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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | 直接甲烷化改进城市煤气的生产显示文摘 | Lin.,YY Lee,A | 1989 | 国外煤气1989，，1： | 2 |
| 3 | Alteration of P16ink4α and P15ink4β genes in gastric carcinomas显示文摘 | Lee YY Kang Sh Choi JY | 1997 | Cancer1997，80，14： | 1 |
| 4 | Improvement of neutralizing activity of human scFv antibodies against hepatitis B virus binding using CDR3 V (H) mutant Library显示文摘 | Park SG Jung YJ Lee YY | 2006 | Viral Immunol2006，19，1： | 1 |
| 5 | Hepatitis B virus neutralizinganti-pre-S1 human antibody fragments from large native antibody phage library显示文摘 | Park SG Jeong YJ Lee YY | 2005 | Antiviral Res2005，68，3： | 1 |
| 6 | Cellulose pretreatment in subcriticalwater:effect of temperature on molecular structure and enzymatic reactivity显示文摘 | Kumar S Gupta R Lee YY | 2010 | Bioresour Technol2010，101，4： | 1 |
| 7 | Homocysteine and C-reactive protein as useful surrogate markers for evaluating CKD risk in adults 显示文摘 | Chuang CH Lee YY Sheu BF | 2013 | Kidney Blood Press Res2013，37，4： | 1 |
| 8 | Increased plasma malondialde-hyde in patients with viral cirrhosis and its relationships to plasma nitric oxide,endotoxin,and portal pressure显示文摘 | Lee KC Yang YY Wang YW | 2010 | Dig Dis Sci2010，55，7： | 1 |
| 9 | Levels of inter- leukin-2, interferon-, and interleukin-4 in bronchoalve- olar lavage fluid from patients with mycoplasma pneumo- nia: implication of tendency toward increased immuno- globulin E production 显示文摘 | Koh YY Park Y Lee H J | 2001 | Pediatrics2001，107，3： | 1 |
| 10 | Vascular endothelial growth factor gene polymorphism and pro- tein expression in the pathogenesis of pterygium显示文摘 | Peng ML Tsai YY Tung JN Chiang CC Huang YC Lee H | 2014 | Br J Oph- thalmol2014，98，4： | 1 |
| 11 | Platelet antiaggregating activity of ginsenosides isolated from processed ginseng 显示文摘 | Lee-JG Lee YY Kim SY | 2009 | Pharmaz- ie2009，64，9： | 1 |
| 12 | Prognosis of ovarian clear cell carcinoma compared to other histological subtypes: a meta-analysis显示文摘 | Lee YY Kim TJ Kim M J | 2011 | Gynecol Oncol2011，122，3： | 1 |
| 13 | Adipogenic differentiation of adipose tissue derived adult stem cells in nude mouse 显示文摘 | Choi YS Cha SM Lee YY | 2006 | Biochem Biophys Res Commun2006，345，2： | 1 |
| 14 | Laparoendoscopic single-slte (LESS) myomectomy : characteristics of the appropriate myoma显示文摘 | Yoon A Kim T J Lee YY | 2014 | Eur J Ob- stet Gynecol Reprod Biol2014，175，： | 1 |
| 15 | The Gardenia jasminoides extract and its constituent, geniposide, elicit anti-allergic effects on atopic dermatitis by inhibiting histamine in vitro and in vivo 显示文摘 | Sung YY Lee AY Kim HK | 2014 | J Ethnopharmacol2014，156，： | 1 |
| 16 | Lipid peroxidation dysregulaion in ischemic stroke:plasma 4-HNE as a potential biomarker显示文摘 | Lee WC Wong HY Chai YY | 2012 | Biochem Biophys Res Commun2012，425，4： | 1 |
| 17 | Adiponectin induces growth arrest and apoptosis of MDA-MB-231 breast cancer cell显示文摘 | Kang JH Lee YY Yu BY | 2005 | Arch Pharm Res2005，28，11： | 1 |
| 18 | Alterations of p16INK4A and p15INK4B genes in gastric carcinomas显示文摘 | Lee YY Kang SH Seo JY | 1997 | Cancer1997，80，10： | 1 |
| 19 | Clinicopathologic efficacy of copper Bromide Plus Yellow Laser (578 nm with 511 nm) for treatment of melasma in Asian patients 显示文摘 | Lee HI Lim YY Kim BJ | 2010 | Dermatol Surg2010，36，6： | 1 |
| 20 | Prognostic value of pre- treatment circulating monocyte count in patients with cer- vical cancer:comparison with SCC-Ag level 显示文摘 | Lee YY Choi CH Sung CO | 2012 | Gynecol Oncol2012，124，1： | 1 |
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