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| 1 | 基于灰色关联模型的贫困地区生态安全综合评价——以恩施贫困地区为例显示文摘将灰色系统理论与熵值赋权法相结合,采用压力—状态—响应模型,对恩施贫困地区生态安全状况进行综合评价,并将生态安全综合指数分别与各县农民人均纯收入及贫困村比重进行空间耦合。计算结果表明恩施贫困地区生态安全呈现以下特点:1研究区当前生态安全综合指数总体处于较安全水平,生态环境较好;2研究区各县市生态安全综合指数与农民人均纯收入没有必然的联系,说明在贫困地区开展扶贫工作,若只注重经济发展并不一定能改善当地生态安全状况;3各县市生态安全综合指数与贫困村比重存在反相关性,表明扶贫开发在消除贫困的同时,能够改善当地生态环境,提升整体生态安全水平。 | 张家其 吴宜进 葛咏 王程昊 Hsiangte Kung | 2014 | 地理研究2014，33，8： | 72 |
| 2 | 近40年艾比湖湿地自然保护区生态干扰度时空动态及景观格局变化显示文摘以新疆艾比湖湿地为研究区,利用1972、1998、2007年及2013年4个时期的Landsat遥感影像作为数据源,并结合湿地的土地覆被状况,参考《全国土地利用分类》建立艾比湖湿地生态干扰类型分类系统。借助生态干扰度指数、景观格局指数以及GIS空间分析方法,探讨艾比湖湿地的生态干扰度的时空动态及景观响应机制。结果表明:(1)1972—2013年,研究区的生态干扰度总体呈现较为稳定的趋势,但其空间分布发生变化。生态干扰度类型之间的转化速率有加快的趋势。(2)1972—2013年,边缘密度指数(ED),平均形状指数(MSI),面积加权的平均斑块分形指数(AWMPFD)及景观分离度(DIVISION)4项景观格局指数大体呈上升的趋势,2013年区域的景观指数较为稳定。(3)景观格局指数与生态干扰程度有密切的一致性。生态干扰度与景观格局指数空间分布相关性大小依次为:边缘密度指数(ED)<景观丰度密度(PRD)<香农多样性指数(SHDI)<平均形状指数(MSI)<面积加权的平均斑块分形指数(AWMPFD)<景观分离度(DIVISION)。客观系统的认识和评价艾比湖湿地的生态系统及环境,可为干旱区实现自然环境的保护,协调土地利用及环境保护之间的关系提供较为实用的参考。 | 张月 张飞 王娟 任岩 Abduwasit Ghulam Hsiang-te KUNG 陈芸 | 2017 | 生态学报2017，37，21： | 50 |
| 3 | 主题村落再造:非物质文化遗产旅游开发模式研究显示文摘非物质文化遗产是重要的文化旅游资源,村落是非物质文化遗产的主要载体,适宜的旅游开发模式有助于非物质文化遗产的保护与传承,有利于文化旅游业的可持续发展。以三峡步步升文化村为案例,在分析所依托资源特点、开发现状及旅游开发策略的基础上,归纳提炼得出传统手工技艺类非物质文化遗产旅游开发的'主题村落再造'模式,即以主题村落为载体,以文化旅游为功能,以活态传承为方式,以聚集开发为手段,整体形成一个极富活力的生态文化博物村落。 | 阚如良 王桂琴 周军 Hsiang-te Kung | 2014 | 地域研究与开发2014，33，6： | 34 |
| 4 | 1998—2014年艾比湖湿地自然保护区生态系统服务价值及其时空变异显示文摘湿地的生态系统服务价值是生态学研究的热点之一。以艾比湖湿地自然保护区为研究区,以1998年的TM影像、2006年的Landsat ETM+影像及2014年的Landsat OLI影像为数据源,采用Costanza生态系统服务价值公式进行生态系统服务价值评估,结合空间自相关模型,定量探讨了艾比湖湿地自然保护区生态系统服务价值时空分异特征。结果表明:(1)近20年来,研究区的土地利用/覆被变化显著,除了水体和裸地面积减少,其它土地覆被类型面积都有不同比例的增加。(2)在生态系统服务价值方面,近20年来ESV(Ecosystem Services Values)整体变化不大,但近年ESV有所降低,生态环境出现恶化趋势。(3)在生态系统服务的时空变异方面,研究区ESV空间正相关显著,空间集聚程度高值区主要集中在艾比湖水域和湿地,并且高值区有增加向减少转变的趋势,低值聚集区在湖区四周,且逐年增加。(4)近20年来,影响研究区生态系统服务价值时空变化的驱动力因素主要包括自然因素和人为因素,人为因素是研究区生态系统服务价值时空变化的主要驱动因素。 | 李哲 张飞 Hsiang-te Kung 张月 井云清 | 2017 | 生态学报2017，37，15： | 34 |
| 5 | 基于LUCC的艾比湖区域生态风险评价及预测研究显示文摘以新疆内陆艾比湖流域典型区域为研究区,基于RS和GIS技术分析1998、2013年土地利用变化,尝试用CA-Markov模型预测2028年土地利用/覆盖变化.借助Fragstats3.4软件,基于土地利用/覆盖变化构建景观生态风险评价模型,分析1998~2028年景观生态风险的时空分异特征.结果表明:(1)1998~2013年,研究区土地类型面积变化明显.耕地面积增加量最大,增加的面积为152139hm^2,而未利用地面积减少量最大,减少的面积为67605hm^2.2013~2028年,耕地和裸露的河床及盐渍地的面积增加明显,增加的面积分别为30730hm^2,12427hm^2,而未利用地和水体的面积分别从954376hm^2和44889hm^2,减至921079hm^2和37157hm^2.(2)1998~2028年,研究区生态风险等级空间分布差异明显.高生态风险区面积变化较为显著,其面积分别约占总面积的36.6%,7.3%,23.7%.1998~2028年,全局Moran’s I值分别为0.436962,0.442202,0.506622,表现为一定程度的正相关.(3)1998~2028年,耕地分布在低,较低生态风险的比重上升,所占百分比分别为58.46%,78.58%,79.9%.林、草地类型的各生态风险等级的所占的比重的波动较大. | 张月 张飞 王娟 任岩 Abduwasit Ghulam Hsiang-te KUNG | 2016 | 中国环境科学2016，36，11： | 31 |
