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| 1 | Comparative analysis of the effectiveness of abiraterone before and after docetaxel in patients with metastatic castration-resistant prostate cancer显示文摘AIM: To study the efficacy and safety of abiraterone in patients with and without prior chemotherapy.METHODS: The databases including Pub Med and abstracts presented at the American Society of Clinical Oncology meetings up to April 2014 were systematically searched. Eligible studies included randomized controlled trials(RCTs) in which abiraterone plus prednisone was compared to placebo plus prednisone in metastatic castration-resistant prostate cancer(CRPC) patients. The summary incidence, relative risk, hazard ratio and 95%CI were calculated using random or fixed-effects models. Heterogeneity test was performed to test between-study differences in efficacy and toxicity.RESULTS: A total of two phase III RCTs were included in our analysis, with metastatic CPRC patients before(n = 1088) and after chemotherapy(n = 1195). Prior chemotherapy did not significantly alter the effect of abiraterone on overall survival(P = 0.92) and prostatespecific antigen(PSA) progression-free survival(P = 0.13), but reduced its effect on radiographic-prog-ression-free survival(P = 0.04), objective response rate(P < 0.001), and PSA response rate(P < 0.001). Prior chemotherapy significantly increased the specific risk of fluid retention and edema(P < 0.001) and hypokalemia(P < 0.001), but decreased the risk of all-grade hypertension(P < 0.001) attributable to abiraterone. There was no significant difference of cardiac disorders associated with abiraterone between the two settings(P = 0.58). CONCLUSION: Prior chemotherapy may reduce the effectiveness of abiraterone in patients with metastatic CRPC. | Raji Shameem Muhammad Saad Hamid Kevin Y Xu Shenhong Wu | 2015 | World Journal of Clinical Oncology2015，6，4： | 3 |
| 2 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 3 | Anti-hypertensive drugs in children and adolescents显示文摘Worldwide the prevalence of essential hypertension inchildren and adolescents continues to increase. Tradi-tionally providers have used 'off-label' drugs to treatpediatric hypertension, meaning that rigorous clinicaltrials of these drugs have not been specifically per-formed in pediatric patient populations. Consequentlyproviders have extrapolated dosing, safety and efficacyfrom trials in adults. This practice is sub-optimal as chil-dren demonstrate unique differences in drug metabo-lism and response. Use of unstudied or understudieddrugs increases risk of adverse events and/or can leadto sub-optimal efficacy. Recognizing these concerns,regulatory agencies have created financial incentivesfor industry to conduct pediatric clinical trials. Theseincentives, coupled with the emerging pediatric hyper-tension epidemic, have spurred over 30 clinical trialsof anti-hypertensive drugs over the past 15 years andhave resulted in labeling of 10 new drugs by the UnitedStates Food and Drug Administration for treatment ofhypertension in children and adolescents. Unfortunatelythe financial incentive structures focus on newer drugsand drug classes. Consequently there is now a relativedearth of trial data for older but sometimes commonlyprescribed pediatric antihypertensive drugs. This article reviews recent pediatric antihypertensive drug trials with a focus on trial design and endpoints, drug dosing, safety, efficacy and specific drug indications. We also review the available data and experience for some of the more commonly prescribed, but less well studied 'older' pediatric antihypertensive drugs. | Patricia Y Chu Michael J Campbell Stephen G Miller Kevin D Hill | 2014 | World Journal of Cardiology2014，6，5： | 2 |
| 4 | Effectiveness of treatment for class Ⅱ malocclusion with the Herbst or Twinblock appliance:A randomized,controlled trial显示文摘 | Kevin O'Brien Wright J Sanjie Y | 2003 | Am J Orthod Dentofac Orthod2003，124，： | 1 |
| 5 | Marketing on the Internet- Who Can Benefit from an Online Marketing Approach显示文摘 | Melidy Y Kiang T S Raghu Kevin Huei-MinShang | 2000 | Decision Support System2000，27，： | 1 |
| 6 | Higher median levels of free hCG and PAPP-A in a Chinese ethnic group显示文摘 | Tak Y L Kevin S Tse N L | 2006 | Fetal Diagn Ther2006，21，1： | 1 |
| 7 | Decision trees for uncertain data显示文摘 | Smith Tsang Ben Kao Kevin Y YIP | | 0，，01： | 1 |
| 8 | Birth characteristics and risk of neuroblastoma in young children显示文摘 | Kevin Y Julie V | | 0，，5： | 1 |
| 9 | Helical conjugated polymers:Synthesis,stability,and chiroptical properties of poly(alkyl phenylpropiolate)s bearing stereogenic pendants显示文摘 | Jacky W Y Lam Dong Yuping Kevin K L Cheuk | 2004 | Macromolecules2004，37，18： | 1 |
| 10 | Antioxidant inhibition of oxygen radicals for measurement of total antioxidant capacity in biological samples显示文摘 | Simon Y L Ching Jon Hall Kevin Croft | 2006 | Analytical Biochemistry2006，353，2： | 1 |
| 11 | Seed phosphorus and inositol phosphate phenotype of barley low phytic acid geno- types 显示文摘 | John A D Allen C Kevin A Y | 2003 | Phytochemistry2003，62，5： | 1 |
| 12 | Pork farm odourmodelling using multiple-component multiple-factor anal-ysis and neural networks显示文摘 | Kevin R J Simon X Y Roger R H | 2005 | Applied Soft Computing2005，6，1： | 1 |
| 13 | Detection and taxonomic placement of endophytic fungi within frond tissues of Livistona chinensis based on rDNA sequences显示文摘 | Guo L D Kevin D Edward C Y | 2001 | Mol Phylogenet Evol2001，20，1： | 1 |
| 14 | Biosensors employing ionic self-assembled multilayers adsorbed on long- period fiber gratings显示文摘 | Wang Z Y Heflin J R Kevin V C | 2009 | Sensors and Actuators B:Ohemical2009，139，2： | 1 |
| 15 | Long - range transport of anthropogenic aerosols to the National Oceanic and Atmospheric Administra- tion baseline station at Mauna Ix)a Observatory Hawaii 显示文摘 | Pen'y Kevin D Cahill Thomas A Schnell Russell C | 1999 | Journal of Geophysical Research1999，104，18： | 1 |
| 16 | Supply networks and complex adaptive systems: control versus emergence 显示文摘 | Thomas Y Choi Kevin J Dooley Manus Rungtusanatham | 2001 | Journal of Operations Management2001，19，： | 1 |
| 17 | Birth characteristics and risk of neuroblastoma in young children 显示文摘 | Kevin Y Julie V | 2007 | Am J Epidemio12007，165，5： | 1 |
| 18 | Tool nose radius effects on finish hard turning显示文摘 | Kevin Chou Y Hui Song | 2004 | International Journal of Machine Tools & Manufacture2004，，148： | 1 |
| 19 | High-performance Enhancement-mode A1GaN/GaN HEMTs Using Fluoride- based Plasma Treatment显示文摘 | Y Cai Y Zhou Kevin J Chen | 2005 | IEEE Electron Devices2005，26，7： | 1 |
| 20 | Birth characteristics and risk of neuroblastoma in young children 显示文摘 | Kevin Y Julie V | 2007 | Am J Epidemiol2007，165，5： | 1 |
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