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| 1 | Usefulness of serum des-γ-carboxy prothrombin in detection of hepatocellular carcinoma显示文摘AIM: To evaluate whether DCP is better than AFP for differentiating HCC from nonmalignant liver disease and further evaluate the usefulness of DCP in early diagnosis of small HCC.METHODS: Serum DCP and AFP levels were determined in 127 patients. Among these patients, 32 were with noncirrhotic chronic hepatitis, 34 were with compensated cirrhosis, and 61 were with HCC. The cut-off value for the DCP and AFP were set as 40 mAU/mL and 20 ng/mL,respectively. To compare the diagnostic value of DCP and AFP in distinguishing HCC from nonmalignant chronic liver disease, receiver operating characteristic (ROC) curves were constructed for each assay.RESULTS: The accuracy, sensitivity, and specificity of DCP were higher than AFP in detecting HCC (81.9%, 77%,and 86.4% vs 68.5%, 59%, and 77.3%, respectively).The area under the ROC (AUROC) curves revealed that DCP had a better accuracy than AFP in diagnosis of HCC (0.85 [95%CT, 0.78-0.91] vs 0.73 [95%CI, 0.65-0.81],P = 0.013). In 39 patients with solitary HCC, the positive rates of DCP were 100% in patients with tumor size larger than 3 cm, 66.7% in patients with tumor size 2-3 cm and50% in patients with tumor size less than 2 cm. The positive rates of AFP in patients with tumor size larger than 3 cm, 2-3 cm and less than 2 cm were 55.6%, 50%,and 33.3%, respectively. The median level of DCP in HCC patients with tumor size larger than 3 cm was significantly higher than those with tumor size 2-3 cm and those with the size of less than 2 cm.CONCLUSION: Our study indicates that DCP has a better diagnostic value than AFP in differentiating HCC from nonmalignant chronic liver disease. DCP has not only a stronger correlation with HCC than AFP in tumor size but also more effectiveness than AFP in detecting small size of HCC. | Chaur-Shine Wang Chin-Lin Lin Hsi-Chang Lee Kuan-Yang Chen Ming-Feng Chiang Hung-Sheng Chen Tsung-Jung Lin | 2005 | World Journal of Gastroenterology2005，11，39： | 18 |
| 2 | Osthole treatment ameliorates Th2-mediated allergic asthma and exerts immunomodulatory effects on dendritic cell maturation and function显示文摘Osthole,an active component of Chinese herbal medicines,reportedly possesses various pharmacological properties and has potential therapeutic applications.This study explored the anti-allergic effects of osthole in asthmatic mice and investigated the immunomodulatory actions of osthole on dendritic cells(DCs)and T cells.Herein,we show that oral administration of osthole to BALB/c mice after ovalbumin(OVA)sensitization ameliorated all of the cardinal features of T helper 2(Th2)-mediated allergic asthma;namely,the production of OVA-specific immunoglobulin E,airway hyperresponsiveness,airway inflammation and the production of Th2-type cytokines including interleukin(IL)-4,IL-5 and IL-13.Surprisingly,IL-10 production was not inhibited and was even enhanced by osthole treatment.We observed a significant increase in the percentages of IL-10-producing DCs and forkhead box P3-positive regulatory T(Treg)cells in osthole-treated asthmatic mice.Additionally,in vitro analyses revealed that osthole-treated bone-marrow-derived DCs had a partial maturation phenotype,secreting large amounts of IL-10 and low levels of proinflammatory cytokines,such as IL-12,IL-6 and tumor necrosis factor-α,and displaying reduced levels of MHC class II surface molecules.These DCs displayed immunosuppressive capacity by directly inhibiting effector T-cell responses or inducing Treg cells.In addition,osthole directly inhibited the activated CD4+T-cell proliferation and Th1/Th2-type cytokine production in this system.Collectively,these results suggest that DCs and T cells are potential target cells responsible for the action of osthole against allergic asthma. | Chen-Yuan Chiang Chen-Chen Lee Chia-Kwung Fan Huei-Mei Huang Bor-Luen Chiang Yueh-Lun Lee | 2017 | Cellular & Molecular Immunology2017，14，11： | 15 |
