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| 1 | Endoscopy and polyps-diagnostic and therapeutic advances in management显示文摘Despite multiple efforts aimed at early detection through screening, colon cancer remains the third leading cause of cancer-related deaths in the United States, with an estimated 51000 deaths during 2013 alone. The goal remains to identify and remove benign neoplastic polyps prior to becoming invasive cancers. Polypoid lesions of the colon vary widely from hyperplastic, hamartomatous and inflammatory to neoplastic adenomatous growths. Although these lesions are all benign, they are common, with up to one-quarter of patients over 60 years old will develop pre-malignant adenomatous polyps. Colonoscopy is the most effective screening tool to detect polyps and colon cancer, although several studies have demonstrated missed polyp rates from 6%-29%, largely due to variations in polyp size. This number can be as high as 40%, even with advanced (> 1 cm) adenomas. Other factors including sub-optimal bowel preparation, experience of the endoscopist, and patient anatomical variations all affect the detection rate. Additional challenges in decision-making exist when dealing with more advanced, and typically larger, polyps that have traditionally required formal resection. In this brief review, we will explore the recent advances in polyp detection and therapeutic options. | Scott R Steele Eric K Johnson Bradley Champagne Brad Davis Sang Lee David Rivadeneira Howard Ross Dana A Hayden Justin A Maykel | 2013 | World Journal of Gastroenterology2013，19，27： | 16 |
| 2 | Cellular response to influenza virus infection: a potential role for autophagy in CXCL10 and interferon-alpha induction显示文摘Historically,influenza pandemics have arisen from avian influenza viruses.Avian influenza viruses H5N1 and H9N2 are potential pandemic candidates.Infection of humans with the highly pathogenic avian influenza H5N1 virus is associated with a mortality in excess of 60%,which has been attributed to dysregulation of the cytokine system.Human macrophages and epithelial cells infected with some genotypes of H5N1 and H9N2 viruses express markedly elevated cytokine and chemokine levels when compared with seasonal influenza A subtype H1N1 virus.The mechanisms underlying this cytokine and chemokine hyperinduction are not fully elucidated.In the present study,we demonstrate that autophagy,a tightly regulated homeostatic process for self-digestion of unwanted cellular subcomponents,plays a role in cytokine induction.Autophagy is induced to a greater extent by H9N2/G1,in association with cytokine hyperinduction,compared with H1N1 and the novel pandemic swine-origin influenza A/H1N1 viruses.Using 3-methyladenine to inhibit autophagy and small interfering RNA to silence the autophagy gene,Atg5,we further show that autophagic responses play a role in influenza virus-induced CXCL10 and interferon-a expression in primary human blood macrophages.Our results provide new insights into the pathogenic mechanisms of avian influenza viruses. | Anna Hing-Yee Law Davy Chun-Wai Lee Kwok-Yung Yuen Malik Peiris Allan Sik-Yin Lau | 2010 | Cellular & Molecular Immunology2010，7，4： | 7 |
| 3 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | C.P Wilkinson Frederick L Ferris Ronald E Klein Paul P Lee Carl David Agardh Matthew Davis Diana Dills Anselm Kampik R Pararajasegaram Juan T Verdaguer | 2003 | Ophthalmology2003，，9： | 4 |
| 4 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | C.P Wilkinson Frederick L Ferris Ronald E Klein Paul P Lee Carl David Agardh Matthew Davis Diana Dills Anselm Kampik R Pararajasegaram Juan T Verdaguer | 2003 | Ophthalmology2003，，9： | 2 |
| 5 | Revised classification scheme of phytoplasmas based on RFL panalyses of 16S rRNA and ribosomal protein gene sequences 显示文摘 | Lee I M Gundersen R D E Davis R E et at | 1998 | Int J Syst Acteriology1998，48，： | 1 |
| 6 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | Wilkinson CP Fen'is FL Klein RE Lee PP Agardh CD Davis M | 2003 | Ophthalmology2003，110，5： | 1 |
| 7 | Universal amplification and analysis of pathogen 16S rRNA for classification and identification of mycoplasmalike organisms 显示文摘 | Lee I M Hammond R W Davis R E | 1993 | Phytopathology1993，83，8： | 1 |
| 8 | Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates显示文摘 | LEE R G WILLINGHAM M C DAVIS M A | 2000 | J Lipid Res2000，41，12： | 1 |
| 9 | Transverse response of underground cavities and pipes to incident SV waves显示文摘 | Davis C A Lee V W Bardet J P | 2001 | Earthquake Engineering and Structural Dynamics2001，30，： | 1 |
| 10 | Pleurodesis of malignant pleural effusions:current controversies and variations in practices显示文摘 | West SD Davies RJ Lee YC | 2004 | Curr Opin Pulm Med2004，10，4： | 1 |
| 11 | Prevalence, Demographics, and Treatment Characteristics of Visual Impairment due to Diabetic Macular Edema in a Representative Canadian Cohort显示文摘 | Robert J. Petrella Julie Blouin Brian Davies Martin Barbeau Andrew G. Lee | 2012 | Journal of Ophthalmology2012，，： | 1 |
| 12 | Hepatic Artery Stenosis in Liver Transplant Recipients: Primary Treatment with Percutaneous Transluminal Angioplasty显示文摘 | Wael E.A. Saad Mark G. Davies Lawrence Sahler David E. Lee Nikhil C. Patel Takashi Kitanosono Talia Sasson David L. Waldman | 2005 | Journal of Vascular and Interventional Radiology2005，，6： | 1 |
| 13 | Phytoplasma:Phtopathogenic mollicutes显示文摘 | Lee I M Davis R E Gundersen D E | 2000 | Annu Rev Microbiol2000，54，： | 1 |
| 14 | Printing via hot embossing of optical variable images in thermoplastic acrylic lacquer显示文摘 | Leech P W Lee R A Davis T J | | 0，，10： | 1 |
| 15 | Binding of fyn to MAP-2c through an SH3 Binding Domain显示文摘 | ZAMORA-LEON S P LEE G DAVIES P | 2001 | J Biolog Chem2001，276，39： | 1 |
| 16 | Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism显示文摘 | Deretic V Singh S Master S Harris J Roberts E Kyei G Davis A Haro S Naylor J Lee HH Vergne I | | Cell Microbiol0，8，5： | 1 |
| 17 | Dynamic contrast-enhanced MR imaging of the pituitary gland with fast spin-echo technique显示文摘 | Davis WL Lee JN King BD | 1994 | J Magn Reson Imaging1994，4，3： | 1 |
| 18 | Pain in chronic pancreatitis and pancreatic cancer 显示文摘 | Fasanella K E Davis B Lyons J Chen Z Lee K K Slivka A | 2007 | Gastroenterol Clin North Am2007，36，： | 1 |
| 19 | Fertilization and early embryolgoy: ATP content of human oocytes and developmental potential and outcome after in-vitro fertilization and embryo transfer 显示文摘 | Van Blerkom J Davis PW Lee J | 1995 | Hum Reprod1995，10，2： | 1 |
| 20 | Pain in Chronic Pancreatitis and Pancreatic Cancer显示文摘 | Kenneth E. Fasanella Brian Davis John Lyons Zongfu Chen Kenneth K. Lee Adam Slivka David C. Whitcomb | 2007 | Gastroenterology Clinics of North America2007，，2： | 1 |
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