| 6 | 艾比湖湿地土地利用/覆被-景观格局和气候变化的生态环境效应研究显示文摘借助Arc GIS与ENVI软件,以1998年、2006年和2014年遥感影像Landsat TM/OLI为数据源,得到3期艾比湖湿地自然保护区土地利用/覆被类型图.在空间尺度上将研究区分为3个特定研究单元来分析土地利用/覆被变化特征,并从景观格局和气候变化两个方面来进行生态环境效应研究.通过计算土地利用/覆被类型生态风险指数,从而获得研究区生态安全指数,最终建立艾比湖湿地自然保护区土地利用/覆被类型与生态环境之间的数量关系,并对整体及局部地区进行生态环境质量动态分析.结果表明,水域和其他(裸地和戈壁)是研究区内的优势景观类型.水域的平均斑块面积最大,水域和其他(裸地和戈壁)的最大斑块指数较高,盐碱地和其他(裸地和戈壁)的分维度指数较高,水域和其他(裸地和戈壁)的聚集度指数较大,林草地空间分布离散,破碎化程度高,连通性差.1998—2014年期间多样性指数增加,说明各景观类型所占比例趋于均衡化,作为优势景观类型的湿地对整个景观的控制作用减小,景观异质性增加.1998—2014年间,艾比湖湿地自然保护区总体生态环境指数呈逐步升高趋势,但生态环境质量的改善与恶化同时存在,并在特定研究单元上出现明显的区域分异特征.盐碱地、其他(裸地和戈壁)向湿地及荒漠向其他(裸地和戈壁)的转化是环境改善的主导因素.湿地向水域和其他(裸地和戈壁)的转变是环境恶化的主导因素.据1998—2014年的气象资料,降水量呈下降趋势,降水减少使植物存活率降低,导致植被覆盖率下降,从而影响生态环境的健康发展.另外,在分析驱动机制的基础上,建立了优选多元线性回归方程,结果表明,在景观指数和年径流量中,艾比湖湿地自然保护区生态环境指数的变化与平均斑块面积和分维度指数均呈显著相关.该研究对艾比湖湿地自然保护区土地利用合理规划管理、生态恢复和经济发展政策的制定有着非常重要的意义. | 井云清 张飞 陈丽华 张月 王小平 李哲 Hsiang-te KUNG | 2017 | 环境科学学报2017，37，9： | 28 |
| 7 | Rapid quantification of semen hepatitis B virus DNA by real-time polymerase chain reaction显示文摘AIM: To examine the sensitivity and accuracy of real-time polymerase chain reaction (PCR) for the quantification of hepatitis B virus (HBV) DNA in semen.METHODS: Hepatitis B viral DNA was isolated from HBV carriers' semen and sera using phenol extraction method and QTAamp DNA blood mini kit (Qiagen, Germany). HBV DNA was detected by conventional PCR and quantified by TaqMan technology-based real-time PCR (quantitative polymerase chain reaction (qPCR)). The detection threshold was 200 copies of HBV DNA for conventional PCR and 10 copies of HBV DNA for real time PCR per reaction.RESULTS: Both methods of phenol extraction and QIAamp DNA blood mini kit were suitable for isolating HBV DNA from semen. The value of the detection thresholds was 500 copies of HBV DNA per mL in the semen. The viral loads were 7.5×107 and 1.67×107 copies of HBV DNA per mL in two HBV infected patients' sera, while 2.L4×105 and 3.02×105 copies of HBV DNA per mL in the semen.CONCLUSION: Real-time PCR is a more sensitive and accurate method to detect and quantify HBV DNA in the semen. | Wei-Ping Qian Yue-Qiu Tan Ying Chen Ying Peng Zhi Li Guang-Xiu Lu Made C. Liu Hsiang-Fu Kung Ming-Ling He Li-Ka Shing | 2005 | World Journal of Gastroenterology2005，11，34： | 25 |
