|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Signal and construction mechanisms for activation of plant defenses against microbial attack显示文摘 | Lamb C J Lawton M A Dron M | 1989 | Cell1989，56，： | 2 |
| 3 | The oxidative busrt in Plant disease re- sistance 显示文摘 | Lamb C Dixon R A | 1997 | Annual Review of Plant Physiology and Plant Mo- lecular Biology1997，48，： | 1 |
| 4 | The Oxidative Burst in Plant Disease Resistance 显示文摘 | LAMB C DIXON R A | 1997 | Annu Rev Plant Mol Biol1997，48，： | 1 |
| 5 | Impact of manure application on soil phosphorus sorption characterisitics and subsequent water quality implications显示文摘 | Laboski C A M Lamb J A | 2004 | Soil Science2004，169，6： | 1 |
| 6 | The oxidative burst in plant disease re- sistance 显示文摘 | LAMB C J DIXON R A | 1997 | Plant Mol Biol1997，48，： | 1 |
| 7 | The oxidative burst in plant disease resist- ance显示文摘 | Lamb C Dixon H A | 1997 | Ann Rev Plant Mol Biol1997，，48： | 1 |
| 8 | The oxidative burst in plant disease resistance显示文摘 | Lamb C J Dixon R A | 1997 | Annu Rev Plant Physiol1997，76，： | 1 |
| 9 | A putative lipid transfer protein involved in systemic resistance signaling in Arabidopsis显示文摘 | Maldonado A M Doerner P Dixon R A Lamb C J Cameron R K | | 0，，： | 1 |
| 10 | Early events in the activation of plant defense responses 显示文摘 | DIXON R A HARRISON M J LAMB C J | 1994 | Annual Review of Physiology1994，11，32： | 1 |
| 11 | Impact of manure applica- tion on soil phosphorus sorption characteristics and sub- sequent water quality implications 显示文摘 | LABOSKI C A M LAMB J A | 2004 | Soil Sci2004，169，： | 1 |
| 12 | Seed dormancy variability in the US peanut Mini-core collection显示文摘 | Wang M L Chen C Y Pinnow D L Barkley N A Pittman R N Lamb M Pederson G C | 2012 | Research Journal of Seed Science2012，5，3： | 1 |
| 13 | The removal of carbon monoxide from air显示文摘 | Lamb A B Bray W C Frazer J C W | 1920 | Ind Eng Chem1920，12，3： | 1 |
| 14 | Chromosome painting using repetitive DNA sequences as probes for somatic chromosome identification in maize显示文摘 | Kato A Lamb J C Birchler J A | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，101，13： | 1 |
| 15 | Novel approaches to the estimation of intake and bioavailability of radiocaesium in ruminants grazing forested areas显示文摘 | Mayes R M Beresford N A Lamb C S | 1994 | Science of the Total Environment1994，，157： | 1 |
| 16 | A plant homolog of the neutrophil NADPH oxidase gp^91phox subunit gene encodes a plasma membrane protein with Ca^2- binding motifs显示文摘 | KELLER T DAMUDE H G WERNER D DOERNER P DIXON R A LAMB C | 1998 | Plant Cell1998，10，2： | 1 |
| 17 | Signal interactions between nitric oxide and reactive oxygen intermediates in the plant hypersensitive disease resistance response 显示文摘 | Delledonne M Zeier J Marocco A Lamb C | 2001 | Proceeding of the National Academy of the United States of America2001，98，13： | 1 |
| 18 | Frequent downregulation of KAII (CD82) metastasis suppressor protein in human cancer cell lines显示文摘 | White A Lamb P W Barrett J C | 1998 | Oncogene1998，16，24： | 1 |
| 19 | Signal and construction mechanisms for activation of plant defenses against microbial attack 显示文摘 | Lamb C J Lawton M A Dron M | 1989 | Cell1989，56，： | 1 |
| 20 | Model for resilient modulus and permanent strain of subgrade soils显示文摘 | MUHANNA A S RAHMAB M S LAMBE P C | 1998 | Transportation Research Record1998，1619，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员