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| 1 | Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade显示文摘 | Clifford R Jack David S Knopman William J Jagust Leslie M Shaw Paul S Aisen Michael W Weiner Ronald C Petersen John Q Trojanowski | 2010 | Lancet Neurology2010，，1： | 4 |
| 2 | Pharmacokinetics and toxicology of therapeutic proteins:Advances and challenges显示文摘Significant progress has been made in understanding pharmacokinetics (PK),pharmacodynamics (PD),as well as toxicity profiles of therapeutic proteins in animals and humans,which have been in commercial development for more than three decades.However,in the PK arena,many fundamental questions remain to be resolved.Investigative and bioanalytical tools need to be established to improve the translation of PK data from animals to humans,and from in vitro assays to in vivo readouts,which would ultimately lead to a higher success rate in drug development.In toxicology,it is known,in general,what studies are needed to safely develop therapeutic proteins,and what studies do not provide relevant information.One of the major complicating factors in nonclinical and clinical programs for therapeutic proteins is the impact of immunogenicity.In this review,we will highlight the emerging science and technology,as well as the challenges around the pharmacokinetic-and safety-related issues in drug development of mAbs and other therapeutic proteins. | Yulia Vugmeyster Frank-Peter Theil Leslie A Khawli Michael W Leach | 2012 | World Journal of Biological Chemistry2012，3，4： | 3 |
| 3 | Exergy, power and work in the US economy, 1900–1998显示文摘 | Robert U Ayres Leslie W Ayres Benjamin Warr | 2002 | Energy2002，，3： | 2 |
| 4 | Duckling toxicity and the production of fumonisin and moniliformin by isolates in the A and F mating populations of Gibberella fujikuroi (Fusarium verticillioides) 显示文摘 | Leslie J F Marasas W F Shephard GS | 1996 | Appl Eviron Microbial1996，62，： | 1 |
| 5 | Renewable-resource Thermoplastic Elastomers Based on Poly- lactide and Polymenthide显示文摘 | Carolyn L W Leslie E O Nathaniel A L | 2007 | Biomacromolecules2007，，8： | 1 |
| 6 | Countercurrent extraction of nicotine from tobacco juice显示文摘 | Leslie D Millen C Raymond Murphy W | 1993 | Industrial and Engineering Chemistry Research1993，32，12： | 1 |
| 7 | Dynamic Light Scattering Study of Calnodulin-target Peptide Complexes 显示文摘 | ANDRIYKA L P LESLIE W T HANS J V | 2002 | Biophys J2002，83，3： | 1 |
| 8 | Hemolytic and sphingomyelinase activities of Clostridium perfringens alphatoxin are dependent on a domain homologous to that of an enzyme from the human arachidomic acid pathway 显示文摘 | Titball R W Leslie D L Harvey S | 1991 | Infect Immun1991，59，： | 1 |
| 9 | Molecular mass distribution of sodium alginate by high-liquid size-exclusion chromatography 显示文摘 | Sherry X Ci Tanya H Huynh Leslie W Louie | 1999 | Chrom A1999，864，： | 1 |
| 10 | Countercurrent extraction of nicotine from tobacco juice显示文摘 | LESLIE D MILLEN C RAYMOND M W | 1993 | Industrial & Engineering Chemistry Research1993，32，12： | 1 |
| 11 | Perceived legitimacy of decision making and academic governance pat- terns in higher education; a comparative analysis 显示文摘 | MORTIMER K P GUNNE M G LESLIE D W | 1976 | Research in Higher Education1976，，3： | 1 |
| 12 | Synthesis and cross-coupling reactions of solid-supported alkylzinc reagents 显示文摘 | Richard F W Jackson Leslie J Oales Michael H Block | 2000 | Chem Commun2000，2，： | 1 |
| 13 | A pulse system for spectrum analysis of magnetoelastic biosensors显示文摘 | SHEN W LESLIE C M VALERY A P | 2010 | Applied Physics Letters2010，96，16： | 1 |
| 14 | Calcium nephrolithiasis; effect of water hardness on urinary electrolytes 显示文摘 | Schwartz B F Schenkman N S Bruce J E Leslie S W Stoller M L | 2002 | Urology2002，60，： | 1 |
| 15 | Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study显示文摘 | Ronenn Roubenoff Helen Parise Hélène A Payette Leslie W Abad Ralph D’Agostino Paul F Jacques Peter W.F Wilson Charles A Dinarello Tamara B Harris | 2003 | The American Journal of Medicine2003，，6： | 1 |
| 16 | Ethanol inhibits NMDA-induced increases in free intracellular Ca2+ in dissociated brain cells 显示文摘 | Jo Ellen Dildy Steven W Leslie | 1989 | Brain Res1989，499，： | 1 |
| 17 | Mechanism of work hardening in hadfield manganese steel显示文摘 | Dastur Y N Leslie W C | 1981 | Metallurgical Transactions A1981，12，： | 1 |
| 18 | Cold-induced freezing tolerance in arabidopsis显示文摘 | Leslie A W Olavi J | 1999 | Plant Physiol1999，120，： | 1 |
| 19 | Production of fusaric acid by Fusarium species 显示文摘 | Bacon C Porter J Norred W Leslie J | 1996 | Appl Environ Microbiol1996，62，11： | 1 |
| 20 | The Effect of Aluminum on the Work Hardening and Wear Resistance of Hadfield Manganese Steel显示文摘 | Zuidema B K Subramanyam D K Leslie W C | 1987 | Metallurgical Transactions A1987，18，： | 1 |
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