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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Sedated vs unsedated colonoscopy:A prospective study显示文摘AIM:To compare sedated to unsedated colonoscopy in terms of duration,pain and the patient’s willingness to repeat the procedure.METHODS:Consecutive patients who underwent colonoscopies over a 2-year period were invited to participate.All patients who were to undergo our endoscopy unit were offered sedation with standard intravenous sedatives and analgesics,or an unsedated colonoscopy was attempted.Demographic details were recorded.The patient anxiety level prior to the procedure,time to reach the cecum,total discharge time,patient and endoscopist pain assessments,satisfaction after the examination and the patient’s willingness to return for the same procedure in the future were recorded.RESULTS:Among the 403 observed patients,more males were observed in the unsedated group(66.2%vs 55.2%,P=0.04).Additionally,the unsedated group patients were less anxious prior to the procedure(5.1vs 6.0,P<0.01).The colonoscopy completion rates were comparable between the 2 groups(85.9%vs84.2%,P=0.66).The time to reach the cecum was also comparable(12.2 min vs 11.8 min);however,the total discharge times were shorter in the unsedated group(20.7 min vs 83.0 min,P<0.01).Moreover,the average patient pain score(3.4 vs 5.7,P<0.01)was lower in the sedated group,while the satisfaction score(8.8 vs 7.8,P<0.01)was significantly higher.There was no significant difference,however,between the groups in terms of willingness to repeat the procedure if another was required in the future(83.3%vs 77.3%,P=0.17).CONCLUSION:Unsedated colonoscopy is feasible in willing patients.The option saves the endoscopy units up to one hour per patient and does not affect the patient willingness to return to the same physician again for additional colonoscopies if a repeated procedure is needed. | Abdulrahman M Aljebreen Majid A Almadi Felix W Leung | 2014 | World Journal of Gastroenterology2014，20，17： | 3 |
| 3 | Sedation-risk-free colonoscopy for minimizing the burden of colorectal cancer screening显示文摘Unsedated colonoscopy is available worldwide,but is not a routine option in the United States(US).We conducted a literature review supplemented by our experience and expert commentaries to provide data to support the use of unsedated colonoscopy for colorectal cancer screening.Medline data from 1966 to 2009 were searched to identify relevant articles on the subject.Data were summarized and co-authors provided critiques as well as accounts of unsedated colonoscopy for screening and surveillance.Diagnostic colonoscopy was initially dev eloped as an unsedated procedure.Procedure-re lated discomfort led to wide adoption of sedation in the US,although unsedated colonoscopy remains the usual practice elsewhere.The increased use of colonoscopy for colorectal cancer screening in healthy,asymptomatic individuals suggests a reass-essment of the burden of sedation in colonoscopy for screening is appropriate in the US for lowering costs and minimizing complications for patients.A water method developed to minimize discomfort has shown promise to enhance outcomes of unsedated colonoscopy.The use of scheduled,unsedated colono scopy in the US appears to be feasible for colorectal cancer screening.Studies to assess its applicability in diverse practice settings deserve to be conducted and supported. | Felix W Leung Abdulrahman M Aljebreen Emilio Brocchi Eugene B Chang Wei-Chih Liao Takeshi Mizukami Melvin Schapiro Konstantinos Triantafyllou | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，3： | 3 |
| 4 | Green tea polyphenols as an anti-oxidant and anti-inflammatory agent for cardiovascular protection 显示文摘 | TIPOE G L LEUNG T M HUNG M W | 2007 | Cardiovasc Hematol Disord Drug Targets2007，7，2： | 1 |
| 5 | A prospective randomized study of chemotherapy adjunctive to definitive radiotherapy in advanced nasopharyngeal carcinoma显示文摘 | Chan A T Teo P M Leung T W | 1995 | Int J Radiat Oncol Biol Phys1995，33，3： | 1 |
| 6 | Distinguishing between different pathways of bilayer disruption by the related antimicrobial peptides cecropin B, B1 and B3显示文摘 | CHEN H M LEUNG K W THAKUR N N | 2003 | Eur J Biochem2003，270，5： | 1 |
| 7 | Human infection with influenza H9N2显示文摘 | Peiris M Yuen K Y Leung C W | 1999 | lancet1999，354，： | 1 |
| 8 | Applications of genetic search and simulated annealing to the two-dimensional non-guillotine cutting stock problem显示文摘 | Leung T W Yung C H Tmutt M D | 2001 | Computers & Industrial Engineering2001，40，3： | 1 |
| 9 | Learning Nonlinear Multi- regression Networks Based on Evolutionary Computation 显示文摘 | Leung K S Wong M L Lam W | 2002 | IEEE Transaction on Systems Man and Cybernetics Part B2002，32，： | 1 |
| 10 | Visualization of anterior chamber angle dynamics using optical coherence mography 显示文摘 | Leung C K Chan W M Ko C Y | 2005 | Ophthalmology2005，112，6： | 1 |
| 11 | A Rough Set Approach for The Discovery of Classification Rules in Interval valued Information Systems 显示文摘 | Leung Y Fisher M M Wu W Z | 2008 | International Journal Of Approximate Reasoning2008，47，： | 1 |
| 12 | The rode of chemotherapy in the management of nasopharyngea carcinomal显示文摘 | Chan A T C Teo P M Leung T W | 1998 | Cancer1998，82，6： | 1 |
| 13 | Comparative Study of Artificial Neural Networks and Multiple Regression Analysis for Predicting Hoisting Times of Tower Cranes显示文摘 | Arthur W T Leung C M Tam D K Liu | 2000 | Building and Environment2000，36，4： | 1 |
| 14 | Radiation dose from cone beam computed tomography for image-guided radiation therapy 显示文摘 | Kan M W Leung L H Wong W | 2008 | Int J Radiat Oncol Biol Phys2008，70，1： | 1 |
| 15 | Rule acquisition and complexity reduction in formal decision contexts显示文摘 | Shao M W Leung Y Wu W Z | 2004 | International Journal of Approximate Reasoning In Press2004，163，： | 1 |
| 16 | Distribution,fate and risk assessment of antibiotics in sewage treatment plants in Hong Kong,South China显示文摘 | Leung H W Minh T B Murphy M B | | 0，，： | 1 |
| 17 | The Avrlb locus of Phytophthora sojae encodes an elicitor and a regulator required for avirulence on soybean plants carrying resistance gene Rpslb显示文摘 | Shan W Cao M Leung D | 2004 | Mol Plant Microbe Interact2004，17，： | 1 |
| 18 | Human infection withinfluenza H9N2显示文摘 | Peiris M Yuen K Y Leung C W | 1999 | Lancet1999，354，91： | 1 |
| 19 | A rough set approach for discovery of classification rules in interval- valued information systems显示文摘 | Leung Y Fischer M M Wu W Z | 2008 | Int J of Approximate Reasoning2008，47，2： | 1 |
| 20 | Fate of Listeria monocyto genes and Aeromonas hydrophilia on packaged channel catfish fillets stored显示文摘 | Leung C K Huang Y W Harrison M A | 1992 | Journal of Food Protection1992，55，9： | 1 |
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