| 3 | Peliosis hepatis complicated by portal hypertension following renal transplantation显示文摘Peliosis hepatis(PH)is a vascular lesion of the liver that mimics a hepatic tumor.PH is often associated with underlying conditions,such as chronic infection and tumor malignancies,or with the use of anabolic steroids,immunosuppressive drugs,and oral contraceptives.Most patients with PH are asymptomatic,but some present with abdominal distension and pain.In some cases,PH may induce intraperitoneal hemorrhage and portal hypertension.This study analyzed a 46-year-old male who received a transplanted kidney nine years prior and had undergone long-term immunosuppressive therapy following the renal transplantation.The patient experienced progressive abdominal distention and pain in the six months prior to this study.Initially,imaging studies revealed multiple liver tumor-like abnormalities,which were determined to be PH by pathological analysis.Because the hepatic lesions were progressively enlarged,the patient suffered from complications related to portal hypertension,such as intense ascites and esophageal varices bleeding.Although the patient was scheduled to undergo liver transplantation,he suffered hepatic failure and died prior to availability of a donor organ. | Chia-Ying Yu Liang-Che Chang Li-Wei Chen Tsung-Shih Lee Rong-Nan Chien Ming-Fang Hsieh Kun-Chun Chiang | 2014 | World Journal of Gastroenterology2014，20，9： | 11 |
| 4 | Ursolic acid: An overview on its cytotoxic activities against breast and colorectal cancer cells显示文摘Ursolic acid(UA) is a pentacyclic triterpene of the ursane type. As a common chemical constituent among species of the family Lamiaceae, UA possesses a broad spectrum of pharmacological properties. This overview focuses on the anticancer properties of UA against breast cancer(BC) and colorectal cancer(CRC)that are most common among women and men, respectively. In vitro studies have shown that UA inhibited the growth of BC and CRC cell lines through various molecular targets and signaling pathways.There are several in vivo studies on the cytotoxic activity of UA against BC and CRC. UA also inhibits the growth of other types of cancer. Studies on structural modifications of UA have shown that the –OH groups at C3 and at C28 are critical factors influencing the cytotoxic activity of UA and its derivatives.Some needs for future research are suggested. Sources of information were from ScienceDirect, Google Scholar and PubMed. | Eric Wei Chiang Chan Chu Yong Soon Joash Ban Lee Tan Siu Kuin Wong Yew Woh Hui | 2019 | Journal of Integrative Medicine2019，17，3： | 11 |
| 5 | Lower serum folate is associated with development and invasiveness of gastric cancer显示文摘AIM: To evaluate the associations of serum folate levelwith development, invasiveness and patient survival of gastric cancer. METHODS: In this nested case-control study, patients with newly diagnosed gastric cancer undergoing gastrectomy were enrolled, and patients receiving chemotherapy prior to surgery, with other concurrent malignancy, or of the aboriginal and alien populations were excluded. In total, 155 gastric cancer patients and 149 healthy controls were enrolled for determination of serum folate levels and their correlation with gastric cancer. Using the median value of serum folate computed among the overall population as the cutoff value, the associations between serum folate and gastric cancer in all cases and different age and gender subgroups were analyzed by multivariate logistic regression analysis. In the patient cohort of gastric cancer, receiver-operating characteristic analyses were performed to calculate the best cutoff values of serum folate, and the associations between serum folate levels and