| 8 | 艾比湖区域景观格局与河流水质关系探讨显示文摘为进一步明确景观格局对河流水质的影响.本研究选择新疆艾比湖区域为研究对象,以28个水质采样点为中心,建立100、200、300、400 m的河流缓冲区,并提取土地利用/覆被-景观格局数据.首先,通过主成分分析获得水环境的主要水质变量.其次,利用多元线性回归探讨研究区不同宽度缓冲区土地利用/覆被-景观格局变化对河流水质的影响,获得水质管理的有效缓冲区.结果表明:(1)2015年5月,在艾比湖区域测得的18个地表水水质指标中提取TDS、SO_4^(2-)、NH_4^+-N、HCO_3^-、Na^+和TP这6个水质指标.(2)对斑块密度(PD)、最大斑块指数(LPI)、边缘密度(ED)、景观形状指数(LSI)、蔓延度指数(CONTAG)进行统计分析,发现人类活动在4个缓冲区内强弱不均.(3)本文在不同尺度的缓冲区下,将PD、LPI、ED、LSI、CONTAG和TDS、SO_4^(2-)、NH_4^+-N、HCO_3^-、Na^+、TP分别进行相关性分析,发现300m缓冲区相关性最为显著.(4)在300m缓冲区内,通过多元线性回归分析,将TDS、HCO_3^-与其各自对应的景观指数的关系进行定量化表达,进一步探明区域流域地表水与周围一定缓冲区范围内的景观格局的内在关系. | 曹灿 张飞 阿依尼格尔·亚力坤 朱世丹 郭苗 阿丽米热·塔力甫江 Kung Hsiangte | 2018 | 环境科学2018，39，4： | 26 |
| 9 | 民族文化遗产旅游地妇女社会角色变迁研究——以三峡步步升文化村为例显示文摘妇女是民族文化遗产旅游地的主要参与者,其社会角色变迁是一个亟待研究的新课题。该研究以三峡步步升文化村为案例,通过田野调查和定量分析,从经济收入、家庭地位、思想意识和社会生活等方面深入剖析了妇女参与旅游活动后的社会角色变迁,揭示了旅游业影响妇女社会角色变迁的规律。研究表明,发展民族文化遗产旅游为妇女创造了本土就业机会,增加了更为直接的显性收入,进而提升了妇女在家庭的劳动地位和决策地位,引发了妇女消费观念、职业理念以及生活方式、社会互动模式的变化,妇女社会角色变迁为更为复杂的社会身份,但新的社会角色只是妇女原本角色的调整、补充和拓展。妇女参与文化旅游活动不仅促进了民族文化遗产的保护与传承,还促使妇女获得更加平等的发展机会,有助于家庭和谐与社会稳定,政府、企业、妇女三方仍需努力,充分释放旅游业在促进妇女发展与民族文化遗产旅游开发的积极功效。 | 阚如良 史亚萍 Hsiang-te Kung 周宜君 | 2014 | 旅游学刊2014，29，4： | 19 |
| 10 | 基于主成分分析法的梁子湖水质评价分析显示文摘依据梁子湖区2012年7月、10月和12月的水质监测数据,分析不同时期水质的主要污染因子和水质空间分布特征.选取氨氮(NH+4-N)、总氮(TN)、总磷(TP)、高锰酸盐指数(CODMn)和溶解氧(DO)等5个水质指标,利用SPSS软件和主成分分析法,分别得到丰水期、平水期、枯水期梁子湖区水质主要影响因子及综合水质评价函数;基于Arc GIS软件,采用普通克里金插值和半变异函数模型,分别得到丰水期、枯水期和平水期的水质等级分布图,并对不同时期梁子湖水质进行空间变异特征分析.分析得到,不同时期梁子湖水质主要影响因子和污染特点有所差异,主要以富营养污染为主,梁子湖的水质污染存在明显的区域性,湖区中心的水质较好,入湖口附近水质较差;不同时期梁子湖水质状况为,枯水期优于平水期,平水期优于丰水期.实验结果表明,基于SPSS软件,利用主成分分析方法对水质监测数据进行综合水质评价是一种较好的统计分析方法;基于Arc GIS软件,使用普通克里金插值方法对于显示水质的空间分布和水质变化具有较好的效果. | 王红 姚君兰 李艳蔷 KUNG Hsiang-te 陈红兵 | 2017 | 湖北大学学报(自然科学版)2017，39，6： | 16 |
| 11 | 新疆艾比湖流域地表水丰水期和枯水期水质分异特征及污染源解析显示文摘采用2015年艾比湖流域54个采样点的10个地表水水质指标数据,首先利用水质指数模型(WQI)和地统计学方法对流域水质污染情况进行全局评价,然后利用层次聚类法、判别分析法和因子分析法分析艾比湖流域地表水丰水期和枯水期水质分异特征.在水质时空分异特征研究的基础上,利用主成分回归分析法对艾比湖流域水质进行污染源解析.结果表明:艾比湖流域丰水期WQI值介于38~70之间,枯水期WQI值介于31~71之间,艾比湖流域丰水期的地表水水质污染情况比枯水期严重,而艾比湖、博尔塔拉河和精河靠近艾比湖湖区的河道污染程度均比其他河道严重.由聚类分析和判别分析得出艾比湖流域丰水期和枯水期的水质采样点在空间上均被分成A、B两组,A组包括艾比湖湖区西部、奎屯河、古尔图河和四棵树河,B组包括艾比湖湖区东部、精河和博尔塔拉河.艾比湖流域丰水期和枯水期的水体主要受到化学需氧量、溶解氧、氨氮和悬浮物浓度等指标的影响,B组水质污染指标的值相比于A组的值偏高,B组区域内存在高污染企业,艾比湖流域水环境治理工作需主要集中在B组所包括的艾比湖湖区、博尔塔拉河和精河.(4)艾比湖湖区、精河和博尔塔拉河地表水体的污染主要来自于有机物污染和营养物质污染,其次为工矿业污染;而奎屯河、古尔图河、四棵树河地表水体的污染主要来自于有机物污染,其次为营养物质污染,生物污染的影响较为微弱.该研究结果可为艾比湖流域地表水水环境改善和治理提供一定参考. | 任岩 张飞 王娟 张月 杨胜天 Abduwasit Ghulam Kung Hsiangte | 2017 | 湖泊科学2017，29，5： | 15 |
