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| 1 | Optical cross-talk reduction in a quantumdot-based full-color micro-light-emitting-diode display by a lithographic-fabricated photoresist mold显示文摘In this study, a full-color emission red–green–blue(RGB) quantum-dot(QD)-based micro-light-emitting-diode(micro-LED) array with the reduced optical cross-talk effect by a photoresist mold has been demonstrated. The UV micro-LED array is used as an efficient excitation source for the QDs. The aerosol jet technique provides a narrow linewidth on the micrometer scale for a precise jet of QDs on the micro-LEDs. To reduce the optical cross-talk effect,a simple lithography method and photoresist are used to fabricate the mold, which consists of a window for QD jetting and a blocking wall for cross-talk reduction. The cross-talk effect of the well-confined QDs in the window is confirmed by a fluorescence microscope, which shows clear separation between QD pixels. A distributed Bragg reflector is covered on the micro-LED array and the QDs' jetted mold to further increase the reuse of UV light.The enhanced light emission of the QDs is 5%, 32%, and 23% for blue, green, and red QDs, respectively. | HUANG-YU LIN CHIN-WEI SHER DAN-HUA HSIEH XIN-YIN CHEN HUANG-MING PHILIP CHEN TENG-MING CHEN KEI-MAY LAU CHYONG-HUA CHEN CHIEN-CHUNG LIN HAO-CHUNG KUO | 2017 | Photonics Research2017，5，5： | 26 |
| 2 | Full-color monolithic hybrid quantum dot nanoring micro light-emitting diodes with improved efficiency using atomic layer deposition and nonradiative resonant energy transfer显示文摘Full-color displays based on micro light-emitting diodes(μLEDs) can be fabricated on monolithic epitaxial wafers. Nanoring(NR) structures were fabricated on a green LED epitaxial wafer; the color of NR-μLEDs was tuned from green to blue through strain relaxation. An Al_2O_3 layer was deposited on the sidewall of NR-μLEDs,which improved the photoluminescence intensity by 143.7%. Coupling with the exposed multiple quantum wells through nonradiative resonant energy transfer, red quantum dots were printed to NR-μLEDs for a full-color display. To further improve the color purity of the red light, a distributed Bragg reflector is developed to reuse the excitation light. | SUNG-WEN HUANG CHEN CHIH-CHIANG SHEN TINGZHU WU ZHEN-YOU LIAO LEE-FENG CHEN JIA-ROU ZHOU CHUN-FU LEE CHIH-HAO LIN CHIEN-CHUNG LIN CHIN-WEI SHER PO-TSUNG LEE AN-JYE TZOU ZHONG CHEN HAO-CHUNG KUO | 2019 | Photonics Research2019，7，4： | 23 |
| 3 | Current Tracking on Effectiveness and Mechanisms of Acupuncture Therapy: A Literature Review of High-Quality Studies显示文摘The scientific evidenee of acupuncture studies has been improved in recent years,and one of the important manifestations is that more and more acupuncture clinical trials and mechanism researches have been published in the source periodicals of Science Citation Index(SCI).This study summarized the dominant diseases of acupuncture focusing on of acupuncture efficacy and mechanisms,and discussed the existing problems,highlight!ng the directi on of future developme nts.Most clinical studies were published in journals with journal impact factor(JIF)score of 10 or above,and majority of the basic researches had JIF scores of 5 to 10.The above literature were further divided according to the International Classification of Diseases(ICD).The most concerned diseases in these articles were neurological diseases,musculoskeletal system and connective tissue diseases,tumor and digestive system diseases.The therapeutic effect and mechanism