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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | The serial cultivation of human diploid cell strains显示文摘 | Hayflick L Moorhead PS | 1961 | Exp Cell Res1961，25，： | 2 |
| 3 | Stability of serum cell counts, hematologic parameters and reticulocytes indexes on the Advia 120 hematologic analyzer显示文摘 | Giuseppe L Gian LS Gian PS | 2005 | J Lab Clin Med2005，146，6： | 1 |
| 4 | Outcomes analysis of delayed antibiotic treatment for hospital-acquired Staphylococcus aureus bacteremia显示文摘 | Lodise TP Mckinnon PS Swiderski L | 2003 | Clin Infect Dis2003，36，： | 1 |
| 5 | Role of EGF receptor tyrosine kinase activity in antiapoptotic effect of EGF on mouse hepatocytes显示文摘 | Musallam L Ethier C Haddad PS | 2001 | Am J Physiol Gastrointest Liver Physiol2001，280，6： | 1 |
| 6 | Evidence for a novel gene associated with low tumor metastatic potiential显示文摘 | Steeg PS Bevilacque G Kopper L etal | 1988 | J Natl Cancer Inset1988，80，3： | 1 |
| 7 | Evidence for a novel gene associated with low tumor metastatic potential显示文摘 | Steeg PS Bevilacqua G Kopper L | 1988 | J Natl Cancer Inst1988，80，： | 1 |
| 8 | Food-related illness and death inthe United States显示文摘 | Mead PS Slutsker L Dietz V | 1999 | Emerg Inf Dis1999，5，5： | 1 |
| 9 | The impactofobesity on surgical outcomes: a review显示文摘 | Choban PS Flancbaum L | 1997 | J Am Coil Surg1997，185，6： | 1 |
| 10 | Food-related illness and death in the United States显示文摘 | Mead PS Slutsker L Dietz V | 1999 | Emerg lnfect Dis1999，5，： | 1 |
| 11 | Resistance to Fas-induced apoptosis in hepatocytes:role of GSH depletion by cell isolation and culture显示文摘 | Musallam L Ethier C Haddad PS | 2002 | Am J Physiology Gastrointest Liver Physiol2002，283，3： | 1 |
| 12 | Evidence for a noval gene associated with low tumor metastasis potential显示文摘 | Steeg PS Bevilacqua G Kopper L | 1988 | J Nat Cancer Inst1988，80，： | 1 |
| 13 | Food -related illness and death in the United States显示文摘 | Mead PS Slutsker L Dietz V | 1999 | Emerg Infect Dis1999，5，5： | 1 |
| 14 | Costimulatiou of T cells for tumor immunity显示文摘 | Chen L Linstey PS Hellstrom KE | 1993 | Immunol Today1993，14，： | 1 |
| 15 | The Mullerian inhibiting substance type 2 receptor suppresses tumorigenesis in testes with sustained beta-catenin signaling 显示文摘 | Tanwar PS Commandeur AE Zhang L | 2012 | Carcinogenesis2012，33，： | 1 |
| 16 | An epididymis-specific beta-defensin is important for the initiation of sperm maturation显示文摘 | Zhou CX Zhang YL Xiao L Zheng M Leung KM Chan MY Lo PS Tsang LL Wong HY Ho LS | | 0，，05： | 1 |
| 17 | Effect of outliers and nonheahhy individuals on reference interval estimation 显示文摘 | HORN PS FENG L LI Y | 2001 | Clin Chem2001，47，12： | 1 |
| 18 | Road maps to achieve glycemic control in type 2 daiabetes mellitus: ACE/ AACE Diabetes Road Map Task Force 显示文摘 | Davidson JA Blonde L Jellinger PS | 2007 | Endocr Pract2007，13，3： | 1 |
| 19 | Nigral glutathione deficiency is not specific for idiopathic Parkinsen's disease 显示文摘 | Fitzmaurice PS Ang L Guttman M | 2003 | Mov Disord2003，18，： | 1 |
| 20 | Bispectral analysis measures sedating and memory effects of propofol, midazolam, isoflurane, and alfentanil in healty volunteers显示文摘 | GLASS PS BLOOM M KEARSE L | 1997 | Anesthesio-logy1997，86，4： | 1 |
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