| 12 | Transactivation of the TIEG1 confers growth inhibition of transforming growth factor-β-susceptible hepatocellular carcinoma cells显示文摘AIM:To investigate the role of transforming growth factor(TGF)-β-inducible early gene 1(TIEG1) in TGF-β-induced growth inhibition in hepatocellular carcinoma(HCC) cells.METHODS:Human hepatocyte and HCC cell lines with varied susceptibilities to TGF-β1 were tested by methylthiazoletetrazolium(MTT) assay.The expression changes of Smad2,Smad3,Smad4,Smad7,TIEG1 and TIEG2 gene following treatment with TGF-β1 in a TGF-β-sensitive hepatocyte cell line(MIHA),a TGF-β-sensitive hepatoma cell line(Hep3B) and two TGF-β-insensitive hepatoma cell lines(HepG2 and Bel7404) were examined.SiRNA targeting TIEG1 was transfected into Hep3B cells and the sensitivity of cells to TGF-β1 was examined.Overexpression of TIEG1 was induced by lentiviral-mediated transduction in TGF-β1-resistant hepatoma cell lines(Bel7404 and HepG2).MTT assay and 4',6-Diamidino-2-phenylindole staining were used to identify cell viability and apoptosis,respectively.The expression level of stathmin was measured by reverse transcriptase polymerase chain reaction and Western-blotting analysis,and stathmin promoter activity by TIEG1 was monitored by a luciferase reporter gene system.RESULTS:TIEG1 was significantly upregulated by TGF-β1 in the TGF-β1-sensitive HCC cell line,Hep3B,but not in the resistant cell lines.The suppression of TIEG1 by siRNAs decreased the sensitivity of Hep3B cells to TGF-β1,whereas the overexpression of TIEG1 mediated growth inhibition and apoptosis in TGF-β1-resistant HCC cell lines,which resembled those of TGF-β1-sensitive HCC cells treated with TGF-β1.Our data further suggested that stathmin was a direct target of TIEG1,as stathmin was signif icantly downregulated by TIEG1 overexpression,and stathmin promoter activity was inhibited by TIEG1 in a dose-dependent manner.CONCLUSION:Our data suggest that transactivation of TIEG1 conferred growth inhibition of TGF-β-susceptible human HCC cells. | Lei Jiang Yiu-Kay Lai Jin-Fang Zhang Chu-Yan Chan Gang Lu Marie CM Lin Ming-Liang He Ji-Cheng Li Hsiang-Fu Kung | 2012 | World Journal of Gastroenterology2012，18，17： | 13 |
| 13 | 新疆艾比湖主要入湖河流精河与博尔塔拉河三维荧光光谱特性及其与水质的关系显示文摘以艾比湖主要入湖河流——精河与博尔塔拉河为研究对象,分别分析了精河与博尔塔拉河的水体溶解性有机质(DOM)的组成结构及水质参数与荧光指数的关系.利用平行因子分析法对三维荧光光谱(EEM)分析发现,精河与博尔塔拉河均含有C1(260/420 nm)腐殖酸等有机质、C2(240,240/490 nm)UVC类腐殖质、C3(220/280,300/450 nm)蛋白质类有机质和C4(260,270/530 nm)类腐殖质,且不同荧光组分结构具有一定差异性.为了进一步了解DOM组分特征,采用三维荧光区域积分法分析各区域标准体积百分比,结果表明精河与博尔塔拉河EEM的区域Ⅰ与区域Ⅱ蛋白质有机质含量最高,区域Ⅲ富里酸含量最低.相关性分析表明,主要入湖河流的水质参数与荧光指数中,自生源指数(BIX)与总氮(TN)浓度以及腐殖化指数(HIX)与铵态氮(NH_4^+-N)浓度的相关性较强,相关系数分别为0.831和0.684,且具有显著性;HIX与TN浓度的相关系数为0.604,达到显著性水平.进而对相关性较强的水质参数与荧光指数进行3次拟合,其中HIX与NH_4^+-N浓度的拟合效果最好,相关性系数为0.908,其次是BIX与TN浓度,相关性系数为0.844.总之,通过分析精河与博尔塔拉河三维荧光特征,以及探讨荧光指数与水质参数的关系,可为治理干旱区水环境问题提供理论依据和参考. | 张海威 张飞 李哲 Abduwasit Ghulam Kung Hsiangte 任岩 陈芸 | 2017 | 湖泊科学2017，29，5： | 13 |
