|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 2 | Moving Mass Trim Control for Aerospace Vehicles 显示文摘 | Robinett R D Sturgis B R and Kerr S A | 1996 | Journal of Guidance Control and Dynamics1996，19，5： | 1 |
| 3 | Wound healing dressings and drug delivery systems: A review显示文摘 | Joshua S B Kerr H M Howard N E S | 2008 | J Pharma- ceutical Sci2008，97，8： | 1 |
| 4 | Moving mass trim control for aerospace vehicles显示文摘 | Sturgis B R and Kerr S A | 1996 | Journal of Guidance Control and Dynamics1996，19，5： | 1 |
| 5 | Manure composition of swine as affected by dietary protein and cellulose concentrations显示文摘 | Kerr B J Ziemer C J Trabue S L | 2006 | Journal of Animal Science2006，84，6： | 1 |
| 6 | Manure composition of swine as affected by dietary protein and cellulose concentrations 显示文摘 | Kerr B J Zieiner C J Trabue S L | 2006 | Journal of Animal Science2006，84，： | 1 |
| 7 | The role of Li-ion battery electrolyte reactivity in performance decline and self-discharge显示文摘 | SLOOP S E KERR J B K1NOSHITA K | 2003 | Journal of Power Sources2003，，1： | 1 |
| 8 | I- deal ratios of isoleucine, methionine, methionine plus cystine, threonine, tryptophan, and valine relative to ly- sine for white leghorn-type laying hens of twenty-eight to thirty-four weeks of age 显示文摘 | BREGENDAHL K ROBERTS S A KERR B | 2008 | Poultry Science2008，87，4： | 1 |
| 9 | Effects of dietary fiber and reduced crude protein on nitrogen balance and egg production in laying hens显示文摘 | Roberts S A Xin H Kerr B J | 2007 | Poult Sci2007，86，8： | 1 |
| 10 | The role of human HtrAl in arthritic Disease显示文摘 | Grau S Rechards PJ Kerr B | 2006 | J Biol Chem2006，281，10： | 1 |
| 11 | Effects of dietary fiber and reduced crude protein on nitrogen balance and egg production in laying hens显示文摘 | Roberts S A Xin H Kerr B J | 2007 | Poultry Science2007，86，： | 1 |
| 12 | Moving mass trim control for aerospace vehicles显示文摘 | Robinett R D Sturgis B R Kerr S A | 1996 | Journal of Guidance Control and Dynamics1996，19，5： | 1 |
| 13 | Involvement of quinolinic acid in AIDS dementia complex 显示文摘 | GUILLEMIN G J KERR S l BREW B J | 2005 | Nenrotox Res2005，7，12： | 1 |
| 14 | Hsp90 inhibitors:small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation显示文摘 | Blagg B S Kerr T D | 2006 | Med Res Rev2006，26，3： | 1 |
| 15 | Electrical stimulation in cerebral palsy, a review of effects on strength and motor functlon显示文摘 | Kerr C Mcdowell B Mcdonough S | 2004 | Dev Med Child Neurol(S0012 1622)2004，46，3： | 1 |
| 16 | Moving Mass Trim Control for Aerospace Vehicles 显示文摘 | Robinet R D Sturgis B R Kerr S A | 1996 | Journal of Guidance Control and Dynamics1996，19，5： | 1 |
| 17 | Effects of endotracheal suctioning on cerebral oxygenation in traumatic brain- injured patients 显示文摘 | KERR ME WEBER B B SEREIKA S M | 1999 | Crit Care Med1999，22，： | 1 |
| 18 | Moving Mass Trim Control for Aerospace Vehicles 显示文摘 | Robinett R D Rainwater B A Kerr S A | 1996 | Journal of Guiance Control and Dynamics1996，19，5： | 1 |
| 19 | Effect of neuromuscular blockers and opiates on the cerebrovascular response to endotracheal suctioning in adults with severe head injuries 显示文摘 | KERR ME SEREIKA S M WEBER B B | 1998 | Am J Crit Care1998，7，： | 1 |
| 20 | Genotype-phenotype correlation in Costello syndrome: HRAS mutation analysis in 43 cases显示文摘 | Kerr B Delrue M-A Sigaudy S | 2006 | J Med Genet2006，43，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员