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| 1 | Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa显示文摘AIM: To analyze possible relationships between CA ⅠⅩ/CA Ⅻ and pVHL expression in normal and neoplastic colorectal mucosa.METHODS: Immunohistochemical staining of 42 tissue specimens obtained from 17 cancer patients was performed to evaluate the distribution and semi-quantitatively assess the levels of CA ⅠⅩ, CA Ⅻ and pVHL. VHL mRNAs from 14 fresh-frozen tumors was amplified by RT-PCR and subjected to sequencing. CA9 and CA12 mRNA levels were analyzed by semi-quantitative RT-PCR in comparison with VEGFas an indicator of hypoxia that uncouples the pVHL control.RESULTS: Tumor tissues were associated with a borderline increase of CA ⅠⅩ staining signal and slight but significant decrease of CA Ⅻ immunoreactivity, whereas no association was found for pVHL. Sequence analysis of RT-PCR-amplified VHL mRNAs revealed no deletions/mutations, suggesting that they were VHL-competent. We did not observe any correlation between pVHL and CA ⅠⅩ/CA Ⅻ proteins as well as between VEGF and CA9 mRNAs, but the tumor-associated changes in mRNA levels of VEGF and CA12 showed a significant inverse relationship.CONCLUSION: Our results indicate that CA9 and CA12 are regulated by different intratumoral factors and that lack of apparent relationship between the levels of CA ⅠⅩ/CA Ⅻ and pVHL cannot be fully assigned to uncoupling of negative regulatory function of pVHL by tumor hypoxia signified by induced VEGF transcription. The interplay between the functional pVHL and CA ⅠⅩ/CA Ⅻ in colorectal tumors seems rather complex and is not evident merely at the expression levels. | Antti J. Kivela Seppo Parkkila Juha Saarnio Tuomo J. Karttunen Jyrki Kivela Anna-Kaisa Parkkila Maria Bartosova Vojtech Mucha Michal Novak Abdul Waheed William S. Sly Hannu Rajaniemi Silvia Pastorekova Jaromir Pastorek | 2005 | World Journal of Gastroenterology2005，11，17： | 10 |
| 2 | Adenovims-mediated extracellular superoxide dismutase gene therapy reduces neointima formation in balloon-denuded rabbit aorta显示文摘 | Kivela A Rissanen T | 2002 | Circulation2002，106，15： | 1 |
| 3 | Angiogenesis vascular endothelial growth factor and platelet-derived growth factor BB expression,iron deposition,and oxidation-specific epitopes in stented human coronary arteries显示文摘 | Brasen JH Kivela A Roser K | 2001 | Arterioscler Thromb Vasc Biol2001，21，11： | 1 |
| 4 | Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation 显示文摘 | Bry M Kivela R Holopainen T | 2010 | Circulation2010，122，17： | 1 |
| 5 | KI-67 immunopositivity in choroidal and ciliary body melanoma with respect to nucleolar diameter and other prognostic factors显示文摘 | A1-Jama| RT Kivela T | 2006 | Curr Eye Res2006，31，： | 1 |
| 6 | Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1-and neuropilin receptor-1-dependent mechanisms 显示文摘 | Lahteenvuo JE Lahteenvuo MT Kivela A | 2009 | Circulation2009，119，6： | 1 |
| 7 | Gastronomy tourism: A meaningful travel market segment 显示文摘 | Kivela J Crotts J C | 2005 | Journal of Culinary Science & Technology2005，4，23： | 1 |
| 8 | A Low Concentration of Carbonic Anhydrase Isoenzyme VI in Whole Saliva Is Associated with Caries Prevalence 显示文摘 | Kivela J Parkkila S Parkkila A K | 1999 | Caries Res1999，33，3： | 1 |
| 9 | Effects of fatiguing jumping exercise on mRNA expression of titincomplex proteins and calpains显示文摘 | LEHTI M KIVELA R KOMI P V | 2009 | Applied Physiology2009，106，： | 1 |
| 10 | Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and atherogenesis via vascular endothelial growth factor receptor-l-and neuropilin receptor 1-de- pendent mechanisms 显示文摘 | Lahteenvuo JE Lahteenvuo MT Kivela A | 2009 | Circulation2009，119，6： | 1 |
| 11 | Restaurant marketing: Selection and segmentation in Hong Kong显示文摘 | Kivela J | 1997 | International Journal of Contemporary Hospitality Management1997，9，3： | 1 |
| 12 | The epidemiological challenge of the most fre quent eye cancer: Retinoblastoma, an issue of birth and death显示文摘 | Kivela T | 2009 | Br J Ophthalmol2009，93，9： | 1 |
| 13 | Dotted collar placed around carotid artery induces asymmetric neointimal lesion formation in rabbits without intravascular manipulations 显示文摘 | Kivela A Hartikainen J Yla-Herttuala S | 2012 | BMC Cardiovasc Disord2012，17，12： | 1 |
| 14 | Clinical applications of vascular gene therapy显示文摘 | Rutanen J Rissanen TT Kivela A | 2001 | Curr Cardiol Rep2001，3，1： | 1 |
| 15 | Metastatic uveal melanoma 显示文摘 | Kivela T Eskelin S Kujala E | 2006 | Int Ophthalmol Clin2006，46，： | 1 |
| 16 | Generalizationsof the clustering coefficient to weighted complex networks显示文摘 | Saramaki J Kivela M Onnela J P | 2007 | Phys Rev E2007，75，02： | 1 |
| 17 | Radiation related complications after ruthenium plaque radiotherapy of uveal melanoma 显示文摘 | Summanen P Immonen I Kivela T | 1996 | Br J Ophthalmol1996，80，8： | 1 |
| 18 | Small but slow world: how network topology and burstiness slow down spreading 显示文摘 | Karsai M Kivela M Pan R K | 2011 | Physics Review E2011，83，2： | 1 |
| 19 | Generalizations of the clustering coefficient to weighted complex networks 显示文摘 | Saramaki J Kivela M Onnela J | 2007 | Physical Review E2007，75，02： | 1 |
| 20 | Social sta- tus, life changes, housing conditions, health, functional abilities andlifestyle as risk factors for recurrent falls among the home-dwelling elderly 显示文摘 | LUUKINEN H KOSKI K KIVELA S L | 1996 | Public Health1996，110，2： | 1 |
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