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39篇 您的检索式：作者名="Khochbin"

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	题名	作者	年代	出处	被引量
1	Processing of p53 mRNA during induced differentiation of murine erythrolen- kemia cells: is an alered splicing mechaniesm respon- sible for the postttranseriptional control of gene expression显示文摘	Khochbin S Lawrece JJ	1998	Gene1998，72，：	1
2	Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia显示文摘T-cell acute lymphoblastic leukemia(T-ALL)is one of the most dangerous hematological malignancies,with high tumor heterogeneity and poor prognosis.More than 60%of T-ALL patients carry NOTCH1 gene mutations,leading to abnormal expression of downstream target genes and aberrant activation of various signaling pathways.We found that chidamide,an HDAC inhibitor,exerts an antitumor effect on T-ALL cell lines and primary cells including an anti-NOTCH1 activity.In particular,chidamide inhibits the NOTCH1-MYC signaling axis by down-regulating the level of the intracellular form of NOTCH1(NICD1)as well as MYC,partly through their ubiquitination and degradation by the proteasome pathway.We also report here the preliminary results of our clinical trial supporting that a treatment by chidamide reduces minimal residual disease(MRD)in patients and is well tolerated.Our results highlight the effectiveness and safety of chidamide in the treatment of T-ALL patients,including those with NOTCH1 mutations and open the way to a new therapeutic strategy for these patients.	Mengping Xi Shanshan Guo Caicike Bayin Lijun peng Florent Chuffart Ekaterina Bourova-Flin Sophie Rousseaux Saadi Khochbin Jian-Qing Mi Jin Wang	2022	Frontiers of Medicine2022，16，3：	1
3	Functional significance of histone deacetylase diversity显示文摘	Khochbin S Verdel A Lemercier C	2001	Curr Opin Genet Dev2001，11，2：	1
4	HDAC6 a new cellular stress surveillance factor显示文摘	Matthias P Youshida M Khochbin S	2008	Cell Cycle2008，7，1：	1
5	CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin显示文摘	Wickstrom SA Masoumi KC Khochbin S	2010	EMBO J2010，29，1：	1
6	HDAC6 a new cellular stress surveillance factor 显示文摘	Matthias P Yoshida M Khochbin S	2008	Cell Cycle2008，7，1：	1
7	The viral control of cellular acetylation signaling显示文摘	Caron C Col E Khochbin S	2003	Bioessays2003，25，1：	1
8	Functional significance of histone deacetylase diversity显示文摘	Khochbin S Verdel A Lemercier C	2001	Curr Opin Genet Dev2001，11，2：	1
9	CYLD negatively regulates cell cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin 显示文摘	Wickstrom SA Masoumi KC Khochbin S	2010	EMBO J2010，29，1：	1
10	Processing of p53 mRNA during induced differentiation of murine erythrolenkemia ceils : Is an alered splicing mechanism responsible for the posttranseriptional control of gene expression? 显示文摘	Khochbin S Lawrece JJ	1998	Gene1998，72，：	1
11	CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin 显示文摘	WickstriJm SA Masoumi KC Khochbin S	2010	EMBO J2010，29，1：	1
12	Functional significance of histone deacetylase diversity显示文摘	Khochbin S Verdel A Lemercier C	2001	Curr Opin Genet Dev2001，11，2：	1
13	Functional significance of histone deacetylase diversity显示文摘	Khochbin S Verdel A Lemercier C	2001	Curr Opin Genet Dev2001，11，2：	1
14	Two catalytic domains are required for protein deacetylation显示文摘	Zhang Y Gilquin B Khochbin S	2006	J Biol Chem2006，281，5：	1
15	HDAC6 a new cellular stress surveillance factor显示文摘	Matthias P Youshida M Khochbin S	2008	Cell Cycle2008，7，1：	1
16	Processing of P53 mRNA during induced differentiation of murine erythrolenkemia cells is an alered splicing mechanism responsible for the posttranseriptional control of gene expression 显示文摘	Khochbin S Law rece J	1998	Gene1998，72，：	1
17	Functional significance of histone deacetylase diversity显示文摘	VERDEL A LEMERCIER C	2001	Curr Opin Genet Dev2001，11，：	1
18	HDAC6 a new cellular stress surveillance factor显示文摘	Matthias P Yoshida M Khochbin S	2008	Cell Cycle2008，7，1：	1
19	Chromatin and epigenetics:Dynamic organization meets regulated function显示文摘	KHOCHBIN S DIMITROV S	2003	Mol Cell2003，12，：	1
20	Functional signifi- cance of histone deacetylase diversity 显示文摘	Khochbin S Verdel A Lemercier C	2001	Curr Opin Genet Dev2001，11，2：	1

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