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| 1 | Evaluating the effectiveness of marine actinobacterial extract and its mediated titanium dioxide nanoparticles in the degradation of azo dyes显示文摘Aim of the present study was to synthesize titanium dioxide nanoparticles(TiO2 NPs) from marine actinobacteria and to develop an eco-friendly azo-dye degradation method. A total of five actinobacterial isolates were isolated from Chennai marine sediments, Tamilnadu, India and analyzed for the synthesis of TiO2 NPs using titanium hydroxide. Among these, the isolate PSV 3 showed positive results for the synthesis of TiO2 NPs, which was confirmed by UV analysis. Further characterization of the synthesized TiO2 NPs was done using XRD, AFM and FT-IR analysis. Actinobacterial crude extract and synthesized TiO2 NPs was found efficient in degrading azo dye such as Acid Red 79(AR-79) and Acid Red 80(AR-80). Degradation percentage was found to be 81% for AR-79, 83% for AR-80 using actinobacterial crude extract and 84% for AR-79, 85% for AR-80 using TiO2 NPs. Immobilized actinobacterial cells showed 88% for AR-79 and 81% for AR-80, dye degrading capacity. Degraded components were characterized by FT-IR and GC-MS analysis. The phytotoxicity test with 500 μg/mL of untreated dye showed remarkable phenotypic as well as cellular damage to Tagetes erecta plant. Comparatively no such damage was observed on plants by degraded dye components. In biotoxicity assay, treated dyes showed less toxic effect as compared to the untreated dyes. | S Priyaragini S Veena D Swetha L Karthik G Kumar K V Bhaskara Rao | 2014 | Journal of Environmental Sciences2014，26，4： | 4 |
| 2 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 3 | Methanolic extract of Momordica cymbalaria enhances glucose uptake in L6 myotubes in vitro by up-regulating PPAR-γ and GLUT-4显示文摘The present study was undertaken to evaluate the influence of the methanolic fruit extract of Momordica cymbalaria(MFMC) on PPARγ(Peroxisome Proliferator Activated Receptor gamma) and GLUT-4(Glucose transporter-4) with respect to glucose transport. Various concentrations of MFMC ranging from 62.5 to 500 μg·mL-1 were evaluated for glucose uptake activity in vitro using L6 myotubes, rosiglitazone was used as a reference standard. The MFMC showed significant and dose-dependent increase in glucose uptake at the tested concentrations, further, the glucose uptake activity of MFMC(500 μg·mL-1) was comparable with rosigilitazone. Furthermore, MFMC has shown up-regulation of GLUT-4 and PPARγ gene expressions in L6 myotubes. In addition, the MFMC when incubated along with cycloheximide(CHX), which is a protein synthesis inhibitor, has shown complete blockade of glucose uptake. This indicates that new protein synthesis is required for increased GLUT-4 translocation. In conclusion, these findings suggest that MFMC is enhancing the glucose uptake significantly and dose dependently through the enhanced expression of PPARγ and GLUT-4 in vitro. | Puttanarasaiah Mahesh Kumar Marikunte V Venkataranganna Kirangadur Manjunath Gollapalle L Viswanatha Godavarthi Ashok | 2014 | Chinese Journal of Natural Medicines2014，12，12： | 2 |
| 4 | Comparative analysis of genetic diversity among Indian populations of Scirpophaga incertulas by ISSR-PCR and RAPD-PCR显示文摘 | Kumar L S Sawant A S Gupta V S | 2001 | Biochem Genet2001，39，： | 1 |
| 5 | Graft copolymerization of acrylonitrilc onto Cassia tora gum with eerie ammonium nitrate - nitricaeid as a redox initiator显示文摘 | Sharma B R Kumar V Soni P L | 2003 | Journal of Applied Polymer Science2003，，1： | 1 |
| 6 | Decolorization and bio- degradation of anaerobically treated digested sugarcane molas- ses spent wash effluent from biomethanation plants by white rot fung显示文摘 | KUMAR V WATI L NIGAM P | 1998 | Process Biochemistry1998，33，： | 1 |
| 7 | HIPI and HIPlr stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains显示文摘 | Hyun T S Rao D S Saint-Dic D Michael L E Kumar P D Bradley S V Mizukami I F | | 0，，14： | 1 |
| 8 | Intensification of nicotinic acid separation using organophosphorous solvating extractants by reactive extraction 显示文摘 | KUMAR S WASEWAR K L BABU B V | 2008 | Chem Eng Technol2008，31，11： | 1 |
| 9 | High-performance liquid chromatographic analysis of ampho-tericin B in rat plasma using α-naphthol as an internal standard显示文摘 | ITALIA J L SINGH D KUMAR M N V R | 2009 | Anal Chim Acta2009，634，1： | 1 |
| 10 | Performance measures for correlation filters 显示文摘 | Vijaya Kumar B V Hassebrook L | 1990 | APPLIED OPTICS1990，29，20： | 1 |
| 11 | Customer Experience Management in Retailing: An Organizing Framework显示文摘 | Dhruv G Michael L Kumar V | 2009 | Journal of Re-tailing2009，85，1： | 1 |
| 12 | A comparimn of histopathology findings of ovarian tissue inadvertently excised with endomctrioma and other kinds of bellign ovarian cyst in patients undergoing laparoscopy vetches lap roomy显示文摘 | Alborzi S Fbrouginia L Kumar P V | 2012 | Fertil Seril2012，92，6： | 1 |
| 13 | Effect of Triphala on dental biofilm显示文摘 | Jagadish L Anand kumar VK Kaviyarasan V | 2009 | Indian J Sci Tech2009，2，10： | 1 |
| 14 | Flexible energy storage devices based on nanocomposite paper 显示文摘 | Pushparaj V L Shaijumon M M Kumar A | 2007 | Proceedings of the National Academy of Sciences2007，104，13： | 1 |
| 15 | A classification of unruptured middle cerebral artery bifurcation aneurysms that can help in choice of clipping technique显示文摘 | Kumar M V Karagiozov K L Chen L Imizu S Yoneda M Watabe T | 2007 | Minim Invasive Neurosurg2007，50，： | 1 |
| 16 | A highthroughput field-programmable gate array implementation of soft output Viterbi algorithm for magnetic recording 显示文摘 | Sun L Horigome T Kumar B V K V | 2004 | IEEE Trans Magnetics2004，40，4： | 1 |
| 17 | Design and fabrication of an automated technique: measurement of spontaneous polarization in two new schiff'base ferroelectric liquid crystals 显示文摘 | Madhu Mohan M L N Goud B V S Kumar P A | 1999 | Materials Research Bulletin1999，34，1415： | 1 |
| 18 | Performance measures for correlation filters显示文摘 | KUMAR V HASSEBROOK L | 1990 | Appl Opt1990，29，20： | 1 |
| 19 | Studies on Leaching and Recycling of Zinc from Rayon Waste Sludge显示文摘 | Jha M K Kumar V Maharaj L | 2004 | Ind Eng Chem Res2004，43，5： | 1 |
| 20 | Segmented flow synthesis of Ag nanoparticles in spiral microreactor :Role of continuous and disperzsed phase显示文摘 | Ravi Kumar D V Prasad B L V Kulkami A A | 2012 | Chemical Engineering Journal2012，192，： | 1 |
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