clinicopathological features were further analyzed by multivariate regression analysis. Survival analyses were conducted using the Cox proportional hazards model.RESULTS: The mean serum folate level was significantly lower in gastric cancer patients than that in controls(3.71 ± 0.30 ng/mL vs 8.00 ± 0.54 ng/mL, P < 0.01), and folate levels were consistently lower in gastric cancer patients regardless of age and gender(all P < 0.01). Using the median serum folate value as the cutoff value, low serum folate was significantly associated with gastric cancer risk in the whole population(OR = 19.77, 95%CI: 10.54-37.06, P < 0.001) and all strata(age < 60 years OR = 17.39, 95%CI: 7.28-41.54, age ≥ 60 years(OR = 21.67, 95%CI: 8.27-56.80), males(OR = 17.95, 95%CI: 7.93-40.62), and females(OR = 20.95, 95%CI: 7.66-57.31); all P < 0.001. In the patient cohort of gastric cancer, the respective cutoff values showed that low serum folate levels were significantly associated with serosal invasion(OR = 2.54, 95%CI: 1.23-5.23), lymphatic invasion(OR = 2.23, 95%CI: 1.17-4.26), and liver metastasis(OR =6.67, 95%CI: 1.28-34.91) of gastric cancer(all P < 0.05). Serum folate level below 1.90 ng/mL was associated with poor patient survival(HR = 1.84, 95%CI: 1.04-3.27, P < 0.05) in univariate analysis.CONCLUSION: Lower serum folate levels were significantly associated with gastric cancer development and invasive phenotypes. The role of folate depletion in gastric cancer invasion warrants further study. | Teng-Yu Lee En-Pei Chiang Yin-Ting Shih Hsien-Yuan Lane Jaw-Town Lin Chun-Ying Wu | 2014 | World Journal of Gastroenterology2014，20，32： | 9 |
| 6 | Arsenic trioxide alleviates airway hyperresponsiveness and eosinophilia in a murine model of asthma显示文摘Asthma is one of the most common chronic airway inflammatory diseases.The clinical hallmarks of asthma include elevated serum levels of immunoglobulin E(IgE),eosinophilic inflammation and airway hyper-responsiveness(AHR).Arsenic trioxide(As2O3)is considered a carcinogen;however,it has also been used to treat diseases,such as syphilis,in traditional Chinese and Western medicine.Today,As2O3 is used as one of the standard therapies for acute promyelocytic leukemia(APL).Previous studies have indicated that As2O3 can induce apoptosis in eosinophils.However,the effect of As2O3 on asthma has not been investigated.We used ovalbumin(OVA)-immunized mice as a model for asthma and treated mice with As2O3 at doses of 2.5 and 5 mg/kg.The mice were then monitored for OVA-specific IgE production,airway inflammatory cell infiltration and AHR.We found that administration of As2O3 in OVA-immunized mice abrogated airway eosinophil recruitment by downregulating eotaxin expression but did not alter serum IgE or IL-5 levels in bronchoalveolar lavage fluid(BALF).Furthermore,the development of AHR and cellular infiltration into the airway were reduced by treating mice with As2O3.In vitro data suggested that low concentrations of As2O3 could induce only a small degree of apoptosis in primary pulmonary cells but could significantly inhibit the secretion of eotaxin by these cells.These results indicate that the administration of As2O3 to OVA-immunized mice can suppress lung allergic inflammatory responses.As2O3 might therefore have therapeutic potential in treating allergic airway inflammatory diseases. | Kuan-Hua Chu Chen-Chen Lee Shao-Chi Hsin Bao-Chang Cai Jin-Hong Wang Bor-Luen Chiang | 2010 | Cellular & Molecular Immunology2010，7，5： | 7 |
