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| 1 | Correlation of neutrophil/lymphocyte and platelet/lymphocyte ratio with visual acuity and macular thickness in age-related macular degeneration显示文摘AIM:To investigate the place of neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in the diagnosis of and prognosis for neovascular age-related macular degeneration(AMD). METHODS:One hundred AMD patients and 100 healthy controls were included in the study. Blood samples were obtained from the venous blood, which is used for routine analysis, and these samples were subjected to complete blood count. NLR was defined as the neutrophil count divided by the number of lymphocytes, and PLR was defined as the platelet count divided by the number of lymphocytes. RESULTS:No statistically significant difference was observed between the two groups under consideration in terms of demographic features(P>0.05). The average NLR in the patient group was found to be significantly higher than that in the healthy control group(P<0.05). The average PLR was significantly higher in the patient group as compared to the control group(P<0.05). As best corrected visual acuity(BCVA) increased, both NLR and PLR decreased(significant negative correlations at 49.8% and 63.0%, respectively), whereas as central macular thickness(CMT) increased, both NLR and PLR increased(significant positive correlations at 59.3% and 70.0%, respectively).CONCLUSION:NLR and PLR levels are higher among neovascular AMD patients as compared to healthy control group. NLR and PLR levels were found to be inversely proportional to BCVA and directly proportional to CMT. | Elvan Alper Sengul Ozgur Artunay Alev Kockar Ceyda Afacan Rifat Rasier Palmet Gun Nazli Gul Yalcin Erdal Yuzbasioglu | 2017 | International Journal of Ophthalmology(English edition)2017，10，5： | 4 |
| 2 | Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats显示文摘AIM: To investigate the preventive effect of kefir on colitis induced with dextran sulfate sodium(DSS) in rats.METHODS: Twenty-four male Wistar-albino rats were randomized into four groups: normal control,kefircontrol,colitis,and kefir-colitis groups. Rats in the normal and kefir-control groups were administered tap water as drinking water for 14 d. Rats in the colitis and kefir-colitis groups were administered a 3% DSS solution as drinking water for 8-14 d to induce colitis. Rats in the kefir-control and kefir-colitis groups were administered 5 m L kefir once a day for 14 d while rats in the normal control and colitis group were administered an identical volume of the placebo(skim milk) using an orogastric feeding tube. Clinical colitis was evaluated with reference to the disease activity index(DAI),based on daily weight loss,stool consistency,and presence of bleeding in feces. Rats were sacrificed on the 15 th day,blood specimens were collected,and colon tissues were rapidly removed. Levels of myeloperoxidase(MPO),tumor necrosisfactor(TNF)-α,interleukin(IL)-10,malondialdehyde,and inducible nitric oxide synthase(i NOS) were measured in colon tissue.RESULTS: The DAI was lower in the kefir-colitis group than in the colitis group(on the 3rd and 5th days of colitis induction; P < 0.01). The DAI was also significantly higher in the colitis group between days 2 and 6 of colitis induction when compared to the normal control and kefir-control groups. The DAI was statistically higher only on the 6th day in the kefircolitis group when compared to that in the normal control groups. Increased colon weight and decreased colon length were observed in colitis-induced rats. Mean colon length in the colitis group was significantly shorter than that of the kefir-control group. Kefir treatment significantly decreased histologic colitis scores(P < 0.05). MPO activity in the colitis group was significantly higher than in the kefir-control group(P < 0.05). Kefir treatment significantly reduced the DSS colitis-induced TNF-α increase(P < 0.01). No statistically significant differences were observed among groups for IL-10 and MDA levels. Colon tissue i NOS levels in the colitis group were significantly higher than those in the control and kefir-colitis groups(P < 0.05).CONCLUSION: Kefir reduces the clinical DAI and histologic colitis scores in a DSS-induced colitis model,possibly via reduction of MPO,TNF-α,and i NOS levels. | Altug Senol Mehmet Isler Recep Sutcu Mete Akin Ebru Cakir Betul M Ceyhan M Cem Kockar | 2015 | World Journal of Gastroenterology2015，21，46： | 3 |
| 3 | Scheduling Framework Using Dynamic Optimal Power Flow for Battery Energy Storage Systems显示文摘Battery energy storage systems(BESS)are instrumental in the transition to a low carbon electrical network with enhanced flexibility,however,the set objective can be accomplished only through suitable scheduling of their operation.This paper develops a dynamic optimal power flow(DOPF)-based scheduling framework to optimize the day(s)-ahead operation of a grid-scale BESS aiming to mitigate the predicted limits on the renewable energy generation as well as smooth out the network demand to be supplied by conventional generators.In DOPF,all the generating units,including the ones that model the exports and imports of the BESS,across the entire network and the complete time horizon are integrated on to a single network.Subsequently,an AC-OPF is applied to dispatch their power outputs to minimize the total generation cost,while satisfying the power balance equations,and handling the unit and network constraints at each time step coupled with intertemporal constraints associated with the state of charge(SOC).Furthermore,the DOPF developed here entails the frequently applied constant current-constant voltage charging profile,which is represented in the SOC domain.Considering the practical application of a 1 MW BESS on a particular 33 kV network,the scheduling framework is designed to meet the pragmatic requirements of the optimum utilization of the available energy capacity of BESS in each cycle,while completing up to one cycle per day. | Fulin Fan Ivana Kockar Han Xu Jingsi Li | 2022 | CSEE Journal of Power and Energy Systems2022，8，1： | 3 |
