESULTS: Mutations of p53 were detected in 11 of 22 Japanese cases and 6 of 18 Hungarian cases (11/22 vs 6/18, P = 0.348). Transition at CpG sites was found in none of 11 Japanese cases and 2 of 6 Hungarian cases; the difference was marginally significant (0/11 vs 2/6, P = 0.110). K-ras mutations were detected in only one of the Hungarian cases. Eight of 19 (42.1%) Japanese cases were MSI-high (presence of novel peaks in more than one of the five loci analyzed), whereas only 1 of 15 (6.7%) Hungarian cases was MSI-high (P = 0.047).CONCLUSION: It appears that the p53 mutations and MSI differ in patients with gallbladder carcinoma between two distinct high-incidence areas. Geographic variation might exist in the process of gallbladder carcinogenesis. | Masayuki Nagahashi Yoichi Ajioka Istvan Lang Zoltan Szentirmay Miklos Kasler Hiroto Nakadaira Naoyuki Yokoyama Gen Watanabe Ken Nishikura Toshifumi Wakai Yoshio Shirai Katsuyoshi Hatakeyama Masaharu Yamamoto | 2008 | World Journal of Gastroenterology2008，14，1： | 9 |
| 8 | 60例亚洲人群原发性皮肤鼻型NK/T细胞淋巴瘤与CD56阳性的外周T细胞淋巴瘤细胞谱系及临床病理分析显示文摘原发性皮肤鼻型NK/T细胞淋巴瘤( PC-ENKTL)是一种罕见的EBV相关肿瘤,其临床病理特征目前尚未明确。作者收集亚洲多国PC-ENKTL及CD56阳性的外周T细胞淋巴瘤(PC-CD56+ PTCL)60例进行回顾性分析,探讨两种淋巴瘤的临床病理特征。 | Katsuyoshi T Min-eui H Panitta S 许文静 余英豪 | 2015 | 临床与实验病理学杂志2015，31，5： | 8 |
| 9 | Endobronchial metastasis from adenocarcinoma of gastric cardia 7 years after potentially curable resection显示文摘Endobronchial metastasis(EBM) is a rare form of metas-tasis from extrapulmonary malignant tumors,although there are few reports of EBM from gastric cancer specifically.We report the case of a 51-year-old woman who had undergone gastrectomy for advanced gastric cancer seven years previously but was diagnosed with a solitary lung tumor by follow-up computed tomography.On diagnosis of primary lung cancer,she underwent pulmonary lobectomy,but immunohistochemical examination confirmed the resected tumor to be an EBM from the gastric cancer.Six months later,she was diagnosed with peritoneal metastases and underwent chemotherapy with gastric cancer regimen.She is still alive at 33 mo after the lobectomy.Generally,the prognosis for EBM is poor although multidisciplinary treatment can lead to long-term survival.Precise diagnosis on the basis of detailed pathological and immunohistochemical evaluation can contribute to deciding the most effective treatment and improving prognosis. | Takaaki Hanyu Tatsuo Kanda Atsushi Matsuki Go Hasegawa Kazuhito Yajima Masanori Tsuchida Shin-ichi Kosugi Makoto Naito Katsuyoshi Hatakeyama | 2010 | World Journal of Gastrointestinal Surgery2010，2，8： | 7 |
| 10 | 钙离子诱导的海藻酸钠/黄原胶凝胶化临界行为研究显示文摘研究了海藻酸钠/黄原胶混合体系的相行为及其对海藻酸钠-钙离子凝胶化临界行为的影响.当海藻酸钠浓度为0.5 wt%时,随着黄原胶的添加,混合体系出现相容、相分离及液晶3种不同的相行为.与纯黄原胶溶液相比,海藻酸钠/黄原胶混合溶液在更低的黄原胶浓度下开始形成液晶,这是由于混合体系中相分离的发生导致了黄原胶有效浓度升高.利用葡萄糖酸内酯(GDL)在线酸化Ca-EDTA,释放钙离子,研究了不同钙离子引入量时(f=[Ca2+]/[COO-])混合体系的黏弹性.Winter-Chambon分析发现临界凝胶点(f gel)随黄原胶浓度的增加而降低.当相分离发生时,临界凝胶点急剧降低,当液晶结构形成后,临界凝胶点呈现上升趋势.通过对比Winter-Chambon方法和临界凝胶点模量松弛法所测得的松弛临界指数(nw和nr),发现黄原胶的添加使海藻酸钠临界凝胶失去结构自相似性.相分离的发生导致临界凝胶结构排列更加致密,而液晶的出现使临界凝胶结构排列相对疏松. | 张帆 毛鹏 孔慧玲 赵萌 方亚鹏 Katsuyoshi Nishinari Glyn O.Phillips | 2013 | 高分子学报2013，23，11： | 7 |
| 11 | Integrated application of February Orchid(Orychophragmus violaceus) as green manure with chemical fertilizer for improving grain yield and reducing nitrogen losses in spring maize system in northern China显示文摘The development of more efficient management systems is crucial to achieving high grain yields with high nitrogen use efficiency(NUE). February Orchid-spring maize rotation system is a newly established planting system with the benefits of ground cover and potential wind erosion in northern China. A field experiment was conducted to evaluate the effects of integrated application of February Orchid as green manure with reduction of chemical fertilizers(INTEGRATED) on spring maize yield, N uptake, ammonium volatilization, and soil residual mineral N in northern China. Compared to farmers' traditional fertilization(CON), integrated application of February Orchid as green manure with 30% reduction of nitrogen fertilizers(INTEGRATED) increased maize grain yield and biomass by 9.9 and 10.2%, respectively. The 0–100 cm soil residual Nmin at harvest was decreased by 58.5% and thus nitrogen use efficiency was increased significantly by 26.7%. The nitrogen balance calculation