of acupuncture on each kind of disease were summarized.The results showed that the therapeutic effect of acupuncture on nerve injury focused on the anti-oxidation pathway,neuroprotective and anti-inflammatory processes.The antiinflammatory effect also played an important role in the treatme nt of musculoskeletal diseases.The an algesic effect was underlined in most of these studies.Clinical trials were well carried out on acupuncture curative effect of tumor complications and side effects of chemo-radiotherapy,but the potential mechanisms have not been clarified.Somato-visceral reflex was suggested to be strongly associated with the effects of acupuncture changing the motor activity of the gastrointestinal tract.Functional magnetic resonance imaging studies indicated that non-specific effects play important roles in acupuncture analgesia.Lines of evidenee have pointed out that the regulation of neuro-endocrine-immune networks may be a common switch of acupuncture on different nerve system diseases. | YANG Fu-ming YAO Lin WANG Shen-jun GUO Yi XU Zhi-fang ZHANG Chien-Hung ZHANG Kuo FANG Yu-xin LIU Yang-yang | 2020 | Chinese Journal of Integrative Medicine2020，26，4： | 17 |
| 4 | Antioxidant and antiglycation properties of different solvent extracts from Chinese olive(Canarium album L.) fruit显示文摘Objective:To evaluate the antioxidant activity,antiglycation property,and bioactivc components content of different solvent extracts from Chinese olive(Canarium album L.) fruit.Methods:The dry powder of Chinese olive fruit was extracted with different solvents,i.e.,water,water/ethanol(1/1,v/v),ethanol,methanol,acetone and ethyl acetate.The total phenolic,total flavonoids and total triterpenoids contents of various extracts were determined by spectrophotometric methods.Phenolic compounds were identified by high performance liquid chromatography.The assayed antioxidant activity was determined in vitro models such as antioxidant capacity by radical scavenging activity using 2,2'-azino-bLs(3-ethylbenzthiazoline-6-sulfonic acid)(ABTS),l,l-diphenyl-2-picryl- hydrazyl(DPPH) and nitrite oxide methods,chelating activity on metal ions,lipid and protein peroxidation methods.In vitro glucosebovine serum albumin assay was used to evaluate the antiglycation of various extracts.Results:The water/ethanol extracts of Chinese olive fruit exerted significant scavenging effects on free radicals and strong inhibitory effects on advanced glycation end products formation.The Chinese olive fruit extracts were rich in phenolic compounds and triterpenoids.Gallic acid,ferulic acid and rutin were identified from the water/ethanol extracts.Correlation analysis indicated that there was a linear relationship between the antioxidant potency,free radical scavenging ability and phenolic compounds content of the Chinese olive fruit extracts.Conclusions:Chinese olive fruit could be a natural candidate for studies of dietary complement to diabetes treatment since it combines antioxidant and antiglycation activities. | Chiung-Tsun Kuo Tzu-Hao Liu Tai-Hao Hsu Fang-Yi Lin Hui-Yin Chen | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，12： | 17 |