| 14 | Macrophage migration inhibitory factor stimulated by He/icobacter py/oriincreases proliferation of gastric epithelial cells显示文摘AIM: Helicobacter pylori (H pylori) is associated with increased gastric inflammatory and epithelial expression of macrophage migration inhibitory factor (MIF) and gastric epithelial cell proliferation. This study aimed at determining whether H pylori directly stimulates release of MIF in monocytes, whether the cay pathogenicity island (PAI) is involved for this function, and whether MIF stimulated by H pylori increases gastric epithelial cell proliferation in vitro.METHODS: A cytotoxic wild-type H pylori strain (TN2),its three isogenic mutants (TN2△cag, TN2△cagA and TN2△cagE) were co-cultured with cells of a human monocyte cell line, THP-1, for 24 h at different organism/cell ratios. MIF in the supernatants was measured by an ELISA. Cells of a human gastric cancer cell line, MKN45,were then co-cultured with the supernatants, with and without monoclonal anti-MIF antibody for 24 h. The cells were further incubated for 12 h after addition of 3H-thymidine, and the levels of incorporation of 3H-thymidine were measured with a liquid scintillation counter.RESULTS: The wild-type strain and the isogenic mutants,TN2△cagA and TN2△cagE, increased MIF release at organism/cell ratios of 200/1 and 400/1, but not at the ratios of 50/1 and 100/1. However, the mutant TN2△cag did not increase the release of MIF at any of the four ratios.3H-thymidine readings for MKN-45 cells were significantly increased with supernatants derived from the wild-type strain and the mutants TN2△cagA and TN2△cagE, but not from the mutant TN2△cag. Moreover, in the presence of monoclonal anti-MIF antibody, the stimulatory effects of the wild-type strain on cell proliferation disappeared.CONCLUSION: H pylori stimulates MIF release in monocytes, likely through its cag PAI, but not related to cagA or cagE. H pylori-stimulated monocyte culture supernatant increases gastric cell proliferation, which is blocked by anti-MIF antibody, suggesting that MIF plays an important role in H pylori-induced gastric epithelial cell proliferation. | Harry Hua-Xiang Xia Shiu Kum Lam Annie O.O.Chan Marie Chia Mi Lin Hsiang Fu Kung Keiji Ogura Douglas E.Berg Benjamin Chun-Yu Wong | 2005 | World Journal of Gastroenterology2005，11，13： | 12 |
