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| 1 | Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer显示文摘AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. | Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling | 2007 | World Journal of Gastroenterology2007，13，37： | 12 |
| 2 | Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in colorectal liver metastases显示文摘AIM:To evaluate the influence of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in liver metastases of stage Ⅳ colorectal cancer(CRC) patients.METHODS:Using Real Time-PCR,enzyme-linked immunosorbent assay,Western Blots and immunohistochemistry,we have analyzed the expression of CCL20,CCR6 and proliferation marker Ki-67 in colorectal liver metastasis(CRLM) specimens from stage Ⅳ CRC patients who received preoperative FOLFOX chemotherapy(n = 53) and in patients who did not receive FOLFOX chemotherapy prior to liver surgery(n = 29).RESULTS:Of the 53 patients who received FOLFOX,time to liver surgery was ≤ 1 mo in 14 patients,≤ 1 year in 22 patients and > 1 year in 17 patients,respectively.In addition,we investigated the proliferation rate of CRC cells in liver metastases in the different patient groups.Both CCL20 and CCR6 mRNA and protein expression levels were significantly increased in patients who received preoperative FOLFOX chemotherapy ≤ 12 mo before liver surgery(P < 0.001) in comparison to patients who did not undergo FOLFOX treatment.Further,proliferation of CRLM cells as measured by Ki-67 was increased in patients who underwent FOLFOX treatment.CCL20 and CCR6 expression levels were significantly increased in CRLM patients who had undergone preoperative FOLFOX chemotherapy.CONCLUSION:This chemokine/receptor up-regulation could lead to increased proliferation/migration through an autocrine mechanism which might be used by surviving metastatic cells to escape cell death caused by FOLFOX. | Claudia Rubie Vilma Oliveira Frick Pirus Ghadjar Mathias Wagner Christoph Justinger Stefan Graeber Jens Sperling Otto Kollmar Martin K Schilling | 2011 | World Journal of Gastroenterology2011，17，26： | 5 |
| 3 | Hepatocellular carcinoma: Surgeon's view on latest findings and future perspectives显示文摘Hepatocellular carcinoma(HCC) is the most common liver-derived malignancy with a high fatality rate. Risk factors for the development of HCC have been identified and are clearly described. However, due to the lack of tumor-specific symptoms, HCC are diagnosed at progressed tumor stages in most patients, and thus curative therapeutic options are limited. The focus of this review is on surgical therapeutic options which can be offered to patients with HCC with special regard to recent findings, not exclusively focused on surgical therapy, but also to other treatment modalities. Further, potential promising future perspectives for the treatment of HCC are discussed. | Jan Erik Slotta Otto Kollmar Volker Ellenrieder B Michael Ghadimi Kia Homayounfar | 2015 | World Journal of Hepatology2015，7，9： | 2 |
| 4 | Neuroprotec tive effect of granulocyte colony- stimulating factor after focal cerebral ischemia显示文摘 | Scabiz WR Kollmar R Schwaninger M | 2003 | Stroke2003，34，3： | 2 |
| 5 | Neuroprotective effect of granulocyte colony - stimulating factor after focal cerebral ische- mia 显示文摘 | Schlibitz WR Kollmar R Schwaninger M | 2003 | Stroke2003，34，3： | 1 |
| 6 | Pancreatojejunal leakage after pancreas headresection:anatomic and surgeon-related factors显示文摘 | Kollmar O Moussavian M R Bolli M | 2007 | J Gastrointest surg2007，11，12： | 1 |
| 7 | Endovascular cooling for moderate hypothermia in patients with acute stroke:first results of a novel approach显示文摘 | Schwarz S Kollmar R | 2001 | Stroke2001，32，： | 1 |
| 8 | Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia显示文摘 | Schabitz WR Kollmar R Schwaninger M | 2003 | Stroke2003，34，3： | 1 |
| 9 | Critical illness polyneuropathy and myopathy in the intensive care unit显示文摘 | Zink W Kollmar R Schwab S | 2009 | Nat Rev Neurol2009，5，7： | 1 |
| 10 | Liver transplantation after organ preservation with normothermic extracorporeal perfusion显示文摘 | Schon MR Kollmar O Wolf S | 2001 | Ann Surg2001，233，1： | 1 |
| 11 | Neuroprotective effect of granalo cyte colony-stimulating factor after focal cerebral ischemia显示文摘 | Schabitz WR Kollmar R Schwaninger M | 2003 | Stroke2003，34，： | 1 |
| 12 | Different degrees of hypothermia after experimental 显示文摘 | Rainer Kollmar Tobias Blank Han L | 2007 | Stroke2007，38，： | 1 |
| 13 | Alpha-stat versus pH-stat guided ventilation in patients with large ischemic stroke treated by hypothermia显示文摘 | Kollmar R Georgiadis D Schwab S | 2009 | Neurocrit Care2009，10，2： | 1 |
| 14 | Endovascular cooling for moderate hypothermia in patients with acute stroke: First result of a novel approach显示文摘 | Georgiadis D Schwarz S Kollmar R | 2001 | Stroke2001，32，： | 1 |
| 15 | A novel hybrid gene prediction method employing protein multiple sequence alignments显示文摘 | KELLER O KOLLMAR M STANKE M eta/ | 2011 | Bioinformatics2011，27，6： | 1 |
| 16 | Neuroprotective effect of delayed moderate hypothermia after focal cerebral ischemia: an MRI study显示文摘 | Kollmar R Schabitz WR Heiland S | 2002 | Stroke2002，33，7： | 1 |
| 17 | Combination therapy of moderate hypothermia and thrombolysis in experimental throm- boembolic stroke-an MRI study显示文摘 | Kollmar R Henninger N5 Bardutzky J | 2004 | Exp Neurol2004，190，1： | 1 |
| 18 | Differential responseof ar- teries and veins to bipolar vessel sealing:evaluation of a novelreusable device显示文摘 | Richter S Kollmar O Neunhoeffer E | 2006 | J Laparoendosc Adv Surg Tech A2006，16，2： | 1 |
| 19 | Aprotinin inhibits local platelet trapping and improves tissue destruction in hepatic cryosurgery 显示文摘 | Kollmar O Richter S Czyborra J | 2004 | Surgery2004，136，3： | 1 |
| 20 | Different Degrees of Hypothermia After Experimental Stroke: Short-and Long-Term Outcome 显示文摘 | Kollmar R Blank T Hart JL | 2007 | Stroke2007，38，5： | 1 |
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