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| 1 | Global secretome analysis identifies novel mediators of bone metastasis显示文摘骨头是稳固的肿瘤的远转移的一个最普通的地点。分泌蛋白质被知道影响在变形癌症房间和骨头基质之间的病理学的相互作用。为了包括地介绍,分泌了与骨头转移联系的蛋白质,我们使用了量、非量的集体 spectrometry 全球性分析改变从多重种类和癌症的变形能力打的骨头的九根细胞线的 secretomes。由比较父母房间和他们的骨头的 secretomes 变形衍生物,我们识别了特别地在这些房间线与骨头转移被联系的分泌蛋白质。我们然后合并了大临床的转移数据集的生物信息的分析获得强烈与临床、试验性的骨头转移被联系的几个功能的班的候选人小说骨头转移蛋白质的一张表。选择蛋白质的功能的确认显示在 vivo,骨头转移能被高表示支持(1 ) 唾液的 cystatins CST1, CST2,和 CST4;(2 ) plasminogen 使活跃之物小块地和 PLAU;或(3 ) 骨胶原功能蛋白质 PLOD2 和 COL6A1。总的来说,我们的学习揭开了骨头转移并且因此的几个新分泌调停人证明 secretome 分析是为新奇 biomarkers 和候选人的鉴定的一个强大的方法治疗学的目标。 | Maria Andres Blanco Gary LeRoy Zia Khan Ma a Ale kovi Barry M Zee Benjamin A Garcia Yibin Kang | 2012 | Cell Research2012，22，9： | 12 |
| 2 | Microcystic transitional cell carcinoma; a report of 2 cases arising in the renal pelvis显示文摘 | Leroy X Leteurtre E De La Taille A | 2002 | Arch Pathol Lab Med2002，126，7： | 1 |
| 3 | Ebola hemorrhagic fever outbI~aks in Gabon, 1994-1997: epidemiologic and health control issues显示文摘 | Georges A J Leroy EM Renaut AA | 1999 | J Infect Dis1999，179，1： | 1 |
| 4 | Prediction of technological and organoleptic properties of beef Longissimus thoracis from near-infrared reflectance and transmission spectra显示文摘 | B Leroy S Lambotte O Dotreppe H Lecocq L Istasse A Clinquart | 2003 | Meat Science2003，，1： | 1 |
| 5 | Intrafamilial phenotypic variability in families with RDS mutations: exclusion of ROM1 as a genetic modifier for those with retinitis pigmentosa显示文摘 | Leroy BP Kailasanathan A de Laey JJ | 2007 | Br J Ophthalmol2007，91，1： | 1 |
| 6 | The use of a fluorescent dye,Nile red,to evaluate the lipid content of single mammalian oocytes显示文摘 | Genicot G Leroy J L Soom A V | 2005 | Theriogenology2005，63，4： | 1 |
| 7 | Vesicoureteral reflux inchildren with urinary tract infection : comparison of diagnosticaccuracy of renal US criteria 显示文摘 | Leroy S Vantalon S Larakeb A | 2010 | Radiology2010，255，3： | 1 |
| 8 | Functional analysis of the subunits of the chromatin assembly factor RSF显示文摘 | Loyola A Huang JY Leroy G | 2003 | Mol Cell Biol2003，23，19： | 1 |
| 9 | Relative influence of the topography and chemistry of TiAl6V4 surfaces on osteoblastic cell behaviour 显示文摘 | Anselme K Linez P Bigerelle M Le Maguer D Le Maguer A Hardouin P Hildebrand H F Iost A Leroy J M | 2000 | Biomaterials2000，21，： | 1 |
| 10 | Long-term results of treatment for ureteroenteric strictures 显示文摘 | DiMarco D S LeRoy A J Thieling S | 2001 | 58(6):909-9132001，58，6： | 1 |
| 11 | Procalcitonin:a key marker in children with urinary tract infection显示文摘 | Leroy S Gervaix A | 2011 | Adv Lro12011，2011，39： | 1 |
| 12 | No-scar transanal total meso- rectal excision: the last step to pure NOTES for colorectal surgery 显示文摘 | Leroy J Barry BD Melani A | 2013 | JAMA Surg2013，148，23： | 1 |
| 13 | Towards the lowering of the pliocene/Pleistocene boundary to the GaussMatuyama reversal显示文摘 | Suc J P Bertini A Leroy S A | 1997 | Quaternary International1997，40，： | 1 |
| 14 | Pharmaco- kinetics of meropenem (ICI 194, 660) and its metabolite (ICI 213,689) in healthy subjects and in patients with renal impairment 显示文摘 | Leroy A Fillastre J P Borsa-Lebas F | 1992 | Antimicrob Agents Chemother1992，36，12： | 1 |
| 15 | The use of a fluorescent dye, nile red, to evaluate the lipid content of single mammalian oocytes 显示文摘 | Genicot G Leroy J L Soom A V | 2005 | Theriogenology2005，63，4： | 1 |
| 16 | Zygomycosis caused by Cunninghamella bertholletiae in a kidney transplant recipient显示文摘 | Quinio D Karam A Leroy JP | 2004 | Med Mycol2004，42，： | 1 |
| 17 | Prediction ofhigh-grade vesicoureteral reflux after pediatric urinary tractinfection: external validation study of procalcitonin-based decisionrule 显示文摘 | Leroy S Bouissou F Femandez-Lopez A | 2011 | PLoS ONE2011，6，29： | 1 |
| 18 | Human Ebola outbreak resulting from direct exposure to fruit bats in Luebo,Democratic Republic of Congo,2007显示文摘 | Leroy E M Epelboin A Mondonge V | 2009 | Vector-Borne and Zoonotic Diseases2009，9，： | 1 |
| 19 | No-scar transanal total mesorectal excision:the last step to pure NOTES for colorectal surgery显示文摘 | Leroy J Barry BD Melani A | | 0，，： | 1 |
| 20 | Diffusion of ionic species in bentonite显示文摘 | LEROY P REVIL A COELHO D | 2006 | Journal of Colloid and Interface Science2006，296，1： | 1 |
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