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| 1 | Heme oxygenase-1 overexpression increases liver injury after bile duct ligation in rats显示文摘AIM: To investigate the effects of heme oxygenase-1 (HO-1) against oxidant-induced injury caused by bile duct ligation (BDL). METHODS: Either cobalt protoporphyrin (CoPP), a HO-1 inducer, or saline were injected intraperitoneally in male SD-rats. Three days later, BDL or sham-operations were performed. Rats were sacrificed 3 wk after BDL and livers were harvested for histology. Fibrosis was evaluated by sirius red staining and image analysis. Alpha-smooth muscular actin, which indicates activation of stellate cells, was detected by immunohistochemical staining, and cytokine and collagen-Ⅰα (Col-Ⅰα) mRNA expression was detected using RNase protection assays. RESULTS: Serum alanine transaminase increased 8-fold above normal levels one day after BDL. Surprisingly, enzyme release was not reduced in rats receiving CoPP. Liver fibrosis was evaluated 3 wk after BDL and the sirius red-positive area was found to be increased to about 7.8%. However, in CoPP pretreated rats sirius red- positive areas were increased to about 11.7% after BDL. Collagen-Ⅰα and TGF-β mRNA increased significantly by BDL. Again, this effect was increased by HO-1 overexpression.CONCLUSION: Hepatic fibrosis due to BDL is not reduced by the HO-1 inducer CoPP. In contrast, HO-1 overexpression increases liver injury in rats under conditions of experimental chronic cholestasis. | Matthias Froh Lars Conzelmann Peter Walbrun Susanne Netter Reiner Wiest Michael D Wheeler Mark Lehnert Takehiko Uesugi Jurgen Scholmerich Ronald G Thurman | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 2 | Ligand stabilized bimetallic colloids identified by HRTEM and EDX显示文摘 | SCHMID G LEHNERT A MALMJ O | 1991 | Angew Chem lnt Ed1991，30，： | 1 |
| 3 | Radiation-induced damage to DNA in drug-and radiation-resistant sublines of a human breast cancer cell line显示文摘 | Alaoui-Jamali MA Batist G Lehnert S | 1992 | Radiat Res1992，129，1： | 1 |
| 4 | Evaluation of an auto-CPAP device for treatment of obstructive sleep apnoea显示文摘 | Ficker JH Wiest GH Lehnert G | 1998 | Thorax1998，53，： | 1 |
| 5 | Long Waves and Evolutionary Chaos in a Simple Schumpeterian Model of Embodies Technical Change 显示文摘 | Silverberg G Lehnert L | 1993 | Structural Change and Economic Dynamics1993，，4： | 1 |
| 6 | Correlation between particle size,in vivo particle persistence, and lung injury 显示文摘 | Oberdoster G Ferin J Lehnert B E | 1994 | Envion - Health -Perspect1994，102，5： | 1 |
| 7 | Correlation between particle size, in vivo particle persistence, and lung injury 显示文摘 | Oberdorster G Ferin J Lehnert B E | 1994 | Environ Health Perspect1994，102，15： | 1 |
| 8 | Correlation between particle size, invivo particle persistence, and lung injury显示文摘 | Oberderster G Ferin J Lehnert B E | 1994 | Environtment Health Perspect1994，102，5： | 1 |
| 9 | The delta-aminolevulinate dehydratase polymorphism: higher blood lead levels in lead workers and environmentally exposed children with 1 - 2 and 2 - 2 isozymes 显示文摘 | Wetmur JG Lehnert G Desnick RJ | 1991 | Environ Res1991，56，： | 1 |
| 10 | Abnormalities of the ARF-p53 pathway in primary angiosarcomas of the liver显示文摘 | Weihrauch M Markwarth A Lehnert G | 2002 | Hum Pathol2002，33，： | 1 |
| 11 | Correlation between particlesize,in vivo particle persistence and lung injury显示文摘 | Oberdorster G Ferin J Lehnert B E | 1994 | Environ Health Perspect1994，102，： | 1 |
| 12 | Theδ-aminolevulinate dehydratase polymorphism:Higher bloodlead levels in lead worker sand environmentally exposed children with the 1-2and 2-2isozymes显示文摘 | Wetmur JG Lehnert G Desnick RJ | 1991 | Environ Res1991，56，： | 1 |
| 13 | Molecular fundamentals ofwound healing in diabetic foot syndrome显示文摘 | Lobmann R Schuhz G Lehnert H | | 0，，： | 1 |
| 14 | Proteases and the diabetic foot syndrome: mechanisms and therapeutic implications 显示文摘 | Lobmann R Schultz G Lehnert H | 2005 | Diabetes Care2005，28，2： | 1 |
| 15 | Polymorphism of δ -aminolevulinic acid dehydratase in lead exposed workers 显示文摘 | Ziemsen B Angerer J Lehnert G | 1986 | Int Arch Occup Environ Health1986，58，： | 1 |
| 16 | Modelling of Mass and Hetat Transport in Planar Substrate, Type SOFCs 显示文摘 | ACKMANN T DEHARRT L G L LEHNERT W | 2003 | Electrocheni Soc2003，150，： | 1 |
| 17 | Correlation between particle size, in vivo particle persistence, and lung injury 显示文摘 | Oberdorster G Ferin J Lehnert B E | 1994 | Environmental Health Perspectives1994，102，5： | 1 |
| 18 | Correlation between particle size,in vivo particle persistence, and lung injury 显示文摘 | Oberdorster G Fefin J Lehnert BE | 1994 | Environ Health Perspect1994，102，5： | 1 |
| 19 | Correlation between particle size, in vivo particle persistence, and lung injury显示文摘 | Oberdorster G Ferin J Lehnert BE | 1994 | Environ Health Perspeet1994，1025，： | 1 |
| 20 | Prognostic value of NT-pro-BNP and hs-CRP for risk stratification in primary care: results from the population-based DETECT study显示文摘 | David M. Leistner Jens Klotsche Lars Pieper Sylvia Palm Günter K. Stalla Hendrik Lehnert Sigmund Silber Winfried M?rz Hans-Ulrich Wittchen Andreas M. Zeiher | 2013 | Clinical Research in Cardiology2013，，4： | 1 |
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