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| 1 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 2 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 3 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 4 | 文化、不平等性与卫生服务提供显示文摘1动态不平等性对基层医疗卫生人力的影响
政治、社会、文化、专业群体皆建立在一致且常规的人类行为之上。当遭受巨大变革和内外压力时,这些群体会变得十分脆弱。尤其在动荡时期,这些群体往往更关注社会和文化的差异性,而非二者的一致性。尽管社会中的个体思维和行为会呈现较大的差异,但对健康的感知具有统一性,并在更广范围人群内尤为突出,这主要归因于文化价值观的作用。广义的文化心态会随着时间和地理位置的不同而不同,就像健康的社会决定因素也会因文化类型的不同而产生差异。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，3： | 2 |
| 5 | Colonization dynamics and facilitative impacts of a nitrogen-fixing shrub in primary succession显示文摘 | Walker L R Clarkson B D Silvester W B | 2003 | J Vegetation Science2003，14，： | 1 |
| 6 | Control of matrix metalloproteinase activity in cancer显示文摘 | Jones J L Walker R A | 1997 | J Pathol1997，183，： | 1 |
| 7 | Biological invasion by Myricafaya in Hawai'i: plant demography, nitrogen fixation, ecosystem effects显示文摘 | VITOUSEK P M WALKER L R | 1989 | Ecological Monographs1989，59，： | 1 |
| 8 | 医疗卫生保健文化的反思及促进健康与文化融合的建议显示文摘1医疗卫生保健文化的反思1.1健康文化与医学知识如果医务人员有充足的时间对患者进行诊断并帮助患者进行社区护理,就可在节省卫生费用的同时改善健康结果。整合型社区护理能缩小不同文化背景和群体健康需求的差异。然而,全球范围内对整合型社区护理的投入较少,原因之一就是20世纪对临床服务的重视弱化了卫生服务提供过程中的同情心理。当然,患者也对医学知识存在显性和隐性的影响(特别是当其因不遵医嘱而受到指责时)。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson JWoolf K | 2016 | 中国卫生政策研究2016，9，4： | 1 |
| 9 | Mast cells and matrix degradation at sites of tumour invasion in rat mammary ade- nocarcinoma显示文摘 | Dabbous MK Walker R Haney L | 1986 | Br J Cancer1986，54，3： | 1 |
| 10 | Three-dimensional localization of maxillary canines with cone-beam computed tomography显示文摘 | Walker L Enciso R Mah J | 2005 | Am J Orthod Dentofacial Orthop2005，128，4： | 1 |
| 11 | Applying lessons from ecological succession to the restoration of land- slides显示文摘 | WALKER L R VELAZQUEZ E SHIELS A B | 2009 | Plant Soil2009，324，12： | 1 |
| 12 | Dynamic control of flexible kinematicatly redundant robot manipulators 显示文摘 | Nguyen L Walker I Defigueiredo R | 1992 | IEEE Transactions on Robotics and Automation1992，8，6： | 1 |
| 13 | Adsorption of acid dyes by granular activated carbon in fixed beds 显示文摘 | WALKER G M WEATHERLEY L R | 1997 | Water Research1997，31，8： | 1 |
| 14 | Splenic T lympho- cytes die preferentially during heat-induced apoptosis: NuMA reorganization as a marker显示文摘 | Sodja C Brown D L Walker P R | 1998 | Journal of cell science1998，111，16： | 1 |
| 15 | Simultaneous,rapid,spectrophotometric determination of total starch,amylose,and amylopectin显示文摘 | Jarvis C E Walker J R L | | 0，，： | 1 |
| 16 | Potassium and other mineral contents of green, roasted and instant coffees显示文摘 | Clarke R J Walker L J | 1974 | Journal of the Science of Food and Agriculture1974，，11： | 1 |
| 17 | Three-dimensional localization of maxillary canines with cone-beam computed tomography显示文摘 | WALKER L ENCISO R MAH J | 2005 | Am J Orthodontics & Dentofacial Orthop2005，128，4： | 1 |
| 18 | Biological invasion by myrica-faya in hawaii - plant demography, nitrogenfixation, ecosystem effects显示文摘 | Vitousek P M Walker L R | 1989 | Ecological Monographs1989，59，3： | 1 |
| 19 | The synthesis and antiviral properties of E-5- (2-bromovinyl) -4'-thio-deoxyurichine 显示文摘 | Dyson M R Coe P L Walker R T | 1991 | J Chem Soc Chem Commun1991，，： | 1 |
| 20 | Place attachment and landscape preservation inrural New England: a main case study显示文摘 | Walker A J Ryan R L | 2008 | Landscape Urban Plann2008，86，2： | 1 |
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