| 15 | Spatial disparities of regional forest land change based on ESDA and GIS at the county level in Beijing-Tianjin-Hebei area显示文摘福雷斯特土地是必需品和为人的幸存和开发提供强壮的支持的重要自然资源。因此,关于在关于它的特征,规则,和空间模式的县水平的森林陆地变化的研究为地区性的资源保护和社会经济的持续发展是重要的。在这研究,我们选择了 GIS 和 Geoda 软件包裹在 Beijing-Tianjin-Hebei 区域县水平探索森林陆地变化的空间不同,基于探索空间数据的全球、本地的空间自相关分析。结果显示出那:1 ) 在 1985-2000 期间,森林陆地变化的全球空间自相关在学习区域是重要的。全球 Moran 的我价值为全部时间时期是 0.3122 并且显示重要积极空间关联(p < 0.05 ) 。Moran 的我在时间阶段从 0.3084 森林陆地变化减少珍视我到 0.3024 在时间阶段 II;2 ) 森林土地的空间聚类特征变化在 Beijing-Tianjin-Hebei 总体上出现区域。Moran 的我从我上演到时间的时间阶段珍视减少 II,哪个森林陆地变化的空间聚类的趋势在 Beijing-Tianjin-Hebei 区域被削弱的工具;3 ) 我为每个县反映的本地 Moran 的格子地图森林陆地变化的本地空间同质,它意味着关于高价值和低价值的区域的那个空间聚类是特别重要的。有高高度的关联的区域主要位于向北多山的区域。然而,有低低的关联的区域在学习区域的中间被散布。因此,保护策略和具体措施应该在学习区域为每地区性的簇被放在地方[出版摘要] | Hualin XIE Chih-Chun KUNG Yuluan ZHAO | 2012 | Frontiers of Earth Science2012，6，4： | 10 |
| 16 | 近十年中国陆地AOD时空分布及与城市化的关系研究显示文摘选取2008-2017年MODIS(Moderate-resolution Imaging Spectrometer)Aqua C006气溶胶产品数据,分析近10年中国陆地气溶胶光学厚度(Aerosol optical depth,AOD)时间序列变化规律、空间格局分布特征,同时比较了'三区十群'区域内外的AOD变化差异.同时,通过DMSP/OLS(Defense Meteorological Satellite System/Operational Linescan System)夜间灯光产品与AOD关系研究分析,以反映城市化进程中人类活动对AOD时空分布的影响.结果表明:①中国陆地AOD多年平均、季节分布特征符合'胡焕庸线'.在时间尺度上,2008-2017年中国陆地AOD年际变化范围是0.279~0.368,整体呈现下降趋势且变化幅度较小;在空间分布上,2008-2017年高值区为京津冀地区、华中地区、长三角地区、珠三角地区及塔里木盆地,低值区为青藏高原、云贵高原、内蒙古高原等;AOD时空分布呈较强的季节性,春季AOD最高,秋季最低.②中国区域的夜间灯光图与AOD时空分布具有较好的一致性,也符合'胡焕庸线'.人口稠密、城市化较快的东部地区出现大片光带,快速发展的城市光斑覆盖明显.2008-2013年间,城市亮度范围有一定程度的扩大,说明人类经济生产活动增加明显.③2010-2013年省级行政区的DMSP/OLS夜间灯光与其AOD表现为显著正相关,二者幂函数拟合度R2分别为0.8036、0.8263、0.7701、0.8277、0.8331.DMSP/OLS夜间灯光与AOD呈显著正相关,说明城市化发展水平对气溶胶分布的影响作用显著. | 郭婉臻 张飞 夏楠 Hsiang-te KUNG 王敬哲 | 2019 | 环境科学学报2019，39，7： | 10 |
| 17 | Heme oxygenase-1 system and gastrointestinal inflammation:A short review显示文摘Heme oxygenase-1(HO-1) system catalyzes heme to biologically active products:carbon monoxide,biliverdin/bilirubin and free iron.It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes.A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract.This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date.The ability to upregulate HO-1 by pharmacological means or using gene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future. | Xiao Zhu Wen-Guo Fan Dong-Pei Li Hsiangfu Kung Marie CM Lin | 2011 | World Journal of Gastroenterology2011，17，38： | 9 |