| 5 | Endoscopic diagnosis of cervical esophageal heterotopic gastric mucosa with conventional and narrow-band images显示文摘AIM:To compare the diagnostic yield of heterotopic gastric mucosa(HGM)in the cervical esophagus with conventional imaging(CI)and narrow-band imaging(NBI).METHODS:A prospective study with a total of 760patients receiving a CI examination(mean age 51.6years;47.8%male)and 760 patients undergoing NBI examination(mean age 51.2 years;45.9%male).The size of HGM was classified as small(1-5 mm),medium(6-10 mm),or large(>1 cm).A standardized questionnaire was used to obtain demographic characteristics,social habits,and symptoms likely to be related to cervical esophageal HGM,including throat symptoms(globus sensation,hoarseness,sore throat,and cough)and upper esophageal symptoms(dysphagia and odynophagia)at least 3 mo in duration.The clinicopathological classification of cervical esophageal HGM was performed using the proposal by von Rahden et al.RESULTS:Cervical esophageal HGM was found in 36of 760(4.7%)and 63 of 760(8.3%)patients in the CI and NBI groups,respectively(P=0.007).The NBI mode discovered significantly more small-sized HGM than CI(55%vs 17%;P<0.0001).For the 99 patients with cervical esophageal HGM,biopsies were performed in 56 patients;37(66%)had fundic-type gastric mucosa,and 19 had antral-type mucosa.For the clinicopathological classification,77 patients(78%)were classified as HGMⅠ(asymptomatic carriers);21 as HGMⅡ(symptomatic without morphologic changes);and one as HGMⅢ(symptomatic with morphologic change).No intraepithelial neoplasia or adenocarcinoma was found.CONCLUSION:NBI endoscopy detects more cervical esophageal HGM than CI does.Fundic-type gastric mucosa constitutes the most common histology.One-fifth of patients have throat or dysphagic symptoms. | Chi-Liang Cheng Cheng-Hui Lin Nai-Jen Liu Jui-Hsiang Tang Yen-Lin Kuo Yi-Ning Tsui | 2014 | World Journal of Gastroenterology2014，20，1： | 13 |
| 6 | Micro-light-emitting diodes with quantum dots in display technology显示文摘Micro-light-emitting diodes(μ-LEDs)are regarded as the cornerstone of next-generation display technology to meet the personalised demands of advanced applications,such as mobile phones,wearable watches,virtual/augmented reality,micro-projectors and ultrahigh-definition TVs.However,as the LED chip size shrinks to below 20μm,conventional phosphor colour conversion cannot present sufficient luminance and yield to support highresolution displays due to the low absorption cross-section.The emergence of quantum dot(QD)materials is expected to fill this gap due to their remarkable photoluminescence,narrow bandwidth emission,colour tuneability,high quantum yield and nanoscale size,providing a powerful full-colour solution for μ-LED displays.Here,we comprehensively review the latest progress concerning the implementation of μ-LEDs and QDs in display technology,including μ-LED design and fabrication,large-scale μ-LED transfer and QD full-colour strategy.Outlooks on QD stability,patterning and deposition and challenges of μ-LED displays are also provided.Finally,we discuss the advanced applications of QD-based μ-LED displays,showing the bright future of this technology. | Zhaojun Liu Chun-Ho Lin Byung-Ryool Hyun Chin-Wei Sher Zhijian Lv Bingqing Luo Fulong Jiang Tom Wu Chih-Hsiang Ho Hao-Chung Kuo Jr-Hau He | 2020 | Light(Science & Applications)2020，9，1： | 12 |
| 7 | Cost-effectiveness analysis of population-based screening of hepatocellular carcinoma: Comparing ultrasonography with two-stage screening显示文摘AIM: To assess the cost-effectiveness of two populationbased hepatocellular carcinoma(HCC) screening programs, two-stage biomarker-ultrasound method and mass screening using abdominal ultrasonography(AUS).METHODS: In this study, we applied a Markov decision model with a societal perspective and a lifetime horizon for the general population-based cohorts in an area with high HCC incidence, such as Taiwan. The