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| 1 | Pit-and trench-forming osteoclasts:a distinction that matters显示文摘Osteoclasts(OCs)seeded on bone slices either drill round pits or dig long trenches.Whereas pits correspond to intermittent resorption,trenches correspond to continuous and faster resorption and require a distinct assembly of the resorption apparatus.It is unknown whether the distinction between pits and trenches has any biological relevance.Using OCs prepared from different blood donors,we found that female OCs achieved increased resorption mainly through pit formation,whereas male OCs did so through trench formation.Trench formation went along with high collagenolytic activity and high cathepsin K(CatK)expression,thereby allowing deeper demineralization.A specific CatK inhibitor abrogated the generation of trenches,while still allowing the generation of pits.OCs obtained from bone marrow were more prone to generate trenches than those obtained from blood.Scanning electron microscopy of bone surfaces eroded in vivo showed trenches and pits of similar size as those made by OCs in culture.We conclude that the distinction between trench-and pit-forming OCs is relevant to the differences among OCs from different skeletal sites,different individuals,including gender,and results from differences in colIagenolytic power.This indicates a biological relevance and highlights the importance of discriminating between pits and trenches when assessing resorption. | Ditte MH Merrild Dinisha C Pirapaharan Christina M Andreasen Per Kjxrsgaard-Andersen Anas MJ Mùller Ming Ding Jean-Marie Delaissé Kent Sùe | 2015 | Bone Research2015，3，4： | 2 |
| 2 | Meat tenderness and muscle growth: is there any relationship? 显示文摘 | Koohmaraie M Kent M P Shackelford S D Veiseth E Wheeler T L | 2002 | Meat Science2002，62，： | 1 |
| 3 | Performance Appraisals: Usage, Criteria and Obserbations显示文摘 | Pettijohn L S Stephen Parker R Pettijohn C E Kent J L | 2001 | Journal of Management Development2001，20，9： | 1 |
| 4 | Interactions between terminally substituted amino acids in an aqueous and a non-aqueous environment显示文摘 | Lilley T H Milburn P J | 1985 | J Soln Chem1985，14，： | 1 |
| 5 | How systematic reviews can foster evidence - based clinical decisions显示文摘 | Fineout- Overholt E O' Mathuna DP Kent B | 2008 | Worldviews Evid Based Nurs2008，5，1： | 1 |
| 6 | Rough Concept Analysis:A Synthesis of Rough Sets and Form al Concept Analysis显示文摘 | Kent R E | 1996 | Fundamenta Inform Aticae1996，，16： | 1 |
| 7 | The information flow foundation for conceptual knowledge organization显示文摘 | Kent R E | 2000 | Advances in Knowledge Organiza- tion2000，37，1： | 1 |
| 8 | Electrolytically ac- tivqted contractile polymers 显示文摘 | Hamlen R P Kent C E Sharer S N | 1965 | Nature1965，206，： | 1 |
| 9 | Shape transformation for polyhedral objects 显示文摘 | Kent J 1L Carlson W E Parent R E | 1992 | Computer Graphics (ACM)1992，26，2： | 1 |
| 10 | Pollen-mediated gene flow in California cotton depends on pollinator activity显示文摘 | ALLEN E V D Frederick J S Kent J B | 2005 | Crop Science2005，45，4： | 1 |
| 11 | 显示文摘 | Hamlem R P Kent C E Shafer S N | 1965 | Nature1965，206，： | 1 |
| 12 | Environmental con- cern: Doesn make a difference how it is measured? 显示文摘 | Van LIERE KENT D DTMLAP R E | 1981 | Environment and Behavior1981，12，6： | 1 |
| 13 | Alternative Flotation Methods, Adverse Seletion and Ownership Structure:Evidence from Seasoned Equity Issuance in the UK显示文摘 | Slovin Myron B Marie E Sushka and Kent W L Lai | 2001 | Journal of Financial Economics2001，，57： | 1 |
| 14 | A computational fluid dynamics study of wood fire extinguishment by water sprinkler 显示文摘 | NOVOZHILOV V HARVIE D J E KENT H | 1997 | Fire Safety Journal1997，29，： | 1 |
| 15 | The New Environmental Paradigm: A Proposed Measuring Instrument And Preliminary Results显示文摘 | Kent D Van Liere | 1978 | Journal of Environmental Education1978，9，： | 1 |
| 16 | Tissue distribution and clearance of tritium-labeled dihydro microcystin-LR epimers administered to Atlantic salmon via intraperitoneal injention显示文摘 | Williams D E Kent M L Andersen R J | 1995 | Toxicon1995，33，： | 1 |
| 17 | A computational fluid dynamics study of wood fire extinguishment by water sprinkler显示文摘 | NOVOZHILOV V HARVIE D J E KENT J H | 1997 | Fire Safety Journal1997，29，： | 1 |
| 18 | Initial experience using the transconjunctival sutureless vitrectomy system for vitreoretinal surgery显示文摘 | Fujii GY De Juan E Jr Humayun MS Chang TS Pieramici DJ Barnes A Kent D | | 0，，10： | 1 |
| 19 | Shape transformation for polyhedral objects 显示文摘 | Kent J R Carlson W E Parent R E | 1992 | Computer graphics1992，29，3： | 1 |
| 20 | Central and peripheral renin-angiotensin systems in ouabain-induced hypertension显示文摘 | Cheung WJ Kent MA E1-Shahat E | | 0，，： | 1 |
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