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| 1 | Calcium signaling and T-type calcium channels in cancer cell cycling显示文摘Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers. | James T Taylor Xiang-Bin Zeng Jonathan E Pottle Kevin Lee Alun R Wang Stephenie G Yi lennifer A S Scruggs Suresh S Sikka Ming Li | 2008 | World Journal of Gastroenterology2008，14，32： | 12 |
| 2 | Cardiac biomarkers in pediatric heart disease:A state of art review显示文摘Every year there are more than 11000 hospitalizations related to heart failure in children resulting in significant morbidity and mortality.Over the last two decades,our understanding,diagnosis and management of pediatric heart failure is evolving but our ability to prognosticate outcomes in pediatric heart acute heart failure is extremely limited due to lack of data.In adult heart failure patients,the role of cardiac biomarkers has exponentially increased over the last two decades.Current guidelines for management of heart failure emphasize the role of cardiac biomarkers in diagnosis,management and prognostication of heart failure.It is also noteworthy that these biomarkers reflect important biological processes that also open up the possibility of therapeutic targets.There is however,a significant gap present in the pediatric population with regards to biomarkers in pediatric heart failure.Here,we seek to review available data regarding cardiac biomarkers in the pediatric population and also explore some of the emerging biomarkers from adult literature that may be pertinent to pediatric heart failure. | Benedict A Fernandes Kevin O Maher Shriprasad R Deshpande | 2016 | World Journal of Cardiology2016，8，12： | 6 |
| 3 | Robotic surgery of the pancreas显示文摘Pancreatic surgery is one of the most challenging and complex fields in general surgery.While minimally invasive surgery has become the standard of care for many intra-abdominal pathologies the overwhelming majority of pancreatic surgery is performed in an open fashion.This is attributed to the retroperitoneal location of the pancreas,its intimate relationship to major vasculature and the complexity of reconstruction in the case of pancreatoduodenectomy.Herein,we describe the application of robotic technology to minimally invasive pancreatic surgery.The unique capabilities of the robotic platform have made the minimally invasive approach feasible and safe with equivalent if not better outcomes(e.g.,decreased length of stay,less surgical site infections)to conventional open surgery.However,it is unclear whether the robotic approach is truly superior to traditional laparoscopy;this is a key point given the substantial costs associated with procuring and maintaining robotic capabilities. | Daniel Joyce Gareth Morris-Stiff Gavin A Falk Kevin El-Hayek Sricharan Chalikonda R Matthew Walsh | 2014 | World Journal of Gastroenterology2014，20，40： | 2 |
| 4 | Neuroimaging in human immun odeficiency virus infection显示文摘 | Karen A Tucker Kevin R | 2004 | Journal of Neuroimmunology2004，157，1： | 1 |
| 5 | Empirical Regularities in the diffusion of innovation 显示文摘 | Brown Lawrence A Cox Kevin R | | Annals of the0，，： | 1 |
| 6 | Seismic refraction at Horse Mesa Dam: an application of the generalized reciprocal method 显示文摘 | Kevin T K Reger A N W R McLamore | 1986 | Geophysics1986，51，： | 1 |
| 7 | Synthesis, sintering, microstructure and mechanical properties of ceramics made by exothermic reactions 显示文摘 | CUTLER R A KEVIN M R | 1992 | J Am Ceram Soc1992，75，1： | 1 |
| 8 | Evaluation of autogenous deformation of concrete at early ages 显示文摘 | SLATNICK S KYLE A R KEVIN J F | 2011 | ACI Materials Journal2011，30，2： | 1 |
| 9 | IL-la and IL-113 are en- dogenous mediators linking cell injury to the adaptive alloim- mune response显示文摘 | Deepak A R Kevin J T Jordan S P | 2007 | J Immunol2007，179，： | 1 |
| 10 | Detection of adulteration in Australian orange juices by stable carbon isotope ratio analysis (SCIRA)显示文摘 | MICHAEL A XIA LI KEVIN R | 2001 | J Agric Food Chem2001，49，5： | 1 |
| 11 | Pretreatment of wet-milled com fiber to improve recovery of com fiber oil and phytosterols 显示文摘 | Vijay Singh David B Johnston Robert A Moreau Kevin B Hicks Bruce S Dien R J Bothast | 2003 | Cereal Chem2003，80，9： | 1 |
| 12 | Cultured endometrial cancer cells exhibit autocrine growth factor stimulation that is not observed in cultured normal endometrial cells显示文摘 | Catherine A Owens James A | 1996 | Gynecol1996，60，： | 1 |
| 13 | c-Jun N-terminal kinase (JNK) signaling:Recent advances and challenges显示文摘 | MARIE A B KEVIN R W N TERESA T Z | 2010 | Biochemical Biophysica Acta (BBA) -Proteins & Proteomics2010，1804，3： | 1 |
| 14 | IL-1αand IL-1βareendogenous mediators linking cell injury to the adaptivealloimmune response显示文摘 | Deepak A R Kevin J T Jordan S P | 2007 | J Immunol2007，179，： | 1 |
| 15 | The metabolic fate of dietary polyphenols in humans显示文摘 | Andreas R Rechner Gunter Kuhnle Paul Bremner Gary P Hubbard Kevin P Moore Catherine A Rice-Evans | 2002 | Free Radical Biology and Medicine2002，，2： | 1 |
| 16 | Speaker recognition using neural networks and conventional classifiers 显示文摘 | Kevin R F Richard J M Khaled T A | 1994 | IEEE Trans on Speech and Audion processing1994，2，1： | 1 |
| 17 | Speaker recognition using neural networks and conventional classifiers 显示文摘 | Kevin R F Richard J M Khaled T A | 1994 | IEEE Trans on Speech and Audio processing1994，2，1： | 1 |
| 18 | Availability of phosphorus and trace elements in low- phytate varieties of barley and corn for rainbow trout (On- corhynchus mykiss) 显示文摘 | Shozo H S Victor R Kevin A Y | 1999 | Aquaculture1999，170，34： | 1 |
| 19 | Synthesis and properties of waterborne self-crosslinkable sulfo-urethane silanol dispersions 显示文摘 | Kevin Lewandowski Larry R Krepski Daniel E Mickus Ralph R Roberts Steven M Heilmann Wayne K Larson Mark D Purgett Steven D Koecher Stephen A Johnson Daniel J Mcgurran Chris J Rueb Sadanand V Pathre Khalid A M Thakur | 2002 | Journal of Polymer Science Part A : Polymer Chemistry2002，40，17： | 1 |
| 20 | Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6,11,16, and 18 显示文摘 | Luisa L V Kevin A A Anna R G | 2006 | Vaccine2006，24，： | 1 |
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