|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mechanistic links between gut microbial community dynamics, microbial functions and metabolic health显示文摘Gut microbes comprise a high density, biologically active community that lies at the interface of an animal with its nutritional environment. Consequently their activity profoundly influences many aspects of the physiology and metabolism of the host animal. A range of microbial structural components and metabolites directly interact with host intestinal cells and tissues to influence nutrient uptake and epithelial health. Endocrine, neuronal and lymphoid cells in the gut also integrate signals from these microbial factors to influence systemic responses. Dysregulation of these host-microbe interactions is now recognised as a major risk factor in the development of metabolic dysfunction. This is a two-way process and understanding the factors that tip host-microbiome homeostasis over to dysbiosis requires greater appreciation of the host feedbacks that contribute to regulation of microbial community composition. To date, numerous studies have employed taxonomic profiling approaches to explore the links between microbial composition and host outcomes(especially obesity and its comorbidities), but inconsistent host-microbe associations have been reported. Available data indicates multiple factors have contributed to discrepancies between studies. These include the high level of functional redundancy in host-microbiome interactions combined with individual variation in microbiome composition; differences in study design, diet composition and host system between studies; and inherent limitations to the resolution of r RNA-based community profiling. Accounting for these factors allows for recognition of the common microbial and host factors driving community composition and development of dysbiosis on high fat diets. New therapeutic intervention options are now emerging. | Connie WY Ha Yan Y Lam Andrew J Holmes | 2014 | World Journal of Gastroenterology2014，20，44： | 4 |
| 2 | 高血压合并2型糖尿病患者是否需要个体化的收缩压管理目标?显示文摘目前糖尿病管理的趋势支持用个体化的、以患者为中心的收缩压目标取代单一的标准。但是对于收缩压的治疗目标仍未达成共识。该研究目的是评估收缩压和糖尿病患者心血管病风险、全因死亡之间的联系,从而明确以患者为中心的治疗目标。研究者对接受社区医疗的糖尿病合并高血压的中国成年患者95086例进行了回顾性研究。通过收缩压年平均记录和中位数为5.9年的随访,应用Cox比例风险回归,对总体心血管病风险、全因死亡以及它们与收缩压的相关性进行评估。 | 刘莉 叶鹏 Wan EYF Yu EYT Fung CSC Chin WY Fong DYT Chan AKC Lam CLK | 2017 | 中华高血压杂志2017，25，11： | 3 |
| 3 | Porokeratotic eccrine ostial and dermal duct naevus with dermatomal trunk involvement: literature review and report on the efficacy of laser treatment 显示文摘 | Leung CS Tang WY Lam WY | 1998 | Br J Dermatol1998，138，4： | 1 |
| 4 | Rapid multiplex nested PCR for detection of respiratory viruses显示文摘 | Lam WY | 2007 | Journal of Clinical Microbiology2007，45，11： | 1 |
| 5 | A cross - sectional magnetic resonance imaging assessment of organ specific hemosiderosis in 180 thalassemia major patients in Hong Kong 显示文摘 | Au WY Lam WW Chu WW | 2008 | Haematologica2008，93，5： | 1 |
| 6 | Ethyl acetate extract of Chinese medicinal herb Sarcandra glabra induces growth inhibition on human leukemic HL-60 cells, associated with cell cycle arrest and up-regulation of pro-apoptotic Bax/Bcl-2 ratio 显示文摘 | Li WY Chiu L Lam WS | 2007 | Oncol Rep2007，17，2： | 1 |
| 7 | Hypophysitis presented as inflammatory pseudotumor in immunoglobulin G4-related systemic disease显示文摘 | Wong S Lam WY Wong WK | 2007 | Hum Pathol2007，38，11： | 1 |
| 8 | Immunohistological evidences of Ginkgo biloba extract altering Bax to Bcl-2 expression ratio in the hippocampus and motor cortex of senescence accelerated mice显示文摘 | Mak YT Chan WY Lam WP | 2006 | Microsc Res Tech2006，69，8： | 1 |
| 9 | Rapid multiplex nested PCR for detection of respiratory viruses显示文摘 | Lam WY Yeung AC Tang JW | 2007 | J Clin Microbiol2007，45，： | 1 |
| 10 | Tetraploid acute promyelocytic leukemia with large bizarre blast cell morphology显示文摘 | Au WY Ma SK Lam CC | 1999 | Cancer Genet Cytogenet1999，115，1： | 1 |
| 11 | Hypophysitis presented as inflammatory pseudotumor in immunaglobulin G4-related systemic disease显示文摘 | Wong S Lam WY Wong WK | 2007 | Hum Pathol2007，38，11： | 1 |
| 12 | Guess what! Angiosarcoma of the face and scalp显示文摘 | Chan LY Tang WY Lam WY | 2001 | Eur J Dermatol2001，11，3： | 1 |
| 13 | Effect of naturally occurring visual acuity differences between two eyes in stereoacuity显示文摘 | lain AK Chau AS Lam WY | 1996 | Ophthal Physiol1996，16，： | 1 |
| 14 | Rapid multiplexnested PCR for detection of respiratory viruses显示文摘 | Lam WY Yeung AC Tang JW | 2007 | J Clina Microbiol2007，45，11： | 1 |
| 15 | Rapid multiplex nested PCR for detection of respiratory viruses显示文摘 | Lam WY Yeung AC Tang JW | 2007 | J Clin Microbiol2007，45，11： | 1 |
| 16 | A T2 magnetic resonance imaging study of pancreatic iron overload in thalassemia major显示文摘 | Au WY Lam WW Chu W | 2008 | Haema- tologica2008，93，： | 1 |
| 17 | A Chinese version of the Sleep Apnea Quality of Life Index was evaluated for reliability,validity,and responsiveness显示文摘 | Mok WY Lam CL Lam B | 2004 | J Clin Epidemiol2004，57，5： | 1 |
| 18 | Randomized study of three non-surgical treatments in mild to moderate obstructive sleep apnea显示文摘 | Lam B Sam K Mok WY | 2007 | Thorax2007，62，4： | 1 |
| 19 | Immunohistological evidences of Ginkgo biloba extract altering Bax to Bcl-2 expression ratio in the hippocampus and motor cortex of senescence accelerated mice显示文摘 | Mak YT Chan WY Lam WP | 2006 | Microsc Res Tech2006，69，8： | 1 |
| 20 | Two factor XI muta?tions in a Chinese family with factor XI deficiency显示文摘 | Au WY Cheung JW Lam CC | 2003 | Am J Hematol2003，74，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员