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| 1 | Interaction of insulin with prokinetic drugs in STZ-induced diabetic mice显示文摘AIM:To study the possible interactions of metoclopramide,domperidone and erythromycin in streptozotocin-induced diabetic mice treated with insulin by various parameters.METHODS:Effects of the individual as well as combined drugs were studied in diabetic mice via estimation of the blood glucose and serum insulin levels,small intestinal transit(SIT),gastric emptying(GE),xylose absorption and glucose tolerance tests.Groups were given insulin 2 IU/kg s.c.,metoclopramide 20 mg/kg p.o.,domperidone 20 mg/kg p.o.and erythromycin 6 mg/kg p.o.individually and in combination.There were also normal and diabetic control groups.The first set of experiments was carried out to investigate the subchronic effect on blood glucose and serum insulin levels in diabetic mice of one week of daily dose administration of the tested drugs individually as well as the combination of insulin with each prokinetic drug.The other five sets of experiments were carried out to investigate the acute effect of a single dose of each drug individually and in combination on blood glucose and serum insulin levels,SIT,GE,oral xylose absorption and glucose tolerance tests.RESULTS:The study included the prokinetic drugs metoclopramide(20 mg/kg),domperidone(20 mg/kg) and erythromycin(6 mg/kg),as well as insulin(2 IU/kg),which was individually effective in decreasing SIT,enhancing GE and increasing xylose absorption significantly in diabetic mice.Erythromycin tended to decrease blood glucose level and increase serum insulin level after 1 wk of daily administration in diabetic mice.Erythromycin potentiated the effect of insulin on blood glucose level and serum insulin level whereas other prokinetic agents failed to do so after repeated dose administration in diabetic mice.Metoclopramide or erythromycin in combination with insulin significantly decreased SIT,in diabetic mice,to lower levels than with insulin alone.Administration of prokinetic drugs along with insulin antagonized the action of insulin on xylose absorption.These combinations also increased the rate of glucose absorption from the gut.CONCLUSION:The present study suggests that prokinetic drugs could potentially improve glycemic control in diabetic gastroparesis by allowing a more predictable absorption of nutrients,matched to the action of exogenous insulin.The use of prokinetics,such as erythromycin,may be interesting in the clinic in decreasing the need for insulin in diabetic patients.The dose of insulin may be safely decreased with erythromycin in chronic treatments. | Mohamed A Fouad Shalaby Hekma A Abd El Latif Mostafa E El Sayed | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，2： | 3 |
| 2 | Antiheart antibodies following open heart surgery:incidence and correlation with postpericardiotomy syndrome 显示文摘 | Akl E S Latif N Dunn M J | 1992 | Eur J Cardiothorac Surg1992，6，9： | 1 |
| 3 | A generalized temporal role based access control model显示文摘 | Joshi J B D Bertino E Latif U | 2005 | IEEE Trans on Knowledge and Data Engineering2005，17，1： | 1 |
| 4 | Quantitative myocardial eytokine expression and activation of the apoptotic pathway in patients who require left ventricular assist devices显示文摘 | Birks E J Latif N Owen V | 2001 | Circulation2001，1，1： | 1 |
| 5 | A Generalized Temporal Role-Based Access Control Model 显示文摘 | JOSHI J B D BERTINO E LATIF U | 2005 | IEEE Trans on Knowledge and Data Engineering2005，17，1： | 1 |
| 6 | A generalized temporal role-based access control model显示文摘 | Joshi J B D Bertino E Latif U | 2005 | IEEE Transactions on Knowledge and Data Engineering2005，17，1： | 1 |
| 7 | A Generalized Tempo-ral Role-based Access Control Model显示文摘 | Joshi J B D Bertino E Latif U | 2005 | IEEE Transactions on Knowledge and Data Engineering2005，7，1： | 1 |
| 8 | Reconstructing, monitoring, and predicting multidecadal-scale changes in the north Atlantic thermohaline circulation with sea surface temperature 显示文摘 | LATIF M ROECKNER E BOTZET M | 2004 | Climate2004，17，： | 1 |
| 9 | A Generalized Temporal Role-based Access Control Model显示文摘 | Joshi J B D Bertino E Latif U | 2005 | IEEE Transactions on Knowledge and Data Engineering2005，17，1： | 1 |
| 10 | Phyllodes tumor of the prostate: a rare condition requiring careful surveillance显示文摘 | Latif Z Clark D Nairn E R | 2003 | J Urol2003，170，： | 1 |
| 11 | A generalized temporal role-based access control model显示文摘 | JOSHI J B D BERTINO E LATIF U | 2005 | IEEE Transactions on Knowledge and Data Engineering2005，17，1： | 1 |
| 12 | Effects of graphite on the corrosion behavior of aluminum-graphite composite in sodium chloride solutions显示文摘 | Sherif E M Almajid A A Latif F H | 2011 | Inter J Electrochem Sci2011，，06： | 1 |
| 13 | Comparison of propofol-Lipuro with propofol mixed with lidocaine 10 mg on propofol injection pain显示文摘 | Am E Abdul - Latif McCluskey A | 2004 | Anaesthesia2004，59，12： | 1 |
| 14 | Novel 2,4-dianilino- 5-fluoropyrimidine derivatives possessing ALK inhibitory activities 显示文摘 | YUN J I YANG E H LATIF M | 2014 | Arch Pharm Res2014，37，7： | 1 |
| 15 | A generalized temporal role-based access control model 显示文摘 | Joshi J B D Bertino E Latif U el al | 2005 | IEEE Transactions on Knowledge and Data Engineering2005，17，1： | 1 |
| 16 | ,QuE/ntitative myocardial cytokine expression and activation of the apoptotic pathway in patients who require left ventricular assist devices显示文摘 | Birks E J Latif N Owen V | 2001 | Circulation2001，104，121： | 1 |
| 17 | Efficacy of subcutaneous insulin lispro versus continuous intravenous regular insulin for the treatment of patients with diabetic ketoaeidosis 显示文摘 | UMPIRREZ G E LATIF K STOEVER J | 2004 | Am J Med2004，117，5： | 1 |
| 18 | A generalized temporal role-based access control model显示文摘 | Joshi E Bertino U Latif | 2005 | IEEE Transactions on Knowledge and Data Engineering2005，17，1： | 1 |
| 19 | Reconstructing, monitoring, and predicting multidecadal-scale changes in the North Atlantic thermohaline circulation with sea surface temperature 显示文摘 | LATIF M ROECKNER E BOTZET M | 2004 | Journal of Climate2004，17，： | 1 |
| 20 | A Generalized Temporal Role-Based Access Control Model 显示文摘 | JOSHI J B D BERTINO E LATIF U | 2005 | IEEE Trans on Knowledge and Data Engineering2005，17，1： | 1 |
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