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| 1 | Role of gastroesophageal reflux disease in lung transplantation显示文摘Lung transplantation is one of the highest risk solid organ transplant modalities. Recent studies have demonstrated a relationship between gastroesophageal reflux disease(GERD) and lung transplant outcomes, including acute and chronic rejection. The aim of this review is to discuss the pathophysiology, evaluation, and management of GERD in lung transplantation, as informed by the most recent publications in the field. The pathophysiology of reflux-induced lung injury includes the effects of aspiration and local immunomodulation in the development of pulmonary decline and histologic rejection, as reflective of allograft injury. Modalities of reflux and esophageal assessment, including ambulatory p H testing, impedance, and esophageal manometry, are discussed, as well as timing of these evaluations relative to transplantation. Finally, antireflux treatments are reviewed, including medical acid suppression and surgical fundoplication, as well as the safety, efficacy, and timing of such treatments relative to transplantation. Our review of the data supports an association between GERD and allograft injury, encouraging a strategy of early diagnosis and aggressive reflux management in lung transplant recipients to improve transplant outcomes. Further studies are needed to explore additional objective measures of reflux and aspiration, better compare medical and surgical antireflux treatment options, extend followup times to capture longer-term clinical outcomes, and investigate newer interventions including minimally invasive surgery and advanced endoscopic techniques. | Kelly E Hathorn Walter W Chan Wai-Kit Lo | 2017 | World Journal of Transplantation2017，7，2： | 8 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Esophageal squamous cell cancer in a highly endemic region显示文摘AIM: To identify risk factors associated with esophageal cancer in Zambia and association between dietary intake and urinary 8-iso prostaglandin F2α(8-iso PGF2α).METHODS: We conducted a prospective, case control study at the University Teaching Hospital. Subjects included both individuals admitted to the hospital and those presenting for an outpatient upper endoscopy. Esophageal cancer cases were compared to age and sex-matched controls. Cases were defined as patients with biopsy proven esophageal cancer; controls were defined as subjects without endoscopic evidence ofesophageal cancer. Clinical and dietary data were collected using a standard questionnaire, developed a priori. Blood was collected for human immunodeficiency virus(HIV) serology. Urine was collected, and 8-iso PGF2α was measured primarily by enzyme-linked immunosorbent assay and expressed as a ratio to creatinine.RESULTS: Forty five controls(mean age 54.2 ± 15.3, 31 male) and 27 cases(mean age 54.6 ± 16.4, 17 males) were studied. Body mass index was lower in cases(median 16.8) than controls(median 23.2), P = 0.01. Histopathologically, 25/27(93%) were squamous cell carcinoma and 2/27(7%) adenocarcinoma. More cases smoked cigarettes(OR = 11.24, 95%CI: 1.37-92.4, P = 0.02) but alcohol consumption and HIV seropositivity did not differ significantly(P = 0.14 for both). Fruit, vegetables and fish consumption did not differ significantly between groups(P = 0.11, 0.12, and 0.10, respectively). Mean isoprostane level was significantly higher in cases(0.03 ng/mg creatinine) than controls(0.01 ng/mg creatinine)(OR = 2.35, 95%CI: 1.19-4.65, P = 0.014).CONCLUSION: Smoking and isoprostane levels were significantly associated with esophageal cancer in Zambians, but diet, HIV status, and alcohol consumption were not. | Akwi W Asombang Violet Kayamba Mpala M Lisulo Kathryn Trinkaus Victor Mudenda Edford Sinkala Stayner Mwanamakondo Themba Banda Rose Soko Paul Kelly | 2016 | World Journal of Gastroenterology2016，22，9： | 2 |
| 4 | Synthetic seismograms,a finite difference approach显示文摘 | Kelly K R Ward R W Treiter S | 1976 | Geophysics1976，41，1： | 2 |
| 5 | Synthetic seismograms, a finite difference approach显示文摘 | Kelly K R Ward R W Treitel S | 1976 | Geophysics1976，41，： | 2 |
| 6 | Initial performance results of the OMEGA laser system显示文摘 | T.R Boehly D.L Brown R.S Craxton R.L Keck J.P Knauer J.H Kelly T.J Kessler S.A Kumpan S.J Loucks S.A Letzring F.J Marshall R.L McCrory S.F.B Morse W Seka J.M Soures C.P Verdon | 1997 | Optics Communications1997，，1： | 2 |
| 7 | Endocrine regulation of menstruation 显示文摘 | Jabbour H N Kelly R W Fraser H M | 2006 | Endocr Rew2006，27，1： | 1 |
| 8 | 显示文摘 | | 1988 | J Anim Sci1988，66，： | 1 |
| 9 | Micro-oxygenation of Wine in Barrels显示文摘 | Kelly M David W | 2005 | The Australian & New Zealand Grapegrower & Winemaker2005，，6： | 1 |
| 10 | Genetic epidcmiology of obesity 显示文摘 | Yang W Kelly T He J | 2007 | Epidemiol Rev2007，29，： | 1 |
| 11 | Evaluation of approaches for determining design allowables for bolted joints in laminated composites显示文摘 | WANG J BANBURY A KELLY D W | 1998 | Composite Structures1998，41，： | 1 |
| 12 | Using simple environmental variables to estimate below-ground productivity in grasslands显示文摘 | Gill R A Kelly R H Parton W J | | 0，，01： | 1 |
| 13 | Clinical and polysomnographic predictors of short-term continuous positive airway pressure compliance显示文摘 | Collen J Lettieri C Kelly W | | 0，，3： | 1 |
| 14 | Later Life Leisure: How They Play in Peoria显示文摘 | KELLY J R STEINKAMP M W | 1986 | The Gerontologist1986，26，5： | 1 |
| 15 | Modelling tourism destination energyconsumption and greenhouse gas emissions: Whistler, BritishColumbia, Canada显示文摘 | Kelly J Williams P W | 2007 | Journal of Sustainable Tourism2007，15，1： | 1 |
| 16 | Colo- rectal cancer screening显示文摘 | RANDALL W B JAMES S B KELLI B D | 2010 | J Natl Compr Cane Netw2010，8，： | 1 |
| 17 | Progesterone control of interleukin -8 production in endometrium and chorio - decidual cells underlines the role of the neutrophil in menstruation and parturition 显示文摘 | Kelly R W Illingworth P Baldie G | 1994 | Hum Repord1994，9，2： | 1 |
| 18 | A family of transcripts encoding water channel proteins: tissue-specific expression in the common ice plant显示文摘 | YAMADA S KATSUHARA M KELLY W B | 1995 | Plant Cell1995，7，8： | 1 |
| 19 | Late paleocene to eocene paleocenography of the equatorial pacific ocean: stable isotopes recorded at ocean drilling program site 865, allison guyot显示文摘 | Zachos J C Thomas E Parrow M Paul C K Kelly D C Silva I P Sliter W V Lohmann K C | 1995 | Paleoceanography1995，10，： | 1 |
| 20 | Relation of fish growth to the durability of two dyes in jaw -injected trout 显示文摘 | Kelly W H | 1967 | N Y Fish Game J1967，14，2： | 1 |
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