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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | Calcium signaling and T-type calcium channels in cancer cell cycling显示文摘Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers. | James T Taylor Xiang-Bin Zeng Jonathan E Pottle Kevin Lee Alun R Wang Stephenie G Yi lennifer A S Scruggs Suresh S Sikka Ming Li | 2008 | World Journal of Gastroenterology2008，14，32： | 12 |
| 3 | Seismic refraction at Horse Mesa Dam: an application of the generalized reciprocal method 显示文摘 | Kevin T K Reger A N W R McLamore | 1986 | Geophysics1986，51，： | 1 |
| 4 | Simulation, fabrication and testing of Bulk Micromachined 6H-SiC High-g Piezoresistive Accelerometer 显示文摘 | Andrew R Atwelll Robert S Okojie Kevin T Kornegay Scott L Roberson Alain Beliveau | 2003 | Sensors and Actuators A: Physics (S0924-4247)2003，104，1： | 1 |
| 5 | Three-dimensional streamlined finite elements : Design of extrusion dies 显示文摘 | Kevin R J Ellwood T C Papanastasiou J O Wilkes | 1992 | International Journal for Numerical Methods in Fluids1992，14，1： | 1 |
| 6 | IL-la and IL-113 are en- dogenous mediators linking cell injury to the adaptive alloim- mune response显示文摘 | Deepak A R Kevin J T Jordan S P | 2007 | J Immunol2007，179，： | 1 |
| 7 | c-Jun N-terminal kinase (JNK) signaling:Recent advances and challenges显示文摘 | MARIE A B KEVIN R W N TERESA T Z | 2010 | Biochemical Biophysica Acta (BBA) -Proteins & Proteomics2010，1804，3： | 1 |
| 8 | IL-1αand IL-1βareendogenous mediators linking cell injury to the adaptivealloimmune response显示文摘 | Deepak A R Kevin J T Jordan S P | 2007 | J Immunol2007，179，： | 1 |
| 9 | The effect of pregabalin on pain- related sleep interference in diabetic peripheral ncuropathy or postherpetic neuralgia: a review of nine clinical trials显示文摘 | Roth T Van Seventer R Kevin Murphy T | 2010 | Curr Med Rcs Opin2010，26，10： | 1 |
| 10 | Syn- thesis and antibacterial activity of new tropone substi- tuted phenyloxazolidinone antibacterial agents 显示文摘 | MICHAEL R B DANA S T KEVIN C G | 1996 | Bioorg Med Chem Lett1996，6，9： | 1 |
| 11 | Speaker recognition using neural networks and conventional classifiers 显示文摘 | Kevin R F Richard J M Khaled T A | 1994 | IEEE Trans on Speech and Audion processing1994，2，1： | 1 |
| 12 | Simulation,Fbrication and Testing of Bulk Micromachined 6H-SiC High-g Piezoresistive Accelerometers显示文摘 | Andrew R Atwell Robert S Okojie Kevin T Kornegay Scott L Roberson Alain Beliveau | 2003 | Sensors and Actuators2003，104，1： | 1 |
| 13 | Speaker recognition using neural networks and conventional classifiers 显示文摘 | Kevin R F Richard J M Khaled T A | 1994 | IEEE Trans on Speech and Audio processing1994，2，1： | 1 |
| 14 | Simulation, Fabrication and Testing of Bulk Micro-machined 6H-SiC High-g Resistive Accelero-meter 显示文摘 | Andrew R Atwelll Robert S Okojie Kevin T Kornegay | 2003 | Sensors and Actuators A2003，104，1： | 1 |
| 15 | Semi-batch absorption and regeneration studies for CO2 capture by aqueous ammonia显示文摘 | James T Y Kevin P R Kathy R | 2005 | Fuel Processing Technology2005，86，1415： | 1 |
| 16 | Bioresor- bable polylaetide interbody implants in an ovine anterior cervi- cal discectomy and fusion model 显示文摘 | KEVIN A T JEFFREY M T NElL R C | 2008 | Spine2008，33，： | 1 |
| 17 | Freeform optical surfaces: a revolution in imaging optical design显示文摘 | T Kevin R Jannick | 2012 | Opt& Photon News2012，23，6： | 1 |
| 18 | Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche显示文摘 | Janine T E Kevin L B Thomas R C | 2009 | Cancer Cell2009，15，1： | 1 |
| 19 | Relationships between xylem vessel characteristics,calculated axial hydraulic conductance and size-controlling capacity of peach rootstocks显示文摘 | Sergio T Johnson R S Kevin R D | 2010 | Annals of Botany2010，105，： | 1 |
| 20 | Simulation,Fabrication and Testing of Bulk Micromachined 6H SiC High g Piezoresistive Accelerometer显示文摘 | Andrew R Atwell1 Robert S Okojie Kevin T Kornegay | 2003 | Sensors and Actuators A:Physics (S0924-4247)2003，104，1： | 1 |
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