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| 1 | Reversibility of minimal hepatic encephalopathy following liver transplantation in Egyptian cirrhotic patients显示文摘AIM To evaluate the reversibility of minimal hepatic encephalopathy(MHE) following liver transplantation(LT) in Egyptian cirrhotic patients. METHODS This prospective study included twenty patients with biopsy-proven liver cirrhosis listed for LT and twenty ageand sex-matched healthy control subjects. All underwent neuro-psychiatric examination, laboratory investigations, radiological studies and psychometric tests including trail making test A(TMT A), TMT B, digit symbol test and serial dotting test. The psychometric hepatic encephalopathy score(PHES) was calculated for patients to diagnose MHE. Psychometric tests were repeated six months following LT in the cirrhotic patient group. RESULTS Before LT, psychometric tests showed highly significant deficits in cirrhotic patients in comparison to controls(P < 0.001). There was a statistically significant improvement in test values in the patient group after LT; however, their values were still significantly worse than those of the controls(P < 0.001). The PHES detected MHE in 16 patients(80%) before LT with a median value of -7 ± 3.5. The median PHES value was significantly improved following LT, reaching-4.5 ± 5(P < 0.001), and the number of patients with MHE decreased to 11(55%). The pre-transplant model for end-stage liver disease(MELD) score ≥ 15 was significantly related to the presence of post-transplant MHE(P = 0.005). More patients in whom reversal of MHE was observed had a pre-transplant MELD score < 15.CONCLUSION Reversal of MHE in cirrhotic patients could be achieved by LT, especially in those with a MELD score < 15. | Mahmoud A Osman Moataz M Sayed Khaled A Mansour Shereen A Saleh Wesam A Ibrahim Sara M Abdelhakam Mohamed Bahaa Wael A Yousry Hosam S Elbaz Reginia N Mikhail Azza M Hassan Ehab H Elsayed Dalia A Mahmoud | 2016 | World Journal of Hepatology2016，8，30： | 11 |
| 2 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 3 | 对由磁性的回声成像的灰色的事 heterotopia 的评价显示文摘 AIM:To evaluate magnetic resonance imaging(MRI) features of different types of gray matter heterotopia.METHODS:Between June 2005 and December 2009,the medical records and MRI studies of patients with gray matter heterotopia were reviewed.The MRI morphologic findings of heterotopia were recorded along with the presence and type of associated cranial malformations.Available clinical and electrophysiological data were also recorded.RESULTS:20 patients were included in the study.Their ages ranged from 9 mo to 39 years with a mean age of 15 years.All patients suffered from epileptic seizures.According to the location of heterotopia,patients were classified into three groups:subependymal(12),subcortical(5) and band(3) heterotopia.CONCLUSION:MRI was useful in diagnosing and differentiating between various types of gray matter heterotopia.The severity of clinical manifestations of heterotopia was related to the location and pattern of heterotopia.Determination of heterotopia type and its extent is useful for management planning and predicting prognosis. | Ragab H Donkol Khaled M Moghazy Alaeddin Abolenin | 2012 | World Journal of Radiology2012，4，3： | 4 |
| 4 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 5 | One-time password system with infinite nested hash chains显示文摘 | MOHAMED H E MUHAMMAD K K KHALED A | 2010 | Communications in Computer and Information Science2010，122，： | 1 |
| 6 | A mini review on cancer of un- known primary site: A clinical puzzle for the oneologists 显示文摘 | Pavlidis N Khaled H Gaafar R | 2015 | J Adv Res2015，6，3： | 1 |
| 7 | Enhancement of wear resistance of ductile cast iron by Ni-SiC composite coating显示文摘 | ABDEL A A KHALED M I ABDEL H Z | 2006 | Wear2006，260，910： | 1 |
| 8 | Loss of PTEN expression as a prognostic marker for tongue cancer显示文摘 | Janet IL Jean-Charles S Khaled A H | 2001 | Arch Otolaryngol2001，127，14： | 1 |
| 9 | Compressed sensing for real-time energy-efficient ECG compression on wireless body sensor nodes显示文摘 | Mamaghanian H Khaled N Atienza D | | 0，，09： | 1 |
| 10 | Tethering of tricuspid valve resulting from aberrant tendinous cords mimic Ebstein's anomaly, three-dimensional echocardiography approach 显示文摘 | Khaled H Sebastien H Yves D | 2014 | Echocardiography2014，3，2： | 1 |
| 11 | Zebra blenny (Sala-ria basilisca) viscera as a source of solvent-stable proteases:Char- acteristics,potential application in the deproteinization of shrimp wastes and evaluation in liquid laundry commercial detergents显示文摘 | KTARI N KHALED H B YOUNES I | 2012 | Journal of Food Science and Technology2012，49，4： | 1 |
| 12 | Horizontal connection for precast concrete shear walls subjected to cyclic deformations显示文摘 | Khaled A Rizkall A H | 1995 | PC/ Journal1995，，4： | 1 |
| 13 | RBS polymer coneretewall part I: experimental study and theoretical provision for flexure and shear显示文摘 | Ali H Charour Khaled A | 2005 | Construetion and Building Materials2005，19，： | 1 |
| 14 | Design and exploration of low-power analog to information conversion based on compressed sensing显示文摘 | MAMAGHANIAN H KHALED N ATIENZA D | 2012 | IEEE Journal on Emerging and Selected Topics in Circuits and Systems2012，2，3： | 1 |
| 15 | Compressed Sensingfor iieal-Tinie Energy-Efficient ECG Compression on WirelessBody Sensor No(ies 显示文摘 | Mamaghanian H Khaled N Atienza D et ai | | IEEE Transactions on Biomedical Engi-neering0，58，9： | 1 |
| 16 | Megastigmane glycosides from seeds of Trifoliumalexandrinum显示文摘 | Khaled M Mohamed Mahmoud H Mohamed Kazuhiro Ohtani Ryoji Kasai Kazuo Yamasaki | 1999 | Phytochemistry1999，，5： | 1 |
| 17 | Mansouramycins A-D,cytotoxic isoquinolinequinones from a marine Streptomyces 显示文摘 | Usama W H Mohamed S Khaled A S | 2009 | Journal of Natural Products2009，，72： | 1 |
| 18 | nevus lipomatosus cutaneous superficialis:report of eight case显示文摘 | Goucha S Khaled h Ze' glaoui F | 2011 | Dermatol Ther(Heidelb)2011，1，2： | 1 |
| 19 | A novel animal-component-free medium for rabies virus production in Vero cells grown on Cytodex 1 microcarriers in a stirred bioreactor显示文摘 | Samia Rourou Arno Ark Samy Majoul Khaled Trabelsi Tiny Velden Héla Kallel | | 0，，： | 1 |
| 20 | On modeling of toolwear using sensor fusion and polynomial classifiers显示文摘 | Ibrahim D Khaled A Firas H | 2009 | Mechanical Systems and Signal Processing2009，23，5： | 1 |
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