accuracy of biomarkers and ultrasonography was estimated from published meta-analyses. The costs of surveillance, diagnosis, and treatment were based on a combination of published literature, Medicare payments, and medical expenditure at the National Taiwan University Hospital. The main outcome measure was cost per lifeyear gained with a 3% annual discount rate. RESULTS: The results show that the mass screening using AUS was associated with an incremental costeffectiveness ratio of USD39825 per life-year gained, whereas two-stage screening was associated with an incremental cost-effectiveness ratio of USD49733 per life-year gained, as compared with no screening. Screening programs with an initial screening age of 50 years old and biennial screening interval were the most cost-effective. These findings were sensitive to the costs of screening tools and the specificity of biomarker screening.CONCLUSION: Mass screening using AUS is more cost effective than two-stage biomarker-ultrasound screening. The most optimal strategy is an initial screening age at 50 years old with a 2-year inter-screening interval. | Ming-Jeng Kuo Hsiu-Hsi Chen Chi-Ling Chen Jean Ching-Yuan Fann Sam Li-Sheng Chen Sherry Yueh-Hsia Chiu Yu-Min Lin Chao-Sheng Liao Hung-Chuen Chang Yueh-Shih Lin Amy Ming-Fang Yen | 2016 | World Journal of Gastroenterology2016，22，12： | 12 |
| 8 | Thymoquinone suppresses migration of Lo Vo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation显示文摘AIM To identify potential anti-cancer constituents in natural extracts that inhibit cancer cell growth and migration.METHODS Our experiments used high dose thymoquinone(TQ) as an inhibitor to arrest Lo Vo(a human colon adenocarcinoma cell line) cancer cell growth, which was detected by cell proliferation assay and immunoblotting assay. Low dose TQ did not significantly reduce Lo Vo cancer cell growth. Cyclooxygenase 2(COX-2) is an enzyme that is involved in the conversion of arachidonic acid into prostaglandin E2(PGE2) in humans. PGE2 can promote COX-2 protein expression and tumor cell proliferation and was used as a control.RESULTS Our results showed that 20 μmol/L TQ significantly reduced human LoV o colon cancer cell proliferation. TQ treatment reduced the levels of p-PI3 K, p-Akt, p-GSK3β, and β-catenin and thereby inhibited the downstream COX-2 expression. Results also showed that the reduction in COX-2 expression resulted in a reduction in PGE2 levels and the suppression of EP2 and EP4 activation. Further analysis showed that TG treatment inhibited the nuclear translocation of β-catenin in LoV o cancer cells. The levels of the cofactors LEF-1 and TCF-4 were also decreased in the nucleus following TQ treatment in a dose-dependent manner. Treatment with low dose TQ inhibited the COX-2 expression at the transcriptional level and the regulation of COX-2 expression efficiently reduced LoV o cell migration. The results were further verified in vivo by confirming the effects of TQ and/or PGE2 using tumor xenografts in nude mice.CONCLUSION TQ inhibits LoV o cancer cell growth and migration, and this result highlights the therapeutic advantage of using TQ in combination therapy against colorectal cancer. | Hsi-Hsien Hsu Ming-Cheng Chen Cecilia Hsuan Day Yueh-Min Lin Shin-Yi Li Chuan-Chou Tu Viswanadha Vijaya Padma Hui-Nung Shih Wei-Wen Kuo Chih-Yang Huang | 2017 | World Journal of Gastroenterology2017，23，7： | 12 |