further demonstrated that the INTEGRATED approach performed better than CON with lower apparent nitrogen loss(decreased by 48.9%) which evidenced by the ammonium volatilization of top-dressing fertilizer was decreased by 31.1%, the N_(min) movement to the deeper soil layers was reduced, and the apparent nitrogen leaching loss nearly equal to 0 under the INTEGRATED treatment. Therefore, in northern China, integrated application of green manure and chemical fertilizers is an efficient management approach for improving maize yields and NUE simultaneously. | BAI Jin-shun CAO Wei-dong XIONG Jing ZENG Nao-hua GAO Song-juan Shimizu Katsuyoshi | 2015 | Journal of Integrative Agriculture2015，14，12： | 7 |
| 12 | Low preoperative platelet counts predict a high mortality after partial hepatectomy in patients with hepatocellular carcinoma显示文摘AIM: To assess the validity of our selection criteria for hepatectomy procedures based on indocyanine green disappearance rate (KICG), and to unveil the factors affecting posthepatectomy mortality in patients with hepatocellular carcinoma (HCC).METHODS: A retrospective analysis of 198 consecutive patients with HCC who underwent partial hepatectomies in the past 14 years was conducted. The selection criteria for hepatectomy procedures during the study period were KICG≥0.12 for hemihepatectomy, KICG≥0.10 for bisegmentectomy, KICG≥0.08 for monosegmentectomy, and KICG ≥0.06 for nonanatomic hepatectomy. The hepatectomies were categorized into three types: major hepatectomy (hemihepatectomy or a more extensive procedure),bisegmentectomy, and limited hepatectomy. Univariate (Fishers exact test) and multivariate (the logistic regression model) analyses were used.RESULTS: Postoperative mortality was 5% after major hepatectomy, 3% after bisegmentectomy, and 3% after limited hepatectomy. The three percentages were comparable (P = 0.876). The platelet count of ≤ 10x 104/μL was the strongest independent factor for postoperative mortality on univariate (P = 0.001) and multivariate (risk ratio,12.5; P= 0.029) analyses. No patient with a platelet count of >7.3x 104/μL died of postoperative morbidity, whereas 25% (6/24 patients) of patients with a platelet count of ≤7.3x 104/μL died (P<0.001).CONCLUSION: The selection criteria for hepatectomy procedures based on KICG are generally considered valid,because of the acceptable morbidity and mortality with these criteria. The preoperative platelet count independently affects morbidity and mortality after hepatectomy, suggesting that a combination of KICG and platelet count would further reduce postoperative mortality. | Kazuhiro Kaneko Yoshio Shirai Toshifumi Wakai Naoyuki Yokoyama Kohei Akazawa Katsuyoshi Hatakeyama | 2005 | World Journal of Gastroenterology2005，11，37： | 7 |
| 13 | Risk factors and prevention of biliary anastomotic complications in adult living donor liver transplantation显示文摘AIM: To evaluate risk factors of biliary anastomotic complications (BACs) and outcomes according to type of biliary reconstruction. METHODS: A total of 33 consecutive adult living donor liver transplantation (LDLT) were reviewed, 17 of which had undergone Duct-to-Duct anastomosis (D-D). The remaining 16 patients received Roux-en-Y anastomosis (R-Y). The perioperative factors, such as the type of graft and the number of graft bile ducts, were analyzed retrospectively. RESULTS: The overall incidence of BACs was 39.4%. The incidence of BACs was significantly higher in the patients with than without neoadjuvant chemotherapy (71.4% vs 10%, P = 0.050). There was no signifi cant difference in the incidence of biliary leakage in patients with D-D vs those with R-Y. The incidence of biliary strictures following the healing of biliary leakage was significantly higher in D-D (60%) than in R-Y (0%) (P = 0.026). However, the incidence of BACs related bacteremia was signifi cantly higher in R-Y than in D-D (71.4% vs 0%, P = 0.008). In D-D, use of T-tube stent remarkably reduced the incidence of BACs, compared with straight tube stent (0% vs 50%, P = 0.049). CONCLUSION: Our experience showed an increase of BACs related bacteremia in the patients with R-Y. Therefore, D-D might be a preferred biliary reconstruction. However, the surgical refi nement of D-D should be required because of the high incidence of biliary strictures. Use of the T-tube stent might lead to a signifi cant reduction of BACs in D-D. | Satoshi Yamamoto Yoshinobu Sato Hiroshi Oya Hideki Nakatsuka Takashi Kobayashi Yoshiaki Hara Takaoki Watanabe Isao Kurosaki Katsuyoshi Hatakeyama | 2007 | World Journal of Gastroenterology2007，13，31： | 6 |
