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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 3 | Acute hemodynamic effects of biventricular DDD pacing in patients with end stage heart failure 显示文摘 | LECLERCG C CAZEAU L LE B H | 1998 | J Am Coil Cardiol1998，32，： | 1 |
| 4 | Signaling and endocytosis: a team effort for cell migration显示文摘 | Le Roy C Wrana J L | 2005 | Dev Cell2005，9，2： | 1 |
| 5 | A hybrid intelligent system for predicting bank holding structures显示文摘 | R R Hashemi L A Le Blanc C T Rucks | 1998 | European Journal of Operational Research1998，109，： | 1 |
| 6 | Potential impacts of clean air regulations on system operations显示文摘 | Le K D Golden J L Stansberry C J | 1995 | IEEE Transactions on Power Systems1995，，： | 1 |
| 7 | The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration 显示文摘 | Le MAITRE C L FREEMONT A J HOYLAND J A | 2005 | Arthritis Res Ther2005，7，4： | 1 |
| 8 | Flavonoid intake and cognitive decline over a 10-year period显示文摘 | LETENNEUR L PROUST-LIMA C LE GOUGE A | 2007 | American Journal of Epidemiology2007，165，12： | 1 |
| 9 | Self-repelling snakes for topology-preserving segmentation models显示文摘 | Le GUYADER C VESE L A | 2008 | IEEE Transactions on Image Processing2008，17，5： | 1 |
| 10 | Cloning and expression of five heat shock protein genes in relation to cold hardening and development in the leafminer, Liriomyza sativa 显示文摘 | Huang L H Wang C Z Le K | 2009 | Journal of lnsect Physiology2009，55，： | 1 |
| 11 | The laser welding technique applied to the non precious dental alloys procedure and results显示文摘 | Bertrand C Le Petitcorps Y Albingre L | 2001 | Br Dent J2001，190，5： | 1 |
| 12 | Capacity of myeloid and plasmacytoid dendritic cells especially at mature stage to express and secrete HLA - G molecules 显示文摘 | Le Friec G Gins F Sebti Y Guilloux V Panganlt C Fauchet R Amiot L | 2004 | J Leukoc Biol2004，76，6： | 1 |
| 13 | Detection of HLA - G in serum and graft biopsy associated with fewer acute rejections following combined liver-kidney transplantation: possible implications for monitoring patients 显示文摘 | Creput C Le Friec G Bahri R Amiot L Charpentier B Carosella E Rouas - Freiss N Durrbach A | 2003 | Hum Immunol2003，64，11： | 1 |
| 14 | BMP-2 sig-naling in ovarian cancer and its association with poor prognosis显示文摘 | Le Page C Puiffe M L Meunier L | 2009 | J Ovarian Res2009，2，： | 1 |
| 15 | Klf4 transcription factor is expressed in the cytoplasm of prostate cancer cells显示文摘 | Le Magnen C Bubendorf L Ruiz C | 2013 | Eur J Cancer2013，49，4： | 1 |
| 16 | DDT-induced oxidative damage in human blood mononuclear cells 显示文摘 | Pérez-Maldonado IN Herrera C Batres LE González-Amaro R Díaz-Barriga F Yá?ez L | 2005 | Environ Res2005，98，2： | 1 |
| 17 | Factors influencing long term modification of the irradiated skin thickness in patients conservatively treated for breast carcinoma 显示文摘 | Le Floch O Gonzague L Feil-Bastid C | 1998 | Radiother Oncol1998，48，1： | 1 |
| 18 | Psychologic morbidities prior to loop electrosurgical excision procecdure in the treatment of cervical in- traepithelial neoplasis 显示文摘 | Le T Hopkins L Menard C | 2006 | Int J Gynecol Cancer2006，16，3： | 1 |
| 19 | Pooled analysis of the CYP1A1 Exon 7 polymorphism and lung cancer (United States)显示文摘 | Le Marchand L Guo C Benhamou S | 2003 | Cancer Causes and Control2003，14，4： | 1 |
| 20 | Volatile components of dry-cured ham 显示文摘 | BERDAGUAE J L DENOYER C LE Q J L | 1991 | Journal of Agricultural and Food Chemistry1991，39，7： | 1 |
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