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| 1 | T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis显示文摘AIM To investigate whether normal thickness cartilage in osteoarthritic knees demonstrate depletion of proteoglycan or collagen content compared to healthy knees.METHODS Magnetic resonance(MR) images were acquired from5 subjects scheduled for total knee arthroplasty(TKA)(mean age 70 years) and 20 young healthy control subjects without knee pain(mean age 28.9 years). MR images of T1ρ mapping, T2 mapping, and fat suppressed proton-density weighted sequences were obtained.Following TKA each condyle was divided into 4 parts(distal medial, posterior medial, distal lateral, posterior lateral) for cartilage analysis. Twenty specimens(bone and cartilage blocks) were examined. For each joint,the degree and extent of cartilage destruction was determined using the Osteoarthritis Research Society International cartilage histopathology assessment system.In magnetic resonance imaging(MRI) analysis, 2 readers performed cartilage segmentation for T1ρ/T2 values and cartilage thickness measurement.RESULTS Eleven areas in MRI including normal or near normal cartilage thickness were selected. The corresponding histopathological sections demonstrated mild to moderate osteoarthritis(OA). There was no significant difference in cartilage thickness in MRI between control and advanced OA samples [medial distal condyle, P = 0.461;medial posterior condyle(MPC), P = 0.352; lateral distal condyle, P = 0.654; lateral posterior condyle, P = 0.550],suggesting arthritic specimens were morphologically similar to normal or early staged degenerative cartilage.Cartilage T2 and T1ρ values from the MPC were significantly higher among the patients with advanced OA(P= 0.043). For remaining condylar samples there was no statistical difference in T2 and T1ρ values between cases and controls but there was a trend towards higher values in advanced OA patients. CONCLUSION Though cartilage is morphologically normal or near normal, degenerative changes exist in advanced OA patients. These changes can be detected with T2 and T1ρ MRI techniques. | Benjamin S Kester Philip M Carpenter Hon J Yu Taiki Nozaki Yasuhito Kaneko Hiroshi Yoshioka Ran Schwarzkopf | 2017 | World Journal of Orthopedics2017，8，4： | 12 |
| 2 | Reduction of pain catastrophizing mediates the outcome of both physical and cognitive-behavioral treatment inchronic low back pain 显示文摘 | Smeets R J Vlaeyen JW Kester AD | 2006 | J Pain2006，17，： | 1 |
| 3 | Farfield impact of water injection dredging in the Crouch River 显示文摘 | Winterwerp J C Wang Z B Kester J A Th M van | 2002 | Water & maritime engineering2002，，4： | 1 |
| 4 | Asymptomatic peripheral arterial occlusive disease predicted cardiovascular morbidity and motality in a 7-year-follow-up study显示文摘 | Hooi J D Kester AD Stoffers HE | 2004 | J Clin Epidemiol2004，57，3： | 1 |
| 5 | Combining shared control with variability over surface features: Effects on transfer test performance and task involvement显示文摘 | CORBALAN G KESTER L VAN MERRIE NBOER J J | 2009 | Computers in Human Behavior2009，25，29： | 1 |
| 6 | Minimal incision total knee arthroplasty using the suspended leg technique 显示文摘 | Bonutti PM Neal D J Kester MA | 2003 | Orthopedics2003，26，9： | 1 |
| 7 | Lateral extensor release for tennis elbow: aprospective long term follow ing-up study显示文摘 | VERHAAR J A N WALENKAMP G KESTER A | 1993 | J Bone Joint Surg (Am)1993，75，： | 1 |
| 8 | Lat- eral extensor release for tennis elbow a rospective long- term following regulates androgen receptor phosphoryla- tion transcrip-tionand localization 显示文摘 | VERHAAR J WALENKAMP G KESTER A | 2006 | Mol Endocrinol2006，20，3： | 1 |
| 9 | Early cleavage is a valuable addition to existing embryo selection parameters:a study using single embryo transfers显示文摘 | Van Montfoort A P Dumoulin J C Kester A D | 2004 | Hum Reprod2004，19，9： | 1 |
| 10 | Development and validation of a three-dimensional morphological model显示文摘 | Lesseer G R Roelvink J A van Kester J A T M | 2004 | Coastal Engineering2004，51，： | 1 |
| 11 | Edible films and coatings: A Review显示文摘 | Kester J J Fennema O R | 1986 | Food Technology1986，40，12： | 1 |
| 12 | Dynamic task selection: Effects of feedback and learner control on efficiency and motivation显示文摘 | CORBALAN G KESTER L VAN MERRI:NBOER J J | 2009 | Learning and Instruction2009，19，6： | 1 |
| 13 | Transforming growth factor - beta - stimulated clone - 22 is a member of a family of leucine zipper proteins that can homo - and heterodimerize and has transcriptional repressor activity 显示文摘 | KESTER H A BLANCHETOT C DEN HERTOG J | 1999 | J Biol Chem1999，274，27： | 1 |
| 14 | Patients with Alzheimer disease with multiple microbleeds: relation with cerebrospinal fluid biomarkers and cognition 显示文摘 | Goos J D Kester M I Barkhof F | 2009 | Stroke2009，40，11： | 1 |
| 15 | Lipid type and location of the relative humidity gradient influence on the barrierproperties of lipids to water vapor显示文摘 | Fennema 0 Donhowe I G Kester J J | 1994 | Journal of Food Engineering1994，22，14： | 1 |
| 16 | Edible films and coating: a review 显示文摘 | J J Kester O R Fennema | 1986 | Food Technology1986，40，12： | 1 |
| 17 | Contribution of nitrification and denitrification to the NO and N2O emissions of an acid forest soil, a river sediment and a fertilized grassland soil显示文摘 | Kester R A Meijer M E Libochant j A | 1997 | Soil Biology and Biochemistry1997，29，1112： | 1 |
| 18 | Asymptomatic pekipheral arterial oculusive disease pedicted cardiovascular morbidity and mortality in a 7-year follow-upstudy显示文摘 | Hooi J D Kester ADK Stoffers HEJH | 2004 | J Clin Epidemiol2004，57，： | 1 |
| 19 | Development and validation of a three-dimensional morphological model显示文摘 | LESSER G R ROELVINK J A van KESTER J A T M | 2004 | Coastal Engineering2004，51，： | 1 |
| 20 | Incidence of and Risk Factors for Asymptomatic Peripheral Arterial Occlusive Disease : A Longitudinal Study显示文摘 | Hooi J D Kester A D M Henri E J H | 2003 | Am J Epidemiol2003，153，： | 1 |
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