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| 1 | 在血压控制不良的高血压患者中使用数字化干预的家庭和在线血压管理:随机对照试验显示文摘HOME BP试验(The home and online management and evaluation of blood pressure)的目的是评估在初级预防中结合自我监测和自我管理的数字化干预在高血压管理中的作用。研究者纳入英国76个治疗中心经过治疗但血压控制不好(>140/90 mm Hg, 1 mm Hg=0.133 kPa)并能上网的患者622例,进行自动确定主要终点的公开随机对照试验。 | McMa-nus RJ Little P Stuart B Morton K Raftery J Kelly J Bradbury K Zhang J Zhu S Murray E May CR Mair FS Michie S Smith P Band R Ogburn E AllenJ Rice C Nut-tall J Williams B Yardley L 陈嘉睿(译) 叶鹏(审校) | 2021 | 中华高血压杂志2021，29，5： | 15 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | Second order elastic deformation of solids显示文摘 | HUGHES D S KELLY J L | 1953 | Physical Review1953，92，5： | 1 |
| 4 | A Survey of Emergency Department 2009 Pandemic Influenza A(H1N1) Surge Preparedness-Atlanta,Georgia,July-October 2009显示文摘 | David S Kelly H Kathryn L | 2011 | Clin Infcet Dis2011，52，1： | 1 |
| 5 | Pharmacist and physician views on col- laborative practice: Findings from the community pharmaceutical care pro- ject显示文摘 | Kelly DV Bishop L Young S | 2013 | CPJ/RPC2013，146，4： | 1 |
| 6 | 查看详情显示文摘 | Regan S P Marozas J A Craxton R S Kelly J H Donaldson W R Jaanimagi P A Jacobs-Perkins D Keck R L Kessler T J Mey-erhofer D D Sangster T C Seka W Smalyuk V A Sknpsky S Zuegel J D | | 0，，： | 1 |
| 7 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 8 | Importance of the forest canopy to flux of methylmercury and total mercury to boreal ecosystems显示文摘 | Vincent L Louis S T John W M Kelly C A | 2001 | Environmental Science and Technology2001，35，： | 1 |
| 9 | Classification comparisons between dual-pol,compact polarimetric and quad-pol SAR imagery显示文摘 | Ainsworth T L Kelly J P Lee J S | 2009 | ISPRS Journal of Photogrammetry and Remote Sensing2009，64，5： | 1 |
| 10 | The influence of protein aggregates on the fouling of microfiltration membranes during stirred cell filtration显示文摘 | KELLY S T OPONG W S ZYDNEY A L | 1993 | J Membr Sci1993，80，： | 1 |
| 11 | Dual en- ergy X-Ray absorptiometry body composition reference values from NHANES 显示文摘 | KELLY T L WILSON K E HEYMSFIELD S B | 2009 | PLoS ONE2009，4，9： | 1 |
| 12 | Vaginal prostaglandin(PGE2 and PGF2a)for induction of labour at term显示文摘 | KELLY A MALIK S SMITH L | 2009 | The Co-chrane Library2009，4，4： | 1 |
| 13 | Wheat bran lipophilic compounds w ith in vitro anticancer effects显示文摘 | Liu L Kelly MW Lesley S | 2012 | Food Chem2012，130，1： | 1 |
| 14 | Mechanical property measurements of MEMS devices显示文摘 | Stephens L S Kelly K W Simhadri S | 2001 | Micro electro Mechanical Systems2001，10，3： | 1 |
| 15 | Precuneus shares in- trinsic functional arehiteeture in humans and monkeys显示文摘 | Margulies D S Vineent J L Kelly C | 2009 | Proc Natl Acad Sci USA2009，106，47： | 1 |
| 16 | Characterization of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics显示文摘 | Hefnawy T E Raja S Kelly L | 2004 | Clinical Chemistry2004，50，3： | 1 |
| 17 | Characterization of the MHC I region of the Japanese pufferfish(Fugu rubripes)显示文摘 | Clark M S Shaw L Kelly A | 2001 | Immunogenetics2001，52，7： | 1 |
| 18 | Reservoir surfaces as sources of greenhouse gases to the atmosphere: a global estimate显示文摘 | Louis V L S Kelly C A Duchemin | 2000 | Bioscience2000，0，9： | 1 |
| 19 | Characteriza- tion of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics 显示文摘 | EI-Hefnawy T Raja S Kelly L | 2004 | Clin Chem2004，50，3： | 1 |
| 20 | Endometrial tis- sue inperitoneal fluid显示文摘 | BARTOSIK D JACOBS S L KELLY L J | 1986 | Fertil Steril1986，46，5： | 1 |
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