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| 1 | Recent trends in liver transplantation for alcoholic liver disease in the United States显示文摘AIM To examine temporal changes in the indications for liver transplantation(LT) and characteristics of patients transplanted for alcoholic liver disease(ALD).METHODS We performed a retrospective cohort analysis of trends in the indication for LT using the United Network for Organ Sharing(UNOS) database between 2002 and 2015. Patients were grouped by etiology of the liver disease and characteristics were compared using χ~2 and t-tests. Time series analysis was used identifying any year with a significant change in the number of transplants per year for ALD, and before and after eras were modeled using a general linear model. Subgroup analysis of recipients with ALD was performed by age group, gender, UNOS region and etiology(alcoholic cirrhosis, alcoholic hepatitis and hepatitis C-alcoholic cirrhosis dual listing).RESULTS Of 74216 liver transplant recipients, ALD(n = 9400, 12.7%) was the third leading indication for transplant after hepatitis C and hepatocellular carcinoma. Transplants for ALD, increased from 12.8%(553) in 2002 to 16.5%(1020) in 2015. Time series analysis indicated a significant increase in the number of transplants per year for ALD in 2013(P = 0.03). There were a stable number of transplants per year between 2002 and 2012(linear coefficient 3, 95%CI:-4.6, 11.2) an increase of 177 per year between 2013 and 2015(95%CI: 119, 234). This increase was significant for all age groups except those 71-83 years old, was observed for both genders, and was incompletely explained by a decrease in transplants for hepatitis C and ALD dual listing. All UNOS regions except region 9 saw an increase in the mean number of transplants per year when comparing eras, and this increase was significant in regions 2, 3, 4, 5, 6, 8, 10 and 11.CONCLUSION There has been a dramatic increase in the number of transplants for ALD starting in 2013. | Catherine E Kling James D Perkins Robert L Carithers Dennis M Donovan Lena Sibulesky | 2017 | World Journal of Hepatology2017，9，36： | 6 |
| 2 | Con trasting cardiac regional responses o A-type and B-type natri- uretic peptide to experimental chronic heart failure显示文摘 | HYSTAD M E KLINGE R SPURKLAND A | 2000 | Scand J Clin Lab Invest2000，60，4： | 1 |
| 3 | Adverse effects of intradermal allogeneic lymphocyte immunotherapy: acute reactions and role of autoimmunity显示文摘 | Kling C Steinmann J Westphal E | 2006 | Hum Reprod2006，21，2： | 1 |
| 4 | Neurotrophin-3 is a target-derived neurotrophic factor for penile erection-inducing neurons显示文摘 | Hiltunen JO Laurikainen A Klinge E | 2005 | Neuroscience2005，133，1： | 1 |
| 5 | Reliability of the bal- anced inventory for spinal disorders, a questionnaire for evaluation of outcomes in patients with various spinal disorders显示文摘 | Svensson E Schillberg B Kling AM | 2012 | J Spinal Disord Tech2012，25，4： | 1 |
| 6 | Changing landscape of hepatitis C virus-positive donors显示文摘With the introduction of the new highly effective antiviral therapies, there has been a dramatic increase in the use of the hepatitis C virus(HCV)-positive livers in HCV-positive recipients. In the majority of studies, HCV positivity was defined as a donor testing HCV Ab positive. In 2015, all Organ Procurement Organizations were mandated to perform and report HCV Nucleic Acid Amplification Testing(NAT) results on all deceased and living donors. Studies are not yet available on how organs are being utilized based on NAT status and whether NAT status affects recipient outcomes. Further studies are needed to maximize the use of these organs. | Catherine E Kling Ajit P Limaye Lena Sibulesky | 2017 | World Journal of Hepatology2017，9，20： | 1 |
| 7 | Age-dependent resistance to porcine reproductive and respiratory syndrome virus replication in swine 显示文摘 | Klinge K L Vaughn E M | 2009 | VirolJ2009，27，1： | 1 |
| 8 | Integration of large scale wind power and use of energy storage in the Netherlands' electricity supply显示文摘 | UMMELSL B C PELGRUM E KLING W L | 2008 | IET Renewable Power Generation2008，2，1： | 1 |
| 9 | Preoperative acute hypervolemic hemodilution with hydroxyethylstarch:an alternative to acute normovolemic hemodilution?显示文摘 | MIELKE L L ENTHOLZNER E K KLING M | 1997 | Anesth Analg1997，84，1： | 1 |
| 10 | Estimating the value of water quality improvements in a recreational demand framework显示文摘 | BOCKSTAEL N E HANEMANN W M KLING C L | 1987 | Water Resources Research1987，23，5： | 1 |
| 11 | Water markets and water quality显示文摘 | WEINBERG M KLING C L WILEN J E | 1993 | American Journal of Agricultural Economics1993，75，2： | 1 |
| 12 | Resveratrol and estradiol rapidly activate MAPK sig- naling through estrogen receptors alpha and beta in endothelial cell显示文摘 | Klinge C M Blankenship K A Risinger K E | 2005 | J Biol Chem2005，280，9： | 1 |
| 13 | Variation in dissolved organic matter controls bacterial production and community composition 显示文摘 | Judd K E Crump B C Kling G W | 2006 | Ecology2006，87，8： | 1 |
| 14 | Estradiol-induced proliferation of papillary and follicular thyroid cancer cells is mediated by estrogen receptors alpha and beta显示文摘 | Kumar A Klinge C M Goldstein R E | 2010 | Int J Oncol2010，36，5： | 1 |
| 15 | Mars Dust Counter 显示文摘 | Igenbergs E Klinge D Miyamoto H | 1998 | Earth Planets Space1998，，50： | 1 |
| 16 | Ecological consequences of acentury of warming in Lake Tanganyika显示文摘 | Verburg P Hecky R E Kling H | 2003 | Science2003，301，5632： | 1 |
| 17 | Nitrogen fertilizer management effects on maize grain quality in the west frican moistsavanna显示文摘 | Oikeh S O Kling J G Okoruwa A E | 1998 | Crop Science1998，38，4： | 1 |
| 18 | Estradiol-induced proliferation of papillary and follicular thyroid cancer cells is mediated by estrogen receptors alpha and beta显示文摘 | KUMAR A KLINGE C M GOLDSTEIN R E | | Int J Oncol0，36，5： | 1 |
| 19 | Estradiol-induced proliferation of papillary and follicular thyroid cancer cells is mediated by estrogen receptors alpha and beta显示文摘 | KUMAR A KLINGE C M GOLDSTEIN R E | 2010 | Int J Oncol2010，36，5： | 1 |
| 20 | Brillouin microscopy of collagen crosslinking: noncontact depth-dependent analysis of corneal elastic modulus显示文摘 | Scarcelli G Kling S Quijano E | 2013 | Invest Ophthalmol Vis Sci2013，54，2： | 1 |
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