| 4 | Hypoxia and cytokines regulate carbonic anhydrase 9 expression in hepatocellular carcinoma cells in vitro显示文摘AIM: To study the expression of carbonic anhydrase(CA) 9 in human hepatocellular carcinoma(HCC) cells.METHODS: We studied CA9 protein, CA9 m RNA and hypoxia-inducible factor-1 alpha(HIF-1α) protein levels in Hep3 B cells exposed in different parallel approaches. In one of these approaches, HCC cells were exposed to extreme in vitro hypoxia(24 h 0.1% O2) without or with interleukin(IL)-1, IL-6, tumor necrosis factoralpha(TNF-α) and transforming growth factor-beta(TGF-β) stimulation for the same hypoxic exposure time or exposed to normoxic oxygenation conditions without or with cytokine stimulation.RESULTS: The tumour cell line analysed showed a strong hypoxic CA9 m RNA expression pattern in response to prolonged severe hypoxia with cell-line specific patterns and a marked induction of CA9 protein in response to severe hypoxia. These results were paralleled by the results for HIF-1α protein under identical oxygenation conditions with a similar expression tendency to that displayed during the CA9 protein expression experimental series. Continuous stimulation with the cytokines, IL-1, IL-6, TNF-α and TGF-β, under normoxic conditions significantly increased the carbonic anhydrase 9 expression level at both the protein and m RNA level, almost doubling the CA9 m RNA and CA9 and HIF-1α protein expression levels found under hypoxia. The findings from these experiments indicated that hypoxia is a positive regulator of CA9 expression in HCC, and the four signal transduction pathways, IL-1, IL-6, TNF-α and TGF-β, positively influence CA9 expression under both normoxic and hypoxic conditions.CONCLUSION: These findings may potentially be considered in the design of anti- cancer therapeutic approaches involving hypoxia-induced or cytokine stimulatory effects on expression. In addition, they provideevidence of the stimulatory role of the examined cytokine families resulting in an increase in CA9 expression under different oxygenation conditions in human cancer, especially HCC, and on the role of the CA9 gene as a positive disease regulator in human cancer. | Feray Kockar Hatice Yildrim Rahsan Ilikci Sagkan Carsten Hagemann Yasemin Soysal Jelena Anacker Ahmed Ayad Hamza Dirk Vordermark Michael Flentje Harun M Said | 2012 | World Journal of Clinical Oncology2012，3，6： | 2 |
| 5 | Z-BUS Loss Allocation显示文摘 | Conejo J Gliana D Ivana Kockar | 2001 | IEEE Trans on Power Systems2001，16，1： | 1 |
| 6 | Diabetic gastroparesis in associstion with autonomic neuropathy and microvaxct nauropathy opathy显示文摘 | Kockar MC Kayahan IK Bavbek N | 2002 | Acta Med Okayama2002，56，5： | 1 |
| 7 | Influence of the emissions trading scheme on genera- tion scheduIing显示文摘 | Ivana Kockar Antnio J Conejo James R McDonald | 2009 | Electrical Power and Energy Sys- tem2009，，： | 1 |
| 8 | Z bus loss allocation 显示文摘 | CONEJO A J GALIANA F D KOCKAR I | 2001 | IEEE Trans on Power Systems2001，16，1： | 1 |
| 9 | Incremental Transmission Loss Allocation Under Pool Dispatch显示文摘 | Galiana F D Conejo J A Kockar I | 2002 | IEEE Trans on Power Systems2002，17，1： | 1 |
| 10 | Fixed-bed pyrolysis of safflower seed:Influence of pyrolysis parameters on product yields and compositions显示文摘 | Beis S H Onay O Kockar O M | 2002 | Renewable Energy2002，26，1： | 1 |
| 11 | Dynamic optimal power flow for active distribution network显示文摘 | Gill S Kockar I Ault G W | 2014 | IEEE Transactions on Smart Grid2014，29，1： | 1 |
| 12 | incremental transmission loss allocation under pool dispatch 显示文摘 | Galiana F D Conejo A J Kockar Ivana | 2002 | IEEE Trans on Power Systems2002，17，1： | 1 |
| 13 | Z - bus loss allocation 显示文摘 | Conejo A J Galiana F D Kockar I | 2001 | IEEE Transactions on Power Systems2001，16，1： | 1 |
| 14 | Z-bus loss allocation显示文摘 | Conejo A J Galiana F D Kockar I | 2001 | IEEE Transactions on Power Systems2001，16，1： | 1 |
| 15 | Combined pool/bilateral dispatch--Pan I: performance of trading strategies显示文摘 | Galiana F D Kockar I Franco P C | 2002 | IEEE Transactions on Power Systems2002，17，11： | 1 |
| 16 | Thermomechanical cyclic response of an ultrafine-grained NiTi shape memory alloy 显示文摘 | KOCKAR B KARAMAN I KIM J I CHUMLYAKOV Y I SHARP J YU C J | 2008 | Acta Materialia2008，56，14： | 1 |
| 17 | A Method to Enchance Cyclic Reversibility of NiTiHf High Temperature Shape Memory Alloys显示文摘 | Kockar B Karaman I Kim I J | 2006 | Scripta Materialia2006，54，： | 1 |
| 18 | Diabetic gastroparesis in associadon with autonomic neuropathy and microvaseulopathy显示文摘 | Kockar MC Kayahen LK Bavbek N | 2002 | Acta Med Okayama2002，56，5： | 1 |
| 19 | Comparison of the genera-tion of oil by the extraction and the hydropyrolysis of biomass显示文摘 | ONAY O GAINES A F KOCKAR M O | 2006 | Fuel2006，85，3： | 1 |
| 20 | Slow,fast,and flash pyrolysis of rapeseed显示文摘 | Onay O Kockar O M | 2003 | Renewable Energy2003，28，15： | 1 |
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