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| 1 | Carbonic anhydrases in normal gastrointestinal tract and gastrointestinal tumours显示文摘Carbonic anhydrases (CAs) catalyse the hydration of CO2to bicarbonate at physiological pH. This chemical interconversion is crucial since HCO3- is the substrate for several biosynthetic reactions. This review is focused on the distribution and role of CA isoenzymes in both normal and pathological gastrointestinal (GI) tract tissues. It has been known for many years that CAs are widely present in the GI tract and play important roles in several physiological functions such as production of saliva, gastric acid, bile, and pancreatic juice as well as in absorption of salt and water in intestine. New information suggests that these enzymes participate in several processes that were not envisioned earlier. Especially, the recent reports on plasma membranebound isoenzymes Ⅸ and Ⅻ have raised considerable interest since they were reported to participate in cancer invasion and spread. They are induced by tumour hypoxia and may also play a role in von Hippel-Lindau (VHL)-mediated carcinogenesis. | Antti J. Kivel Jyrki Kivel Juha Saarnio Seppo Parkkila | 2005 | World Journal of Gastroenterology2005，11，2： | 4 |
| 2 | Carbonic anhydrase enzymes Ⅱ, Ⅶ, Ⅸ and Ⅻ in colorectal carcinomas显示文摘AIM To investigate expression of four alpha-carbonic anhydrases(CAs) in colorectal carcinomas(CRC) and compare the results with patients' survival.METHODS Colorectal carcinoma samples from 539 CRC patients and control tissues were arranged as tissue microarrays and analyzed with antibodies against CA Ⅱ, CA Ⅶ, CA Ⅸ, and CA Ⅻ. Intensity and extent of staining were both scored from 0 to 3 in each sample. These enzyme expression levels were then correlated to patients' survival and clinicopathological parameters, which were tumor differentiation grade and stage, site of tumor, patients' age, and gender. Kaplan-Meier analysis and Cox regression hazard ratio model were used to analyze survival data. RESULTS CA Ⅱ and CA Ⅻ staining intensities correlated with patients' survival in that higher expression indicated poorer prognosis. In Cox regression analysis one unit increase in the CA Ⅱ intensity increased the hazard ratio to 1.19 fold(CI: 1.04-1.37, P = 0.009). A significant correlation was also found when comparing CA Ⅻ staining intensity with survival of CRC patients(HR = 1.18, 95%CI: 1.01-1.38, P = 0.036). The extent of CA Ⅻ immunostaining did not correlate to the patients' survival(P = 0.242, Kaplan-Meier analysis). A significant interaction between age group and extent of the CA Ⅱ staining was found. Increased extent of CA Ⅱ had a significant hazard ratio among patients 65 years and older(1.42, 95%CI: 1.16-1.73, P = 0.0006). No correlations were found between CA Ⅶ(intensity P = 0.566, extent P = 0.495, Kaplan-Meier analysis), or CA Ⅸ(intensity P = 0.879, extent P = 0.315, KaplanMeier analysis) immunostaining results and survival, or the other parameters. CONCLUSION The present findings indicate that CA Ⅱ and CA Ⅻ could be useful in predicting survival in CRC. | Pia Viikil? Antti J Kivel? Harri Mustonen Selja Koskensalo Abdul Waheed William S Sly Jaromir Pastorek Silvia Pastorekova Seppo Parkkila Caj Haglund | 2016 | World Journal of Gastroenterology2016，22，36： | 3 |
| 3 | Exfoliation syndrome and exfoliation glauco-ma显示文摘 | Vesti E Kivel AT | 2000 | Prog Retin Eve Res2000，19，： | 1 |
| 4 | A Low Concentration of Carbonic Anhydrase Isoenzyme VI in Whole Saliva Is Associated with Caries Prevalence 显示文摘 | Jyrki Kivel/i Seppo Parkkila Anna-Kaisa Parkkila | 1999 | Caries Res1999，33，： | 1 |
| 5 | Small but slow world: How network topology and burstiness slow down spreading显示文摘 | Karsai M Kivel~i M Pan R K | 2011 | Physical Review E2011，83，02： | 1 |
| 6 | Space time budgets, public transport, and spatial choice显示文摘 | Forer P C Kivell H | 1981 | Environment and Planning A1981，13，： | 1 |
| 7 | Different evolutionary pathways underlie the morphology of wrist bones in hominoids显示文摘 | Kivell T L Barros A P Smaers J B | 2013 | BMC Evolution Biology2013，13，： | 1 |
| 8 | Effect of kappa-opioid reeeptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats 显示文摘 | Morani AS Kivell B Prisinzano TE | 2009 | Pharmacol Biochem Behav2009，94，2： | 1 |
| 9 | Tumor-infiltrating macrophages(CD68+ cells)and prognosis in malignant uveal melanoma显示文摘 | M(a)kitie T Summanen P Tarkkanen A Kivel(a)T | | 0，，07： | 1 |
| 10 | A comparative study of social network models: network evolution models and nodal attribute models 显示文摘 | Ritta Toivonen Lauri Kovanen mikko Kivel? et? al | 2009 | Social Networks2009，31，4： | 1 |
| 11 | Sequential algorithm for fast clique percolation 显示文摘 | Kumpula J M Kivele M Kaski K | 2008 | Physical review E2008，78，02： | 1 |
| 12 | Multilayer networks显示文摘 | KivelM Arenas A Barthelemy M | 2014 | Journal of Complex Networks2014，2，3： | 1 |
| 13 | The effect of thiourea on alkaline electroless deposition显示文摘 | Kivel J Sallo J S | 1965 | Journal of the Electrochemical Society1965，112，12： | 1 |
| 14 | Very long-term prognosis of pa tients with malignant uveal melanoma显示文摘 | Kujala E M(a)kitie T Kivel(a) T | 2003 | Invest Ophthalmol Vis Sci2003，44，11： | 1 |
| 15 | Characterizing the community structure of complex networks显示文摘 | Lancichinetti A Kivel M Saramki J | 2010 | PloS One2010，5，11： | 1 |
| 16 | Characterizing the Community Structure of Complex Networks显示文摘 | Lancichinetti A KivelM Saramki J | 2010 | Plos One2010，5，11： | 1 |
| 17 | Diagnosis of uveal melanoma 显示文摘 | Kivel T | 2012 | Dev Ophthalmol2012，49，： | 1 |
| 18 | Photon Distribution Amplitudes in QCD显示文摘 | Ball P Braun V M Kivel N | 2003 | Nucl Phys B2003，649，12： | 1 |
| 19 | Regulation of Nrf2-dependent gene expression by 15-deoxy-Delta12,14-prostaglandin J2显示文摘 | Kansanen E KivelAM Levonen AL | 2009 | Free Radic Biol Med2009，47，9： | 1 |
| 20 | Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis,vascular leak,or inflammation显示文摘 | Bry M Kivel(a) R Holopainen T | 2010 | Circulation2010，122，： | 1 |
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