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68篇 您的检索式:作者名="L Hold"
    题名 作者 年代 出处 被引量
1Cellular and molecular aspects of gastric cancer显示文摘胃的癌症与变的负担仍然是一个全球杀手从发展了到发展中的世界。癌症沿着被定义由的一个多级式的过程发展不同组织学并且 pathophysiological 阶段。几基因、渐成说的改变调停从一个的转变上演到另外一个,这些在 oncogenes 包括变化,瘤压制或基因和房间骑车并且错配修理基因。在对胃的癌症的战斗的最重要的进展为这癌症作为最重要的获得的病因论的代理人与 Helicobacter pylori (H pylori ) 的角色的识别来了。最近的工作在阐明上集中了位于肿瘤的过程下面的复杂 host/microbial 相互作用。现在进这癌症的致病和阻止并且根除的前景有可观的卓见疾病成为了现实。也许更重要地, H 导致 pylori 的胃的致癌作用的学习为理解更复杂的人的癌症提供一个范例。在这评论,我们检验位于 H 下面的分子、细胞的事件导致 pylori 的胃的癌症。Malcolm G Smith Georgina L Hold Eiichi Tahara Emad M El-Omar 2006World Journal of Gastroenterology2006,12,19:29
2Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?显示文摘Our understanding of the microbial involvement in inflammatory bowel disease(IBD) pathogenesis has increased exponentially over the past decade. The development of newer molecular tools for the global assessment of the gut microbiome and the identification of nucleotide-binding oligomerization domain-containing protein 2 in 2001 and other susceptibility genes for Crohn's disease in particular has led to better understanding of the aetiopathogenesis of IBD. The microbial studies have elaborated the normal composition of the gut microbiome and its perturbations in the setting of IBD. This altered microbiome or 'dysbiosis' is a key player in the protracted course of inflammation in IBD. Numerous genome-wide association studies have identified further genes involved in gastrointestinal innate immunity(including polymorphisms in genes involved in autophagy: ATG16L1 and IGRM), which have helped elucidate the relationship of the local innate immunity with the adjacent luminal bacteria. These developments have also spurred the search for specific pathogens which may have a role in the metamorphosis of the gut microbiome from a symbiotic entity to a putative pathogenic one. Here we review advances in our understanding of microbial involvement in IBD pathogenesis over the past 10 years and offer insight into how this will shape our therapeutic management of the disease in the coming years.Georgina L Hold Megan Smith Charlie Grange Euan Robert Watt Emad M El-Omar Indrani Mukhopadhya 2014World Journal of Gastroenterology2014,20,5:21
3The microbiology of butyrate formation in the human colon显示文摘PRYDE S E DUNCAN S H HOLD G L 2002FEMS Microbiology Letters2002,217,2:1
4The microbiology of butyrate formation in the human colon显示文摘Pryde S E Duncan S H Hold G L 2002FEMS Microbiology Letters2002,217,:1
5Oligonucleotied probes that detect quantitatively significant groups of butyrate- producing bacteria in human feces显示文摘HOLD G L SCHWIERTZ A AMINOV R I 2003Applied and Environmental Microbiology2003,69,7:1
6Coordinate gene activity in response to agents that in- duce systemic acquired resistance显示文摘WARD E R UKNESS S J WILLIAMS S C DINCHER S S WIEDER- HOLD D L ALEXANDER D C AHL-GOY P METRAUX J P RYALS J A 1991Plant Cell1991,3,10:1
7De-elopment of a method for the quantification of haddock ( Melanogrammu- saeglefinus) in commercial products using real -time PCR 显示文摘Hird H J Hold G L Chisholm J 2005Eur Food Res Technol2005,220,5:1
8Cellular and humoral immune responses in patients with metastatic renal cell carcinoma after vaccination with antigen pulsed dendritic cells显示文摘Hold L Rieser C Papesh C 1999J Urol1999,161,3:1
9The microbi- ology of butyrate formation in the human colon显示文摘Pryde S EfDuncan S H Hold G L 2002FEMS Microbiol Lett2002,217,2:1
10Assessment of microbial diversity in human colonic samples by 16S rDNA sequence anal- ysis显示文摘Hold G L Pryde S E Russell V J 2002FEMS Microbiology Ecology2002,39,1:1
11Use of autologous platelet concentrate in blepharoplasty surgery显示文摘VICK V L HOLDS J B HARTSTEIN M E 2006Ophthal Plast Reconstr Surg2006,22,2:1
12Validation of a PCR-RFLP based method for the identification of salmon species in food products显示文摘G L Hold V J Russell 2001Eur Food Res Technol2001,212,:1
13Genetic aspects of inflammation and cancer 显示文摘Hold G L E1-Omar M E 2008Biochem J2008,410,2:1
14-Fragment hazards from failures of pressurized liquefied gas vessels显示文摘Holde P L Reeves A B 1985The Assessment and Control of Major Hazards1985,,93:1
15Assessment of microbial diversity in human colonic samples by 16S rDNA sequence analysis显示文摘Hold G L Pryde S E Russell V J 2002FEMS Microbiology Ecology2002,39,1:1
16Use of restriction fragment length polym orphism to distinguish detween salm on species显示文摘Russell V J Hold G L 2000J Agric Food Chem2000,48,6:1
17Use of restriction fragment length polymorphism to distinguish between salmon species显示文摘Stevens V J Hold G L Pryde S E 2000Journal of Agricultural and Food Chemistry2000,48,6:1
18The microbiology of butyrate formation in the human colon 显示文摘PRYDE S E DUNCAN S H HOLD G L 2002FEMS Microbiology Letters2002,217,2:1
19Use of restriction fragment length polymorphism to distinguish between salmon species显示文摘Russell V J Hold G L 2000J Agric Food Chem2000,48,6:1
20Update on myocardial bridging 显示文摘Mohlenkamp S Hold W Ge J et a l 2002Circulation2002,106,:1
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