| 9 | Full-color micro-LED display with high color stability using semipolar(20-21) InGaN LEDs and quantum-dot photoresist显示文摘Red-green-blue(RGB)full-color micro light-emitting diodes(μ-LEDs)fabricated from semipolar(20-21)wafers,with a quantum-dot photoresist color-conversion layer,were demonstrated.The semipolar(20-21)In Ga N/Ga Nμ-LEDs were fabricated on large(4 in.)patterned sapphire substrates by orientation-controlled epitaxy.The semipolarμ-LEDs showed a 3.2 nm peak wavelength shift and a 14.7%efficiency droop under 200 A∕cm2injected current density,indicating significant amelioration of the quantum-confined Stark effect.Because of the semipolarμ-LEDs’emission-wavelength stability,the RGB pixel showed little color shift with current density and achieved a wide color gamut(114.4%NTSC space and 85.4%Rec.2020). | SUNG-WEN HUANG CHEN YU-MING HUANG KONTHOUJAM JAMES SINGH YU-CHIEN HSU FANG-JYUN LIOU JIE SONG JOOWON CHOI PO-TSUNG LEE CHIEN-CHUNG LIN ZHONG CHEN JUNG HAN TINGZHU WU HAO-CHUNG KUO | 2020 | Photonics Research2020，8，5： | 12 |
| 10 | Effect of Arctium lappa L.in the dextran sulfate sodium colitis mouse model显示文摘AIM:To analyze the possible protective role of Arctium lappa L.(AL)in a murine model of ulcerative colitis(UC).METHODS:BALB/c mice were administered 100 mg/kg AL powder orally each day.After 7 d,colitis was induced by administration of dextran sulfate sodium(DSS)(5% W/V)in drinking water for a further 8 consecutive days.Diarrhea and bloody stools as well as colonic histology were observed.The level of interleukin-6(IL-6)and tu-mor necrosis factor-α(TNF-α)in colonic sections were detected by immunohistochemistry.RESULTS:There were significant differences in mean body weight values and disease activity indices between controls and AL-treated animals.Moreover,the histological findings showed that AL treatment can prevent mucosal edema,submucosal erosions,ulceration,inflammatory cell infiltration and colon damage.In addition,immunohistochemistry analysis showed that the levels of the inflammatory cytokines,IL-6 and TNF-α were also decreased in AL-treated groups.CONCLUSION:We suggest that AL can prevent intestinal damage and decrease inflammatory cytokines in mice with DSS-induced colitis.Thus,AL could prove to be a useful food for UC. | Tzou-Chi Huang Shinn-Shyong Tsai Li-Fang Liu Yu Lin Liu Hung-Jen Liu Kuo Pin Chuang | 2010 | World Journal of Gastroenterology2010，16，33： | 10 |
| 11 | 预测中国男性前列腺癌切片检查阳性率的视距诺模图:基于台湾地区的研究显示文摘最近有许多前列腺癌检测的视距诺模图被开发出来。然而,中国男性前列腺癌的发病率较低,这些针对于其他人群所开发的视距诺模图可能无法直接应用于中国男性身上。因此,我们根据临床与实验室数据,开发了一个预测中国男性前列腺切片检查阳性率的模型。我们收集893位转诊来做初步前列腺切片检查的中国男性病人资料,利用其中697位的资料来开发新的视距诺模图,然后再用其他196位来做外部验证。我们分析了年龄、前列腺体积、总前列腺特异性抗原、前列腺特异性抗原密度、直肠指检以及经直肠超声波回声结果。统计使用罗吉斯回归分析来估算胜算比、95%置信区间以及P值。切片检查阳性率的独立预测因子包括年龄、前列腺体积、总前列腺特异性抗原升高、异常直肠指检以及经直肠超声波高回声或低回声。我们使用这些独立预测因子开发了一个预测切片检查阳性几率的视距诺模图。此视距诺模图的接收操作特征曲线下面积为88.8%,高于单独以总前列腺特异性抗原的预测力(接收操作特征曲线下面积为74.7%)。我们将此视距诺模图做外部验证,发现预测概率为0.827,准确率为78.1%。结合临床和实验室数据所开发出的视距诺模图,比起用其他个别因子,大大提高了预测前列腺癌的准确率。 | Shu-Chun Kuo Shun-Hsing Hung Hsien-Yi Wang Chih-Chiang Chien Chin-Li Lu Hung-Jung Lin How-Ran Guo Jian-Fang Zou Chian-Shiung Ling Chien-Cheng Huangs | 2013 | Asian Journal of Andrology2013，15，6： | 8 |
| 12 | Cyr61/CTGF/Nov family proteins in gastric carcinogenesis显示文摘Gastric cancer(GC)is the second leading cause of cancer-related death.The poor survival rate may reflect the relatively aggressive tumor biology of GC.Recently,the importance of the tumor microenvironment in carcinogenesis has emerged.In the tumor microenvironment,tumor cells and the surrounding stromal cells aberrantly secrete matricellular proteins capable of modulating carcinogenesis and regulating metastasis.The Cyr61/CTGF/Nov(CCN)proteins are a family of matricellular proteins with variable roles in many physiological and pathological processes.The evidence suggests that CCN family proteins contribute to GC carcinogenic processes.Here,we briefly review recent research on the effects of CCN family proteins in GC carcinogenesis and the development of new targeted agents in this field. | Tsu-Yao Cheng Ming-Shiang Wu Kuo-Tai Hua Min-Liang Kuo Ming-Tsan Lin | 2014 | World Journal of Gastroenterology2014，20，7： | 8 |