| 14 | Effects of long-term application of different green manures on ferric iron reduction in a red paddy soil in Southern China显示文摘Dissimiiatory Fe(Ⅲ) reduction is an important process in the geochemicai cycle of iron in anoxic environment.As the main products of dissimiiatory iron reduction,the Fe(Ⅱ) species accumulation could indicate the reduction ability.The effects of different green manures on Fe(Ⅲ) reduction in paddy soil were explored based on a 31-year rice-rice-winter green manure cropping experiment.Four treatments were involved,i.e.,rice-rice-milk vetch(RRV),rice-rice-rape(RRP),rice-rice-ryegrass(RRG) and rice-rice-winter fallow(RRF).Soils were sampled at flowering stage of milk vetch and rape(S1),before transplantation(S2),at tillering(S3),jointing(S4),and mature(S5) stages of the early rice,and after the harvest of the late rice(S6).The contents of TFe_(HCI)(HCI-extractable total Fe),Fe(Ⅱ)_(HCI)(HCI-extractable Fe(ll) species) and Fe(Ⅲ)_(HCI)(HCIextractable Fe(Ⅲ) species) were measured.The correlations among those Fe species with selected soil environmental factors and the dynamic characteristics of Fe(Ⅱ)_(HCI) accumulation were investigated.The results showed that TFe_(HCI) in RRF was significantly higher than those in the green manure treatments at most of the sampling stages.Fe(Ⅱ)_(HCI) increased rapidly after the incorporation of green manures in all treatments and kept rising with the growth of early rice.Fe(Ⅱ)_(HCI) in RRG was quite different from those in other treatments,i.e.,it reached the highest at the S2 stage,then increased slowly and became the lowest one atthe S4 and S5 stages.Fe(Ⅲ)_(HCI) showed oppositely,and Fe(Ⅱ)_(HCI)/Fe(Ⅲ)_(HCI) performed similarly to Fe(Ⅱ)_(HCI).The maximum accumulation potential of Fe(Ⅱ)_(HCI) was significantly higher in RRF,while the highest maximum reaction rate of Fe(Ⅱ)_(HCI) accumulation appeared in RRG.Significant correlations were found between the indexes of Fe(Ⅱ)_(HCI)accumulation and soil pH,oxidation-reduction potential(Eh) and total organic acids,respectively.In together,we found that long-term application of green manures decreased the TFe_(HCI) in red paddy soils,but promoted the ability of Fe(Ⅲ)reduction,especially the ryegrass;Fe(Ⅱ)_(HCI) increased along with the growth of rice and was affected by soil conditions and environmental factors,especially the water and redox ability. | GAO Song-juan CAO Wei-dong GAO Ju-sheng HUANG Jing BAI Jin-shun ZENG Nao-hua CHANG Dan-na SHIMIZU Katsuyoshi | 2017 | Journal of Integrative Agriculture2017，16，4： | 6 |
| 15 | Narrow portion of the terminal choledochus is a cause of upstream biliary dilatation in patients with anomalous union of the pancreatic and biliary ducts显示文摘AIM: To clarify the pathogenesis of biliary dilatation associated with anomalous union of the pancreatic and biliary ducts (AUPBD).METHODS: Direct cholangiopancreatograms of 350 adult patients with or with suspicion of hepatobiliary or pancreatic disorders were reviewed. AUPBD was diagnosed cholangiopancreatographically, when the pancreaticobiliary ductal union was located above the narrow distal segment of the bile duct, which represents the action of the sphincter of Oddi. The narrow portion of the terminal choledochus was defined as symmetrical stricture of the common bile duct just above the pancreaticobiliary ductal union.RESULTS: AUPBD was found in 36 patients. Among cholangiopancreatographic features, the narrow portion of the terminal choledochus was the most pathognomonic for AUPBD (accuracy, 98%); it was present in 29 (81%)patients with AUPBD, but was not found in any patients without AUPBD. Among patients with AUPBD, biliary dilatation (>10 mm) was more frequent in those with the narrow portion of the terminal choledochus (23/29)than in those without (2/7; P = 0.018) AUPBD. Among the patients with both AUPBD and the narrow portion of the terminal choledochus, there was a strong negative correlation between the minimum diameter of the narrow portion and the maximum diameter of the choledochus (r = -0.78, P<0.001), suggesting that the degree of biliary narrowing at the narrow portion correlates with that of upstream biliary dilatation.CONCLUSION: The narrow portion of the terminal choledochus, a pathognomonic radiologic feature of AUPBD, may be a cause of biliary dilatation in patients with AUPBD. | Tatsuya Nomura Yoshio Shirai Toshifumi Wakai Naoyuki Yokoyama Jun Sakata Katsuyoshi Hatakeyama | 2005 | World Journal of Gastroenterology2005，11，41： | 5 |