| 7 | Primary squamous cell carcinoma of the liver:A successful surgically treated case显示文摘Primary squamous cell carcinoma (SCC) of the liveris rare. Totally nine such cases have been reportedin the literature. Primary SCC of the liver has beenreported to be associated with hepatic teratoma,hepatic cyst, or hepatolithiasis. Complete remission ofpoorly differentiated SCC of the liver could be achievedby systemic chemotherapy followed by surgery orremarkably respond to hepatic arterial injection of lowdose chemotherapeutic drugs. Here we report the fi rstcase of primary SCC of the liver presenting as a solidtumor and receiving successful hepatic resection with9-mo disease free survival. | Hsiang-Lin Lee Yu-Yin Liu Chun-Nan Yeh Kun-Chun Chiang Tse-Ching Chen Yi-Yin Jan | 2006 | World Journal of Gastroenterology2006，12，33： | 6 |
| 8 | Prognostic analysis of patients with pancreatic head adenocarcinoma less than 2cm undergoing resection显示文摘AIM:To investigate the differences in clinicopathological features between patients with pancreatic cancer greater or less than 2 cm situated over the pancreatic head and the prognostic factors for survival of patients with pancreatic cancer<2 cm over the pancreatic head. METHODS:From 1983 to 2006,159 patients with histologically proven pancreatic adenocarcinoma(PAC) at the pancreatic head undergoing curative resection at the Department of Surgery,Chang Gung Memorial Hospital,Taipei,Taiwan were reviewed,comprising 123 cases of large(L)-PAC(tumor>2 cm)and 36 cases of small(S)-PAC(tumor≤2 cm).We compared the clinicopathological characteristics and prognosis of L-PAC and S-PAC patients.The clinicopathological characteristics of S-PAC were investigated to clarify the prognosis predictive factors of S-PAC. RESULTS:One hundred and fifty-nine PAC patients, aged 16-93 years(median,59.0 years)with a tumor at the pancreatic head undergoing intentional curative resection were investigated.The S-PAC and L-PAC patients had similar demographic data,clinical features,and tumor markers(a similar positive rate of carcinoembryonic antigen and carbohy- drate antigen 19-9).There were also similar rates of lymph node metastasis,portal vein invasion,stage distribution,tumor differentiation,positive resection margin,surgical morbidity and mortality observedbetween the two groups.During a follow-up period ranging from 1.0 to 122.7 mo(median,10.9 mo), S-PAC and L-PAC patients had a similar prognosis after resection(P=0.4805).Among the S-PAC patients group,patients with higher albumin level(>3.5 g/dL) had more favorable survival than those with lower albumin levels,which was the only favorable predictive prognostic factor.Meanwhile,early-staged(stageⅠ,Ⅱ) S-PAC patients tended to have a more favorable outcome than late-stage(stageⅢ,Ⅳ)S-PAC patients, but this was not statistically significant. CONCLUSION:S-PAC patients should not be regarded as early PAC.Only higher albumin level(>3.5 g/dL) and early stage disease(stageⅠ,Ⅱ)were the favorable prognosis factors for S-PAC patients. | Kun-Chun Chiang Chun-Nan Yeh Wei-Chen Lee Yi-Yin Jan Tsann-Long Hwang | 2009 | World Journal of Gastroenterology2009，15，34： | 6 |
| 9 | Rolling route for refining grains of super light Mg-Li alloys containing Sc and Be显示文摘Pioneering work on Sc or/and Be added Mg-Li alloys with refined grains was initiated.Various rolling-based thermo-mechanical treatments on these Mg-Li alloys were carried out.Four Mg-Li alloys were prepared by vacuum melting process.A unique route for producing fine grains was applied which concluded solution treatment at 350°C,cold rolling with 60% thickness reduction and 250°C annealing,successively. | CHIANG Chih-Te LEE Shyong | 2010 | Transactions of Nonferrous Metals Society of China2010，20，8： | 5 |