| 13 | Association of USP26 haplotypes in men in Taiwan, China with severe spermatogenic defect显示文摘瞄准:为肥沃、不肥沃的人完成 USP26 的全面 haplotype 分析。方法:有严重 oligospermia 或非妨碍的精子缺乏的 200 个不肥沃的人被使遭到为 USP26 基因的全部编码序列定序分析。有证明富饶的 200 个人是由教材延期方法的 genotyped。等位基因 / 遗传型频率,连接不平衡(LD ) 特征和肥沃的人的 haplotypes 与不肥沃的人相比。结果:五单个核苷酸多型性的等位基因频率(370 371insACA, 494T >C, 576G >A, ss6202791C>T, 1737G >A ) 比控制题目在不肥沃的病人是显著地更高的。在不肥沃的人的主要 haplotypes 是 TACCGA (28% 人口) , TGCCGA (15%) , TACCAA (8%) , TGCCAA (6%) , TATCAA (5%) 和 CATCAA (5%) 。为控制题目的主要 haplotypes 是 TACCGA (58% 人口) , CACCGA (7%) , CATCGA (6%) 和 TGCCGA (5%) 。而 haplotypes TACCGA, CACCGA,和 CATCGA 在这些病人是下面播送的, Haplotypes TGCCGA, TATCAA, CATCAA, CATCGC, TACCAA 和 TGCCAA 在有 spermatogenic 缺点的病人是过去播送的。结论:一些 USP26 等位基因和 haplotypes 在台湾在汉国籍与 spermatogenic 缺点被联系,中国。 | I-Wen Lee Long-Ching Kuan Chien-Hung Lin Hsien-An Pan Chao-Chin Hsu Yung-Chieh Tsai Pao-Lin Kuo Yen-Ni Teng | 2008 | Asian Journal of Andrology2008，10，6： | 7 |
| 14 | Filtrate of fermented mycelia from Antrodia camphorata reduces liver fibrosis induced by carbon tetrachloride in rats显示文摘瞄准:为了在肝上从 Antrodia camphorata (FMAC ) 调查使发酵的 mycelia 的 filtrate 的效果,纤维变性在老鼠由四氯化碳(CCl (4 )) 导致了。方法:四十只 Wistar 老鼠随机被划分成控制组和模型组。所有模型老鼠被给 200 mL/L CCl (4 )(2 mL/Kg, po ) 两次为 8 wk 的一个星期。在 CCl (4 ) 处理以后的四个星期,三十只模型老鼠进一步随机被划分成 3 亚群:CCl (4 ) 和二 FMAC 亚群。在 CCl (4 ) 和 2 FMAC 亚群的老鼠与 FMAC 0, 0.5 和 1.0 g/kg,经由胃管饲法在第五个星期开始的日报和第八个星期的结束被对待。怒气重量,血合成标记(白朊和前凝血酶时间) 和羟脯氨酸(HP ) 集中被决定。骨胶原的表示我, metalloproteinases (TIMP ) 的织物禁止者 -1 和转变生长因素 beta1 (TGF-beta1 ) mRNA 被 RT-PCR 检测。组织化学的染色马森是三色的被执行。结果:CCl (4 ) 引起了肝纤维变性,展示重量和减少的血浆白蛋白铺平的增加的前凝血酶时间,肝的 MDA 和 HP 内容,和怒气。与 CCl ( 4 )亚群相比, FMAC 亚群( 1 g/kg )显著地减少了前凝血酶时间(分别地,在 CCl ( 4 )和 FMAC 的 36.7+/-7.2 和 25.1+/-10.2 组织 P<0.05 )并且增加的血浆白蛋白集中(分别地,在 CCl ( 4 )和 FMAC 的 22.7+/-1.0 和 30.7+/-2.5 组织 P<0.05 )。怒气重量在与 CCl (4 ) 对待的老鼠是显著地更低的,与 CCl (4 ) 相比的 FMAC (1 g/kg ) 仅仅对待老鼠(分别地,在 CCl (4 ) 和 FMAC 的 2.7+/-0.1 和 2.4+/-0.2 组织 P<0.05 ) 。在亚群也是的 CCl (4 )+FAMC (1 g/kg ) 的肝的 MDA 和 HP 的数量在 CCl (4 ) 亚群比那些降低(MDA:在 CCl (4 ) 和 CCl (4 ) 的 3.9+/-0.1 和 2.4+/-0.6 分别地, +FMAC 组织 P<0.01;HP:在 CCl (4 ) 和 CCl (4 ) 的 1730.7+/-258.0 和 1311.5+/-238.8 分别地, +FMAC 组织 P<0.01 ) 。Histologic 考试证明 CCl (4 )+FMAC 亚群比 CCl (4 ) 组有更薄或不太纤维变性的氏族 a。RT-PCR 分析显示 FMAC (1 g/kg ) 减少了骨胶原的 mRNA 层次我, TIMP-1 和 TGF-beta1 (骨胶原我:在 CCl (4 ) 和 CCl (4 ) 的 5.63+/-2.08 和 1.78+/-0.48 分别地, +FMAC 组织 P<0.01;TIMP-1:在 CCl (4 ) 和 CCl (4 ) 的 1.70+/-0.82 和 0.34+/-0.02 分别地, +FMAC 组织 P<0.01;在 CCl (4 ) 和 CCl (4 ) 的 TGF-beta1:38.03+/-11.9 和 4.26+/-2.17 分别地, +FMAC 组织 P<0.01 ) 在对待的 CCl (4 ) 肝。结论:它证明 FMAC 能延迟肝纤维变性的前进在老鼠由 CCl (4 ) 导致了。 | Wen-Chuan Lin Shu-Ching Kuo Wei-Lii Lin Hsun-Lang Fang Bor-Chen Wang | 2006 | World Journal of Gastroenterology2006，12，15： | 6 |