| 16 | Effects of estradiol and progesterone on the proinflammatory cytokine production by mononuclear cells from patients with chronic hepatitis C显示文摘AIM:To investigate the effects of estradiol (E2) and progesterone on the unstimulated and oxidative stressstimulated production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-8, and macrophage chemotactic protein (MCP)-1 by peripheral blood mononuclear cells (PBMCs) from patients with chronic hepatitis C and healthy controls. METHODS:The PBMCs were separated from agematched 72 males and 71 females with and without chronic hepatitis C, who were divided into two groups based on a mean menopausal age of 50 years. Oxidative stress was induced by hydrogen peroxide in the cells incubated in serum-free media. Cytokines in the culture supernatant were measured by an enzyme-linked immunosorbent assay. RESULTS:The highest levels of the spontaneous production of TNF-α, IL-1β, IL-8, and MCP-1 by the unstimulated PBMCs were in the older male patients with chronic hepatitis C and the lowest levels were in the premenopausal female healthy controls. E2 inhibited the cytokine production by the unstimulated PBMCs from the older male and post-menopausal female patients, which was further stimulated by progesterone. The exposure to hydrogen peroxide in the PBMCs from the younger male and pre-menopausal female healthy subjects induced the production of cytokines. The change rates of the hydrogen peroxide-stimulated cytokine production were suppressed by E2 and enhanced by progesterone. CONCLUSION:These findings suggest that E2 may play a favorable role in the course of persistent liver injury by preventing the accumulation of monocytes-macrophages and by inhibiting proinflammatory cytokine production, whereas progesterone may counteract the favorable E2 effects. | Ying Yuan Ichiro Shimizu Mi Shen Eriko Aoyagi Hidetaka Takenaka Tatuzo Itagaki Mari Urata Katsutaka Sannomiya Nao Kohno Katsuyoshi Tamaki Masayuki Shono Tetsuji Takayama | 2008 | World Journal of Gastroenterology2008，14，14： | 5 |
| 17 | Field survey of a sustainable sanitation system in a residential house显示文摘Sustainable sanitation is an approach for more ecological and sustainable water resources management. In this paper, we proposed one of the new integrated waste treatment systems: an “sustainable sanitation system” that includes separation of the black water from water system by a non-flushing toilet (bio-toilet), and a gray water treatment based on a biological and ecological concept. Sustainable sanitation system also converts the domestic waste to soil conditioners and fertilizers, for farmland use. As one of the case studies, Environmentally Symbiotic Housing in which people actually live using the bio-toilet for the black water treatment and the household wastewater treatment facility for the gray water was introduced. The availability of this system was investigated by analyzing the sawdust used in the bio-toilet and the quality of the effluent in the household wastewater treatment facility. As the result, the water content of the sawdust did not exceed 60% in any of the sampling points and the BOD and COD of the effluent of the household wastewater treatment facility were below 10 and 20 mg/L respectively, due to the low loading. Compared to the pollution load on the water environment created by the conventional system, it was found that the effluent of the house has a lower load than the tertiary treatment and the volume of the water consumption is 75% of the conventional system. | Naoko NAKAGAWA Masahiro OTAKI Shinji MIURA Hironobu HAMASUNA Katsuyoshi ISHIZAKI | 2006 | Journal of Environmental Sciences2006，18，6： | 4 |