| 18 | Macrophage migration inhibitory factor as a potential prognostic factor in gastric cancer显示文摘AIM:To investigate macrophage migration inhibitory factor(MIF) expression and its clinical relevance in gastric cancer,and effects of MIF knockdown on proliferation of gastric cancer cells. METHODS:Tissue microarray containing 117 samples of gastric cancer and adjacent non-cancer normal tissues was studied for MIF expression by immunohistochemistry(IHC) semiquantitatively,and the association of MIF expression with clinical parameters was analyzed. MIF expression in gastric cancer cell lines was detected by reverse transcriptionpolymerase chain reaction(RT-PCR) and Western blot. Two pairs of si RNA targeting the MIF gene(MIF si-1 and MIF si-2) and one pair of scrambled si RNA as a negative control(NC) were designed and chemically synthesized. All si RNAs were transiently transfected in AGS cells with OligofectamineTM to knock down the MIF expression,with the NC group and mock group(OligofectamineTM alone) as controls. At 24,48,and 72 h after transfection,MIF m RNA was analyzed by RTPCR,and MIF and proliferating cell nuclear antigen(PCNA) proteins were detected by Western blot.The proliferative rate of AGS cells was assessed by methylthiazolyl tetrazolium(MTT) assay and colony forming assay.RESULTS:The tissue microarray was informative for IHC staining,in which the MIF expression in gastric cancer tissues was higher than that in adjacent noncancer normal tissues(P < 0.001),and high level of MIF was related to poor tumor differentiation,advanced T stage,advanced tumor stage,lymph node metastasis,and poor patient survival(P < 0.05 for all). After si RNA transfection,MIF m RNA was measured by real-time PCR,and MIF protein and PCNA were assessed by Western blot analysis. We found that compared to the NC group and mock group,MIF expression was knocked down successfully in gastric cancer cells,and PCNA expression was downregulated with MIF knockdown as well. The cell counts and the doubling times were assayed by MTT 4 d after transfection,and colonies formed were assayed by colony forming assay 10 d after transfection; all these showed significant changes in gastric cancer cells transfected with specific si RNA compared with the control si RNA and mock groups(P < 0.001 for all).CONCLUSION:MIF could be of prognostic value in gastric cancer and might be a potential target for small-molecule therapy. | Long-Jun He Dan Xie Pin-Jin Hu Yi-Ji Liao Hai-Xia Deng Hsiang-Fu Kung Sen-Lin Zhu | 2015 | World Journal of Gastroenterology2015，21，34： | 9 |