| 15 | Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity显示文摘AIM: To evaluate whether the effect of Gln dipeptideenriched total parenteral nutrition (TPN) on postoperative cytokine alteration depended on the disease severity of surgical patients.METHODS: Forty-eight patients with major abdominal surgery were allocated to two groups to receive isonitrogenous (0.228 g nitrogen/kg per d) and isocaloric(30 kcal/kg per d) TPN for 6 d. Control group (Conv)using conventional TPN solution received 1.5 g amino adds/kg per day, whereas the test group received 0.972 g amino acids/kg per day and 0.417 g L-alanyl-L-glutamine(Ala-Gln)/kg per day. Blood samples were collected on d 1 and d 6 postoperatively for plasma interleukin (IL)-2,IL-6, IL-8, and interferon (IFN)-γ analysis.RESULTS: Plasma IL-2 and IFN-γ were not detectable.IL-6 concentrations were significantly lower on the 6th postoperative day in the Ala-Gln group than those in the Conv group in patients with APACHE Ⅱ≤6, whereas no difference was noted in patients with APACHE Ⅱ>6. There was no difference in IL-8 levels between the two groups.No difference in cumulative nitrogen balance was observed on d 2-5 after the operation between the two groups(Ala-Gln -3.2±1.6 g vs Conv -6.5±2.7 g). A significant inverse correlation was noted between plasma IL-6 levels and cumulative nitrogen balance postoperatively in the Ala-Gln group, whereas no such correlation was observed in the Conv group.CONCLUSION: TPN supplemented with Gln dipeptide had no effect on plasma IL-8 levels after surgery. However,Gln supplementation had a beneficial effect on decreasing systemic IL-6 production after surgery in patients with low admission illness severity, and lower plasma IL-6 may improve nitrogen balance in patients with abdominal surgery when Gln was administered. | Ming-Tsan Lin Sung-Pao Kung Sung-Ling Yeh Koung-Yi Liaw Ming-Yang Wang Ming-Liang Kuo Po-Houng Lee Wei-Jao Chen | 2005 | World Journal of Gastroenterology2005，11，39： | 5 |
| 16 | Recent advances in high-pressure science and technology显示文摘Recently we are witnessing the boom of high-pressure science and technology from a small niche field to becoming a major dimension in physical sciences.One of the most important technological advances is the integration of synchrotron nanotechnology with the minute samples at ultrahigh pressures.Applications of high pressure have greatly enhanced our understanding of the electronic,phonon,and doping effects on the newly emerged graphene and related 2D layered materials.High pressure has created exotic stoichiometry even in common Group 17,15,and 14 compounds and drastically altered the basic σ and π bonding of organic compounds.Differential pressure measurements enable us to study the rheology and flow of mantle minerals in solid state,thus quantitatively constraining the geodynamics.They also introduce a new approach to understand defect and plastic deformations of nano particles.These examples open new frontiers of high-pressure research. | Ho-Kwang Mao Bin Chen Jiuhua Chen Kuo Li Jung-Fu Lin Wenge Yang Haiyan Zheng | 2016 | Matter and Radiation at Extremes2016，1，1： | 5 |
| 17 | 850/940-nm VCSEL for optical communication and 3D sensing显示文摘 | Chih-Hsien Cheng Chih-Chiang Shen Hsuan-Yun Kao Dan-Hua Hsieh Huai-Yung Wang Yen-Wei Yeh Yun-Ting Lu Sung-Wen Huang Chen Cheng-Ting Tsai Yu-Chieh Chi Tsung Sheng Kao Chao-Hsin Wu Hao-Chung Kuo Po-Tsung Lee Gong-Ru Lin | 2018 | Opto-Electronic Advances2018，1，3： | 5 |