| 18 | Possible role of human cytomegalovirus in pouchitis after proctocolectomy with ileal pouch-anal anastomosis in patients with ulcerative colitis显示文摘AIM: To detect the presence of human cytomegalovirus (HCMV) proteins and genes on the ileal pouch of patients with ulcerative colitis who have undergone proctocolectomy with ileal pouch-anal anastomosis (iPAA). METHODS: immunohistochemistry, polymerase chain reaction (PCR) and PCR sequencing methods were utilized to test the presence of HCMV in pouch specimens taken from 34 patients in 86 endoscopies. RESULTS: HCMV genes and proteins were detected in samples from 12 (35.2%) patients. The rate of detection was significant in the endoscopies from patients diagnosed with pouchitis (5 of 12, 41.6%), according to the Japanese classification of pouchitis, in comparison to patients with normal pouch (7 of 62, 11.2%; P = 0.021). in all patients with pouchitis in which the HCMV was detected, it was the first episode of pouchitis. The virus was not detected in previous biopsies taken in normal endoscopies of these patients. During the follow- up, HCMV was detected in one patient with recurrent pouchitis and in 3 patients whose pouchitis episodes improved but whose positive endoscopic findings persisted. CONCLUSION: HCMV can take part in the inflammatory process of the pouch in some patients with ulcerative colitis who have undergone proctocolectomy with iPAA. | Damian Casadesus Tatsuo Tani Toshifumi Wakai Satoshi Maruyama Tsuneo iiai Haruhiko Okamoto Katsuyoshi Hatakeyama | 2007 | World Journal of Gastroenterology2007，13，7： | 4 |
| 19 | Primary intestinal follicular lymphoma:How to identify follicular lymphoma by routine endoscopy显示文摘A 69-year-old Japanese female was diagnosed with primary intestinal follicular lymphoma. Esophagogas-troduodenoscopy with high-definition imaging revealed not only the typical feature of whitish polyps of up to 2 mm in diameter in the duodenal second and third portions, but also more detailed morphology, such as enlarged whitish villi and tiny whitish depositions. These findings appeared to reflect the pathological structures; infiltration of lymphoma cells into the villi were probably seen as enlargement of the villi, and the formation of lymphoid follicles were shown as opaque white spots or tiny white depositions. Thus, the above features might contribute to the distinct diagnosis of intestinal follicular lymphoma. This case indicates that routine esophagogastroduodenoscopy can visualize microsurface structures, which can be pathognomonic and help to diagnose intestinal follicular lymphoma, even without magnifying endoscopy. | Masaya Iwamuro Yoshinari Kawai Katsuyoshi Takata Seiji Kawano Tadashi Yoshino Hiroyuki Okada Kazuhide Yamamoto | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，1： | 4 |
| 20 | Peroral cholangioscopy for non-invasive papillary cholangio-carcinoma with extensive superficial ductal spread显示文摘Papillary carcinoma arising from the extrahepatic bile duct often shows superficial ductal spread. We report herein the case of a patient with extensive superficial spread of non-invasive papillary cholangiocarcinoma,which was depicted with peroral cholangioscopy. A 65-year-old woman presented with the sudden-onset of severe epigastric pain. Ultrasonography revealed acute acalculous cholecystitis. Endoscopic retrograde cholangiography found small protruding lesions around the confluence of the cystic duct, suggestive of a cholangiocarcinoma. As the contour of the middle and upper bile ducts it was slightly irregular on the cholangiogram, the presence of superficial ductal spread was suspected. Peroral cholangioscopy revealed small papillary lesions around the confluence of the cystic duct and fine granular mucosal lesions in the middle and upper bile ducts and the right hepatic duct, suggesting a superficially spreading tumor. A right hepatectomy with bile duct resection was performed and no residual tumor was found. Histological examination revealed a non-invasive papillary carcinoma arising from the cystic duct with extensive superficial spread. Our experience of this case and a review of the literature suggest that a fine granular or fine papillary appearance of the ductal mucosae on cholangioscopy indicates superficial spread of papillary cholangiocarcinoma, for which peroral cholangioscopy is an efficient diagnostic option. | Toshifumi Wakai Yoshio Shirai Katsuyoshi Hatakeyama | 2005 | World Journal of Gastroenterology2005，11，41： | 3 |
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