| 19 | Sensor Networking: Concepts, Applications, and Challenges显示文摘Sensor network has experienced world-wide explosive interests in recent years. It combines the technology of modern microelectronic sensors, embedded computational processing systems, and modern computer and wireless networking methodologies. In this overview paper, we first provide some rationales for the growth of sensor networking. Then we discuss various basic concepts and hardware issues. Four basic application cases in the US. National Science Foundation funded Ceneter for Embedded Networked Sensing program at UCLA are presented. Finally, six challenging issues in sensor networks are discussed. Numerous references including relevant papers, books, and conferences that have appeared in recent years are given. | YAO Kung | 2006 | 自动化学报2006，32，6： | 8 |
| 20 | High Expression of p300 in Human Breast Cancer Correlates with Tumor Recurrence and Predicts Adverse Prognosis显示文摘Objective:Transcriptional coactivator p300 has been shown to play a variety of roles in the transcription process and mutation of p300 has been found in certain types of human cancers.However,the expression dynamics of p300 in breast cancer (BC) and its effect on BC patients' prognosis are poorly understood.Methods:In the present study,the methods of tissue microarray and immunohistochemistry (IHC) were used to investigate the protein expression of p300 in BCs.Receiver operating characteristic (ROC) curve analysis,Spearman's rank correlation,Kaplan-Meier plots and Cox proportional hazards regression model were utilized to analyze the data.Results:Based on the ROC curve analysis,the cutoff value for p300 high expression was defined when the H score for p300 was more than 105.High expression of p300 could be observed in 105/193 (54.4%) of BCs,in 6/25 (24.0%) of non-malignant breast tissues,respectively (P=0.004).Further correlation analysis showed that high expression of p300 was positively correlated with higher histological grade,advanced clinical stage and tumor recurrence (P<0.05).In univariate survival analysis,a significant association between high expression of p300 and shortened patients' survival and poor progression-free survival was found (P<0.05).Importantly,p300 expression was evaluated as an independent prognostic factor in multivariate analysis (P<0.05).Conclusion:Our findings provide a basis for the concept that high expression of p300 in BC may be important in the acquisition of a recurrence phenotype,suggesting that p300 high expression,as examined by IHC,is an independent biomarker for poor prognosis of patients with BC. | Xiang-sheng Xiao Mu-yan Cai Jie-wei Chen Xin-yuan Guan Hsiang-fu Kung Yi-xin Zeng Dan Xie | 2011 | Chinese Journal of Cancer Research2011，23，3： | 8 |
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