| 18 | Highly stable full-color display device with VLC application potential using semipolarμLEDs and all-inorganic encapsulated perovskite nanocrystal显示文摘A promising approach for the development of effective full-color displays is to combine blue micro LEDs(μLEDs)with color conversion layers.Perovskite nanocrystals(PNCs)are notable for their tolerance to defects and provide excellent photoluminescence quantum yields and high color purity compared to metal chalcogenide quantum dots.The stability of PNCs in ambient conditions and under exposure to blue light can be improved using a SiO;coating.This study proposes a device that could be used for both display and visible light communication(VLC)applications.The semipolar blueμLED array fabricated in this study shows a negligible wavelength shift,indicating a significant reduction in the quantum confined Stark effect.Owing to its shorter carrier lifetime,the semipolar μLED array exhibits an impressive peak 3 dB bandwidth of 655 MHz and a data transmission rate of1.2 Gb/s corresponding to an injection current of 200 m A.The PNC-μLED device assembled from a semipolarμLED array with PNCs demonstrates high color stability and wide color-gamut features,achieving 127.23% and 95.00%of the National Television Standards Committee standard and Rec.2020 on the CIE 1931 color diagram,respectively.These results suggest that the proposed PNC-μLED device is suitable for both display-related and VLC applications. | TINGZHU WU YUE LIN YU-MING HUANG MENG LIU KONTHOUJAM JAMES SINGH WANSHENG LIN TINGWEI LU XI ZHENG JIANYANG ZHOU HAO-CHUNG KUO ZHONG CHEN | 2021 | Photonics Research2021，9，11： | 5 |
| 19 | Input of microenvironmental regulation on colorectal cancer: Role of the CCN family显示文摘Colorectal cancer(CRC)is a major health problem causing significant morbidity and mortality.Previous results from various studies indicate that CRC tumorigenicity encompasses tumor microenvironment,emphasizing the complex interacting network between cancer cells and nearby host cells,which triggers diverse signaling pathways to promote the growth and spread ofcancer cells.The CCN family proteins share a uniform modular structure,mediating a variety of physiological functions,including proliferation,apoptosis,migration,adhesion,differentiation,and survival.Furthermore,CCN proteins are also involved in CRC initiation and development.Many studies have shown that CCN members,such as CCN1,CCN2,CCN3,Wnt-induced secreted protein(WISP)-1,WISP-2,and WISP-3,are dysregulated in CRC,which implies potential diagnostic markers or therapeutic targets clinically.In this review,we summarize the research findings on the role of CCN family proteins in CRC initiation,development,and progression,highlighting their potential for diagnosis,prognosis,and therapeutic application. | Cheng-Chi Chang Been-Ren Lin Tai-Sheng Wu Yung-Ming Jeng Min-Liang Kuo | 2014 | World Journal of Gastroenterology2014，20，22： | 4 |
| 20 | Hybrid-type white LEDs based on inorganic halide perovskite QDs: candidates for wide color gamut display backlights显示文摘We demonstrate inorganic halide perovskite quantum-dots-based white light-emitting diodes via three different geometries, including liquid, solid, and hybrid types. Problems of fast anion exchange and aggregation in the cases of liquidand solid-type devices are discussed in detail and push us to move towards the fabrication of a hybrid-type device structure. The experiment results illustrate that a hybrid-type device has the highest luminance efficiency(51 lm/W) and a wide color gamut(122% of NTSC and 91% of Rec. 2020). Therefore, we conclude that a hybrid-type device can provide an outstanding color gamut for high color gamut display applications. | Chih-Hao Lin Akta Verma Chieh-Yu Kang Yung-Min Pai Tzu-Yu Chen Jin-Jia Yang Chin-Wei Sher Ya-Zhu Yang Po-Tsung Lee Chien-Chung Lin Yu-Chuan Wu S. K. Sharma Tingzhu Wu Shu-Ru Chung Hao-Chung Kuo | 2019 | Photonics Research2019，7，5： | 4 |
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