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| 1 | Systematic review: The placebo effect of psychological interventions in the treatment of irritable bowel syndrome显示文摘AIM To determine the placebo response rate associated with different types of placebo interventions used in psychological intervention studies for irritable bowel syndrome. METHODS Randomized controlled trials comparing psychological interventions(stress management/relaxation therapy(cognitive) behavioral therapy, short-term psychodynamic therapy, and hypnotherapy) for the treatment of adult patients with irritable bowel syndrome(IBS) diagnosed with the Manning or Rome criteria with an adequate placebo control treatment and reporting data on IBS symptom severity were identified by searching Pub Med, Embase, the Cochrane Library, CINAHL and Psyc INFO databases. Full-text articles that were written in English and published between 1966 and February 2016 in peer-reviewed journals were selected for the present review. Placebo interventions were considered to be adequate if the number of sessions and the amount of time spent with the therapist were the same as in the active treatment. The placebo response rate(PRR) was computed for IBS symptom severity(primary outcome measure) as well as for anxiety, depression and quality of life(secondary outcome measures). RESULTS Six studies, with a total of 555 patients met the inclusion criteria. Four studies used an educational intervention, whereas two studies used a form of supportive therapy as the placebo intervention. The PRR for IBS symptom severity ranged from 25% to 59%, with a pooled mean of 41.4%. The relative PRR for the secondary outcome measures ranged from 0% to 267% for anxiety, 6% to 52% for depression 20% to 125% for quality of life. The PRR associated with pharmacological treatments, treatment with dietary bran and complementary medicine ranged from 37.5% to 47%. Contrary to our expectations, the PRR in studies on psychological interventions was comparable to that in studies on pharmacological, dietary and alternative medical interventions.CONCLUSION The PRR is probably determined to a larger extent by patient-related factors, such as expectations and desire for the treatment to be effective, than the content of the placebo intervention. | Carla E Flik Laura Bakker Wijnand Laan Yanda R van Rood André JPM Smout Niek J de Wit | 2017 | World Journal of Gastroenterology2017，23，12： | 7 |
| 2 | The determination of gemcitabine and 2'-deoxycytidine in human plasma and tissue by APCI tandem mass spectrometry 显示文摘 | Honeywell R Laan AC van Groeningen C J | 2007 | J Chromatogr B Analyt Technol Biomed Life Sci2007，847，2： | 1 |
| 3 | The extracellular PI-type proteinase of Lactococcus lactis hydrolyzes beta-ca-sein into more than one hundred different oligopeptides显示文摘 | Juillard V Laan H Kunji E R S | 1995 | Journal Bacteriology1995，177，12： | 1 |
| 4 | Lead-time effects in PUSH and PULL controlled manufacturing/remanufacturing systems 显示文摘 | VAN DER LAAN E A SALOMON M DEKKER R | 1999 | European Journal of Operational Research1999，115，1： | 1 |
| 5 | Fate of nonylphenolethoxylates and til eir metabolites in two Dutchestuaries : Evidence of biodegradation in the field 显示文摘 | Jonkers N Laane R De Voogt P | 2003 | Environmental Science and Technology2003，37，2： | 1 |
| 6 | Dissolved alu- minium and the silicon cycle in the Arctic Ocean 显示文摘 | MIDDAG R DE BAAR H J W LAAN P | 2009 | Marine Chemistry2009，115，34： | 1 |
| 7 | Inventory control in hybrid systems with remanufacturing显示文摘 | VAN DER LAAN E A SALOMON M DEKKER R | 1999 | Management Science1999，45，5： | 1 |
| 8 | Environmental and toxicity effects of perfluoroalkylated substances显示文摘 | Hekster F M Laane R W de Voogt P | 2003 | Reviews of Environmental Contamination and Toxicology2003，179，： | 1 |
| 9 | Inventory control in hybrid systems with remanufacturing显示文摘 | Van der Laan E Salomon M Dekker R | 1999 | Management Science1999，45，5： | 1 |
| 10 | An investigation of lead- time effects in manufaeturing/remanufaeturing systems under simple PUSH and PULL control strategies 显示文摘 | Van der Laan E Salomon M Dekker R | 1999 | European Journal of Operational Research1999，115，1： | 1 |
| 11 | The human gene for xanthine dehydrogenase (XDH) is localized on chromosome band 2q22 显示文摘 | Rytkonen EM Halila R Laan M | 1995 | Cytogenet Cell Genet1995，68，12： | 1 |
| 12 | Enantiomeric Enrichment of Chiral Pesticides in the Environment显示文摘 | HEGEMAN W J M LAANE R W P M | 2002 | Rev Enviro Contam Toxico2002，173，： | 1 |
| 13 | Enantiomeric En-richment of Chiral Pesticides in the Environment显示文摘 | HEGEMAN W J M LAANE R W P M | 2002 | RevEnviro Contam Toxico2002，，173： | 1 |
| 14 | Inventory control in hybrid systems with remanufacturing显示文摘 | Van der laan E Salomon M Dekker R | 1999 | Management Science1999，145，5： | 1 |
| 15 | An investigation of lead-time effects in manufacturing/remanufacturing systems under simple push and pull control strategiea显示文摘 | Van der Laan E Salomon M Dekker R | 1999 | European Journal of Operational Research1999，115，1： | 1 |
| 16 | Multicomponent reaction engineering model for Fe-catalyzed Fischer-Tropsch synthesis in commercial scale slurry bubble column reactors 显示文摘 | VAN der LAAN G P BEENACKERS A A C M KRISH- NA R | 1999 | Chemical Engi- neering Science1999，54，21： | 1 |
| 17 | Molecular cloning and analysis of the gene encoding the thermostable penicillin G acylase from Alcaligenes faecalis显示文摘 | Verhaert R M D Riemens A M van der Laan J M | 1997 | Applied and Environmental Microbiology1997，63，9： | 1 |
| 18 | Surgical clipping as the preferred treatment for aneurysms of the middle cerebral artery 显示文摘 | van Dijk JM Groen R J Ter Laan M | 2011 | Acta Neurochir ( Wien )2011，153，11： | 1 |
| 19 | Inventory Control in Hybrid Systems with Remanufacturing显示文摘 | DEKKER R SALOMON M | 1999 | Management Science1999，45，5： | 1 |
| 20 | How to set the holding cost rates in average cost inventory models with reverse logistics?显示文摘 | TEUNTER R H LAAN E V D INDERFURTH K | 2000 | OMEGA the international journal of management science2000，28，4： | 1 |
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