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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Polyaniline as a suport for urease immobilization显示文摘 | Wlodarczyk J Zaborska W | 1999 | J Molecular Catalysis B:Enzymatic1999，6，： | 1 |
| 3 | Analog-to-informa- tion conversion via random demodulation显示文摘 | Kirolos S Laska J Wakin M | 2006 | Dallas ICAS Workshop on Design Applications Integration and Software2006，2006，2： | 1 |
| 4 | Polyaniline as a support for urease immobilization 显示文摘 | Laska J Wlodarczyk J Zaborska W | 1999 | Journal of Molec- ular Catalysis B : Enzymatic1999，6，6： | 1 |
| 5 | Relationships between en ergy balance knowledge and the home environment 显示文摘 | Slater M E Sirard J R Laska M N | 2011 | J Am Diet Assoc2011，111，4： | 1 |
| 6 | A modified method for the isolation and determination of brain hista- mine using Bio-Rex 70 显示文摘 | Lewis S J Fennessy MR Laska FJ | 1980 | Inflamm Res1980，10，3： | 1 |
| 7 | Beyond Nyquist:efficient sampling of sparse bandlimited signals显示文摘 | Tropp J A Laska J N Duarte M F Romberg J K Baraniuk R G | 2010 | IEEE Transaction on Information Theory2010，58，1： | 1 |
| 8 | Water Soluble Polyaniline显示文摘 | Laska J Widlara J | 2003 | Synthetic Metals2003，135，4： | 1 |
| 9 | Beyond Nyquist: efficient sampling of sparse bandlimited signals 显示文摘 | Tropp J A Laska J N Duarte M F Romberg J K and Baraniuk R G | 2010 | IEEE Transactions on Information Theory2010，56，1： | 1 |
| 10 | Beyond Nyquist : Efficient sampling of sparse, bandlimited signals 显示文摘 | Tropp J A Laska J N Duarte M F Romberg J and Bara- niuk R G | 2009 | IEEE Transactions on Information Theory2009，56，1： | 1 |
| 11 | Processable conducting polymers obtained via protonation of polyaniline with phosphoric acid esters显示文摘 | Pron A Laska J Smith P | 1993 | Polymer1993，34，20： | 1 |
| 12 | Beyond Nyquist: Efficient Sampling of Sparse Bandlimited Signals 显示文摘 | Tropp J A Laska J Duarte M | 2010 | IEEE Transactions on Information Theory2010，56，1： | 1 |
| 13 | Beyond nyquist:Efficient sampling of sparse bandlimited signals显示文摘 | Tropp J Laska J Duarte M | 2010 | IEEE Transactions on Information Theory2010，56，1： | 1 |
| 14 | Long-term efficacy and safety of iloperidone: results from 3 clinical trials for tile treatment of schizophrenia显示文摘 | KANE JM LAURIELLO J LASKA E et td | 2008 | J Clit Psyehopharmacol2008，28，2： | 1 |
| 15 | Beyond nyquist :Effi- cient sampling of sparse bandlimited signals 显示文摘 | TROPP J A LASKA J N DUARTE M F | 2010 | IEEE Trans on In-formation Theory2010，56，1： | 1 |
| 16 | Beyond Nyquist: efficient sampling of sparse bandlimited sig- nals显示文摘 | Tropp J A Laska J N Duarte M F | 2010 | IEEE Trans on Information Theory2010，56，1： | 1 |
| 17 | Trust,but verify:fast and accurate signal recovery from 1-bit compressive measurements显示文摘 | LASKA J N WEN Z YIN W | 2011 | IEEE Transactions on Signal Processing2011，59，11： | 1 |
| 18 | The different influences of newspaper and television news reports of a natural hazard on response behavior显示文摘 | Spencer J W Seydlitz R Laska S | 1992 | Communication Research1992，19，3： | 1 |
| 19 | Beyond Nyquist: Efficient sampling of sparse bandlimited signals 显示文摘 | Tropp J A Laska J N Duarte M F | 2010 | IEEE Trans on Information Theory2010，56，1： | 1 |
| 20 | Beyond nyquist efficient sampling of sparse bandlimited signals显示文摘 | TROPP J A LASKA J N DUARTEM F | 2010 | IEEE Trans Inform Theory2010，56，1： | 1 |
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