| 10 | Rotablation in the treatment of high-risk patients with heavily calcified left-main coronary lesions显示文摘Objective Heavily calcified left-main coronary diseases (LMCA) remain a formidable challenge for percutaneous interventions (PCI). This study was to investigate the safety and efficacy of using rotational atherectomy (RA) in treating such lesions in actual practice. Methods From February 2004 to March 2012, all consecutive patients who received RA for heavily-calcified LMCA lesions in our cath lab were en-rolled. The relevant clinical and angiographic characteristics at the time of index PCI, as well as the clinical follow-up outcomes, were re-trieved and analyzed. Results A total of 34 consecutive patients were recruited with a mean age 77.2 ± 10.2 years. There were 82.4%pre-sented with acute coronary syndrome and 11.8%with cardiogenic shock. Chronic renal disease and diabetes were seen in 64.7%and 52.9%, respectively. Triple-vessel coronary disease was found in 76.5%of them. The mean SYNTAX score was 50 ± 15 and EuroSCORE II scale 5.6 ± 4.8. The angiographic success rate was 100%with a procedural success rate of 91.2%. The mean number of burrs per patient was 1.7 ± 0.5. Crossing-over stenting was used in 64.7%. Most stents were drug-eluting (67.6%). Intra-aortic ballon pump was used in 20.6%of the procedures. Three patients died during hospitalization, all due to presenting cardiogenic shock. No major complication occurred. Among 31 hospital survivors, the major adverse cardiac events (MACE) rate was 16.1%, all due to target lesion revascularization or target vessel revas-cularization. Conclusions In high-surgical-risk elderly patients, plaque modification with RA in PCI of heavily-calcified LMCA could be safely accomplished with a minimal complication rate and low out-of-hospital MACE. | Meng-Hsiu Chiang Hung-Tao Yi Cheng-Rong Tsao Wei-Chun Chang Chieh-Shou Su Tsun-Jui Liu Kae-Woei Liang Chih-Tai Ting Wen-Lieng Lee | 2013 | Journal of Geriatric Cardiology2013，10，3： | 4 |
| 11 | A new prognostic model for hepatocellular carcinoma based on total tumor volume: The Taipei Integrated Scoring system显示文摘 | Chia-Yang Hsu Yi-Hsiang Huang Cheng-Yuan Hsia Chien-Wei Su Han-Chieh Lin Che-Chuan Loong Yi-You Chiou Jen-Huey Chiang Pui-Ching Lee Teh-Ia Huo Shou-Dong Lee | 2010 | Journal of Hepatology2010，，1： | 3 |
| 12 | Clinical approach to incidental pancreatic cysts显示文摘The approach to incidentally noted pancreatic cysts is constantly evolving. While surgical resection is indicated for malignant or higher risk cysts, correctly identifying these highest risk pancreatic cystic lesions remains difficult. Using parameters including cyst size, presence of solid components, and pancreatic duct involvement, the 2012 International Association of Pancreatology(IAP) and the 2015 American Gastroenterological Association(AGA) guidelines have sought to identify the higher risk patients who would benefit from further evaluation using endoscopic ultrasound(EUS). Not only can EUS help further assess the presence of solid component and nodules, but also fine needle aspiration of cyst fluid aids in diagnosis by obtaining cellular, molecular, and genetic data. The impact of new endoscopic innovations with novel methods of direct visualization including confocal endomicroscopy require further validation. This review also highlights the differences between the 2012 IAP and 2015 AGA guidelines, which include the thresholds for sending patients for EUS and surgery and methods, interval, and duration of surveillance for unresected cysts. | Austin L Chiang Linda S Lee | 2016 | World Journal of Gastroenterology2016，22，3： | 3 |
| 13 | The impact of the COVID‑19 outbreak on Chinese‑listed tourism stocks显示文摘This research explored the effects of the coronavirus disease(COVID-19)outbreak on stock price movements of China’s tourism industry by using an event study method.The results showed that the crisis negatively impacted tourism sector stocks.Further quantile regression analyses supported the non-linear relationship between the government’s responses and stock returns.The results present that the resurgence of the virus in Beijing did bring about a short-term negative impact on the tourism industry.The empirical results can be used for future researchers to conduct a comparative study of cultural differences concerning government responses to the COVID-19. | Wenmin Wu Chien‑Chiang Lee Wenwu Xing Shan‑Ju Ho | 2021 | Financial Innovation2021，7，1： | 3 |
