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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 3 | 同步荧光法检测鱼胆汁中的1-羟基芘显示文摘建立了用同步荧光法测定鱼胆汁中的 1 羟基芘 (1 HP)的方法。该方法通过直接测定鱼胆汁的多环芳烃 (PAHs)的代谢产物之一 1 HP ,用于判断PAHs生物有效部分对海岸带养殖水环境的污染程度。以真鲷(Pargrosomusmajor,简称Pm) , 鱼 (Nibeamiichthys ,简称Nm)为实验对象 。 | 张勇 王淑红 朱亚先 Michael H W Lam Rudolf S S Wu 洪华生 | 2002 | 分析化学2002，30，4： | 6 |
| 4 | Anaerobic bacteria and intrahepatic stones: detections of Clostridium sp. and Bacteroides fragilis显示文摘To detect anaerobic bacteria Clostridium sp . and Bacteroides fragilis in intrahepatic stones by molecular genetic method Methods DNA was extracted from 59 stone samples and subjected to polymerase chain reaction (PCR) amplification targeting the 16S rRNA gene of Clostridium sp . and the glutamine synthetase gene of Bacteroides fragilis Single-strand conformational polymorphism (SSCP) analysis was performed to identify the Clostridium sp Results 16S rRNA gene sequences for Clostridium sp. were identified in 49 stones (83%, 49/59) The two most common groups were detected in 19 (41%) and 17 (37%) of the 46 samples using SSPC analysis, and 25/59 (42%) stones were tested positive for Bacteroides fragilis Conclusions Anaerobes such as Clostridium sp and Bacteroides fragilis present in intrahepatic stones and may play a role in stone formation PCR is a useful technique to detect fastidious pathogens, which are difficult to culture SSCP of PCR products is a rapid method in differentiating bacterial | LIU Yanlei Kan Lam Yajarayma J Tang Paul H Gumerlock Dong Ki Lee Myung Hwa Kim Sum P Lee Joseph SilvaJr Joseph W Leung | 2000 | Chinese Medical Journal2000，，9： | 2 |
| 5 | A Traffic Flow Simulator for Network Reliabihty Assessment显示文摘 | LAM W H K XU G | 1999 | Journal of Advanced Transportation1999，33，2： | 1 |
| 6 | Evaluation of count location selection methods for O-D matrices from traffic counts 显示文摘 | YIM K N | 1998 | Journal of Transportation Engineering1998，124，4： | 1 |
| 7 | Semi-active control of automotive suspention systems 显示文摘 | Lam A H Liao W H | 2003 | Int J of Vehicle Design2003，31，1： | 1 |
| 8 | The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population显示文摘 | Wang A H Lam W J Han D Y | 2011 | Human Immunology2011，72，： | 1 |
| 9 | Interdaily volatility in continuous order-driven market显示文摘 | Lam P H Tong W H | 1999 | Journal of Business Finance and Accounting1999，26，78： | 1 |
| 10 | Transport policy ap- praisal with equilibrium models I : generalized traffic and highway investment benefits 显示文摘 | Williams H C W L Lam W M | 1991 | Transportation Research Part B: Methodological1991，25，5： | 1 |
| 11 | Study of the destructive effect to inherent quality of Angelicae dahur icae radix(Bai Zhi)by sulfur fumigated process using chroma to grphic finger printing analysis显示文摘 | Wang X H Xie P S Lam Chris W K | 2009 | J Pharm Biomed Anal2009，49，5： | 1 |
| 12 | Preferred risk allocation in target cost contracts in con- struction显示文摘 | Joseph H L Chan Daniel W M Chan Patrick T I Lam | 2011 | Facilities2011，29，1314： | 1 |
| 13 | Simulating pedestrian movements at signalized crosswalks in Hong Kong显示文摘 | Lee J Y S Lam W H K | 2008 | Transportation Research Part A2008，42，10： | 1 |
| 14 | Modeling park-and-ride services in a multimodal transport network with elastic demand 显示文摘 | Li Zhi-chun Lam W H K Wong S C Zhu Dao-li Huang Hai-jun | 2007 | Transportation Research Record2007，1994，： | 1 |
| 15 | Chinese hotel employees in the smiling masks : roles of job satisfaction, burnout, and supervi- sory support in relationships between emotional labor and performance 显示文摘 | Chen Z Sun H Lam W | 2012 | The International Journal of Human Re- source Management2012，23，4： | 1 |
| 16 | New technology and the modeling of risk-taking behavior in congested road networks显示文摘 | YIN Y LAM W H K lEDA H | 2004 | Transportation Research Part C2004，12，34： | 1 |
| 17 | Transcriptomic analyses of sexual dimorphism of the zebrafish liver and the effect of sex hormones 显示文摘 | Zheng W Xu H Lam S H | 2013 | PLOS ONE2013，8，53： | 1 |
| 18 | A reliability- based stochastic traffic assignment model for net- work with multiple user classes under uncertainty in demand显示文摘 | SHAO H LAM W H K TAM M L | 2006 | Network and Spatial Economics2006，，6： | 1 |
| 19 | Identificationand characterization of a new degradation product ofIrgarol 1051 in mercuric chloride-catalyzed hydrolysisreaction and in coastal waters显示文摘 | Lam K H Lam M H W Lam P K S | 2004 | Marine PollutionBulletin2004，49，： | 1 |
| 20 | Integrated model for lane-use and signal-phase designs显示文摘 | Lam W H K Poon A C K Mung G K S | 1997 | Journal of Transportation Engineering1997，123，2： | 1 |
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