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| 1 | 不同晶相成分及结晶态的生物活性玻璃体外降解性的研究显示文摘采用sol-gel方法合成生物活性玻璃材料,采用600℃、900℃、1100℃高温处理后,形成不同晶相成分及结晶态的三种材料SG600,SG900和SG1100。原代培养破骨细胞接种在材料表面并培养4h和48h。采用细胞化学法对破骨细胞actin进行标记,采用分光光度计测量Ca和P离子浓度,采用扫描电镜(SEM)观察破骨细胞的形态及吸收陷窝。结果显示,三种材料表面均可显示破骨细胞环状actin。SG600的钙离子浓度明显高于对照组及其他两种材料组,当破骨细胞存在时,三种材料钙磷离子浓度均比无细胞时有所增加。在三种材料表面破骨细胞均形成良好的附着与伸展,吸收陷窝的形态及深度无明显差异。说明生物活性玻璃材料由于晶相成分及结晶度的不同,在体外具有不同的溶解性。体外破骨细胞在三种材料表面均显示出明显的降解活性。 | 张玉梅 蔡玉荣 王勤涛 赵铱民 Monchau F Lefevre A Hildebrand H.F | 2005 | 生物医学工程学杂志2005，22，5： | 3 |
| 2 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 3 | 迷走神经刺激和意识水平显示文摘研究表明,植物人状态的患者皮质皮质间和丘脑-皮质间远程通路中断.自我恢复的神经特征与丘脑-皮质活动的增加和前额叶功能连接改善有关.本研究通过刺激-位植物状态患者的植物神经评估来评估丘脑-皮质刺激的作用.该案例研究报道了-名35岁的有创伤性脑损伤史的男性,他15年来-直处于植物人状态.基线评估包括行为、脑电图和18F-FDGPET记录.然后患者接受了手术植入迷走神经刺激器,刺激增加至最大强度为1.5mA. | 李建华 Corazzol M Lio G Lefevre A | 2017 | 中国康复2017，32，6： | 2 |
| 4 | The rodent uterotrophic assay critical protocol features, Studies with nonyl phenols, and comparison with a Yeast Estrogenicity Assay 显示文摘 | Odum J Lefevre P A Tittensor S | 1997 | Regulatory Toxicology and Pharmacology1997，25，： | 1 |
| 5 | Neuropathic pain depends upon d - serine co - activation of spinal NMDA eceptors in rats显示文摘 | Lefevre Y Amadio A Vincent P | 2015 | Neurosci Lett2015，603，： | 1 |
| 6 | Calculation of corona losses beyond the critical gradient in alternating voltage显示文摘 | Clade J J Gary C H Lefevre C A | 1969 | IEEE Transactions on Power Apparatus and Systems1969，88，5： | 1 |
| 7 | Order-induced strength- ening in NiMo显示文摘 | Chakravarti B Starke E A Lefevre B G | 1970 | Journal of Materials Science1970，5，5： | 1 |
| 8 | Evolution of the diameters of the largest healthy and atretie follicles during the humanmenstrual eyele显示文摘 | Gougeon A Lefevre B | 1983 | Reprod Fertil1983，69，49： | 1 |
| 9 | Biological charac-terization of experimental carbon samples 显示文摘 | Delfosse C Monchau F Lefevre A | 2002 | Bull Group Int Rech Sci Stomatol Odontol2002，44，3： | 1 |
| 10 | Pharmacokinetics of a novel transdermal rivastigmine patch for the treatment of Alzheimer's disease: a review 显示文摘 | KURZ A FARLOW M LEFEVRE G | 2009 | 3(5): 799-8052009，3，5： | 1 |
| 11 | All-single-mode fiber-optic gyroscope显示文摘 | Bergh R A Lefevre H C | 1981 | Opt Lett1981，6，4： | 1 |
| 12 | Coronary angiography through the radial or the femoral approach:The CARAFE study显示文摘 | Louvard Y Lefevre T Allain A | 2001 | Catheter Cardiovasc Interv2001，52，2： | 1 |
| 13 | Coronary angiography through the radial or the femoral approach: The CARAFE study 显示文摘 | Louvard Y Lefevre T Allain A | 2001 | Catheter Cardiovasc Interv2001，52，2： | 1 |
| 14 | Coronary angiography through the radial or the femoral approach z The CARAFE study 显示文摘 | Louvard Y Lefevre T Allain A | 2001 | Catheter Cardiovasc Interv2001，52，： | 1 |
| 15 | 查看详情显示文摘 | Lefevre G Bessiere J Walcarius A | | 0，，： | 1 |
| 16 | Structure and mechanical properties of spider silk films at the air-water interface 显示文摘 | RENAULT A RIOUX-DUBE J F LEFEVRE T | 2013 | Langmuir2013，29，25： | 1 |
| 17 | Classical swine fever: the global situation显示文摘 | Edwards S Sukusho A Lefevre P C | 2000 | Vet M icrobiol2000，73，23： | 1 |
| 18 | Peste des Petits Ruminants显示文摘 | LEFEVRE P C DIALLO A | 1990 | Rev Sci Tech1990，9，4： | 1 |
| 19 | Compensation of the optical Kerr effect in fiber-optic gyroscopes显示文摘 | Lefevre H C Shaw H J | 1982 | Optic Letters1982，7，6： | 1 |
| 20 | Three-year clinical outcome of percutaneous treatment of bifurcation lesions in multivessel coronary artery disease with the sirolimus-elutiag stem: insights from the Arterial Revaseularisation Therapies Study, partⅡ (ARTS 1] ) 显示文摘 | Routledge HC Lefevre T Colombo A | 2009 | Eurolntervention2009，5，2： | 1 |
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