| 14 | Advanced gastrointestinal stromal tumor patients with complete response after treatment with imatinib mesylate显示文摘瞄准:大多数胃肠的基质肿瘤(大意) 快车组成地激活工具包激酶或导出血小板的生长因素受体高山的变异的 isoforms 哈(PDGFRA ) ,它是为 imatinib mesylate (Glivec ) 的潜在的治疗学的目标。部分反应发生在与 Glivec 对待的几乎三分之二个大意病人。然而,在 Glivec 治疗以后的完全的反应(CR ) 偶发地被报导。这里,我们在 Glivec 治疗以后与 CR 说明了先进大意病人。方法:在 2001 年 1 月和 2005 年 6 月之间, 42 个先进大意病人与 Glivec 被对待。病人们被管理在 100-mg 囊的 Glivec 的 400 mg,每天与食物口头上地拿。到 Glivec 的肿瘤的反应此后在一个月,三个月,和每三个月以后被评估或每当医药需要被显示时。病人的每个肿瘤为工具包或 PDGFRA 的变化被调查。结果:与 Glivec 对待的 42 个先进大意病人的中部的后续时间是 16.9 个月(范围, 1.0-47.0 月) 。总的来说,有的 3 个病人完成反应 CR (7.1%) , 26 部分反应(67.8%) , 5 静止疾病(11.9%) ,和 3 进步疾病(11.9%) 。为三个病人的 Glivec 管理的中部的持续时间是 36 个月(范围, 23-36 月) 。在 Glivec 治疗以后的 CR 的中部的时间是 20 个月(范围, 9-26 月) 。11 上的 c 工具包前的删除和插入变化和 9 上的 c 工具包前的插入变化分别地在二种情况和一个案例中被发现。结论:完全的反应(CR ) 能在与 Glivec 对待的选择先进大意病人被完成。在 Glivec 治疗以后的 CR 的中部的时间是 20 个月。11 上的工具包前的删除和插入变化和 9 上的工具包前的插入变化在这些选择盒子中贡献基因特征。 | Kun-Chun Chiang Tsung-Wen Chen Chun-Nan Yeh Hsiang-Lin Lee | 2006 | World Journal of Gastroenterology2006，12，13： | 3 |
| 15 | 甲状腺术中喉返神经监测技术的标准化显示文摘目的在甲状腺手术中缺少术中神经监测(intra operative neuromonitoring,IONM)的标准化操作可导致结果变异性强,这些结果可产生错误信息并增加喉返神经损伤的危险性。因此有必要进行IONM操作的标准化。方法本研究共招募了289例进行过甲状腺切除术的患者(435根神经有危险),均由一位外科医师实施手术。每例患者均由同一位麻醉师使用EMG气管导管进行插管。每例患者均进行标准化IONM操作。该操作包括术前和术后对声带运动进行录像监测、保证电极在正确位置、喉返神经剥离前后刺激迷走神经并记录EMG信号,并摄像记录暴露的喉返神经。结果5例患者出现IONM波形异常,是由于电极错位所致,这一问题被立刻监测到。监测到1例患者在手术较早阶段出现非喉返神经损伤。甲状腺剥离时18例患者的神经失去了EMG信号,使用我们的标准化IONM操作后神经损伤的原因得以清楚阐明。结论标准化IONM操作不仅在消除错误的IONM结果方面有用且有帮助,而且有助于阐明喉返神经损伤的机制。在确定外科手术的缺陷并提高外科手术技巧后,本研究显著降低了神经麻痹的发生率。 | Chiang FY Lee KW | 2011 | 中国医学文摘(耳鼻咽喉科学)2011，26，1： | 3 |
| 16 | Five-year sequential changes in secondary antibiotic resistance of Helicobacter pylori in Taiwan显示文摘AIM: To determine changes in the antibiotic resistance of Helicobacter pylori(H. pylori) in southern Taiwan after failure of first-line standard triple therapy.METHODS: We analyzed 137 H. pylori-infected isolates from patients who experienced eradication failure after standard first-line triple therapy from January2010 to December 2014. The H. pylori strains were tested for susceptibility to amoxicillin, clarithromycin,levofloxacin, metronidazole and tetracycline using the E-test method. The minimal inhibitory concentration(MIC) was determined by the agar dilution test.MIC values of ≥ 0.5, ≥ 1, ≥ 1, ≥ 4 and ≥ 8 mg/L were considered to be the resistance breakpoints for amoxicillin, clarithromycin, levofloxacin, tetracycline and metronidazole, respectively.RESULTS: A high resistance rate was found for clarithromycin(65%-75%) and metronidazole(30%-40%)among patients who failed first-line standard therapy.The resistance levels to amoxicillin and tetracycline remained very low; however, levofloxacin resistance was as high as 37.5% in 2010 but did not increase any further during the past 5 years. The rates of resistance to these antibiotics did not show a statistically significant upward or downward trend.CONCLUSION: Antibiotic resistance of H. pylori remains a problem for the effective eradication of this pathogen and its associated diseases in Taiwan. High clarithromycin resistance indicated that this antibiotic should not be prescribed as a second-line H. pylori eradication therapy. Moreover, levofloxacin-based second-line therapy should be used cautiously, and the local resistance rates should be carefully monitored. | I-Ting Wu Seng-Kee Chuah Chen-Hsiang Lee Chih-Ming Liang Lung-Sheng Lu Yuan-Hung Kuo Yi-Hao Yen Ming-Luen Hu Yeh-Pin Chou Shih-Cheng Yang Chung-Mou Kuo Chung-Huang Kuo Chun-Chih Chien Yu-Shao Chiang Shue-Shian Chiou Tsung-Hui Hu Wei-Chen Tai | 2015 | World Journal of Gastroenterology2015，21，37： | 3 |
