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| 1 | Emerging roles of the intestine in control of cholesterol metabolism显示文摘The liver is considered the major “control center” for maintenance of whole body cholesterol homeostasis. This organ is the main site for de novo cholesterol synthesis, clears cholesterol-containing chylomicron remnants and low density lipoprotein particles from plasma and is the major contributor to high density lipoprotein (HDL; good cholesterol) formation. The liver has a central position in the classical definition of the reverse cholesterol transport pathway by taking up periphery-derived cholesterol from lipoprotein particles followed by conversion into bile acids or its direct secretion into bile for eventual removal via the feces. During the past couple of years, however, an additional important role of the intestine in maintenance of cholesterol homeostasis and regulation of plasma cholesterol levels has become apparent. Firstly, molecular mechanisms of cholesterol absorption have been elucidated and novel pharmacological compounds have been identified that interfere with the process and positively impact plasma cholesterol levels. Secondly, it is now evident that the intestine itself contributes to fecal neutral sterol loss as a cholesterol-secreting organ. Finally, very recent work has unequivocally demonstrated that the intestine contributes significantly to plasma HDL cholesterol levels. Thus, the intestine is a potential target for novel anti-atherosclerotic treatment strategies that, in addition to interference with cholesterol absorption, modulate direct cholesterol excretion and plasma HDL cholesterol levels. | Janine K Kruit Albert K Groen Theo J van Berkel Folkert Kuipers | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 2 | Angiogenic markers endoglin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine tumors显示文摘AIM:To investigate the expression and potential prognostic role of vascular endothelial growth factor(VEGF) and endoglin in gastroenteropancreatic neuroendocrine tumors(GEP-NETs) . METHODS:Microvessel density(MVD) in GEP-NETs was evaluated using endoglin and CD31 immunohistochemistry.In addition,tissue levels of endoglin and VEGF were determined in homogenates by ELISA. RESULTS:Endoglin was highly expressed on tumor endothelial cells.CD31 MVD in GEP-NETs was significantly higher compared to endoglin MVD(P<0.01) .Two-tofour-fold higher tissue levels of endoglin and VEGF were seen in tumors compared to associated normal tissue. This increased endoglin tissue expression in tumors was significantly related to tumor size(P<0.01) ,presence of metastases(P=0.04) ,and a more advanced tumor stage(P=0.02) ,whereas expression of VEGF was not. CONCLUSION:We suggest that endoglin is a potential marker to indicate and predict metastases,which might be useful in the post-resection therapeutic approach of patients with GEP-NETs. | Patricia Kuiper Lukas JAC Hawinkels Eveline SM de Jonge-Muller Izk Biemond Cornelis BHW Lamers Hein W Verspaget | 2011 | World Journal of Gastroenterology2011，17，2： | 4 |
| 3 | A numerical model of gas-fluidized beds显示文摘 | Kuipers J A M Van Duin K J Van Beckum F P H | 1992 | Chem Eng Sci1992，47，5： | 4 |
| 4 | Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β显示文摘 | Kuiper GG Carlsson B Grandien K | 1997 | Endocrinology1997，138，3： | 1 |
| 5 | Evaluation o{ the as- tronomical time scale for the Paleocene and earliest Eocene 显示文摘 | Hilgen F J Kuiper K F Lourens L J | 2010 | Earth and Planetary Science Letters2010，300，13： | 1 |
| 6 | Comparison of the ligand binding specificity and transcript tissue distribution of estrogen recep- tors alpha and beta 显示文摘 | Kuiper G G Carlsson B Grandien K | 1997 | Endocrinology1997，138，3： | 1 |
| 7 | Synchronizing rock clocks of Earth history显示文摘 | Kuiper K F Deino A Hilgen F J | 2008 | Science2008，320，： | 1 |
| 8 | Differentiallig and activation of estrogen receptors ERαand Erβat API sites 显示文摘 | Paech K Webb P Kuiper GG | 1997 | Science1997，277，： | 1 |
| 9 | Comparison of the ligand binding specificity and transcript tissuedistributian of estrogen receptors alpha and beta显示文摘 | Kuiper G G Carlsson B Grandien K | 1997 | Endocrinology1997，138，3： | 1 |
| 10 | BiNGO:a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks显示文摘 | MAERE S HEYMANS K KUIPER M | 2005 | Bioinformatics2005，21，： | 1 |
| 11 | Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites显示文摘 | Paech K Webb P Kuiper GG | 1997 | Scioce1997，277，5331： | 1 |
| 12 | Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta显示文摘 | Kuiper GG Carlsson B Grandien K | 1997 | Endocrinology1997，138，3： | 1 |
| 13 | Differential ligand activation of estrogen receptors ER-a and ER-β at AP1 sites 显示文摘 | PAECH K WEBB P KUIPER G | 1997 | Secience1997，277，5331： | 1 |
| 14 | Bingo : A cytoscape plugin to assess overrepresentation of gene ontology cate- gories in biological networks 显示文摘 | MAERE S HEYMANS K KUIPER M | 2005 | Bioinformatics2005，21，： | 1 |
| 15 | Differential ligand activation of estrogen receptors ERα and ER-β at AP1 sites显示文摘 | Paech K Webb P Kuiper GGJM | 1997 | Science1997，277，： | 1 |
| 16 | Structure and function of antifreeze proteins显示文摘 | Davies Peter L. Baardsnes Jason Kuiper Michael J. Walker Virginia K | 2002 | Philosophical Transactions of the Royal Society B: Biological Sciences2002，，1423： | 1 |
| 17 | Differential ligand activation of estrogen receptors ER alpha and ER beta at AP1 sites 显示文摘 | Paech K Webb P Kuiper GG | 1997 | Science1997，277，5331： | 1 |
| 18 | Differential ligand activation of estrogen receptors ERα and ERβ at API sites 显示文摘 | Paech K Webb P Kuiper GG | 1997 | Science1997，277，5331： | 1 |
| 19 | Differential ligand activation of estrogen receptors ER alpha and ER beta at API sites显示文摘 | Paech K Webb P Kuiper GG | 1997 | Science1997，277，5331： | 1 |
| 20 | A theoretical model of a plant anfifreeze protein from Lolium perenne显示文摘 | Kuiper M J Davies P L Walker V K | 2001 | Biophys J2001，81，6： | 1 |
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