| 17 | Low-power laser irradiation inhibits arecoline-induced fibrosis:an in vitro study显示文摘Oral submucous fibrosis(OSF) is a potentially malignant disorder that is characterized by a progressive fibrosis in the oral submucosa. Arecoline, an alkaloid compound of the areca nut, is reported to be a major aetiological factor in the development of OSF. Low-power laser irradiation(LPLI) has been reported to be beneficial in fibrosis prevention in different damaged organs.The aim of this study was to investigate the potential therapeutic effects of LPLI on arecoline-induced fibrosis. Arecolinestimulated human gingival fibroblasts(HGFs) were treated with or without LPLI. The expression levels of the fibrotic marker genes alpha-smooth muscle actin(α-SMA) and connective tissue growth factor(CTGF/CCN2) were analysed by quantitative realtime reverse transcription polymerase chain reaction(RT-PCR) and western blots. In addition, the transcriptional activity of CCN2 was further determined by a reporter assay. The results indicated that arecoline increased the messenger RNA and protein expression of CCN2 and α-SMA in HGF. Interestingly, both LPLI and forskolin, an adenylyl cyclase activator, reduced the expression of arecoline-mediated fibrotic marker genes and inhibited the transcriptional activity of CCN2. Moreover, pretreatment with SQ22536, an adenylyl cyclase inhibitor, blocked LPLI's inhibition of the expression of arecoline-mediated fibrotic marker genes. Our data suggest that LPLI may inhibit the expression of arecoline-mediated fibrotic marker genes via the c AMP signalling pathway. | Mei-Chun Yeh Ker-Kong Chen Min-Hsuan Chiang Chia-Hsin Chen Ping-Ho Chen Huey-Er Lee Yan-Hsiung Wang | 2017 | International Journal of Oral Science2017，9，1： | 2 |
| 18 | Superplastic elongation characteristic of fine grained magnesium alloy ZK60显示文摘This paper employs simple rolling process plus annealing to refine the grain size of magnesium alloy ZK60.This goal is effectively achieved,obtaining grains as fine as ~3.7 μm.Such a specimen shows an elongation of 642%,and its ultimate fracture surface exhibits intergranular separation and significant grain growth.Additionally,the effects of the specimen's geometry and tensile test axis with respect to the rolling direction on superplastic elongation is studied,which has not been done before. | LEE Shyong CHIANG Chihte LEU Jyhshyan CHEN Yunghung | 2010 | Rare Metals2010，29，4： | 2 |
| 19 | Self-Power Consumption Research with the Thermal Effects and Optical Properties of the HCRI-BIPV Window System显示文摘The building integrated photovoltaics(BIPV) application is one of the main study topics in the sustainable building field.In this paper,the high color rendering index(HCRI)-BIPV window system is developed to be used in the indoor environmental control,whose module material has appeared to be effective in improving the visible transmittance and reducing the absorption.This paper describes the performance of grid-connected HCRI-BIPV window system with 0.75 kWp capacity installed in an office building for a natural ventilation solution.The experimental results indicate that accumulative power generation of the HCRI-BIPV window system is 157.60 WKh during the 7-month experiment period.For consideration of each evaluated factors,the HCRI-BIPV window system not only offers the passive energy situation for its power loading but also improves the indoor thermal environment by natural ventilation. | Hsuan-Jui Chen Che-Ming Chiang Shin-Ku Lee | 2012 | Journal of Electronic Science and Technology2012，10，1： | 2 |
| 20 | Effects of Maternal Screening and Universal Immunization to Prevent Mother-to-Infant Transmission of HBV显示文摘 | Huey–Ling Chen Lung–Huang Lin Fu–Chang Hu Jian–Te Lee Wen–Terng Lin Yao–Jung Yang Fu–Chen Huang Shu–Fen Wu Solomon Chih–Cheng Chen Wan–Hsin Wen Chia–Hsiang Chu Yen–Hsuan Ni Hong–Yuan Hsu Pei–Lin Tsai Cheng–Lun Chiang Ming–Kwang Shyu Ping–Ing Lee Feng–Yee | 2012 | Gastroenterology2012，，4： | 2 |
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